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2025-05-09 18:27:02, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_000833 14468 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate
2A (GRIN2A), transcript variant 2, mRNA.
ACCESSION NM_000833
VERSION NM_000833.3 GI:197313634
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 14468)
AUTHORS Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI,
Ripke S, Santangelo S and Sullivan PF.
CONSRTM Cross-Disorder Group of the Psychiatric Genomics Consortium
TITLE Identification of risk loci with shared effects on five major
psychiatric disorders: a genome-wide analysis
JOURNAL Lancet 381 (9875), 1371-1379 (2013)
PUBMED 23453885
REMARK Erratum:[Lancet. 2013 Apr 20;381(9875):1360]
REFERENCE 2 (bases 1 to 14468)
AUTHORS Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
Johnson,J.A. and Boerwinkle,E.
TITLE Genome-wide association analyses suggest NELL1 influences adverse
metabolic response to HCTZ in African Americans
JOURNAL Pharmacogenomics J. (2013) In press
PUBMED 23400010
REMARK Publication Status: Available-Online prior to print
REFERENCE 3 (bases 1 to 14468)
AUTHORS Lieberman,R., Levine,E.S., Kranzler,H.R., Abreu,C. and Covault,J.
TITLE Pilot study of iPS-derived neural cells to examine biologic effects
of alcohol on human neurons in vitro
JOURNAL Alcohol. Clin. Exp. Res. 36 (10), 1678-1687 (2012)
PUBMED 22486492
REMARK GeneRIF: After 7 days of chronic alcohol exposure there are
significant increases in mRNA expression of GRIN2A in cultured
neurons derived from alcoholic subjects, but not in cultures from
nonalcoholics.
REFERENCE 4 (bases 1 to 14468)
AUTHORS Liu,L., Li,J., Yao,J., Yu,J., Zhang,J., Ning,Q., Wen,Z., Yang,D.,
He,Y., Kong,X., Song,Q., Chen,M., Yang,H., Liu,Q., Li,S. and Lin,J.
TITLE A genome-wide association study with DNA pooling identifies the
variant rs11866328 in the GRIN2A gene that affects disease
progression of chronic HBV infection
JOURNAL Viral Immunol. 24 (5), 397-402 (2011)
PUBMED 22004137
REMARK GeneRIF: Polymorphism rs11866328 in the GRIN2A gene might be a
genetic variant underlying the susceptibility of HBV carriers to
disease progression.
REFERENCE 5 (bases 1 to 14468)
AUTHORS Tarabeux J, Kebir O, Gauthier J, Hamdan FF, Xiong L, Piton A,
Spiegelman D, Henrion E, Millet B, Fathalli F, Joober R, Rapoport
JL, DeLisi LE, Fombonne E, Mottron L, Forget-Dubois N, Boivin M,
Michaud JL, Drapeau P, Lafreniere RG, Rouleau GA and Krebs MO.
CONSRTM S2D team
TITLE Rare mutations in N-methyl-D-aspartate glutamate receptors in
autism spectrum disorders and schizophrenia
JOURNAL Transl Psychiatry 1, E55 (2011)
PUBMED 22833210
REMARK GeneRIF: Two de novo mutations in GRIN2A are identified in patients
with sporadic schizophrenia.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 14468)
AUTHORS Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
TITLE Domain interaction between NMDA receptor subunits and the
postsynaptic density protein PSD-95
JOURNAL Science 269 (5231), 1737-1740 (1995)
PUBMED 7569905
REFERENCE 7 (bases 1 to 14468)
AUTHORS Magnuson,D.S., Knudsen,B.E., Geiger,J.D., Brownstone,R.M. and
Nath,A.
TITLE Human immunodeficiency virus type 1 tat activates
non-N-methyl-D-aspartate excitatory amino acid receptors and causes
neurotoxicity
JOURNAL Ann. Neurol. 37 (3), 373-380 (1995)
PUBMED 7695237
REFERENCE 8 (bases 1 to 14468)
AUTHORS Sakimura,K., Kutsuwada,T., Ito,I., Manabe,T., Takayama,C.,
Kushiya,E., Yagi,T., Aizawa,S., Inoue,Y., Sugiyama,H. et al.
TITLE Reduced hippocampal LTP and spatial learning in mice lacking NMDA
receptor epsilon 1 subunit
JOURNAL Nature 373 (6510), 151-155 (1995)
PUBMED 7816096
REFERENCE 9 (bases 1 to 14468)
AUTHORS Sokolov,B.P. and Prockop,D.J.
TITLE A rapid and simple PCR-based method for isolation of cDNAs from
differentially expressed genes
JOURNAL Nucleic Acids Res. 22 (19), 4009-4015 (1994)
PUBMED 7524031
REFERENCE 10 (bases 1 to 14468)
AUTHORS Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
TITLE Heteromeric NMDA receptors: molecular and functional distinction of
subtypes
JOURNAL Science 256 (5060), 1217-1221 (1992)
PUBMED 1350383
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from U90277.1, U09002.1, AC007218.6
and R43097.1.
This sequence is a reference standard in the RefSeqGene project.
On Aug 28, 2008 this sequence version replaced gi:6006002.
Summary: N-methyl-D-aspartate (NMDA) receptors are a class of
ionotropic glutamate-gated ion channels. These receptors have been
shown to be involved in long-term potentiation, an
activity-dependent increase in the efficiency of synaptic
transmission thought to underlie certain kinds of memory and
learning. NMDA receptor channels are heteromers composed of the key
receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2
subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and
NMDAR2D (GRIN2D). Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
[provided by RefSeq, Aug 2008].
Transcript Variant: This variant (2) is alternatively spliced at
the 5' end, hence contains a different 5' UTR compared to variant
1. Transcript variants 1 and 2 encode the same isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no quality transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U90277.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025083 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-4740 U90277.1 1-4740
4741-5192 U09002.1 4586-5037
5193-14315 AC007218.6 120366-129488 c
14316-14468 R43097.1 1-153 c
FEATURES Location/Qualifiers
source 1..14468
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.2"
gene 1..14468
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="glutamate receptor, ionotropic, N-methyl
D-aspartate 2A"
/db_xref="GeneID:2903"
/db_xref="HGNC:4585"
/db_xref="HPRD:00698"
/db_xref="MIM:138253"
exon 1..101
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
exon 102..292
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
misc_feature 227..229
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="upstream in-frame stop codon"
exon 293..724
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
CDS 311..4705
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="isoform 1 precursor is encoded by transcript
variant 2; N-methyl-D-aspartate receptor channel, subunit
epsilon-1; glutamate [NMDA] receptor subunit epsilon-1;
N-methyl-D-aspartate receptor subunit 2A; NMDA receptor
subtype 2A; hNR2A; N-methyl D-aspartate receptor subtype
2A; glutamate receptor ionotropic, NMDA 2A"
/codon_start=1
/product="glutamate receptor ionotropic, NMDA 2A isoform 1
precursor"
/protein_id="NP_000824.1"
/db_xref="GI:4504125"
/db_xref="CCDS:CCDS10539.1"
/db_xref="GeneID:2903"
/db_xref="HGNC:4585"
/db_xref="HPRD:00698"
/db_xref="MIM:138253"
/translation="
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNPATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV
"
sig_peptide 311..370
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
mat_peptide 371..4702
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/product="glutamate receptor ionotropic, NMDA 2A isoform
1"
misc_feature 404..1486
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="N-terminal leucine/isoleucine/valine-binding
protein (LIVBP)-like domain of the NR2 subunit of NMDA
receptor family; Region: PBP1_iGluR_NMDA_NR2; cd06378"
/db_xref="CDD:107373"
misc_feature order(548..550,554..559,566..571,668..670,875..877,
884..886,926..928,932..934)
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="putative dimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:107373"
misc_feature 1328..1330
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
/citation=[10]
misc_feature 1682..>1951
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="Bacterial periplasmic transport systems use
membrane-bound complexes and substrate-bound,
membrane-associated, periplasmic binding proteins (PBPs)
to transport a wide variety of substrates, such as, amino
acids, peptides, sugars, vitamins and inorganic...;
Region: PBPb; cd00134"
/db_xref="CDD:29040"
misc_feature 1790..1792
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
/citation=[10]
misc_feature 1841..1849
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
Region: Glutamate binding (By similarity)"
misc_feature 1853..1855
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
/citation=[10]
misc_feature 1976..2794
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="Ligand-gated ion channel; Region: Lig_chan;
pfam00060"
/db_xref="CDD:189368"
misc_feature 1976..2038
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
transmembrane region"
misc_feature 2150..2152
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="non-experimental evidence, no additional
details recorded"
/note="Functional determinant of NMDA receptors (By
similarity); propagated from UniProtKB/Swiss-Prot
(Q12879.1); other site"
misc_feature 2210..2272
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
transmembrane region"
misc_feature <2351..2698
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="Bacterial periplasmic transport systems use
membrane-bound complexes and substrate-bound,
membrane-associated, periplasmic binding proteins (PBPs)
to transport a wide variety of substrates, such as, amino
acids, peptides, sugars, vitamins and inorganic...;
Region: PBPb; cd00134"
/db_xref="CDD:29040"
misc_feature 2375..2380
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
Region: Glutamate binding (By similarity)"
misc_feature order(2450..2452,2462..2464,2480..2482)
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="membrane-bound complex binding site; other site"
/db_xref="CDD:29040"
misc_feature 2579..2596
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="hinge residues; other site"
/db_xref="CDD:29040"
misc_feature 2759..2821
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
transmembrane region"
misc_feature 2825..4702
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/note="N-methyl D-aspartate receptor 2B3 C-terminus;
Region: NMDAR2_C; pfam10565"
/db_xref="CDD:151103"
misc_feature 3623..3625
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 4004..4006
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:00449"
misc_feature 4109..4111
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 4181..4183
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:06532"
misc_feature 4181..4183
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:12127"
misc_feature 4319..4321
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 4469..4471
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01819"
misc_feature 4556..4558
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01498"
misc_feature 4694..4702
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
Region: PDZ-binding"
variation 598
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:74853460"
variation 707
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:77288930"
exon 725..1317
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
variation 732
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:78631453"
variation 1213
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:78241448"
exon 1318..1432
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
variation 1379
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:78929970"
variation 1415
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:77772378"
exon 1433..1638
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
variation 1585
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229193"
exon 1639..1807
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
exon 1808..1961
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
exon 1962..2087
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
exon 2088..2317
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
exon 2318..2478
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
variation 2334
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="c"
/db_xref="dbSNP:75130648"
exon 2479..2666
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
exon 2667..2905
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
exon 2906..14446
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/inference="alignment:Splign:1.39.8"
variation 3070
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:80138441"
variation 3193
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:77705198"
STS 3685..3820
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="D16S2608E"
/db_xref="UniSTS:151676"
variation 3888
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:75761674"
STS 4443..4667
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="Grin2a"
/db_xref="UniSTS:143261"
variation 4469
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="t"
/db_xref="dbSNP:78444267"
variation 4515
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:74935155"
variation 4617
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:77029288"
STS 4780..5013
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="G10721"
/db_xref="UniSTS:65875"
STS 4988..5087
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="D16S2596E"
/db_xref="UniSTS:19233"
STS 5011..5065
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="GRIN2A"
/db_xref="UniSTS:480253"
polyA_signal 5158..5163
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
polyA_site 5178
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
variation 5230
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="g"
/db_xref="dbSNP:11575877"
STS 5549..5886
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="SHGC-12942"
/db_xref="UniSTS:56536"
STS 5588..6434
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="GRIN2A_118"
/db_xref="UniSTS:277296"
STS 7294..7459
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="RH15627"
/db_xref="UniSTS:83136"
variation 7455
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="a"
/replace="c"
/db_xref="dbSNP:200830330"
STS 9034..9164
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="RH98186"
/db_xref="UniSTS:85660"
polyA_signal 9276..9281
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
polyA_signal 9312..9317
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
polyA_site 9335
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
STS 11748..11847
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="D16S3229"
/db_xref="UniSTS:73210"
variation 13020
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="g"
/replace="t"
/db_xref="dbSNP:1062722"
STS 13110..13246
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="RH15641"
/db_xref="UniSTS:35717"
STS 13231..13331
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="D16S2599E"
/db_xref="UniSTS:151667"
STS 14137..14382
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="D16S3187"
/db_xref="UniSTS:83252"
STS 14197..14386
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="D16S2952"
/db_xref="UniSTS:61483"
variation 14248
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/replace="c"
/replace="t"
/db_xref="dbSNP:3183295"
STS 14286..14383
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
/standard_name="RH91712"
/db_xref="UniSTS:86107"
polyA_signal 14411..14416
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
polyA_site 14446
/gene="GRIN2A"
/gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
ORIGIN
atcatgggaccgggtgagcgctgagaatcgcggccgcagccatcagccctggagatgaccaggagcggccactgctgagaactatgtggagagaggctgcgagccctgctgcagagcctccggctgggatagccgccccccgtgggggcgatgcggacagcgcgggacagccaggggagcgcgctggggccgcagcatgcgggaacccgctaaacccggtggctgctgaggcggccgagatgctcgtgcgcgcagcgcgccccactgcatcctcgaccttctcgggctacagggaccgtcagtggcgactatgggcagagtgggctattggaccctgctggtgctgccggcccttctggtctggcgcggtccggcgccgagcgcggcggcggagaagggtccccccgcgctaaatattgcggtgatgctgggtcacagccacgacgtgacagagcgcgaacttcgaacactgtggggccccgagcaggcggcggggctgcccctggacgtgaacgtggtagctctgctgatgaaccgcaccgaccccaagagcctcatcacgcacgtgtgcgacctcatgtccggggcacgcatccacggcctcgtgtttggggacgacacggaccaggaggccgtagcccagatgctggattttatctcctcccacaccttcgtccccatcttgggcattcatgggggcgcatctatgatcatggctgacaaggatccgacgtctaccttcttccagtttggagcgtccatccagcagcaagccacggtcatgctgaagatcatgcaggattatgactggcatgtcttctccctggtgaccactatcttccctggctacagggaattcatcagcttcgtcaagaccacagtggacaacagctttgtgggctgggacatgcagaatgtgatcacactggacacttcctttgaggatgcaaagacacaagtccagctgaagaagatccactcttctgtcatcttgctctactgttccaaagacgaggctgttctcattctgagtgaggcccgctcccttggcctcaccgggtatgatttcttctggattgtccccagcttggtctctgggaacacggagctcatcccaaaagagtttccatcgggactcatttctgtctcctacgatgactgggactacagcctggaggcgagagtgagggacggcattggcatcctaaccaccgctgcatcttctatgctggagaagttctcctacatccccgaggccaaggccagctgctacgggcagatggagaggccagaggtcccgatgcacaccttgcacccatttatggtcaatgttacatgggatggcaaagacttatccttcactgaggaaggctaccaggtgcaccccaggctggtggtgattgtgctgaacaaagaccgggaatgggaaaaggtgggcaagtgggagaaccatacgctgagcctgaggcacgccgtgtggcccaggtacaagtccttctccgactgtgagccggatgacaaccatctcagcatcgtcaccctggaggaggccccattcgtcatcgtggaagacatagaccccctgaccgagacgtgtgtgaggaacaccgtgccatgtcggaagttcgtcaaaatcaacaattcaaccaatgaggggatgaatgtgaagaaatgctgcaaggggttctgcattgatattctgaagaagctttccagaactgtgaagtttacttacgacctctatctggtgaccaatgggaagcatggcaagaaagttaacaatgtgtggaatggaatgatcggtgaagtggtctatcaacgggcagtcatggcagttggctcgctcaccatcaatgaggaacgttctgaagtggtggacttctctgtgccctttgtggaaacgggaatcagtgtcatggtttcaagaagtaatggcaccgtctcaccttctgcttttctagaaccattcagcgcctctgtctgggtgatgatgtttgtgatgctgctcattgtttctgccatagctgtttttgtctttgaatacttcagccctgttggatacaacagaaacttagccaaagggaaagcaccccatgggccttcttttacaattggaaaagctatatggcttctttggggcctggtgttcaataactccgtgcctgtccagaatcctaaagggaccaccagcaagatcatggtatctgtatgggccttcttcgctgtcatattcctggctagctacacagccaatctggctgccttcatgatccaagaggaatttgtggaccaagtgaccggcctcagtgacaaaaagtttcagagacctcatgactattccccaccttttcgatttgggacagtgcctaatggaagcacggagagaaacattcggaataactatccctacatgcatcagtacatgaccaaatttaatcagaaaggagtagaggacgccttggtcagcctgaaaacggggaagctggacgctttcatctacgatgccgcagtcttgaattacaaggctgggagggatgaaggctgcaagctggtgaccatcgggagtgggtacatctttgccaccaccggttatggaattgcccttcagaaaggctctccttggaagaggcagatcgacctggccttgcttcagtttgtgggtgatggtgagatggaggagctggagaccctgtggctcactgggatctgccacaacgagaagaacgaggtgatgagcagccagctggacattgacaacatggcgggcgtattctacatgctggctgccgccatggcccttagcctcatcaccttcatctgggagcacctcttctactggaagctgcgcttctgtttcacgggcgtgtgctccgaccggcctgggttgctcttctccatcagcaggggcatctacagctgcattcatggagtgcacattgaagaaaagaagaagtctccagacttcaatctgacgggatcccagagcaacatgttaaaactcctccggtcagccaaaaacatttccagcatgtccaacatgaactcctcaagaatggactcacccaaaagagctgctgacttcatccaaagaggttccctcatcatggacatggtttcagataaggggaatttgatgtactcagacaacaggtcctttcaggggaaagagagcatttttggagacaacatgaacgaactccaaacatttgtggccaaccggcagaaggataacctcaataactatgtattccagggacaacatcctcttactctcaatgagtccaaccctaacacggtggaggtggccgtgagcacagaatccaaagcgaactctagaccccggcagctgtggaagaaatccgtggattccatacgccaggattcactatcccagaatccagtctcccagagggatgaggcaacagcagagaataggacccactccctaaagagccctaggtatcttccagaagagatggcccactctgacatttcagaaacgtcaaatcgggccacgtgccacagggaacctgacaacagtaagaaccacaaaaccaaggacaactttaaaaggtcagtggcctccaaataccccaaggactgtagtgaggtcgagcgcacctacctgaaaaccaaatcaagctcccctagagacaagatctacactatagatggtgagaaggagcctggtttccacttagatccaccccagtttgttgaaaatgtgaccctgcccgagaacgtggacttcccggacccctaccaggatcccagtgaaaacttccgcaagggggactccacgctgccaatgaaccggaaccccttgcataatgaagaggggctttccaacaacgaccagtataaactctactccaagcacttcaccttgaaagacaagggttccccgcacagtgagaccagcgagcgataccggcagaactccacgcactgcagaagctgcctttccaacatgcccacctattcaggccacttcaccatgaggtcccccttcaagtgcgatgcctgcctgcggatggggaacctctatgacatcgatgaagaccagatgcttcaggagacaggtaacccagccaccggggagcaggtctaccagcaggactgggcacagaacaatgcccttcaattacaaaagaacaagctaaggattagccgtcagcattcctacgataacattgtcgacaaacctagggagctagaccttagcaggccctcccggagcataagcctcaaggacagggaacggcttctggagggaaatttttacggcagcctgtttagtgtcccctcaagcaaactctcggggaaaaaaagctcccttttcccccaaggtctggaggacagcaagaggagcaagtctctcttgccagaccacacctccgataaccctttcctccactcccacagggatgaccaacgcttggttattgggagatgcccctcggacccttacaaacactcgttgccatcccaggcggtgaatgacagctatcttcggtcgtccttgaggtcaacggcatcgtactgttccagggacagtcggggccacaatgatgtgtatatttcggagcatgttatgccttatgctgcaaataagaataatatgtactctacccccagggttttaaattcctgcagcaatagacgcgtgtacaagaaaatgcctagtatcgaatctgatgtttaaaaatcttccattaatgttttatctatagggaaatatacgtaatggccaatgttctggagggtaaatgttggatgtccaatagtgccctgctaagaggaagaagatgtagggaggtattttgttgttgttgttgttggctcttttgcacacggcttcatgccataatcttccactcaaggaatcttgtgaggtgtgtgctgagcatggcagacaccagataggtgagtccttaaccaaaaataactaactacataagggcaagtctccgggacatgcctactgggtatgttggcaataatgatgcattggatgccaatggtgatgttatgatttcctatattccaaattccattaaggtcagcccaccatgtaattttctcatcagaaatgcctaatggtttctctaatacagaataagcaatatggtgtgcatgtaaacctgacacagacaaaataaaaacagttaagaatgcatctgcactgtagtgcgattgacatgtgcaagagattaggaagtttggctcgtaacagtttcagctttcttgttatgccttccatcacagcccaggctcaccccaagaactccaggctcccctaaagaatagcaaatcagtgtgttcgtgatgactgtgctaccttcattatagttcatttccaagacacatctggagccaaaggcccgagggaccctcaggtggggagagctacaggaatctctttggatgttgatgtgtgtttctctcaccctcggcttcgatggtcttgttcagagctgcataaactaacacatttatgtctccgagatctaagtgtggatcttctgtctgtgacacagtggccattgtagtttatcccgaagacgcctatgtacgtaagtttgcatttcctcccttctggtgatgactcagggttgtatagtatctgttaccccttccctcccagagtaaccataactcgttccgtttccaaacagccatggtggtgtccaattagctgtgtatcgctcttcccagagttgttaatgtggtgacatgcaccaacagccgtatgtgtactgtgatctgtaagaagtacaatgccatctgtctgccgaaggctagcatggttttaggtttatcttccttcacatccagaaattctgttggacactcacttccaccccaaactcctcaaatcaaaagccttcaaaacacgaggcactcttggatctaccctgagtatcctccaaactgtggatacagtttagtgagacaagcaatttctcccttctgagttattctctctgttggtggcaaaccacttcatagcaccaacagagatgtaggaaaaattcctcaaagtatttgtcatttctgagtcgcctgcattatcccattcttattctcctcaaacctgtgcatatatgacatgaaatgatatccattttttttttaagttagagacagagaggggaatacttatgcatggggagcctgttagcacagtgcctgccacaaaaacaagtgcccccgacaagatagttgctatgttatgacactttctcagatcaggattttctagtttaaaaattaaatatcataaaaccagcaaataatattaactaaaccttttatatagttctactctgttaattagtgtatttcatgtacatgaatatttttgaagtatttgggataactagccatcagtgtttgcagaagacctcagtctgttttgggccattacggaaacactaagctaatgtagactcgcctggccatttcctggtttcctcctgcattctgctttacattcttgaagaaagggataaagtggcaggttgaaaaattatcccatttcttctcctcatggtgtgcgttctgttttgtaagtattattttcttgcatgtgggcaagtgtcagggatgattcccttaaagctcaaggatgcatggaatagctccatctttgggaaagtacacctgacctacagtgttcctataatgaaaagtggttgcaataaatttcagggtcaatcatagggagacagagggaggcagtgggtgagaggagcttcctttcatttttgaaaggcagaaggggctgactaggtgctggggatgcatgtgcttgaaaatgacattttatttcccggatgctgtacctctgctgccccaagacccagccatggagaagcctggatcgaagggcccagaatagtcaccccaacatctgatcctaaatctgaatctccatgactgtgtagccttttagccctttctaccttctgcccttccagtgcattccagaccttaatccaccccagcaaggatcgcctccatttcctcatgagtctgggatgttttgacatgaatgaattaaaaagtcttcccagaatacagaagagtgatttgtcgtcaagccaaagaggctttctgtcttcctctggtgtcctctaaacccagggggctgccaaatgccacagagacctccagggagagtgagagttatacttggactgacttcatcggtcagaaagccttcccctaacagcagcattatttctgctattaaccccatacatctctggataaagaaactgaaaacgtggcctttggaagaatcaacagtaatgttgtgaaaaaaatatatattcttttcactgaccgaagtgttttttcaaataaataatcagaaatgttatgctacacaaagtttatggtatcccttctctactaattcaatgactcttcaatgtgatgatcccaagcaaaaaaaaaaaaaaaaaaaaaaaatcaactactgatcagatggtcaatttctaaggaaaagatgtagagttattcaaaggtcatctaagtcagttcagtctttgcaaaaagaatatcaggaatgtaacgtccagtggtaaatggaacccacagtatgagaagtaacaagaattaaataggaagcctggaagcctgagactatagatctatcacagaagattcccgtaacatatcccagctctgagttcttagatttgttgatgtcaaggagcccaaatttctgaacacaaatgcctgagtttcagctggcttaagtcagagctggcatccataatgatattttgttaattctaattggttttccccacttgagaaggacccaactagtcctcagataggtacacttgaatgcaaacggttgggtctctgtccatgggtaatagcacgcacatgcaaccaatttaaaatactctgggtaagagagtcttctagagcataaactgtacttgagaaacctttgtgcttctggaaaatgggtttcatcatccttacatctgcaggttcttaggccacttatggtttcaatgctctgagctggcaagtccctataggtctatctttctgccagagagacttgcaggattataatctcacaatctcaccactcattactgttatgtcctctgcaaatctctctgcgttattttagccagcaccatgactgggcatccacggattactcttgattttctcttccctgattcacaggatgccagagagtctgagtatttagtttttctggtgaaagcattaaaattcacacattgcagcaaaatctgtcaaatcatttcacgcttattttctggggagaaaaatagaaaattacaccttgtttacaaatgaaatagtttcacttaaatgggactctagccaaggcagttaattagtcaaaagatccacagctgtcatatagtcacacattgtttattctatttgctatgtcgaccactgatgtgtatttaatattctgcatccttcacaggaaatgacaaatgccctgaattatttgcaaatagaattgctaatgaaaaagaaaaaaaatgttgatgttaattaaatggtgattaaaaatttatctcctttaaatctaaaaagtgcagctttaataatcagttgtcatataaataagtaccttgtactgaaatcccttgcggtttaagacctaaataaacactaatttgagaactctaaataccttacagaggagctggatatattcgttaacattatgcacattcctgtactgtttctttgtgcatagctgttgtgcatgaatccttgaaaaggggacatgcgttgtttctgaaatggagcctgtttgtattaaccatggctatagtagacatgattggactcaaagaaaaagaagtttgagtaggtggaagctaaatgtgttgcttgatatttaatgagtgaagggttctatgtaaaggcaattttccttccaaaagtactgtttattttcactggagacaaaattagacctttccagataccccatctctttttggtgaacagggttgaaagtgctgtggggtctatacttgaaaagttctcccaatatgcagttactgtttcccattcaatccctatacattgtactgtgttcatatctaattgtatcagatgaggtcagcttgccacttgatatagatcagagatgatcaaatgcacttatcctgtgaatacaactgcttgtgtacacatgtatataatatacatgcttgatttctacaattcacacgtaagtgtattatccaaataaaattgtacatattgtaaagtttatgttaaaaattaaatggtgatgatggtattaacacatggaaaacccattctggttatttttatgggaggatatttctgtagagagggcactatatttttttaatctcagttgtagggaggatgacagagcctaagtagaatatgggtgttggcgttcttggccccttctttaaaaaacaaaactctgggatgaggggtatagaatatattctgctcgcatttgcttctgaagacaatgccgatatggacttgtgtgtgatttccttaaacacatcaaagggcatagatttcctatttaaattccttatcctctttcctcacctgcactctttctgtgcccagcagtactttcagtatagtattagctagaagtgcctgcccagaagggtcttagaaaaatagagttcgtagaaccacaccaaaagttaggagaaggggaggagagatgagaaaaatgaagtttacaaatgggcagttgcctgtttaagatcatcaagttagagagtatcagagcgaggattagatccaagacatggttcaatttctggctcgattctctgaccgggctgacttatttctaggtttctttcaaggggaaactcctgagtagctctggaataagagccagagatccccataaggctgccctggtttttgttttgttttgttttttgtttttgccacttgccccagaaag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//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2903 -> Molecular function: GO:0004972 [N-methyl-D-aspartate selective glutamate receptor activity] evidence: IEA
GeneID:2903 -> Molecular function: GO:0005234 [extracellular-glutamate-gated ion channel activity] evidence: IEA
GeneID:2903 -> Molecular function: GO:0005262 [calcium channel activity] evidence: IEA
GeneID:2903 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2903 -> Molecular function: GO:0008270 [zinc ion binding] evidence: ISS
GeneID:2903 -> Biological process: GO:0001964 [startle response] evidence: IEA
GeneID:2903 -> Biological process: GO:0001975 [response to amphetamine] evidence: IEA
GeneID:2903 -> Biological process: GO:0006810 [transport] evidence: TAS
GeneID:2903 -> Biological process: GO:0007215 [glutamate receptor signaling pathway] evidence: TAS
GeneID:2903 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
GeneID:2903 -> Biological process: GO:0007611 [learning or memory] evidence: TAS
GeneID:2903 -> Biological process: GO:0007613 [memory] evidence: IEA
GeneID:2903 -> Biological process: GO:0008104 [protein localization] evidence: IEA
GeneID:2903 -> Biological process: GO:0008542 [visual learning] evidence: IEA
GeneID:2903 -> Biological process: GO:0009611 [response to wounding] evidence: IEA
GeneID:2903 -> Biological process: GO:0019233 [sensory perception of pain] evidence: IEA
GeneID:2903 -> Biological process: GO:0022008 [neurogenesis] evidence: IEA
GeneID:2903 -> Biological process: GO:0030431 [sleep] evidence: IEA
GeneID:2903 -> Biological process: GO:0033058 [directional locomotion] evidence: IEA
GeneID:2903 -> Biological process: GO:0042177 [negative regulation of protein catabolic process] evidence: IEA
GeneID:2903 -> Biological process: GO:0042417 [dopamine metabolic process] evidence: IEA
GeneID:2903 -> Biological process: GO:0042428 [serotonin metabolic process] evidence: IEA
GeneID:2903 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:2903 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:2903 -> Biological process: GO:0045471 [response to ethanol] evidence: IDA
GeneID:2903 -> Biological process: GO:0048167 [regulation of synaptic plasticity] evidence: IEA
GeneID:2903 -> Biological process: GO:0051930 [regulation of sensory perception of pain] evidence: IEA
GeneID:2903 -> Biological process: GO:0060079 [regulation of excitatory postsynaptic membrane potential] evidence: IEA
GeneID:2903 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2903 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:2903 -> Cellular component: GO:0008021 [synaptic vesicle] evidence: IEA
GeneID:2903 -> Cellular component: GO:0009986 [cell surface] evidence: ISS
GeneID:2903 -> Cellular component: GO:0014069 [postsynaptic density] evidence: IEA
GeneID:2903 -> Cellular component: GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex] evidence: IDA
GeneID:2903 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
GeneID:2903 -> Cellular component: GO:0042734 [presynaptic membrane] evidence: IEA
GeneID:2903 -> Cellular component: GO:0043005 [neuron projection] evidence: IEA
GeneID:2903 -> Cellular component: GO:0045211 [postsynaptic membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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