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2025-05-09 18:23:27, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005165 1665 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens aldolase C, fructose-bisphosphate (ALDOC), mRNA.
ACCESSION NM_005165
VERSION NM_005165.2 GI:68303552
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1665)
AUTHORS Martins-de-Souza,D., Schmitt,A., Roder,R., Lebar,M.,
Schneider-Axmann,T., Falkai,P. and Turck,C.W.
TITLE Sex-specific proteome differences in the anterior cingulate cortex
of schizophrenia
JOURNAL J Psychiatr Res 44 (14), 989-991 (2010)
PUBMED 20381070
REMARK GeneRIF: This protein has been found differentially expressed in
the anterior cingulate cortex in men patients with schizophrenia.
REFERENCE 2 (bases 1 to 1665)
AUTHORS Sultana,R., Perluigi,M., Newman,S.F., Pierce,W.M., Cini,C.,
Coccia,R. and Butterfield,D.A.
TITLE Redox proteomic analysis of carbonylated brain proteins in mild
cognitive impairment and early Alzheimer's disease
JOURNAL Antioxid. Redox Signal. 12 (3), 327-336 (2010)
PUBMED 19686046
REMARK GeneRIF: Results identified fructose bisphospate aldolase C that
showed elevated levels of protein carbonyls in inferior parietal
lobule (IPL) from subjects with early stage-Alzheimer's disease.
REFERENCE 3 (bases 1 to 1665)
AUTHORS Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Maccarrone,G.,
Hunyadi-Gulyas,E., Eberlin,M.N., Souza,G.H., Marangoni,S.,
Novello,J.C., Turck,C.W. and Dias-Neto,E.
TITLE Proteomic analysis of dorsolateral prefrontal cortex indicates the
involvement of cytoskeleton, oligodendrocyte, energy metabolism and
new potential markers in schizophrenia
JOURNAL J Psychiatr Res 43 (11), 978-986 (2009)
PUBMED 19110265
REMARK GeneRIF: This protein has been found differentially expressed in
the dorsolateral prefrontal cortex from patients with
schizophrenia.
Erratum:[J Psychiatr Res. 2011 Feb;45(2):283]
REFERENCE 4 (bases 1 to 1665)
AUTHORS Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
Marangoni,S., Novello,J.C., Maccarrone,G., Turck,C.W. and
Dias-Neto,E.
TITLE Alterations in oligodendrocyte proteins, calcium homeostasis and
new potential markers in schizophrenia anterior temporal lobe are
revealed by shotgun proteome analysis
JOURNAL J Neural Transm 116 (3), 275-289 (2009)
PUBMED 19034380
REMARK GeneRIF: This protein has been found differentially expressed in
the temporal lobe from patients with schizophrenia.
REFERENCE 5 (bases 1 to 1665)
AUTHORS Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Novello,J.C.,
Marangoni,S., Turck,C.W. and Dias-Neto,E.
TITLE Proteome analysis of schizophrenia patients Wernicke's area reveals
an energy metabolism dysregulation
JOURNAL BMC Psychiatry 9, 17 (2009)
PUBMED 19405953
REMARK GeneRIF: This protein has been found differentially expressed in
the Wernicke's Area from patients with schizophrenia.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1665)
AUTHORS Buono,P., Mancini,F.P., Izzo,P. and Salvatore,F.
TITLE Characterization of the transcription-initiation site and of the
promoter region within the 5' flanking region of the human aldolase
C gene
JOURNAL Eur. J. Biochem. 192 (3), 805-811 (1990)
PUBMED 2209624
REFERENCE 7 (bases 1 to 1665)
AUTHORS Rocchi,M., Vitale,E., Covone,A., Romeo,G., Santamaria,R., Buono,P.,
Paolella,G. and Salvatore,F.
TITLE Assignment of human aldolase C gene to chromosome 17, region
cen----q21.1
JOURNAL Hum. Genet. 82 (3), 279-282 (1989)
PUBMED 2731939
REFERENCE 8 (bases 1 to 1665)
AUTHORS Buono,P., Paolella,G., Mancini,F.P., Izzo,P. and Salvatore,F.
TITLE The complete nucleotide sequence of the gene coding for the human
aldolase C
JOURNAL Nucleic Acids Res. 16 (10), 4733 (1988)
PUBMED 3267224
REFERENCE 9 (bases 1 to 1665)
AUTHORS Tolan,D.R., Niclas,J., Bruce,B.D. and Lebo,R.V.
TITLE Evolutionary implications of the human aldolase-A, -B, -C, and
-pseudogene chromosome locations
JOURNAL Am. J. Hum. Genet. 41 (5), 907-924 (1987)
PUBMED 3674018
REFERENCE 10 (bases 1 to 1665)
AUTHORS Rottmann,W.H., Deselms,K.R., Niclas,J., Camerato,T., Holman,P.S.,
Green,C.J. and Tolan,D.R.
TITLE The complete amino acid sequence of the human aldolase C isozyme
derived from genomic clones
JOURNAL Biochimie 69 (2), 137-145 (1987)
PUBMED 3105602
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC005726.1, AF054987.1 and
BF345067.1.
On Jun 29, 2005 this sequence version replaced gi:4885062.
Summary: This gene encodes a member of the class I
fructose-biphosphate aldolase gene family. Expressed specifically
in the hippocampus and Purkinje cells of the brain, the encoded
protein is a glycolytic enzyme that catalyzes the reversible aldol
cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to
dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or
glyceraldehyde, respectively. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC003613.2, AF054987.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088, ERS025098 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-89 AC005726.1 80879-80967
90-1645 AF054987.1 1-1556
1646-1665 BF345067.1 153-172
FEATURES Location/Qualifiers
source 1..1665
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17cen-q12"
gene 1..1665
/gene="ALDOC"
/gene_synonym="ALDC"
/note="aldolase C, fructose-bisphosphate"
/db_xref="GeneID:230"
/db_xref="HGNC:418"
/db_xref="HPRD:02386"
/db_xref="MIM:103870"
exon 1..133
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
STS 90..1568
/gene="ALDOC"
/gene_synonym="ALDC"
/db_xref="UniSTS:486554"
exon 134..257
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
CDS 146..1240
/gene="ALDOC"
/gene_synonym="ALDC"
/EC_number="4.1.2.13"
/note="fructoaldolase C; aldolase 3; brain-type aldolase;
fructose-1,6-biphosphate triosephosphate lyase"
/codon_start=1
/product="fructose-bisphosphate aldolase C"
/protein_id="NP_005156.1"
/db_xref="GI:4885063"
/db_xref="CCDS:CCDS11236.1"
/db_xref="GeneID:230"
/db_xref="HGNC:418"
/db_xref="HPRD:02386"
/db_xref="MIM:103870"
/translation="
MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGIVVGIKVDKGVVPLAGTDGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKISERTPSALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACPIKYTPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASFNLNAINRCPLPRPWALTFSYGRALQASALNAWRGQRDNAGAATEEFIKRAEVNGLAAQGKYEGSGEDGGAAAQSLYIANHAY
"
misc_feature 182..1174
/gene="ALDOC"
/gene_synonym="ALDC"
/note="Fructose-1,6-bisphosphate aldolase; Region:
FBP_aldolase_I_a; cd00948"
/db_xref="CDD:188635"
misc_feature order(245..253,260..262,467..469,584..586,590..592,
707..709,833..835,956..964,1046..1048,1052..1057)
/gene="ALDOC"
/gene_synonym="ALDC"
/note="active site"
/db_xref="CDD:188635"
misc_feature order(476..478,629..631,638..643,650..652,662..664,
671..673,755..757,767..769,776..778,797..802,806..808,
818..820,917..922,926..928)
/gene="ALDOC"
/gene_synonym="ALDC"
/note="intersubunit interface [polypeptide binding]; other
site"
/db_xref="CDD:188635"
misc_feature 833..835
/gene="ALDOC"
/gene_synonym="ALDC"
/note="catalytic residue [active]"
/db_xref="CDD:188635"
misc_feature 1235..1237
/gene="ALDOC"
/gene_synonym="ALDC"
/experiment="experimental evidence, no additional details
recorded"
/note="Necessary for preference for fructose
1,6-bisphosphate over fructose 1-phosphate; propagated
from UniProtKB/Swiss-Prot (P09972.2); other site"
exon 258..469
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
variation 457
/gene="ALDOC"
/gene_synonym="ALDC"
/replace="c"
/replace="t"
/db_xref="dbSNP:11559066"
exon 470..524
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
exon 525..685
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
variation 535
/gene="ALDOC"
/gene_synonym="ALDC"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229541"
exon 686..769
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
exon 770..944
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
variation 835
/gene="ALDOC"
/gene_synonym="ALDC"
/replace="a"
/replace="g"
/db_xref="dbSNP:2228419"
exon 945..1144
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
exon 1145..1651
/gene="ALDOC"
/gene_synonym="ALDC"
/inference="alignment:Splign:1.39.8"
polyA_signal 1628..1633
/gene="ALDOC"
/gene_synonym="ALDC"
polyA_site 1646
/gene="ALDOC"
/gene_synonym="ALDC"
polyA_site 1651
/gene="ALDOC"
/gene_synonym="ALDC"
ORIGIN
ccggaggagtcacgtagctctgcgacatccgcagcctcatttaccagagggagccagggctgcagcctcatctgtttgcggatcagaacccgagctgtgcttgtggctgcggctgctaactggctgcgcacagggagctgtcaccatgcctcactcgtacccagccctttctgctgagcagaagaaggagttgtctgacattgccctgcggattgtagccccgggcaaaggcattctggctgcggatgagtctgtaggcagcatggccaagcggctgagccaaattggggtggaaaacacagaggagaaccgccggctgtaccgccaggtcctgttcagtgctgatgaccgtgtgaaaaagtgcattggaggcgtcattttcttccatgagaccctctaccagaaagatgataatggtgttcccttcgtccgaaccatccaggataagggcatcgtcgtgggcatcaaggttgacaagggtgtggtgcctctagctgggactgatggagaaaccaccactcaagggctggatgggctctcagaacgctgtgcccaatacaagaaggatggtgctgactttgccaagtggcgctgtgtgctgaaaatcagtgagcgtacaccctctgcacttgccattctggagaacgccaacgtgctggcccgttatgccagtatctgccagcagaatggcattgtgcctattgtggaacctgaaatattgcctgatggagaccacgacctcaaacgttgtcagtatgttacagagaaggtcttggctgctgtgtacaaggccctgagtgaccatcatgtatacctggaggggaccctgctcaagcccaacatggtgaccccgggccatgcctgtcccatcaagtataccccagaggagattgccatggcaactgtcactgccctgcgtcgcactgtgcccccagctgtcccaggagtgaccttcctgtctgggggtcagagcgaagaagaggcatcattcaacctcaatgccatcaaccgctgcccccttccccgaccctgggcgcttaccttctcctatgggcgtgccctgcaagcctctgcactcaatgcctggcgagggcaacgggacaatgctggggctgccactgaggagttcatcaagcgggctgaggtgaatgggcttgcagcccagggcaagtatgaaggcagtggagaagatggtggagcagcagcacagtcactctacattgccaaccatgcctactgagtatccactccataccacagcccttggcccagccatctgcacccacttttgcttgtagtcatggccagggccaaatagctatgcagagcagagatgccttcacctggcaccaacttgtcttcctttctctcttcccttcccctctctcattgctgcacctgggaccataggatgggaggatagggagcccctcatgactgagggcagaagaaattgctagaagtcagaacaggatggctgggtctccccctacctcttccagctcccacaattttcccatgatgaggtagcttctccctgggctctccttcttgcctgccctgtctcctgggatcagagggtagtacagaagccctgactcatgccttgagtacataccatacagcaaataaatggtagcaaaacattctaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:230 -> Molecular function: GO:0004332 [fructose-bisphosphate aldolase activity] evidence: IDA
GeneID:230 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:230 -> Molecular function: GO:0008092 [cytoskeletal protein binding] evidence: IDA
GeneID:230 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:230 -> Biological process: GO:0005975 [carbohydrate metabolic process] evidence: TAS
GeneID:230 -> Biological process: GO:0006000 [fructose metabolic process] evidence: TAS
GeneID:230 -> Biological process: GO:0006006 [glucose metabolic process] evidence: TAS
GeneID:230 -> Biological process: GO:0006094 [gluconeogenesis] evidence: TAS
GeneID:230 -> Biological process: GO:0006096 [glycolysis] evidence: IEA
GeneID:230 -> Biological process: GO:0006096 [glycolysis] evidence: TAS
GeneID:230 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:230 -> Biological process: GO:0007568 [aging] evidence: IEA
GeneID:230 -> Biological process: GO:0010243 [response to organonitrogen compound] evidence: IEA
GeneID:230 -> Biological process: GO:0014070 [response to organic cyclic compound] evidence: IEA
GeneID:230 -> Biological process: GO:0030388 [fructose 1,6-bisphosphate metabolic process] evidence: IDA
GeneID:230 -> Biological process: GO:0031100 [organ regeneration] evidence: IEA
GeneID:230 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:230 -> Biological process: GO:0051289 [protein homotetramerization] evidence: IEA
GeneID:230 -> Biological process: GO:0051290 [protein heterotetramerization] evidence: IEA
GeneID:230 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:230 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:230 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IC
GeneID:230 -> Cellular component: GO:0030424 [axon] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005156 -> EC 4.1.2.13
by
@meso_cacase at
DBCLS
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