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2025-05-09 20:21:28, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003126 8017 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
(SPTA1), mRNA.
ACCESSION NM_003126
VERSION NM_003126.2 GI:115298658
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8017)
AUTHORS van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
TITLE Seventy-five genetic loci influencing the human red blood cell
JOURNAL Nature 492 (7429), 369-375 (2012)
PUBMED 23222517
REFERENCE 2 (bases 1 to 8017)
AUTHORS Shammas,S.L., Rogers,J.M., Hill,S.A. and Clarke,J.
TITLE Slow, reversible, coupled folding and binding of the spectrin
tetramerization domain
JOURNAL Biophys. J. 103 (10), 2203-2214 (2012)
PUBMED 23200054
REMARK GeneRIF: The unusually slow, two-state kinetics of spectrin
assembly in solution, was investigated.
REFERENCE 3 (bases 1 to 8017)
AUTHORS Krobath,H., Estacio,S.G., Faisca,P.F. and Shakhnovich,E.I.
TITLE Identification of a conserved aggregation-prone intermediate state
in the folding pathways of Spc-SH3 amyloidogenic variants
JOURNAL J. Mol. Biol. 422 (5), 705-722 (2012)
PUBMED 22727745
REMARK GeneRIF: These data further suggest that residues 44 and 53, which
are key players in the nucleation-condensation mechanism of
folding, are also important triggers of the aggregation process.
REFERENCE 4 (bases 1 to 8017)
AUTHORS Ruetz,T.J., Lin,A.E. and Guttman,J.A.
TITLE Enterohaemorrhagic Escherichia coli requires the spectrin
cytoskeleton for efficient attachment and pedestal formation on
host cells
JOURNAL Microb. Pathog. 52 (3), 149-156 (2012)
PUBMED 22197999
REMARK GeneRIF: Further studies involving siRNA-mediated knockdowns of
spectrin, adducin, or p4.1 revealed that those proteins are needed
for efficient docking of enterohaemorrhagic Escherichia coli to
host cells.
REFERENCE 5 (bases 1 to 8017)
AUTHORS Wolny,M., Wroblewska,A.M., Machnicka,B. and Sikorski,A.F.
TITLE [Spectrin--variety of functions hidden in the structure]
JOURNAL Postepy Biochem. 58 (3), 245-254 (2012)
PUBMED 23373410
REMARK GeneRIF: In this review, we summarize recent findings concerning
structure and function of spectrin together with its possible role
in pathology.
Review article
REFERENCE 6 (bases 1 to 8017)
AUTHORS Kanzaki,A., Rabodonirina,M., Yawata,Y., Wilmotte,R., Wada,H.,
Ata,K., Yamada,O., Akatsuka,J., Iyori,H., Horiguchi,M. et al.
TITLE A deletional frameshift mutation of the beta-spectrin gene
associated with elliptocytosis in spectrin Tokyo (beta 220/216)
JOURNAL Blood 80 (8), 2115-2121 (1992)
PUBMED 1391962
REFERENCE 7 (bases 1 to 8017)
AUTHORS Speicher,D.W., Weglarz,L. and DeSilva,T.M.
TITLE Properties of human red cell spectrin heterodimer (side-to-side)
assembly and identification of an essential nucleation site
JOURNAL J. Biol. Chem. 267 (21), 14775-14782 (1992)
PUBMED 1634521
REFERENCE 8 (bases 1 to 8017)
AUTHORS Hentati,A., Hu,P., Asgharzadeh,S. and Siddique,T.
TITLE Dinucleotide repeat polymorphism at the human erythroid alpha
spectrin (SPTA1) locus
JOURNAL Hum. Mol. Genet. 1 (3), 218 (1992)
PUBMED 1339473
REFERENCE 9 (bases 1 to 8017)
AUTHORS Gallagher,P.G., Tse,W.T., Coetzer,T., Lecomte,M.C., Garbarz,M.,
Zarkowsky,H.S., Baruchel,A., Ballas,S.K., Dhermy,D., Palek,J. et
al.
TITLE A common type of the spectrin alpha I 46-50a-kD peptide abnormality
in hereditary elliptocytosis and pyropoikilocytosis is associated
with a mutation distant from the proteolytic cleavage site.
Evidence for the functional importance of the triple helical model
of spectrin
JOURNAL J. Clin. Invest. 89 (3), 892-898 (1992)
PUBMED 1541680
REFERENCE 10 (bases 1 to 8017)
AUTHORS Bennett,V. and Stenbuck,P.J.
TITLE The membrane attachment protein for spectrin is associated with
band 3 in human erythrocyte membranes
JOURNAL Nature 280 (5722), 468-473 (1979)
PUBMED 379653
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL353894.14, M61877.1,
CD616351.1 and BU665064.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 22, 2006 this sequence version replaced gi:4507188.
Summary: Spectrin is an actin crosslinking and molecular scaffold
protein that links the plasma membrane to the actin cytoskeleton,
and functions in the determination of cell shape, arrangement of
transmembrane proteins, and organization of organelles. It is a
tetramer made up of alpha-beta dimers linked in a head-to-head
arrangement. This gene is one member of a family of alpha-spectrin
genes. The encoded protein is primarily composed of 22 spectrin
repeats which are involved in dimer formation. It forms weaker
tetramer interactions than non-erythrocytic alpha spectrin, which
may increase the plasma membrane elasticity and deformability of
red blood cells. Mutations in this gene result in a variety of
hereditary red blood cell disorders, including elliptocytosis type
2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided
by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M61877.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025083 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-18 AL353894.14 103055-103072 c
19-74 M61877.1 1-56
75-159 M61877.1 58-142
160-324 M61877.1 147-311
325-325 AL353894.14 101602-101602 c
326-507 M61877.1 313-494
508-508 AL353894.14 99808-99808 c
509-1113 M61877.1 496-1100
1114-1141 AL353894.14 94061-94088 c
1142-1875 M61877.1 1129-1862
1876-1876 AL353894.14 86065-86065 c
1877-3685 M61877.1 1864-3672
3686-3686 AL353894.14 66294-66294 c
3687-4426 M61877.1 3674-4413
4427-4427 AL353894.14 60719-60719 c
4428-4900 M61877.1 4415-4887
4901-5257 CD616351.1 3-359 c
5258-5871 M61877.1 5242-5855
5872-5872 AL353894.14 43355-43355 c
5873-7397 M61877.1 5857-7381
7398-7555 BU665064.1 375-532
7556-7769 AL353894.14 27310-27523 c
7770-8017 M61877.1 7754-8001
FEATURES Location/Qualifiers
source 1..8017
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21"
gene 1..8017
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="spectrin, alpha, erythrocytic 1 (elliptocytosis 2)"
/db_xref="GeneID:6708"
/db_xref="HGNC:11272"
/db_xref="MIM:182860"
exon 1..223
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
misc_feature 1
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="major transcription initiation site"
misc_feature 47..49
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="upstream in-frame stop codon"
variation 74
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:201226811"
variation 140
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:200804863"
CDS 200..7459
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="alpha-I spectrin; spectrin alpha chain,
erythrocyte; erythroid alpha-spectrin"
/codon_start=1
/product="spectrin alpha chain, erythrocytic 1"
/protein_id="NP_003117.2"
/db_xref="GI:115298659"
/db_xref="CCDS:CCDS41423.1"
/db_xref="GeneID:6708"
/db_xref="HGNC:11272"
/db_xref="MIM:182860"
/translation="
MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRGRSHLSGYDYVGFTNSYFGN
"
misc_feature 254..352
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 1"
misc_feature <260..595
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 353..370
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 356..667
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 2"
misc_feature 671..985
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 3"
misc_feature 674..1309
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 986..1003
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 989..1303
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 4"
misc_feature 995..1627
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 1304..1321
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 1307..1621
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 5"
misc_feature 1625..1939
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 6"
misc_feature 1628..2260
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 1940..1957
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 1943..2254
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 7"
misc_feature 1961..2554
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 2255..2272
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 2258..2572
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 8"
misc_feature 2261..2890
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 2573..2590
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 2576..2890
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 9"
misc_feature 2894..3103
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 10"
misc_feature 2903..>3076
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats; Region: SPEC; smart00150"
/db_xref="CDD:197544"
misc_feature 3143..3298
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Src Homology 3 domain superfamily; Region: SH3;
cl17036"
/db_xref="CDD:213143"
misc_feature order(3155..3157,3161..3163,3170..3172,3182..3184,
3236..3241,3278..3280,3284..3289)
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212690"
misc_feature 3443..3742
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 11"
misc_feature 3443..3736
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeat; Region: Spectrin; pfam00435"
/db_xref="CDD:201223"
misc_feature 3746..4060
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 12"
misc_feature 3755..4384
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 4061..4078
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 4064..4378
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 13"
misc_feature 4382..4693
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 14"
misc_feature 4385..5017
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 4694..4711
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 4697..5014
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 15"
misc_feature 5018..5332
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 16"
misc_feature 5021..5656
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 5327..5329
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="ubiquitination site; modified site"
misc_feature 5333..5350
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 5336..5650
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 17"
misc_feature 5342..5977
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 5651..5668
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 5654..5977
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 18"
misc_feature 5981..6298
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 19"
misc_feature 5981..6283
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeat; Region: Spectrin; pfam00435"
/db_xref="CDD:201223"
misc_feature 6326..6640
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 20"
misc_feature 6338..6979
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Spectrin repeats, found in several proteins
involved in cytoskeletal structure; family members include
spectrin, alpha-actinin and dystrophin; the spectrin
repeat forms a three helix bundle with the second helix
interrupted by proline in some sequences; Region: SPEC;
cd00176"
/db_xref="CDD:29138"
misc_feature 6665..6682
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="linker region; other site"
/db_xref="CDD:29138"
misc_feature 6668..6973
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P02549.5);
Region: Spectrin 21"
misc_feature 7022..7228
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:28933"
misc_feature order(7049..7051,7055..7057,7061..7063,7082..7084,
7178..7180,7184..7186,7190..7192,7211..7213)
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28933"
misc_feature 7247..7453
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/note="Ca2+ insensitive EF hand; Region: efhand_Ca_insen;
pfam08726"
/db_xref="CDD:149702"
exon 224..463
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 464..589
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 590..730
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 731..877
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 878..1011
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 997
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:36058424"
exon 1012..1156
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 1157..1311
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 1277
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="a"
/replace="t"
/db_xref="dbSNP:34133563"
exon 1312..1447
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 1448..1549
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 1550..1687
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 1688..1798
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 1732
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:34446973"
exon 1799..1876
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 1840
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:35932551"
exon 1877..2032
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 1930
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="g"
/replace="t"
/db_xref="dbSNP:34211240"
exon 2033..2237
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 2238..2419
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 2420..2663
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 2617
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35318623"
exon 2664..2786
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 2671
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:35856400"
variation 2719
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="g"
/db_xref="dbSNP:34577746"
variation 2757
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="g"
/db_xref="dbSNP:35121052"
exon 2787..3004
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 2871
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:36057043"
exon 3005..3097
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 3011
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="g"
/db_xref="dbSNP:36109350"
variation 3069
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:34706737"
exon 3098..3235
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 3236..3387
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 3307
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:34886778"
variation 3370
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35078963"
exon 3388..3574
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 3575..3676
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 3597
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="g"
/db_xref="dbSNP:35733059"
exon 3677..3768
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 3769..3913
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 3892
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:34773716"
exon 3914..4095
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 4096..4195
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 4188
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="g"
/replace="t"
/db_xref="dbSNP:34214405"
exon 4196..4393
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 4394..4537
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 4538..4641
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 4642..4804
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 4652
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:34973695"
variation 4676
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:35237700"
exon 4805..4936
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 4937..5074
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 5075..5179
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 5180..5388
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 5389..5509
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
variation 5491
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="a"
/replace="c"
/db_xref="dbSNP:3738791"
exon 5510..5631
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 5632..5764
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 5765..5863
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 5864..6032
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 6033..6109
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 6110..6319
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 6320..6616
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 6617..6729
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 6730..6747
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 6748..6799
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 6800..6987
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 6988..7041
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 7042..7188
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 7189..7333
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
exon 7334..8017
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/inference="alignment:Splign:1.39.8"
STS 7452..7663
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/standard_name="GDB:196442"
/db_xref="UniSTS:155850"
STS 7524..7654
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/standard_name="GDB:191077"
/db_xref="UniSTS:155640"
STS 7530..7716
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/standard_name="D1S3249"
/db_xref="UniSTS:46677"
STS 7535..7651
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/standard_name="G15944"
/db_xref="UniSTS:75377"
variation 7589..7590
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace=""
/replace="gt"
/db_xref="dbSNP:68118007"
variation 7626
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:3768535"
variation 7754
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:12601"
polyA_signal 7993..7998
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
polyA_site 8017
/gene="SPTA1"
/gene_synonym="EL2; HPP; HS3; SPH3; SPTA"
ORIGIN
tatgtcttctaaagataatgtcgattgtgtatggctgatgggattctaggaccaagcaagaggtttttttttttcccccacatacttaacgtttctatatttctatttgaattcgactggacagttccatttgaattatttctctctctctctctctctgacacattttatcttgccaggttctaaacctttaggaaaaatggagcaatttccaaaggaaaccgttgtggagagcagtgggccaaaggttttggaaacagcagaagagatccaggagaggcgtcaggaagtgttgactcggtatcaaagtttcaaggagcgggtcgctgagaggggtcagaagcttgaggattcctatcacttacaagttttcaagcgagatgcagatgatctggggaagtggatcatggagaaagtcaatatcttaaccgataagagctatgaagacccaactaatatacaggggaaatatcagaagcatcaatcccttgaagcagaggtgcaaacaaaatcaagactcatgtctgaactggaaaaaacaagggaagaacgatttaccatgggtcattctgcccacgaagaaacgaaggcccatatagaggagctacgccacctgtgggacctgctgttagagctgaccctggagaagggtgaccagttgctgcgggccctgaagttccagcagtatgtacaggagtgtgctgacatcttagagtggattggagacaaggaggctatagcgacatcagtggagctaggtgaagactgggagcgcaccgaagttctgcataagaaatttgaagacttccaagtggagctggtagctaaagaagggagagttgttgaagtgaaccaatatgccaatgagtgtgccgaggaaaaccatcctgacctacccttaattcagtctaagcaaaatgaggtgaatgctgcctgggagcgccttcgtggtttggctctccagagacagaaagctctgtccaatgctgcaaacttacaacgattcaaaagggatgtgactgaagccatccagtggatcaaggagaaggaacctgtactcacctctgaggactatggcaaagaccttgttgcctctgaaggactgtttcacagtcacaagggacttgagagaaatcttgctgtcatgagtgacaaggtgaaggagttatgtgctaaagcagagaagctgacactttcccatccttcagatgcacctcagatccaggagatgaaagaagatctggtctccagctgggagcatattcgtgccctggccaccagcagatatgaaaaactgcaggctacttattggtaccatcgattttcatctgactttgatgaactctcaggctggatgaacgagaagactgctgcgatcaatgctgatgagctgccaacagatgtggctggtggagaagttctgctggacaggcatcagcagcataagcatgagattgactcttacgatgaccgatttcaatctgctgatgagactggtcaagacctcgtgaatgccaatcatgaagcctctgatgaagttcgggaaaagatggaaatacttgacaacaactggactgccctgctggaactgtgggacgagcgtcatcgtcagtatgagcagtgcttggactttcatctcttctacagagacagtgagcaagtggacagttggatgagtagacaagaggccttcctggaaaacgaggatctgggaaactcactgggcagtgcagaagcccttcttcagaagcatgaagactttgaggaagcctttactgcccaggaagagaagatcataactgtagacaagactgcaaccaaattgattggtgatgaccattatgattcagagaacatcaaggctatccgtgacgggctgttagcccggcgggatgccctacgtgaaaaggctgccactagacgtagattgctgaaggagtcattgcttctgcaaaaactgtatgaggactcagatgacctaaagaactggatcaacaagaagaaaaagttggcagatgatgaagattacaaggacatacagaacttgaagagcagggttcaaaagcagcaagtctttgaaaaggagttggcagttaataagacccagctggaaaacatacagaaaactggccaagagatgattgagggtggtcactatgcctctgacaatgtgaccactcgtctgagtgaagttgccagcctctgggaggagttgctggaggctacaaaacagaaagggacccagttgcatgaggccaaccagcagctgcaatttgaaaataatgcagaagatttgcagcgctggctggaggatgttgagtggcaagtcacctctgaggattatgggaaaggcctggccgaggtacagaatcgactcaggaaacacggcctcctggagtcggctgtggctgctcgtcaggatcaggtggatatccttacagacctggctgcatattttgaagaaataggccatcctgattctaaggatataagggcaaggcaagagtccttggtatgccgatttgaagctctgaaagagccactggccacccgaaagaagaagctcttagaccttctccatctgcagctgatttgtagagacacagaggatgaggaggcctggatccaagagactgaaccctcagctacttccacctaccttggaaaggacctgattgcttccaaaaagcttctgaataggcatagagtcatcctggagaacattgccagccatgaaccacgcattcaagagataacagaaaggggaaacaaaatggtagaggaaggacactttgctgcagaagatgtggcctctagggtcaagagtttgaaccagaatatggagtctctccgtgctcgagctgctaggcgacaaaatgatcttgaagccaatgtccagttccagcagtacctggctgacctgcatgaagcagaaacatggatcagagagaaggaacctattgtagataatactaactatggtgctgatgaagaagcagctggggctcttctaaagaagcatgaggcctttctattagatctcaattcatttggagacagtatgaaagctctgcggaatcaggcaaacgcctgccagcaacaacaggctgcaccagtggagggagttgctggagaacaaagggtcatggctttatatgacttccaggcccgcagcccccgagaagtcaccatgaagaaaggtgatgtcttaacgctgctcagttccatcaataaggactggtggaaggtggaagctgctgatcatcagggcattgtcccagctgtctatgtcagaagactggcccacgatgagttcccgatgctcccacagcggcgacgagaagagccaggaaacatcacccagcgccaggagcagattgagaaccaataccgctccctcttggatcgggcagaagaacgcagacgtcgtctattgcaacgttataatgaatttttattggcctatgaggcaggagacatgctggaatggattcaagagaaaaaggcagaaaacactggagtggaactagatgatgtttgggagctgcagaaaaagtttgatgagttccaaaaggatttgaataccaatgagcctcggctaagggatatcaacaaggtagctgatgatctactatttgaaggacttctaacaccagaaggagctcaaatccggcaggaattgaattcccgctggggttctttgcagaggcttgcagatgaacagcggcagctgctgggcagtgcccatgctgttgaagtgtttcacagagaagcagatgacacgaaggagcagattgagaagaaatgccaggccctcagtgctgcagaccctggctcagatctgttcagtgttcaggctcttcagcgacggcatgagggctttgaaagggacctcgtacccctgggagataaggtgaccatactgggggagacagcagagcggctcagtgagtcccatccagatgccactgaggacctgcagagacagaaaatggagctgaatgaggcctgggaagacctgcaggggcgtacaaaggatcgtaaggagagcctaaatgaggcccagaaattctacctgttcctcagcaaggccagggatctgcagaactggatcagtagcattggtggcatggtatcatcacaggagctggccgaagacttaactggcatagagatcttgctggagagacatcaggagcaccgtgctgacatggaggcagaggctcccaccttccaggccttagaggacttcagtgcagaacttatcgacagtgggcaccatgctagccctgaaattgaaaaaaagcttcaagctgtcaagctagagagagatgatttggagaaggcttgggaaaaacgcaagaagatcctagaccagtgcctggagttgcagatgttccaggggaactgtgatcaagttgagagctggatggtggcacgtgagaattccctgaggtcagatgacaaaagttccttagacagtctggaggctttgatgaagaaacgggacgatttggacaaagcaatcactgcccaggaagggaagatcactgacctagaacattttgctgagagcctcattgctgatgaacactatgccaaagaagagattgctacgcggctccaacgtgtactagacaggtggaaggctctcaaagcacaactgattgatgagcggacaaagcttggagactatgccaacctaaaacaattctaccgagaccttgaggagctggaagaatggatcagtgagatgctgcccacagcctgtgatgaatcctacaaagacgccactaacattcagaggaaatacctgaaacaccagacctttgcacatgaagtcgatggccgatctgagcaggtgcatggcgtcatcaacctggggaactccctgattgagtgtagcgcttgtgatggcaatgaagaggccatgaaggagcaactggaacagctgaaggaacattgggatcatctgcttgagagaacaaatgacaaagggaagaagctcaatgaggccagtcgtcaacagaggttcaacacaagcatccgggactttgagttctggctctcagaggcagagacattgctggccatgaaagatcaggccagggacttggcttcagcaggaaacctactcaagaagcatcagctattggagagagagatgttggctcgagaggatgcactcaaggacctgaatacattggctgaagatttgctctccagcgggactttcaacgttgatcagattgtgaagaaaaaagataatgtcaacaagcgtttcctgaatgtccaagaattggcagctgcacaccacgaaaaattgaaagaggcctatgccttgttccagttcttccaggatctagatgatgaggaatcctggatagaggagaagttgatacgagtgagctcccaggactatgggagagatcttcagggggttcagaacttgctgaagaagcacaaacgcctagagggggagctggtggcccatgagcctgccatccagaatgtgctggatatggcagagaagctgaaagacaaggctgctgtggggcaagaggagatccagttgcggctggctcagtttgttgaacactgggagaagctcaaagagttggccaaggcccgaggacttaagttggaagaatccctagaatacttgcaattcatgcagaatgctgaggaagaggaagcttggatcaatgaaaagaatgctttggctgtccgaggagattgtggagatacattagctgctactcagagcttgctaatgaagcatgaagctttggaaaatgactttgctgtccatgagacccgagtacaaaatgtgtgtgcacaaggagaagacatcctaaataaggtgttgcaggaggaaagtcagaacaaagagatttcttccaagatagaggctctgaatgaaaagaccccttctctggctaaggcaatagctgcttggaagttgcaattggaagacgattatgcctttcaggaattcaactggaaggctgatgtggtagaggcttggatagctgataaggaaacaagcctaaagaccaatggcaatggtgcagaccttggtgacttcctcactcttctggcaaaacaggacactctggatgccagtctgcagagtttccagcaagagagacttcccgagatcactgacctgaaggacaaactgatttctgctcaacacaaccagtctaaagccattgaagagcgttatgccgctctgctgaagcgctgggaacagttgctggaagcctcggcagtccacagacagaaattgctggagaaacagctgcctctacagaaggctgaggacctgttcgtggaatttgcacataaggcttcagctttgaacaactggtgtgaaaagatggaagaaaacttgtcagagcctgtgcactgtgtctccctgaatgaaattcggcagctgcagaaagaccatgaggacttcttggcctccctggctagggctcaagcagactttaaatgtttgctggagctagaccagcagattaaggccttaggtgtgccttccagcccttatacctggttaacagtggaggtgctggaaaggacctggaagcacctatctgacatcattgaggaacgggagcaggagctgcaaaaggaagaggcaagacaggtcaagaactttgagatgtgtcaggagtttgaacagaatgccagtaccttccttcaatggatcctggaaaccagggcttactttctggatggatcattgctcaaagaaacaggaactctggaatctcagctggaagcaaataaaagaaaacagaaggagatccaggcgatgaagcgtcaactaaccaagattgtggacctgggggacaacttggaagacgctctgatccttgatatcaaatacagcaccattggattggctcagcagtgggaccagctctaccagcttgggttgcggatgcaacacaacctggagcaacagatccaggccaaggacatcaaaggtgtgagtgaagagactctaaaggaatttagcacaatctataaacactttgatgagaatttgacagggcgcctgactcacaaagagttccggtcctgcctgagaggactcaattactacttgcccatggtggaggaggatgaacatgagcccaagtttgagaagttcctggatgctgtggatccagggaggaagggctatgtctcactggaggactatactgctttcctgattgacaaggagtcagaaaacatcaagtccagtgatgaaatagagaatgccttccaagccctggcagagggcaagtcatatattaccaaagaagacatgaagcaggcccttaccccagagcaagtgtcattctgtgccacacatatgcagcaatatatggacccacggggtcgaagccatctctctggctatgactacgttggcttcaccaattcctactttggcaactaataagcagctcctcgtggatcgtagaaaatcttagtgtcgtgggaaatttactggggggcaaagagtacaggcaaatgtggaagataaagatggcctcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgcttgtgtttgtgtgcatattacatttattgtaggatcttaaaaaatctcaagggtgggagatagaaaggttaatagagttggaggagtggaagctattttgtatgcaactagtcactgctgaggggtgtcaaagtttctatttttatttgttctgttttgcacgtctttatcattttgctttattccgattatagaataaagtaattctttttaaaaatattttttggggcaaagttaagtaaaatgttgagcttctatatttctgggaactgtactcatataagagtgggcagctaattttactgtaaagaagggccatggtatagtagataaataaaatccaaggcaattttcaaacaatttttttaaactttggaatgtgtttaaatttaaatttgaaaataaagatatttgattttctgggg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6708 -> Molecular function: GO:0005200 [structural constituent of cytoskeleton] evidence: TAS
GeneID:6708 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:6708 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6708 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
GeneID:6708 -> Molecular function: GO:0051015 [actin filament binding] evidence: TAS
GeneID:6708 -> Biological process: GO:0002260 [lymphocyte homeostasis] evidence: IEA
GeneID:6708 -> Biological process: GO:0006779 [porphyrin-containing compound biosynthetic process] evidence: IEA
GeneID:6708 -> Biological process: GO:0007009 [plasma membrane organization] evidence: IEA
GeneID:6708 -> Biological process: GO:0007015 [actin filament organization] evidence: TAS
GeneID:6708 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:6708 -> Biological process: GO:0008360 [regulation of cell shape] evidence: IEA
GeneID:6708 -> Biological process: GO:0030097 [hemopoiesis] evidence: IEA
GeneID:6708 -> Biological process: GO:0032092 [positive regulation of protein binding] evidence: IEA
GeneID:6708 -> Biological process: GO:0042102 [positive regulation of T cell proliferation] evidence: IEA
GeneID:6708 -> Biological process: GO:0051693 [actin filament capping] evidence: IEA
GeneID:6708 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6708 -> Cellular component: GO:0008091 [spectrin] evidence: IEA
GeneID:6708 -> Cellular component: GO:0014731 [spectrin-associated cytoskeleton] evidence: IDA
GeneID:6708 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: TAS
GeneID:6708 -> Cellular component: GO:0031235 [intrinsic to internal side of plasma membrane] evidence: TAS
GeneID:6708 -> Cellular component: GO:0032437 [cuticular plate] evidence: IEA
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