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2025-05-09 18:32:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018566 6265 bp mRNA linear PRI 06-JUN-2013
DEFINITION Homo sapiens YOD1 deubiquitinase (YOD1), transcript variant 1,
mRNA.
ACCESSION NM_018566 XR_000127
VERSION NM_018566.3 GI:62751963
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6265)
AUTHORS Ernst,R., Mueller,B., Ploegh,H.L. and Schlieker,C.
TITLE The otubain YOD1 is a deubiquitinating enzyme that associates with
p97 to facilitate protein dislocation from the ER
JOURNAL Mol. Cell 36 (1), 28-38 (2009)
PUBMED 19818707
REMARK GeneRIF: The assignment of a p97-associated ubiquitin processing
function to YOD1 adds to our understanding of p97's role in the
dislocation of misfolded proteins from the endoplasmic reticulum.
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL445493.8.
On Apr 20, 2005 this sequence version replaced gi:61657908.
Summary: Protein ubiquitination controls many intracellular
processes, including cell cycle progression, transcriptional
activation, and signal transduction. This dynamic process,
involving ubiquitin conjugating enzymes and deubiquitinating
enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are
cysteine proteases that specifically cleave ubiquitin from
ubiquitin-conjugated protein substrates. The protein encoded by
this gene belongs to a DUB subfamily characterized by an ovarian
tumor (OTU) domain. Alternative splicing results in multiple
transcript variants. [provided by RefSeq, Jan 2013].
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: BC137166.1, AL833081.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-390 AL445493.8 10158-10547 c
391-6265 AL445493.8 3319-9193 c
FEATURES Location/Qualifiers
source 1..6265
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q32.2"
gene 1..6265
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/note="YOD1 deubiquitinase"
/db_xref="GeneID:55432"
/db_xref="HGNC:25035"
/db_xref="MIM:612023"
exon 1..390
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/inference="alignment:Splign:1.39.8"
CDS 48..1094
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/EC_number="3.4.19.12"
/note="isoform 1 is encoded by transcript variant 1; YOD1
OTU deubiquinating enzyme 1 homolog ( yeast); OTU domain
containing 2; ubiquitin thioesterase OTU1; HIN-7; DUBA-8;
hsHIN7; HIV-1-induced protease 7; OTU domain-containing
protein 2"
/codon_start=1
/product="ubiquitin thioesterase OTU1 isoform 1"
/protein_id="NP_061036.3"
/db_xref="GI:62751964"
/db_xref="CCDS:CCDS31002.1"
/db_xref="GeneID:55432"
/db_xref="HGNC:25035"
/db_xref="MIM:612023"
/translation="
MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVLQGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIIEEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALELADEARRRRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV
"
misc_feature 195..431
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5VVQ6.1);
Region: UBX-like"
misc_feature 318..1088
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/note="Predicted cysteine protease (OTU family)
[Posttranslational modification, protein turnover,
chaperones]; Region: COG5539"
/db_xref="CDD:35098"
misc_feature 510..851
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/note="OTU-like cysteine protease; Region: OTU; pfam02338"
/db_xref="CDD:202209"
exon 391..6265
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/inference="alignment:Splign:1.39.8"
variation 773
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/replace="c"
/replace="g"
/db_xref="dbSNP:2054779"
variation 1847
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2054780"
variation 2050
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1385611"
variation 2659
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/replace="g"
/replace="t"
/db_xref="dbSNP:2629665"
STS 5982..6182
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/standard_name="D8S2025"
/db_xref="UniSTS:18135"
variation 6100
/gene="YOD1"
/gene_synonym="DUBA8; OTUD2; PRO0907; RP11-164O23.1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1044145"
ORIGIN
ccgcaccgaagcgtcgcgataactgcaaccacccgcaacttctcgcgatgtttggccccgctaaaggtcgccattttggagtccacccggcgcctggtttccccggcggcgtctcccaacaggctgccgggaccaaagctggccccgcgggtgcctggcctgtgggcagccggaccgacacgatgtggcggctccgctgcaaggccaaggacggcacccatgttttgcaggggctgtccagccggacccgggtgcgggaactccagggccaaattgccgccatcaccgggatcgcccccggcggtcagcgaatcctcgtcggataccctcccgagtgcctggatctcagcaatggggataccattctggaagacttgcccatccaatctggtgacatgctgatcattgaagaagaccaaaccaggcccagaagttcacctgcatttactaaacgtggtgcttctagttacgtcagggaaactttgcctgtgcttaccagaaccgtggtcccagcagacaactcttgcctctttactagtgtgtactatgtcgtcgaaggaggagtcttgaatccagcttgtgcccctgagatgagacgcctcatagcacaaattgtagcaagcgatccagacttctatagtgaggcaatactgggaaaaacaaatcaagagtactgtgactggatcaaaagggatgacacttggggaggagcaatagagatatcgattttgtccaagttttaccaatgtgaaatatgtgtagtggatacacagacagtaagaattgatcgttttggggaagatgcaggatataccaaaagggttctgcttatttatgatggcatccactatgatccacttcagcgtaacttccctgatccagatacacctcctctgaccattttctcctctaatgatgatattgttcttgtacaagcactggaattagcagatgaagctagaagaaggagacagtttactgatgtcaaccgcttcaccctgagatgcatggtatgtcagaaaggattaactggacaagcagaagcaagggaacatgccaaggagacaggccataccaactttggagaagtgtgacctatgcatgaatgagggttgaagcctactacctcacacatccagaaggctctgggttttccaataagctatggtaaccctaaagaacaaaggatacaatgcttgaaccatccttttaacttaaaaccactaagacactgaaattccttgttaagattaaaattagtgtgcaagtttacagatgtgtgtctacagtggtaaactgtacatacatgcctctttctgctggagtgacagaataggtgatccttgccacctactgacactgacctgaaggttgagattgagtattataaactagcacccagcagctttaacttgtagaagaaagcatcacattttgggtaatgtggaaggcctcctgtgagtccactgggcatacgattgagattgagtattataaactagcacccagcagctttaacttgtagaagaaagcatcacattttgggtaatgtggaaggcctcctgtgagtccactggacatttaccacagtgtctccagtaactgagtctttttaaaaactctgaatgagttaagtttctaaattatgaattgattcatcaaatgaagatactcagaattgtccaaactgattttatattgcaatttggtagacattataaatgtgtgcttaaccactgataagtacatcacaagcaatttttacagggatgagtctcatccttgagaatgttatcacaaaacaggaactgattgtgccctgtttaagatctctagcatataaaacgtagaatgtatgagggaataggtgcctgagcagcttcctgaagctttaaaagaccgttggcctcgtgttttaatgcaattcatgtattggtctttgtcacattggataacattttaaagttaagcagggtacttttttaattgaaattccttgaaattcgagtcctcagttttttcttcatttgcgtaaagtttatcggggggaatttaattttctcagctttttgttaagagcacttcctccaaaaaatttttttcaagtaataatgctctgctttgggttggtttttgtaagattttttgcacacctaaagagtgtttgcttttgtgctagccttatccctccactaaagttattttaaataatttcacatttctgcaaattagcactttgcttatctgcaatcttttactttgatttttgaagttttaaagcaattggagtaatactgttgaatgaactagtttcacttccaaaatagaaaaaattgtaaatccttgccttatgcagctttctcagaattctgcttcttcctagtactagatgtgtagccatttgcttagtggactaatccgcaaggcacaccctctaaaacttagcttcactacaagatcttccagataaaagttttctacctcttttcttaattattctgatcagggatgctaaattataatttgttatgtattatctcacataatgtgaagaggcttaatgtgaagttttgttattttggtctcttttttattaagtatctcacttagaaattcagtggtatactttaaagcacttggatctttttcagcatatctgcctagcaaatgttttaaaattgacatttatttttagcactttcacttggtgaaggtggccatataaaattaaggaacatttgaacaatataagagaaaagaacttttaaggaacaattcacaaagtttgtttgaaattgtcagatgacatttcttgagtaccttttgtgtgcatagttattttagacaatataagctgttatggtcagcataacttaaaagtgtttagttttctattttactgagccttaaaaatagcactgatgagcttatgatacttaatgtttggcaatcataatgtgttcaaattaatgggattgaaaatctctccacacctgactctcatctgatctggatggttttggttttgtatcttttttacttctcccagaaaatactaaatttaaaactgtaaattaagaatataccactagataacaattatcaaattgagctttatgcatcattactcagaaagcttgccttcctttctttgctacttcaggacacagagttgacatttgcttactacagctttagatctagaagtttattcgtgcaacaaatatttattgagtaatttatactgtgccaggcatgttttgatatgtttctgtcatatgttttgatatgttccaacataagtttctgtcactttatattcagtatatattttctacagtgggtaaatttaacaaatggaaaggaatagaacactgatattttacagaattaaaccccttcattgtaagggctttgtttacatattaagtgtcaagtatttattcaggggatcttatttcattgtattttatctgttatctaggttgtccatttaccggttggacactgatactctgtcaaattcctttcaaaaatgactctttagtctgctgaaatttagcactagtactttagtgttctgatcctggaaaattcaaggtgaagctttatttgtggaccatctgatttaattattgaggattaaaaacctaaacctttgctcattctaaactcaagcttttaagcctcacagaatttacaggggtttgctttttgtttgtttgttttttcattttttactgtgcttattaaactcttggaattagttattaaagggagtaaattctcatcttgggaattttgaaaatctatggacttacaactttcaggaggattaaatgtcttaagttttgtactagagcagaatgaaatctttcctattcattgagtttttgcctgccatagaggaatttttttaaaaattaaaatgacagtttatattagtggcaaagtgaataaagacctcactttcccaccccacccttcttcctttctcttacttttctttggattaaaggtcaggtgtagtactatgaagattcactcctgaataaagtgatttcagaagctaaaatttaacatacctggaaattttgtgatgtgttagccaagtgaagacattagtgtgttccatcttttgctaatggttcatggttgatttcttcattgtttcccatgaaattagcatagtcaagtggtacccttgacgcttgactgctggtcagtttgaccctgtttttaacaactaatgtagtcatgccgcttgattattccatgaagtcccagcaaaataataatgaggaattaactaacattatgttatctatctaatttgtctgtgtccctaaatgcccatgcctaacttgcttctctagtttattccttctgtggagggattaaaacgtgggtgttgcaagttgccctaagctaaacatagttttcttacatctttttgggaaaaaaaatggaatgggaagtatgcaagattaagcaagagtgatttttttttttttttgacaaatcaggtggccttcctaaacatactaagaattatgttctttcatgtgtggagacacatttgtttgcagcactttaaaaaatatatatggaataaaagtttacatgttggccctctagggatctaattaaggacattaaagtacaattcttgagctactaaccatcagctcttcttaatcaaagattgccatcagtgtagagtgtatctattggcacaacattctggtgttttgataacagtagaactcaatttcagtaactattaggagcatggtctgtgccctagcattaaaaatgttacttattattatgtgaatatcttgtattattatacaatgcagtattcaaatttgtccttgtagtgcagagatgactgataatttctaaaagattcgatccttaaaacttgtttccaagcagacttataaggaagctgatttttgagtcagaggccttaaacgtgtcatatacaagtggcatcattttaagtccaaagtgaaacacttgatttgaataagctagtttataaactaaagctgttttcttatgttacagtatttcagcacatttcattccacataaaaagaatattaagtgtccctggttgtgggagagtgtttatttttctcaaaattatctagcattttgcttacagtgctttgaatgtttgacttaaaattattattgatgttgaattgtagggtgctgatttaggtcttgattcatacacatttaaaggaggttggtaaccccctcatggtagagtgaagggagaaaagggccaagaagacaaagtaccactgataaagaagagattgtcaaatagatgcattcctagtcatgaattacccttttccaaacatttttaaagcaatgcctttgtgtcaactcaacccttcttccccatttcttgtcatagaatgtagcatggccataggtgaaaaagcttatcattaaagtatgaaaccatgaattataagcattttgccatgatgcccttttatacatatgtttttaaaagtactaaccaacatataggagtttaggaatggtgaagatataatttgattaagttgtaggtaaacagaaaggatcatcttaggctcagaatttctaatatgattacatgagtctactttataaactggtataggctatgtaattagcccgtaagttacttaaaggaccaggggacctaatttttgtcagttttccagtcacattggtgccattcaggactccagctgtttacaggaaatatgtacttagcagaatagtatttttccttgaaaaaaatttgaattcagcctaaatacagaatgaatatgaatagtttgtgaaaagggttagagaacaacaatattcctatagtttctgtattaatgcagtagagacagaggttcctaacgcaaaaagaaaaccacaagtaaagaccgtcaaattagagctttagaatatgacttgaaaaagtagggatgggcaaaacagcataagaaaatattttttcttaatgcagatggacagtgttttcttgttttaaaaatgttttgcctatttgccagcattttttgaagtaatacactgctgctacctggaagatgtctaacttcattttctacaactcttatgtgattttgccattgtcattaagatgcattgattttatttatgaggtgtatgactttaaatatctaaatgctgtattaagtgacttgtttcaaaggaataaatgaagtgaaaacgt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55432 -> Molecular function: GO:0004843 [ubiquitin-specific protease activity] evidence: IDA
GeneID:55432 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:55432 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:55432 -> Biological process: GO:0006520 [cellular amino acid metabolic process] evidence: ISS
GeneID:55432 -> Biological process: GO:0030433 [ER-associated protein catabolic process] evidence: IMP
GeneID:55432 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: IMP
GeneID:55432 -> Biological process: GO:0070536 [protein K63-linked deubiquitination] evidence: IDA
GeneID:55432 -> Biological process: GO:0071108 [protein K48-linked deubiquitination] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_061036 -> EC 3.4.19.12
by
@meso_cacase at
DBCLS
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