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2025-05-09 18:34:05, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001206902 3192 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens Tax1 (human T-cell leukemia virus type I) binding
protein 1 (TAX1BP1), transcript variant 4, mRNA.
ACCESSION NM_001206902
VERSION NM_001206902.1 GI:332634743
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3192)
AUTHORS Charoenthongtrakul,S., Gao,L., Parvatiyar,K., Lee,D. and
Harhaj,E.W.
TITLE RING finger protein 11 targets TBK1/IKKi kinases to inhibit
antiviral signaling
JOURNAL PLoS ONE 8 (1), E53717 (2013)
PUBMED 23308279
REMARK GeneRIF: RNF11 functions together with TAX1BP1 to restrict
antiviral signaling and IFN-beta production.
REFERENCE 2 (bases 1 to 3192)
AUTHORS Komkov,A.Iu., Maschan,M.A., Shvets,V.I. and Lebedev,Iu.B.
TITLE [The functional analysis of polymorphic insertions of Alu
retroelements at acute lymphoblastic leukemia]
JOURNAL Bioorg. Khim. 38 (3), 351-364 (2012)
PUBMED 22997707
REMARK GeneRIF: Allele frequencies of three Alu insertions that are
located in MEF2C (two of them) and TAX1BP1 genes significantly
differ between cohorts of healthy donors and ALL(acute
lymphoblastic leukemia) patients.
REFERENCE 3 (bases 1 to 3192)
AUTHORS Newman,A.C., Scholefield,C.L., Kemp,A.J., Newman,M., McIver,E.G.,
Kamal,A. and Wilkinson,S.
TITLE TBK1 kinase addiction in lung cancer cells is mediated via
autophagy of Tax1bp1/Ndp52 and non-canonical NF-kappaB signalling
JOURNAL PLoS ONE 7 (11), E50672 (2012)
PUBMED 23209807
REMARK GeneRIF: Autophagy of Tax1bp1/Ndp52 promotes non-canonical
NF-kappaB signalling.
REFERENCE 4 (bases 1 to 3192)
AUTHORS Gao,L., Coope,H., Grant,S., Ma,A., Ley,S.C. and Harhaj,E.W.
TITLE ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit
antiviral signaling
JOURNAL J. Biol. Chem. 286 (42), 36592-36602 (2011)
PUBMED 21885437
REMARK GeneRIF: ABIN1 requires its ubiquitin binding domain and cooperates
with TAX1BP1 and A20 to restrict antiviral signaling.
REFERENCE 5 (bases 1 to 3192)
AUTHORS Borbulevych,O.Y., Piepenbrink,K.H. and Baker,B.M.
TITLE Conformational melding permits a conserved binding geometry in TCR
recognition of foreign and self molecular mimics
JOURNAL J. Immunol. 186 (5), 2950-2958 (2011)
PUBMED 21282516
REMARK GeneRIF: In a link with T cell leukemia virus-1-associated
myelopathy/tropical spastic paraparesis, an alphabeta T cell
receptor recognizes a self peptide from neuronal protein HuD in
context of histocompatibility antigen HLA-A2.
REFERENCE 6 (bases 1 to 3192)
AUTHORS Dodon,M.D., Hamaia,S., Martin,J. and Gazzolo,L.
TITLE Heterogeneous nuclear ribonucleoprotein A1 interferes with the
binding of the human T cell leukemia virus type 1 rex regulatory
protein to its response element
JOURNAL J. Biol. Chem. 277 (21), 18744-18752 (2002)
PUBMED 11893730
REFERENCE 7 (bases 1 to 3192)
AUTHORS Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
TITLE Functional redundancy of the zinc fingers of A20 for inhibition of
NF-kappaB activation and protein-protein interactions
JOURNAL FEBS Lett. 498 (1), 93-97 (2001)
PUBMED 11389905
REFERENCE 8 (bases 1 to 3192)
AUTHORS Ling,L. and Goeddel,D.V.
TITLE T6BP, a TRAF6-interacting protein involved in IL-1 signaling
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (17), 9567-9572 (2000)
PUBMED 10920205
REFERENCE 9 (bases 1 to 3192)
AUTHORS De Valck,D., Jin,D.Y., Heyninck,K., Van de Craen,M., Contreras,R.,
Fiers,W., Jeang,K.T. and Beyaert,R.
TITLE The zinc finger protein A20 interacts with a novel anti-apoptotic
protein which is cleaved by specific caspases
JOURNAL Oncogene 18 (29), 4182-4190 (1999)
PUBMED 10435631
REFERENCE 10 (bases 1 to 3192)
AUTHORS Gachon,F., Peleraux,A., Thebault,S., Dick,J., Lemasson,I.,
Devaux,C. and Mesnard,J.M.
TITLE CREB-2, a cellular CRE-dependent transcription repressor, functions
in association with Tax as an activator of the human T-cell
leukemia virus type 1 promoter
JOURNAL J. Virol. 72 (10), 8332-8337 (1998)
PUBMED 9733879
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB455556.1, DC424592.1,
AF090891.1, AL136586.1 and BU679319.1.
Summary: This gene encodes a HTLV-1 tax1 binding protein. The
encoded protein interacts with TNFAIP3, and inhibits TNF-induced
apoptosis by mediating the TNFAIP3 anti-apoptotic activity.
Degradation of this protein by caspase-3-like family proteins is
associated with apoptosis induced by TNF. This protein may also
have a role in the inhibition of inflammatory signaling pathways.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.[provided by RefSeq, May
2011].
Transcript Variant: This variant (4) is missing an internal coding
exon compared to variant 1. This results in the creation of an
upstream ORF (uORF), translation of which will render this
transcript a candidate for nonsense-mediated mRNA decay (NMD).
However, since the uORF has a weak Kozak signal, translation from
an in-frame downstream AUG is possible by leaky scanning, resulting
in an isoform (3) with a shorter N-terminus and missing an internal
protein segment compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK296720.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3 DB455556.1 1-3
4-447 DC424592.1 1-444
448-2290 AF090891.1 554-2396
2291-2670 AL136586.1 2512-2891
2671-3192 BU679319.1 1-522 c
FEATURES Location/Qualifiers
source 1..3192
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p15"
gene 1..3192
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="Tax1 (human T-cell leukemia virus type I) binding
protein 1"
/db_xref="GeneID:8887"
/db_xref="HGNC:11575"
/db_xref="MIM:605326"
exon 1..175
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
variation complement(96)
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/replace="a"
/replace="g"
/db_xref="dbSNP:200640891"
exon 176..344
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 345..447
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
misc_feature 436..438
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="upstream in-frame stop codon"
exon 448..606
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
CDS 466..2238
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="isoform 3 is encoded by transcript variant 4;
TRAF6-binding protein"
/codon_start=1
/product="tax1-binding protein 1 isoform 3"
/protein_id="NP_001193831.1"
/db_xref="GI:332634744"
/db_xref="CCDS:CCDS56471.1"
/db_xref="GeneID:8887"
/db_xref="HGNC:11575"
/db_xref="MIM:605326"
/translation="
MKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD
"
misc_feature <469..>1404
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="Calcium binding and coiled-coil domain (CALCOCO1)
like; Region: CALCOCO1; pfam07888"
/db_xref="CDD:116500"
misc_feature <1048..1794
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/note="chromosome segregation protein SMC, common
bacterial type; Region: SMC_prok_B; TIGR02168"
/db_xref="CDD:162739"
exon 607..755
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 756..846
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 847..1032
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 1033..1257
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 1258..1404
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 1405..1528
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 1529..1632
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 1633..1758
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 1759..1804
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 1805..1953
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 1954..2036
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
exon 2037..3176
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/inference="alignment:Splign:1.39.8"
STS 2068..2813
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="TAX1BP1_2449"
/db_xref="UniSTS:281039"
STS 2124..2223
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="SGC31789"
/db_xref="UniSTS:2823"
polyA_signal 2419..2424
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_site 2461
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_signal 2513..2518
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
STS 2536..2637
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="SGC32601"
/db_xref="UniSTS:62629"
polyA_site 2556
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_signal 2648..2653
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_site 2670
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
STS 3006..3136
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
/standard_name="WI-11921"
/db_xref="UniSTS:57725"
polyA_signal 3060..3065
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_site 3086
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_signal 3141..3146
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
polyA_site 3176
/gene="TAX1BP1"
/gene_synonym="CALCOCO3; T6BP; TXBP151"
ORIGIN
ggaagagaccgccccgtgggcggaagtgacgcaaggcctactgtcggctgggaggggaggtgtagccggtctttgggggtaggcggtagtggcggaagaggttcggcggctgatggcggatcaggatcggaagcctgcgtaactttctcccttgatccgggagtctttccactggattcacaatgacatcctttcaagaagtcccattgcagacttccaactttgcccatgtcatctttcaaaatgtggccaagagttaccttcctaatgcacacctggaatgtcattacaccttaactccatatattcatccacatccaaaagattgggttggtatattcaaggttggatggagtactgctcgtgattattacacgtttttatggtcccctatgcctgaacattatgtggaaggatcaacagtcaattgtgtactagcattccaagttgaaaattgagaaaaccatgaaagaaaaagaagaactgttaaagttaattgccgttctggaaaaagaaacagcacaacttcgagaacaagttgggagaatggaaagagaacttaaccatgagaaagaaagatgtgaccaactgcaagcagaacaaaagggtcttactgaagtaacacaaagcttaaaaatggaaaatgaagagtttaagaagaggttcagtgatgctacatccaaagcccatcagcttgaggaagatattgtgtcagtaacacataaagcaattgaaaaagaaaccgaattagacagtttaaaggacaaactcaagaaggcacaacatgaaagagaacaacttgaatgtcagttgaagacagagaaggatgaaaaggaactttataaggtacatttgaagaatacagaaatagaaaataccaagcttatgtcagaggtccagactttaaaaaatttagatgggaacaaagaaagcgtgattactcatttcaaagaagagattggcaggctgcagttatgtttggctgaaaaggaaaatctgcaaagaactttcctgcttacaacctcaagtaaagaagatacttgttttttaaaggagcaacttcgtaaagcagaggaacaggttcaggcaactcggcaagaagttgtctttctggctaaagaactcagtgatgctgtcaacgtacgagacagaacgatggcagacctgcatactgcacgcttggaaaacgagaaagtgaaaaagcagttagctgatgcagtggcagaacttaaactaaatgctatgaaaaaagatcaggacaagactgatacactggaacacgaactaagaagagaagttgaagatctgaaactccgtcttcagatggctgcagaccattataaagaaaaatttaaggaatgccaaaggctccaaaaacaaataaacaaactttcagatcaatcagctaataataataatgtcttcacaaagaaaacggggaatcagcagaaagtgaatgatgcttcagtaaacacagacccagccacttctgcctctactgtagatgtaaagccatcaccttctgcagcagaggcagattttgacatagtaacaaaggggcaagtctgtgaaatgaccaaagaaattgctgacaaaacagaaaagtataataaatgtaaacaactcttgcaggatgagaaagcaaaatgcaataaatatgctgatgaacttgcaaaaatggagctgaaatggaaagaacaagtgaaaattgctgaaaatgtaaaacttgaactagctgaagtacaggacaattataaagaacttaaaaggagtctagaaaatccagcagaaaggaaaatggaagatggagcagatggtgctttttacccagatgaaatacaaaggccacctgtcagagtcccctcttggggactggaagacaatgttgtctgcagccagcctgctcgaaactttagtcggcctgatggcttagaggactctgaggatagcaaagaagatgagaatgtgcctactgctcctgatcctccaagtcaacatttacgtgggcatgggacaggcttttgctttgattccagctttgatgttcacaagaagtgtcccctctgtgagttaatgtttcctcctaactatgatcagagcaaatttgaagaacatgttgaaagtcactggaaggtgtgcccgatgtgcagcgagcagttccctcctgactatgaccagcaggtgtttgaaaggcatgtgcagacccattttgatcagaatgttctaaattttgactagttactttttattatgagttaatatagtttagcagtaaaaaaaaaaaaaaaaaccacacctaaaatagaccactgaggagaccatagagcggatgctttcatgcaccctttactgcactttctgaccaggagctactttgagtttggtgttactaggatcagggtcagtctttggcttatcaataaattttaatctctgttaatcttacctgctttaaaaaaaagttcttgtgtgttcgtatctttatttattccctagtttgcagaactgtctgaataaaggatacaaggattatttcaatgttactgcactgaaaaacgtgtatgtattagtgtgctagattatttagcagaatattcacaagtttctgttgaccttgttgattgagcatgactactaaatattatgtaataaaaagcatttgtcataacagtcttatgaagtagttcttcgaatatagaaagttctataatttagcccatgaaatgataggtttttaattttcagaaatggagctgcatgtagaatgagatcacatgcttttatatgtgaaatattggttttagcaattaacagaaggcatactttgctaattttatggcaaaattttagaataacctgaatgattatttttaaactatcttgaagttgtatgtatatatctaatgggaaaatggaacaagagatgtcagtataattgttttcctattaaatgatctcataacaggggtgtttgtggcataaaaatcatagaatatatatcagtatcttttttacattttcctgatgagaatataaatttgaaatattctcagtaagtgattaaaagtacaatacataaacccaaatcaaagtaatgtgtttcttcagttatgtctgtgctgtatagaactgtcactaacattaaagaaagaggacacatttttcaagatctgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8887 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8887 -> Molecular function: GO:0019900 [kinase binding] evidence: ISS
GeneID:8887 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:8887 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: ISS
GeneID:8887 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS
GeneID:8887 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:8887 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:8887 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
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