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2025-05-09 18:53:59, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014112 9990 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens trichorhinophalangeal syndrome I (TRPS1), mRNA.
ACCESSION NM_014112
VERSION NM_014112.2 GI:90652850
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9990)
AUTHORS Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G,
Byrne EM, Blackwood DH, Boomsma DI, Cichon S, Heath AC, Holsboer F,
Lucae S, Madden PA, Martin NG, McGuffin P, Muglia P, Noethen MM,
Penninx BP, Pergadia ML, Potash JB, Rietschel M, Lin D,
Muller-Myhsok B, Shi J, Steinberg S, Grabe HJ, Lichtenstein P,
Magnusson P, Perlis RH, Preisig M, Smoller JW, Stefansson K, Uher
R, Kutalik Z, Tansey KE, Teumer A, Viktorin A, Barnes MR, Bettecken
T, Binder EB, Breuer R, Castro VM, Churchill SE, Coryell WH,
Craddock N, Craig IW, Czamara D, De Geus EJ, Degenhardt F, Farmer
AE, Fava M, Frank J, Gainer VS, Gallagher PJ, Gordon SD, Goryachev
S, Gross M, Guipponi M, Henders AK, Herms S, Hickie IB, Hoefels S,
Hoogendijk W, Hottenga JJ, Iosifescu DV, Ising M, Jones I, Jones L,
Jung-Ying T, Knowles JA, Kohane IS, Kohli MA, Korszun A, Landen M,
Lawson WB, Lewis G, Macintyre D, Maier W, Mattheisen M, McGrath PJ,
McIntosh A, McLean A, Middeldorp CM, Middleton L, Montgomery GM,
Murphy SN, Nauck M, Nolen WA, Nyholt DR, O'Donovan M, Oskarsson H,
Pedersen N, Scheftner WA, Schulz A, Schulze TG, Shyn SI, Sigurdsson
E, Slager SL, Smit JH, Stefansson H, Steffens M, Thorgeirsson T,
Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G,
Volzke H, Weilburg JB, Willemsen G, Zitman FG, Neale B, Daly M,
Levinson DF and Sullivan PF.
CONSRTM Major Depressive Disorder Working Group of the Psychiatric GWAS
Consortium
TITLE A mega-analysis of genome-wide association studies for major
depressive disorder
JOURNAL Mol. Psychiatry 18 (4), 497-511 (2013)
PUBMED 22472876
REFERENCE 2 (bases 1 to 9990)
AUTHORS Boraska,V., Davis,O.S., Cherkas,L.F., Helder,S.G., Harris,J.,
Krug,I., Liao,T.P., Treasure,J., Ntalla,I., Karhunen,L.,
Keski-Rahkonen,A., Christakopoulou,D., Raevuori,A., Shin,S.Y.,
Dedoussis,G.V., Kaprio,J., Soranzo,N., Spector,T.D., Collier,D.A.
and Zeggini,E.
TITLE Genome-wide association analysis of eating disorder-related
symptoms, behaviors, and personality traits
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B (7), 803-811
(2012)
PUBMED 22911880
REFERENCE 3 (bases 1 to 9990)
AUTHORS Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
TITLE Genome-wide association study of periodontal pathogen colonization
JOURNAL J. Dent. Res. 91 (7 SUPPL), 21S-28S (2012)
PUBMED 22699663
REFERENCE 4 (bases 1 to 9990)
AUTHORS Ackert-Bicknell,C.L., Demissie,S., Tsaih,S.W., Beamer,W.G.,
Cupples,L.A., Paigen,B.J., Hsu,Y.H., Kiel,D.P. and Karasik,D.
TITLE Genetic variation in TRPS1 may regulate hip geometry as well as
bone mineral density
JOURNAL Bone 50 (5), 1188-1195 (2012)
PUBMED 22306695
REMARK GeneRIF: Genetic variation in TRPS1 may regulate hip geometry as
well as bone mineral density
REFERENCE 5 (bases 1 to 9990)
AUTHORS Sidler,J.A., Filges,I., Boesch,N., Ramelli,G.P., Rothlisberger,B.,
Huber,A.R., Tercanli,S., Bronz,L., Miny,P. and Heinimann,K.
TITLE TRPS1 codon 952 constitutes a mutational hot spot in
trichorhinophalangeal syndrome type I and could be associated with
intellectual disability
JOURNAL Clin. Dysmorphol. 21 (2), 87-90 (2012)
PUBMED 22127049
REMARK GeneRIF: TRPS1 codon 952 constitutes a mutational hot spot in
trichorhinophalangeal syndrome type I and could be associated with
intellectual disability.
REFERENCE 6 (bases 1 to 9990)
AUTHORS Chang,G.T., Steenbeek,M., Schippers,E., Blok,L.J., van
Weerden,W.M., van Alewijk,D.C., Eussen,B.H., van Steenbrugge,G.J.
and Brinkmann,A.O.
TITLE Characterization of a zinc-finger protein and its association with
apoptosis in prostate cancer cells
JOURNAL J. Natl. Cancer Inst. 92 (17), 1414-1421 (2000)
PUBMED 10974077
REFERENCE 7 (bases 1 to 9990)
AUTHORS Momeni,P., Glockner,G., Schmidt,O., von Holtum,D., Albrecht,B.,
Gillessen-Kaesbach,G., Hennekam,R., Meinecke,P., Zabel,B.,
Rosenthal,A., Horsthemke,B. and Ludecke,H.J.
TITLE Mutations in a new gene, encoding a zinc-finger protein, cause
tricho-rhino-phalangeal syndrome type I
JOURNAL Nat. Genet. 24 (1), 71-74 (2000)
PUBMED 10615131
REFERENCE 8 (bases 1 to 9990)
AUTHORS Ludecke,H.J., Schmidt,O., Nardmann,J., von Holtum,D., Meinecke,P.,
Muenke,M. and Horsthemke,B.
TITLE Genes and chromosomal breakpoints in the Langer-Giedion syndrome
region on human chromosome 8
JOURNAL Hum. Genet. 105 (6), 619-628 (1999)
PUBMED 10647898
REFERENCE 9 (bases 1 to 9990)
AUTHORS Hou,J., Parrish,J., Ludecke,H.J., Sapru,M., Wang,Y., Chen,W.,
Hill,A., Siegel-Bartelt,J., Northrup,H., Elder,F.F. et al.
TITLE A 4-megabase YAC contig that spans the Langer-Giedion syndrome
region on human chromosome 8q24.1: use in refining the location of
the trichorhinophalangeal syndrome and multiple exostoses genes
(TRPS1 and EXT1)
JOURNAL Genomics 29 (1), 87-97 (1995)
PUBMED 8530105
REFERENCE 10 (bases 1 to 9990)
AUTHORS Hamers,A., Jongbloet,P., Peeters,G., Fryns,J.P. and Geraedts,J.
TITLE Severe mental retardation in a patient with tricho-rhino-phalangeal
syndrome type I and 8q deletion
JOURNAL Eur. J. Pediatr. 149 (9), 618-620 (1990)
PUBMED 2373110
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF183810.1, DA399687.1 and
AF264784.1.
This sequence is a reference standard in the RefSeqGene project.
On Mar 28, 2006 this sequence version replaced gi:7657658.
Summary: This gene encodes a transcription factor that represses
GATA-regulated genes and binds to a dynein light chain protein.
Binding of the encoded protein to the dynein light chain protein
affects binding to GATA consensus sequences and suppresses its
transcriptional activity. Defects in this gene are a cause of
tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF183810.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-278 AF183810.1 28-305
279-319 DA399687.1 254-294
320-727 AF183810.1 341-748
728-5132 AF264784.1 296-4700
5133-9990 AF183810.1 5154-10011
FEATURES Location/Qualifiers
source 1..9990
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q24.12"
gene 1..9990
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/note="trichorhinophalangeal syndrome I"
/db_xref="GeneID:7227"
/db_xref="HGNC:12340"
/db_xref="MIM:604386"
exon 1..457
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/inference="alignment:Splign:1.39.8"
exon 458..615
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/inference="alignment:Splign:1.39.8"
misc_feature 570..572
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/note="upstream in-frame stop codon"
CDS 579..4463
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/note="zinc finger protein GC79; tricho-rhino-phalangeal
syndrome type I protein"
/codon_start=1
/product="zinc finger transcription factor Trps1"
/protein_id="NP_054831.2"
/db_xref="GI:90652851"
/db_xref="CCDS:CCDS6318.2"
/db_xref="GeneID:7227"
/db_xref="HGNC:12340"
/db_xref="MIM:604386"
/translation="
MPYEVNAGYDFTNMVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEHSLHVQDPSSSSKKDLKSAVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQAQSGQANCQGLSPVSVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCHQCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQDITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKVWTESSSDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLARPIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQTLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNYSPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLNVVKTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHIQRGLHRNNAQVEKNGKPKE
"
misc_feature 996..998
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3291..3293
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3303..3458
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/note="Zinc finger DNA binding domain; binds specifically
to DNA consensus sequence [AT]GATA[AG] promoter elements;
a subset of family members may also bind protein;
zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
Region: ZnF_GATA; cd00202"
/db_xref="CDD:29259"
misc_feature order(3303..3305,3312..3314,3366..3368,3375..3377)
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:29259"
misc_feature order(3330..3335,3339..3341,3366..3398,3447..3449,
3453..3458)
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/note="DNA-binding region [nucleotide binding]; DNA
binding site"
/db_xref="CDD:29259"
misc_feature 3855..3857
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3858..3860
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3870..3872
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 616..1544
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/inference="alignment:Splign:1.39.8"
exon 1545..2674
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/inference="alignment:Splign:1.39.8"
exon 2675..3278
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/inference="alignment:Splign:1.39.8"
exon 3279..3401
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/inference="alignment:Splign:1.39.8"
exon 3402..9990
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/inference="alignment:Splign:1.39.8"
STS 6553..6728
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/standard_name="A007K26"
/db_xref="UniSTS:10749"
STS 6594..6760
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/standard_name="RH16176"
/db_xref="UniSTS:4640"
variation 7226
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/replace="a"
/replace="g"
/db_xref="dbSNP:1661222"
variation 7290
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/replace="a"
/replace="g"
/db_xref="dbSNP:800898"
STS 7880..8707
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/standard_name="TRPS1__5142.2"
/db_xref="UniSTS:468158"
variation 8778
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/replace="g"
/replace="t"
/db_xref="dbSNP:800897"
STS 9351..9513
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/standard_name="STS-H28054"
/db_xref="UniSTS:7612"
STS 9736..9906
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
/standard_name="RH99133"
/db_xref="UniSTS:84461"
polyA_signal 9965..9970
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
polyA_site 9988
/gene="TRPS1"
/gene_synonym="GC79; LGCR"
ORIGIN
aatagtgttggtgtcttgaaactgacgtaatgcgcggagactgaggtcctgacaagcgataacatttctgataaagacccgatcttactgcaatctctagcgtcctcttttttggtgctgctggtttctccagacctcgcgtcctctcgattgctctctcgccttcctatttcttttttttttttttaaacaaaaaacaacaccccctcccctctcccacccggcaccgggcacatccttgctctatttcctttctctttctctctctctctctctctctctcttttttaataagggtgggggagggaaaggggggggaggcaggaaagacctttttctctcccccccgcaataatccaagatcaactctgcaaacaacagaagacggttcatggctttggccgccgcgccaccatctttcgggctgccgagggtgttcttgacgattaatcaacagatgtacagatcagctctcaaaatgtcttctgtgtcttctgagcgtcttctaagacaattgcattagcctcctgctagttgactaatagaattaataattgtaaaaagcactctaaagccacatgccttatgaagtcaatgctgggtatgattttacaaatatggtccggaaaaagaacccccctctgagaaacgttgcaagtgaaggcgagggccagatcctggagcctataggtacagaaagcaaggtatctggaaagaacaaagaattttctgcagatcagatgtcagaaaatacggatcagagtgatgctgcagaactaaatcataaggaggaacatagcttgcatgttcaagatccatcttctagcagtaagaaggacttgaaaagcgcagttctgagtgagaaggctggcttcaattatgaaagccccagtaagggaggaaactttccctcctttccgcatgatgaggtgacagacagaaatatgttggctttctcatctccagctgctgggggagtctgtgagcccttgaagtctccgcaaagagcagaggcagatgaccctcaagatatggcctgcaccccctcaggggactcactggagacaaaggaagatcagaagatgtcaccaaaggctacagaggaaacagggcaagcacagagtggtcaagccaattgtcaaggtttgagcccagtttcagtggcctcaaaaaacccacaagtgccttcagatgggggtgtaagactgaataaatccaaaactgacttactggtgaatgacaacccagacccggcacctctgtctccagagcttcaggactttaaatgcaatatctgtggatatggttactacggcaacgaccccacagatctgattaagcacttccgaaagtatcacttaggactgcataaccgcaccaggcaagatgctgagctggacagcaaaatcttggcccttcataacatggtgcagttcagccattccaaagacttccagaaggtcaaccgttctgtgttttctggtgtgctgcaggacatcaattcttcaaggcctgttttactaaatgggacctatgatgtgcaggtgacttcaggtggaacattcattggcattggacggaaaacaccagattgccaagggaacaccaagtatttccgctgtaaattctgcaatttcacttatatgggcaactcatccaccgaattagaacaacattttcttcagactcacccaaacaaaataaaagcttctctcccctcctctgaggttgcaaaaccttcagagaaaaactctaacaagtccatccctgcacttcaatccagtgattctggagacttgggaaaatggcaggacaagataacagtcaaagcaggagatgacactcctgttgggtactcagtgcccataaagcccctcgattcctctagacaaaatggtacagaggccaccagttactactggtgtaaattttgtagtttcagctgtgagtcatctagctcacttaaactgctagaacattatggcaagcagcacggagcagtgcagtcaggcggccttaatccagagttaaatgataagctttccaggggctctgtcattaatcagaatgatctagccaaaagttcagaaggagagacaatgaccaagacagacaagagctcgagtggggctaaaaagaaggacttctccagcaagggagccgaggataatatggtaacgagctataattgtcagttctgtgacttccgatattccaaaagccatggccctgatgtaattgtagtggggccacttctccgtcattatcaacagctccataacattcacaagtgtaccattaaacactgtccattctgtcccagaggactttgcagcccagaaaagcaccttggagaaattacttatccgtttgcttgtagaaaaagtaattgttcccactgtgcactcttgcttctgcacttgtctcctggggcggctggaagctcgcgagtcaaacatcagtgccatcagtgttcattcaccacccctgacgtagatgtactcctctttcactatgaaagtgtgcatgagtcccaagcatcggatgtcaaacaagaagcaaatcacctgcaaggatcggatgggcagcagtctgtcaaggaaagcaaagaacactcatgtaccaaatgtgattttattacccaagtggaagaagagatttcccgacactacaggagagcacacagctgctacaaatgccgtcagtgcagttttacagctgccgatactcagtcactactggagcacttcaacactgttcactgccaggaacaggacatcactacagccaacggcgaagaggacggtcatgccatatccaccatcaaagaggagcccaaaattgacttcagggtctacaatctgctaactccagactctaaaatgggagagccagtttctgagagtgtggtgaagagagagaagctggaagagaaggacgggctcaaagagaaagtttggaccgagagttccagtgatgaccttcgcaatgtgacttggagaggggcagacatcctgcgggggagtccgtcatacacccaagcaagcctggggctgctgacgcctgtgtctggcacccaagagcagacaaagactctaagggatagtcccaatgtggaggccgcccatctggcgcgacctatttatggcttggctgtggaaaccaagggattcctgcagggggcgccagctggcggagagaagtctggggccctcccccagcagtatcctgcatcgggagaaaacaagtccaaggatgaatcccagtccctgttacggaggcgtagaggctccggtgttttttgtgccaattgcctgaccacaaagacctctctctggcgaaagaatgcaaatggcggatatgtatgcaacgcgtgtggcctctaccagaagcttcactcgactcccaggcctttaaacatcattaaacaaaacaacggtgagcagattattaggaggagaacaagaaagcgccttaacccagaggcacttcaggctgagcagctcaacaaacagcagaggggcagcaatgaggagcaagtcaatggaagcccgttagagaggaggtcagaagatcatctaactgaaagtcaccagagagaaattccactccccagcctaagtaaatacgaagcccagggttcattgactaaaagccattctgctcagcagccagtcctggtcagccaaactctggatattcacaaaaggatgcaacctttgcacattcagataaaaagtcctcaggaaagtactggagatccaggaaatagttcatccgtatctgaagggaaaggaagttctgagagaggcagtcctatagaaaagtacatgagacctgcgaaacacccaaattattcaccaccaggcagccctattgaaaagtaccagtacccactttttggacttccctttgtacataatgacttccagagtgaagctgattggctgcggttctggagtaaatataagctctccgttcctgggaatccgcactacttgagtcacgtgcctggcctaccaaatccttgccaaaactatgtgccttatcccaccttcaatctgcctcctcatttttcagctgttggatcagacaatgacattcctctagatttggcgatcaagcattccagacctgggccaactgcaaacggtgcctccaaggagaaaacgaaggcaccaccaaatgtaaaaaatgaaggtcccttgaatgtagtaaaaacagagaaagttgatagaagtactcaagatgaactttcaacaaaatgtgtgcactgtggcattgtctttctggatgaagtgatgtatgctttgcatatgagttgccatggtgacagtggacctttccagtgcagcatatgccagcatctttgcacggacaaatatgacttcacaacacatatccagaggggcctgcataggaacaatgcacaagtggaaaaaaatggaaaacctaaagagtaaaaccttagcacttagcacaattaaatagaaataggttttcttgatgggaattcaatagcttgtaatgtcttatgaagacctattaaaaaaatacttcatagagcctgccttatccaacatgaaattcccttcttttgttattctttcttttgatgagtaggttaccaagattaaaaagtgagataaatggtcaatgagaaagaatggaagatggtaaacaatcactttttaaaacctgttaagtcaaaaccatcttggctaatatgtactggggaaataatccataagagatatcaccagactagaattaatatatttataaagaaagagaccaaaactgtctagaatttgaaagggtttacatattattatactaaagcagtactggactggccattggaccatttgttccaaaacccataaattgttgcctaaatttataatgatcatgaaaccctaggcagaggaggagaaattgaaggtccagggcaatgaaagaaaaatggcgccctctcaatttagtcttctctcattggccatgtttcagattttgacctagaaatgcgagctgtggttaggcttggttagagtgcagcaagcaacatgacagatggtggcacgctgtttttacccagccctgcctgtacatacacatgcacaccctctctgatatttttgtcctttagatgttcaaatactcagtagtccttttgtttgcggtttagattcattttgtccacacatgtacccattttaaaaaacaatgtcctcgatgcttctgtagtgatttcattttagccaggtatttctttcttgtgtgtgatgaaccagtatggatttgcttttctaagcctcctgttggttactaatctcacttggcacattataactaaaggaatcccctcaattcaaaagcatagatggatacaaatgtcagaccgtgggtttaatttgtttagaacacatggcatttcttcacaaggtaacctgctgtatttatttattttcttttggttaaatataatttccaaactttgtggtcaggcagcgtctaaggttacgttaccacagactgacagttggtatatgtaccagccaatcccttcattaaatgtatacagatttagttaagtagcattaaataggattcttagaagtatgtcctcatagaacttttaatacttaaggctttgtaaaaactatccatgaagggaaagctcctcagcataactgctcagggaaatagggctaaataactgaacattaaataattggttaaaggtgctgttagtcgagcctcaatgcttgctacaaggatgtatgtacaaggactgactttaataatttgcattatattgtcccaaccagtagtttattttttgccacggagatgtagaagatattacaagctactggatgcactgtcagattaacttatttcattaaagaagttgggagaacaaataggaaaaaaaaaacttatttttctagtaaatattaatgtattacatttcaaataatggtgcctgacatattgaataattattttctacagtgtacgtatgcaacaaagatattccatcatgcattagagtcagttctggctctgcctagctgtttacatttgcaaatgtagcaaacaaggtaatgaagcaactatttctattgcagtagatatccttttgtgtgtgtgtgtgtgcattaaagttgtaaacggtaacatgaaacaaatgaaagttcttgctataatggtatggaaaacaagaaggaaatgaaaatatttttatgcctacttaggaaaaaaagggtagcacttattcattccaagtacttttttttttttaatttttaagctcttaactcacattgttatgcttaagatgataaacatatatcctctttttattgctttgtctatgtttcatatgaaacatttcagaaattattttgataagtgttgctggaatctgcaacgctgatttttttttgcattctgtagtcgcatttgcactccatttttacattaattcgcagttgctttgtatcattgttttgtttgggttttgtttctttttcacagtgccgggtcttcgtttcttaaagttggatggcaggtagagttcaaccagttcgtgactgttgtagcgaatgaagttaaaaaaatgtctttctgatgttgtgttgtcattttcatttttgcatttttttgtttgcatattaaaaaaagagaaaagagaaagcaagagacagaaatcaggactaagtcctctgcttcagtttcattgttaacgggccttattctgatctcacctgtcgcgtagctctaatattcacataaactgaaataaagaagtggaatgaggagctttgacattcaaattatgtgatgtaatttatcttccttaggaattttgatggatgcatctcaaaatgtatagccagacttgagaggtgacaattaaagatctaaaaaagagaggagattcccccaaacaacaatatttaattttcttagtaaaaagaataacagaatgcatcgtggcaatccttaagcaacattatctatgtggactgcttaaatcagcaaaacaccagaagtttggttaacttgggcaatatgacaagtattactttttgggcaaaactactcattaagcaatttctctagtgtgtcggacacaaataggttctttatttttggcatgtatgcctttttattttcattcaattttttttttttctcagacagacatagtagtatcaactagcattggaaaatacatatcactattcttggaatatttatggtcagtctactttttagtaaaatatttttggatagcgttgacacgatagatcttattccatacttctttattattgataattttattttcattttttgctttcattattatacatattttggtggagaagaggttgggcttttttgaaagagacaaaaatttattataacactaaacactccttttttgacatattaaagcctttattccatctctcaagatatattataaaatttatttttttaatttaagatttctgaattattttatcttaaattgtgattttaaacgagctattatggtacggaactttttttaatgaggaatttcatgatgatttaggaattttctctcttggaaaaggcttcccctgtgatgaaaatgatgtgccagctaaaattgtgtgccatttaaaaactgaaaatattttaaaattatttgtctatattctaaattgagctttggatcaaactttaggccaggaccagctcatgcgttctcattcttccttttctcactctttctctcatcactcacctctgtattcattctgttgtttgggatagaaaaatcataaagagccaacccatctcagaacgttgtggattgagagagacactacatgactccaagtatatgagaaaaggacagagctctaattgataactctgtagttcaaaaggaaaagagtatgcccaattctctctacatgacatattgagattttttttaatcaacttttaagatagtgatgttctgttctaaactgttctgttttagtgaaggtagatttttataaaacaagcatggggattcttttctaaggtaatattaatgagaagggaaaaaagtatctttaacagctctttgttgaagcctgtggtagcacattatgtttataattgcacatgtgcacataatctattatgatccaatgcaaatacagctccaaaaatattaaatgtatatatattttaaaatgcctgaggaaatacatttttcttaataaactgaagagtctcagtatggctattaaaataattattagcctcctgttgtgtggctgcaaaacatcacaaagtgaccggtcttgagacctgtgaactgctgccctgtttagtaaataaaattaatgcatttctagagggggaatatctgccatccagtggtggaaatgtggagtaaagaagctggtggtctgcttctgtgctgtatgccagccttttgccttaagttgagaggaggtcaactttagctactgtctttggtttgagagccatggcaaaaaaaaaaaaagaaaaaaagatcaagtcgtctttggtgagccagtaaggtgaaagcttgctgactgtccaaggcacaagagaaaattgaggaattgaaatgcaacctgagtatcaaactaaatattctaatcaaaggtaggtactgttaggtggaattctatcagcaggcaactgcaaatgagaagaagatagaaggacgcccgtcgggactttggagggcattgttattttcccaaagaaagacggccaagggcagaggcatggattctttgcagagcacttccttttggtttttcagtactgtttcatagacagtgggctcacatgttcctgatagtgctgcagttgcttagaaagcatcccagttaattgcagtaattagaacttctggaatatgctagggcagaagtatgtcaagtatgtcacatgaagaaaatgtgaaattcaagagtaatccacacgtgagaaactagacaatgtacattcatgtgttctcttgaaaggaaagggagagctgtaagcttcactctgtcctacaccggagaaaagcaggaataactttaccgtggaaataatgtttagcttttatcagagaaaattgtccttctagagcatagagtcccaaaactcaattctggttttcccctgttttttttttttttttttttcccaacatatgaactgcagcatatcactttttctttttgtgcctcaggttcctcacctgtaaaattgaaaaatatatgtattaataatattattaataataataatggtaatgtagtacttgtttgtaaagcactttgagatccttggttgaaaggcaccataggagtgccaagtattattatgtggccaagggggttatttaaactgtcagttcccaaaggccaggaaaggttggggtcatttttcttaaagacgagctgtaaatatcaactaggcagccaatagtgttgactatgaagatgcaaaactattactaggctgataaaatcatagtttcttaatggctaccaataaggcaaatatcacaataataaacgccaaattccttagggcggactatttgacaaccacatggaaaactttgggggaggcatgaggggggaacatctcaaaatgccaatgtaaaatttaacttacagcaatattcaccagcagaaaatgtctttcatatggaatgatttcatgttgctaagaaaaagaattcaatttgtagtcctgatttgaatactagaatgttggctataatagttctgttcttacaacacatgaaattttttcgttttattttattttgttttcatagtgcatgttcatttctactcacaaacatgttcttggtgtatttcttatgcaaacaatcttcaggcagcaaagatgtctgttacatctaaacttgaataataaagttttaccaccagttacaca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7227 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:7227 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7227 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7227 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:7227 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:7227 -> Biological process: GO:0001501 [skeletal system development] evidence: TAS
GeneID:7227 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
GeneID:7227 -> Biological process: GO:0006607 [NLS-bearing substrate import into nucleus] evidence: TAS
GeneID:7227 -> Biological process: GO:0032330 [regulation of chondrocyte differentiation] evidence: ISS
GeneID:7227 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
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