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2025-05-09 18:51:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005401 13443 bp mRNA linear PRI 24-JUN-2013
DEFINITION Homo sapiens protein tyrosine phosphatase, non-receptor type 14
(PTPN14), mRNA.
ACCESSION NM_005401
VERSION NM_005401.4 GI:294862265
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 13443)
AUTHORS Huang,J.M., Nagatomo,I., Suzuki,E., Mizuno,T., Kumagai,T.,
Berezov,A., Zhang,H., Karlan,B., Greene,M.I. and Wang,Q.
TITLE YAP modifies cancer cell sensitivity to EGFR and survivin
inhibitors and is negatively regulated by the non-receptor type
protein tyrosine phosphatase 14
JOURNAL Oncogene 32 (17), 2220-2229 (2013)
PUBMED 22689061
REMARK GeneRIF: YAP forms a protein complex with PTPN14 through the WW
domains of YAP and the PPXY motifs of PTPN14.
REFERENCE 2 (bases 1 to 13443)
AUTHORS Wang,W., Huang,J., Wang,X., Yuan,J., Li,X., Feng,L., Park,J.I. and
Chen,J.
TITLE PTPN14 is required for the density-dependent control of YAP1
JOURNAL Genes Dev. 26 (17), 1959-1971 (2012)
PUBMED 22948661
REMARK GeneRIF: that PTPN14 acts to suppress cell proliferation by
promoting cell density-dependent cytoplasmic translocation of YAP1
REFERENCE 3 (bases 1 to 13443)
AUTHORS Benzinou,M., Clermont,F.F., Letteboer,T.G., Kim,J.H., Espejel,S.,
Harradine,K.A., Arbelaez,J., Luu,M.T., Roy,R., Quigley,D.,
Higgins,M.N., Zaid,M., Aouizerat,B.E., van Amstel,J.K., Giraud,S.,
Dupuis-Girod,S., Lesca,G., Plauchu,H., Hughes,C.C., Westermann,C.J.
and Akhurst,R.J.
TITLE Mouse and human strategies identify PTPN14 as a modifier of
angiogenesis and hereditary haemorrhagic telangiectasia
JOURNAL Nat Commun 3, 616 (2012)
PUBMED 22233626
REMARK GeneRIF: PTPN14 has a role in angiogenesis and/or arteriovenous
fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1
Erratum:[Nat Commun. 2012;3:1148]
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 13443)
AUTHORS Au,A.C., Hernandez,P.A., Lieber,E., Nadroo,A.M., Shen,Y.M.,
Kelley,K.A., Gelb,B.D. and Diaz,G.A.
TITLE Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic
function and choanal development in humans
JOURNAL Am. J. Hum. Genet. 87 (3), 436-444 (2010)
PUBMED 20826270
REMARK GeneRIF: These results suggest a unique and conserved role for
PTPN14 in the regulation of lymphatic development in mammals and a
nonconserved role in choanal development in humans.
REFERENCE 5 (bases 1 to 13443)
AUTHORS Wyatt,L. and Khew-Goodall,Y.
TITLE PTP-Pez: a novel regulator of TGFbeta signaling
JOURNAL Cell Cycle 7 (15), 2290-2295 (2008)
PUBMED 18677119
REMARK GeneRIF: Dysregulation of TGFbeta signaling as a possible link
between Pez mutation and cancer progression.
Review article
REFERENCE 6 (bases 1 to 13443)
AUTHORS Wadham,C., Gamble,J.R., Vadas,M.A. and Khew-Goodall,Y.
TITLE Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to
the nucleus is associated with induction of cell proliferation
JOURNAL J. Cell. Sci. 113 (PT 17), 3117-3123 (2000)
PUBMED 10934049
REFERENCE 7 (bases 1 to 13443)
AUTHORS Aoyama,K., Matsuda,T. and Aoki,N.
TITLE Characterization of newly identified four isoforms for a putative
cytosolic protein tyrosine phosphatase PTP36
JOURNAL Biochem. Biophys. Res. Commun. 266 (2), 523-531 (1999)
PUBMED 10600535
REFERENCE 8 (bases 1 to 13443)
AUTHORS Ogata,M., Takada,T., Mori,Y., Uchida,Y., Miki,T., Okuyama,A.,
Kosugi,A., Sawada,M., Oh-hora,M. and Hamaoka,T.
TITLE Regulation of phosphorylation level and distribution of PTP36, a
putative protein tyrosine phosphatase, by cell-substrate adhesion
JOURNAL J. Biol. Chem. 274 (29), 20717-20724 (1999)
PUBMED 10400706
REFERENCE 9 (bases 1 to 13443)
AUTHORS Ogata,M., Takada,T., Mori,Y., Oh-hora,M., Uchida,Y., Kosugi,A.,
Miyake,K. and Hamaoka,T.
TITLE Effects of overexpression of PTP36, a putative protein tyrosine
phosphatase, on cell adhesion, cell growth, and cytoskeletons in
HeLa cells
JOURNAL J. Biol. Chem. 274 (18), 12905-12909 (1999)
PUBMED 10212280
REFERENCE 10 (bases 1 to 13443)
AUTHORS Smith,A.L., Mitchell,P.J., Shipley,J., Gusterson,B.A., Rogers,M.V.
and Crompton,M.R.
TITLE Pez: a novel human cDNA encoding protein tyrosine phosphatase- and
ezrin-like domains
JOURNAL Biochem. Biophys. Res. Commun. 209 (3), 959-965 (1995)
PUBMED 7733990
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA738908.1, AK291641.1,
AL445305.11, AL603838.6 and AL929236.4.
This sequence is a reference standard in the RefSeqGene project.
On Apr 20, 2010 this sequence version replaced gi:34328898.
Summary: The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains an N-terminal
noncatalytic domain similar to that of band 4.1 superfamily
cytoskeleton-associated proteins, which suggested the membrane or
cytoskeleton localization of this protein. It appears to regulate
lymphatic development in mammals, and a loss of function mutation
has been found in a kindred with a lymphedema-choanal atresia.
[provided by RefSeq, Sep 2010].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK291641.1, X82676.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-356 DA738908.1 1-356
357-627 AK291641.1 289-559
628-827 AL445305.11 3979-4178 c
828-2179 AK291641.1 760-2111
2180-3197 AL603838.6 25863-26880 c
3198-4391 AK291641.1 3130-4323
4392-13443 AL929236.4 107756-116807 c
FEATURES Location/Qualifiers
source 1..13443
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q32.2"
gene 1..13443
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="protein tyrosine phosphatase, non-receptor type 14"
/db_xref="GeneID:5784"
/db_xref="HGNC:9647"
/db_xref="HPRD:04402"
/db_xref="MIM:603155"
exon 1..499
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
variation 357
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="c"
/replace="t"
/db_xref="dbSNP:3806315"
exon 500..827
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
misc_feature 564..566
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="upstream in-frame stop codon"
CDS 654..4217
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/EC_number="3.1.3.48"
/note="cytoskeletal-associated protein tyrosine
phosphatase; protein-tyrosine phosphatase pez"
/codon_start=1
/product="tyrosine-protein phosphatase non-receptor type
14"
/protein_id="NP_005392.2"
/db_xref="GI:34328899"
/db_xref="CCDS:CCDS1514.1"
/db_xref="GeneID:5784"
/db_xref="HGNC:9647"
/db_xref="HPRD:04402"
/db_xref="MIM:603155"
/translation="
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI
"
misc_feature 723..1313
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="Band 4.1 homologues; Region: B41; smart00295"
/db_xref="CDD:197635"
misc_feature 726..962
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="FERM N-terminal domain; Region: FERM_N; pfam09379"
/db_xref="CDD:204220"
misc_feature 978..1313
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="FERM central domain; Region: FERM_M; pfam00373"
/db_xref="CDD:201187"
misc_feature 1293..1562
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl00273"
/db_xref="CDD:206947"
misc_feature order(1305..1328,1335..1355,1362..1376,1425..1439,
1449..1463,1482..1496,1521..1547)
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="PH-like core; other site"
/db_xref="CDD:176275"
misc_feature 2109..2111
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15678.2); phosphorylation site"
misc_feature 2109..2111
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2403..2405
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2424..2426
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15678.2); phosphorylation site"
misc_feature 2433..2435
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15678.2); phosphorylation site"
misc_feature 2577..2579
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q15678.2); phosphorylation site"
misc_feature 3378..4190
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 3456..4190
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(3888..3890,4011..4016,4023..4025,4032..4037)
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/note="active site"
/db_xref="CDD:28929"
misc_feature 4014..4034
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15678.2);
Region: Substrate (By similarity)"
misc_feature 4014..4034
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15678.2);
Region: Substrate binding (By similarity)"
exon 828..997
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 998..1095
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 1096..1163
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 1164..1234
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 1235..1322
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 1323..1411
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 1412..1499
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
variation 1499
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="a"
/replace="g"
/db_xref="dbSNP:35027429"
exon 1500..1582
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 1583..1640
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 1641..1719
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 1720..3197
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
variation 2260
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="c"
/replace="t"
/db_xref="dbSNP:79745253"
exon 3198..3341
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 3342..3560
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 3561..3689
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 3690..3924
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
variation 3905
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="a"
/replace="g"
/db_xref="dbSNP:1135352"
exon 3925..4088
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
exon 4089..13443
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/inference="alignment:Splign:1.39.8"
STS 4212..4344
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/standard_name="STS-X82676"
/db_xref="UniSTS:21364"
STS 4218..4365
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/standard_name="SHGC-76337"
/db_xref="UniSTS:64565"
variation 5823
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="a"
/replace="g"
/db_xref="dbSNP:1060349"
variation 8230
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="c"
/replace="t"
/db_xref="dbSNP:1472441"
variation 8512
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="c"
/replace="t"
/db_xref="dbSNP:1472442"
variation 8518
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="a"
/replace="g"
/db_xref="dbSNP:1472443"
variation 9879
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="c"
/replace="t"
/db_xref="dbSNP:1472439"
variation 10166
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="g"
/replace="t"
/db_xref="dbSNP:1472440"
variation 10493
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="a"
/replace="c"
/db_xref="dbSNP:200638209"
STS 11345..11534
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/standard_name="D1S1425"
/db_xref="UniSTS:149621"
STS 11389..11495
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 12441
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/replace="c"
/replace="t"
/db_xref="dbSNP:11546021"
STS 13215..13340
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/standard_name="A009Q27"
/db_xref="UniSTS:949"
STS 13215..13340
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/standard_name="G32781"
/db_xref="UniSTS:117361"
STS 13299..13425
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
/standard_name="D1S2195"
/db_xref="UniSTS:4899"
polyA_signal 13416..13421
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
polyA_site 13439
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
polyA_site 13443
/gene="PTPN14"
/gene_synonym="PEZ; PTP36"
ORIGIN
actcgcacggccccttcctccctcctctcccggccgctcgcatttcctgccgctctggctctcccggcccctcaaagttctttccaactttttctcggcggagtgagcgcagcgggcgcagactcgggggcaggttgctgtgcttctccgggctcagccgcctgctctcctggctcaggtcctcggggagccctagacagacatcaagtggccactggcgctccttcccctcccagctgagccatcctccccggcctcctcgggcgggacagccccgtgcttaggtttttctccttttctcccccggtgcgcctctgctcggactctcgcgccgggatcgcggcggaaacctccctcccctttcgcctcctgcggctccttcccttcgcccctcctccgccagtcactggaatcaattccgtggggaatcggctccgccgccgcgaaggacagcctttccgcgcgggactccggggcgccacgggggccatgtaagcagctatcttccagagggccacactgggcatggacacccttttccctgcctggaggagcacaggtgatagtgtaattttccagtcacgaaactgctaaggccatctcaggggcgtgtgcgccaggataggcgggcggcgtccgaggaccacatagccatgccttttggtctgaagctccgccggacacggcgctacaacgtcctgagcaagaactgctttgtcacacggattcgcctgctggacagcaatgttatcgagtgcacgctgtcggtggaaagcacagggcaagaatgcctggaggctgtggcccagaggctggagctgcgagagacgcactactttggcctttggtttctcagcaagagccagcaagcacgatgggtggagctggagaaacctctgaagaaacatctggacaaattcgctaatgagcctttgcttttctttggagtcatgttctatgtgccaaatgtgtcatggcttcagcaagaggccacaagatatcagtattacctgcaagtcaaaaaagatgtgcttgaagggcgattacgatgtacattggaccaggtgattcggctagccggcctagctgtgcaagctgattttggagactataatcagtttgattctcaagatttcctcagagagtatgtgctatttcctatggatttggccctggaagaggctgttctggaggagctgacccagaaggtagcccaagaacacaaagcccacagtggaatcctgccagcagaagctgaactgatgtacatcaatgaagttgaacgtttggatggatttggacaggaaatcttccctgtaaaggacaatcatggaaactgtgtacaccttggcattttctttatggggattttcgtgaggaacagaattggaagacaagcggtaatatacaggtggaatgacatggggaatatcactcataacaagtcgaccattctagtggagctcatcaacaaagaagagactgccctctttcacacggatgatatcgaaaatgccaagtatatttctcggttgtttgccacacgacacaagttttacaaacaaaacaaaatctgcactgaacagtcaaattctccaccccccatcagacgccagcccacctggagccgatcctctctgcccaggcagcagccgtacatcctgcctcccgttcacgtccagtgtggtgagcactactcggaaacgcacacctcgcaagacagcatttttcatgggaatgaagaagccttgtattgcaactctcacaacagcctggacttaaattatttaaatggcactgtcaccaatggcagcgtgtgtagcgttcacagcgtcaactccctcaactgctcgcaaagtttcatccaggcctcccctgtatcctccaacctcagtatccctgggagtgacatcatgcgggccgactacatcccgagccaccggcacagcgcgatcatcgtgccctcgtacaggccaacccccgattatgagacagtcatgcgccagatgaagagggggatcctgcatacagacagccagagccagtctctgagaaacctcaacattatcaacacccatgcctacaaccagccagaggatctggtgtacagccaaccggagatgcgggagaggcacccctacactgtcccttatgggccacagggggtctacagcaacaaacttgtcagtccatctgaccagaggaacccaaagaataatgtggtaccaagcaagccgggggcaagcgccatctcgcacacggtgagcaccccagagctggccaacatgcagctgcagggcagccataactacagcacggcccacatgcttaagaactatctcttcaggccaccgcccccctacccacggccacgacctgccaccagcaccccagacctggccagccaccgccacaagtacgtcagcggcagcagcccggacctggtgacccggaaggtgcagctctcggtgaagaccttccaagaggacagctctccggtggttcatcagtctctccaggaggtgagcgagcccctcacggccaccaagcaccacggcactgtgaacaagcgccacagcctggaggtgatgaacagcatggtgcggggcatggaggccatgacgctcaagtcgctccacctccccatggctcgccgcaacacgctccgggagcagggaccgcccgaggaggggtcaggcagccacgaggtcccccagctccctcagtatcaccacaagaagaccttctctgatgccactatgctaatccacagcagcgagagtgaggaggaggaggaggaggctccagaatcggtgccccagatccccatgctccgggagaagatggagtacagtgcccagctgcaggcggccctggcccgcatccccaacaagcccccgcctgagtaccccggtccaaggaagagtgtgagcaatggggctctgaggcaggaccaagccagccttcctcccgccatggccagagccagggtgctgaggcatgggccagccaaggccatcagcatgtctcggactgacccgccggctgtcaacggggcctctctcggcccatccatctcggaacccgacctgactagtgtgaaggagcgggtcaaaaaagagcctgtgaaggagagacctgtgtctgaaatgttttccctggaagacagcattatagagagagagatgatgatcaggaatctagagaagcagaagatggcaggcctggaggcacagaagaggccgctgatgttggcagcattgaatgggctctcggtggctcgagtctcagggcgggaagagaatcgagttgatgccacccgggttcccatggacgagaggttcagaaccctgaagaagaaactagaagagggaatggtgttcacagaatatgagcaaattccaaagaaaaaggcgaatggcattttcagcacagcagctctgccagaaaacgccgagcgcagccgaatccgtgaagttgtcccctatgaggagaatcgagtagagctgataccaaccaaagaaaataacacaggatacattaatgcctcccacatcaaggtggtggttggcggggcagaatggcactacatagccacccaggggcccctgccacacacgtgccacgacttctggcagatggtgtgggagcagggagtgaatgtgattgccatggtcactgcagaggaggagggtggacgaaccaaaagccaccgatactggcccaaactaggttcaaagcacagctcagccacctatggcaagttcaaggtcaccacgaagtttcgaacggattctgtttgctatgcaaccacgggcttgaaggtcaagcaccttttgtctgggcaagaaaggacggtgtggcatttacaatatactgactggccagatcacggctgtccagaagatgtccaaggatttttatcctacttggaggagatccagtcggtccgtcgccataccaacagcatgctggaaggcaccaagaaccggcacccgcccatcgtggtccactgtagtgctggggtgggaaggaccggcgtgctcattctttctgagctgatgatctactgcttggaacataacgaaaaggtggaagtgcccatgatgctgaggctcctcagggagcagaggatgttcatgatccagactatcgctcagtacaagtttgtctaccaagtcctcatccagttcctccaaaactccagactcatttaatcaccccaatccagctcctggaggagggacccagctccatcgcgctggaggagagtcacctccagacaacatctgctccccccacaggggtgcaggtggctggcagcaaacaggctctctgaagacagtagccaagattattcacacataccatgtattattttatatgagataatttatttttttcccctttggaataacttttgtgaattattataatgcagtttccctagtaatatagtacttttcatttgaaccacatcttgactgatctgtattgtaatatatgtcagcaggtaaggttgcctgctggatcattttgaggacagaggcatgagggagcacatctcttgtgaagttgcagccagatttgtaaccaaccctgaaattcatcagcttaattcatttatcagcttgattcattcatcattcattgcttatatccaaagcaaagacggtaagaaaatgaattcatcctgaaatataaagaaaagggtctgaaggaacaaacacgattctcttatattttggggctcatgagccttgatagacagtttcctctcgtcttcatttccacccctcatcctcagtagtctcctctcccccacgccccaccccaacttcccccccaagcttgagttaaagacagaatagctaaagacagtgctgcctttacaatgcagtaattgccatctttggggccgaaagacaagctctgtgttgtgcttttcttgaccaccccttatcctgggctctggagcttgtgtttccctgctggcgact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gctttgtttttagccttcccattttaaaaataaattcaaggacattgagttacaaggcaggagggctggagctactgggcagcctgaatatgacaagcatttgtgtggaaagtcattgctccttctgccacactttgggccatcaggatcattctttcccagaagtgccataaacttgctcaaaagtttctataaatgggaagagggagaggaaggatttttgcatcagtcctgaagttgctatccaaaagttctctgtttcacaaataattttctgaactctggaatgcctctcctactccctgcctccctttctgtaatgtcagagtgatggaaaccaccaagtggcatgctagggaaagcctgcagcagtgttggagtctatttcaccctagctcatagttttaaactgtcttcactgttgaggtagagcttgatgaatgtcatggattatgatgtgtggtttatcatatttgcctggatttgctgatcaaaagcaccatcttccctcgcctgctgctggcagcctttccttgccttgcttgttagcagagcattctgcttacccatgtggctcccagagttagcagccccggctcttggatttcttgattcttctcccctgtgatctcagaggtgctgcagaggacattcccctttagagcaagtcatgtttctattcaggccacaaaactgggatgtacatgcagtgactttggtgttccttgtcttgttcaggggaacgggtgggactgttgtgtgctgtcaccctcttcattccatgagcaccttgttcacttagggtctgctgcctttttttttttctttttctttttttttttttttttagtttttgagatcgtgtctcactcctgttgcgcaggctggagtgcagcctccaaagtagctgggattataggcgtgcaccaccacacccggctaatttttatatttttagtagagacggggttttgccatgttggccagactggtctcaaacctctgacctcgtgatgacccccctcggcctcccaaagtgctgggattacacccagcctctgctgccttttcatatttccccatctgctttatggatcaactctcaacagtacactttttcttttctttacctaccctatgagtgcaacccagatgtaagagttaatcctcgtcagagaatcattgccttaaacctctcagaaatatgtaattaggaaatcttattttaattttttaaaaattgcttgtatagtttcaaagaataagatctggcaaatggccagatgtggtggctcacacctgtaatcaaaccagcactttgggaggctgaggcaggcagatcacctgaggtcaggcgttcaagaccagcctggccaacatggtgaaatcccgtctctactaaaaatacaaaaaaaaaaaaaaaaaaaaaaattagccaggcatggtggcacatgcctgtaatcccagctactcaggaggctgaggcaggataattgcttgaacccgggaggtggaggttgcagtgagccgagatcatgccactgcactccagcctgggcaacagagtgagactttgtctcaaaaaaaaaaaaaaaaaaaaaaaaagatctggcggatgaaaataaccagaatgaaaatagctagaaaactcagcaagcaggaagctccctttctcacccttttgttcccttgccgatagaatcagtcactattagaaaaaatgaaagacgctctgtttaaaacaatgatgacagcagtacttaatatgtatttcgaggtgaacttatatagattgagagaggctgcatttggcagactgatgtataggaagacccatttgtttctagcttctccctgcagggaaaatgctttcgtcattatagcctctttacacagactggccattctagtgaaacaggtggtaaacctttgggctgcccagaaacattttatctgttttcacttacctaggaaggggaaagattagcgggtcatccaaaatctgtatgtaagctatcttcattttcttccccaaccttctcctcctgggaaacacaaatgctatctcatctgacaaaaggttttagaggataaagctgaaaagattggattgggatctttttgtggcttggggcggagccttttgctaaaatctcaagaatgctgctttgagtttagctagggtggctctcagaactggggtgcctggcattctcagcatttctcaggggcctcccacctctgacaactgcagtgttagctaatacataccttgagcatagaactgaatgctgtaattcagagccattttttttttcaacttgaacattgtacaattttactgcaatttcctttgaactttcttgccactgtttggaatcttaaaaattcattagccttctcctttctgacataaagctactcttcatcagagatgagttcctatgtatgtcctttgttccttcaatagctaattaatgtgcttgaggatacttcagtggaaaaaaaggtttaaatatgcaaattactaataaatgtgtaaccttatgtaacttgtgttacatcaagtaacaagctaatctagtttgtttcactggactaggcttgtgctccctacttcagtattttgatgctttccttgatctttgtttcacaaaatgttgtgaattttggtatcattcaaaacaaatgacatttattaggtttcattttgaaacgatgtacagacaagtccccaacttagaaaccggtttgttcttaaggttcttgcgtcagcccatagaagcccactgacctccaccacagcccaaatggagggctgtgatagccagatctggttggcttttgtgggctgacccagacatttaatcaccatctcttatgttgttgccgtaagaaatgcattccaggttgggacttgggatcctgagagcacattcgccccctgtggtggccgcttgccaccttgcaagatggaagcccagtctccttactaccaaactgtagttgtaagcagagggaggggtgagatgtttataggacattccctaagctggggagtgatttttatcactattcatgtcaactgtactttggtatagactccctatcaatttaataatatgaaaagcctaaaataaaactatgcatgctattctatgtgctattttatatcagtaaataagcttatgcttgccagttgtatacacagttatgaggtgtatagaactgactttgacagtattttttgcactgtttcctatctgtttttataaagtcttatttagatattggaccttgttgatgttctcactgcccttgtgcttgctataaaatgtttcatatgtgcctttacaaatgtgagatctttattctaacctttttttgtaaaagatatctattgatttccatatgcaataaacctttttttcagagaaaagtta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5784 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: IMP
GeneID:5784 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: IMP
GeneID:5784 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5784 -> Molecular function: GO:0030971 [receptor tyrosine kinase binding] evidence: IPI
GeneID:5784 -> Biological process: GO:0001946 [lymphangiogenesis] evidence: IMP
GeneID:5784 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:5784 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:5784 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: TAS
GeneID:5784 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IMP
GeneID:5784 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: IMP
GeneID:5784 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: TAS
GeneID:5784 -> Biological process: GO:0046825 [regulation of protein export from nucleus] evidence: IDA
GeneID:5784 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5784 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5784 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005392 -> EC 3.1.3.48
by
@meso_cacase at
DBCLS
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