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2025-05-09 18:34:54, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001253914 2990 bp mRNA linear PRI 14-JUL-2013
DEFINITION Homo sapiens TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
(TBC1D1), transcript variant 4, mRNA.
ACCESSION NM_001253914
VERSION NM_001253914.1 GI:359807050
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2990)
AUTHORS Yamazaki,K., Umeno,J., Takahashi,A., Hirano,A., Johnson,T.A.,
Kumasaka,N., Morizono,T., Hosono,N., Kawaguchi,T., Takazoe,M.,
Yamada,T., Suzuki,Y., Tanaka,H., Motoya,S., Hosokawa,M.,
Arimura,Y., Shinomura,Y., Matsui,T., Matsumoto,T., Iida,M.,
Tsunoda,T., Nakamura,Y., Kamatani,N. and Kubo,M.
TITLE A genome-wide association study identifies 2 susceptibility Loci
for Crohn's disease in a Japanese population
JOURNAL Gastroenterology 144 (4), 781-788 (2013)
PUBMED 23266558
REFERENCE 2 (bases 1 to 2990)
AUTHORS Pehmoller,C., Brandt,N., Birk,J.B., Hoeg,L.D., Sjoberg,K.A.,
Goodyear,L.J., Kiens,B., Richter,E.A. and Wojtaszewski,J.F.
TITLE Exercise alleviates lipid-induced insulin resistance in human
skeletal muscle-signaling interaction at the level of TBC1 domain
family member 4
JOURNAL Diabetes 61 (11), 2743-2752 (2012)
PUBMED 22851577
REMARK GeneRIF: Data suggest that insulin increases phosphorylation of
signaling nexus TBC1D1 independent of prior exercise or
lipid/Intralipid administration.
REFERENCE 3 (bases 1 to 2990)
AUTHORS Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
TITLE Genome-wide association study of periodontal pathogen colonization
JOURNAL J. Dent. Res. 91 (7 SUPPL), 21S-28S (2012)
PUBMED 22699663
REFERENCE 4 (bases 1 to 2990)
AUTHORS Jessen,N., An,D., Lihn,A.S., Nygren,J., Hirshman,M.F., Thorell,A.
and Goodyear,L.J.
TITLE Exercise increases TBC1D1 phosphorylation in human skeletal muscle
JOURNAL Am. J. Physiol. Endocrinol. Metab. 301 (1), E164-E171 (2011)
PUBMED 21505148
REMARK GeneRIF: A single bout of exercise regulates TBC1D1 and AS160
phosphorylation on multiple sites in human skeletal muscle.
REFERENCE 5 (bases 1 to 2990)
AUTHORS Park,S.Y., Jin,W., Woo,J.R. and Shoelson,S.E.
TITLE Crystal structures of human TBC1D1 and TBC1D4 (AS160)
RabGTPase-activating protein (RabGAP) domains reveal critical
elements for GLUT4 translocation
JOURNAL J. Biol. Chem. 286 (20), 18130-18138 (2011)
PUBMED 21454505
REMARK GeneRIF: Crystal structures of human TBC1D1 and TBC1D4 (AS160)
RabGTPase-activating protein (RabGAP) domains reveal critical
elements for GLUT4 translocation.
REFERENCE 6 (bases 1 to 2990)
AUTHORS Chavez,J.A., Roach,W.G., Keller,S.R., Lane,W.S. and Lienhard,G.E.
TITLE Inhibition of GLUT4 translocation by Tbc1d1, a Rab
GTPase-activating protein abundant in skeletal muscle, is partially
relieved by AMP-activated protein kinase activation
JOURNAL J. Biol. Chem. 283 (14), 9187-9195 (2008)
PUBMED 18258599
REFERENCE 7 (bases 1 to 2990)
AUTHORS Roach,W.G., Chavez,J.A., Miinea,C.P. and Lienhard,G.E.
TITLE Substrate specificity and effect on GLUT4 translocation of the Rab
GTPase-activating protein Tbc1d1
JOURNAL Biochem. J. 403 (2), 353-358 (2007)
PUBMED 17274760
REMARK GeneRIF: form of Tbc1d1 also inhibited GLUT4 translocation and that
this effect also required a functional GAP domain
REFERENCE 8 (bases 1 to 2990)
AUTHORS Stone,S., Abkevich,V., Russell,D.L., Riley,R., Timms,K., Tran,T.,
Trem,D., Frank,D., Jammulapati,S., Neff,C.D., Iliev,D., Gress,R.,
He,G., Frech,G.C., Adams,T.D., Skolnick,M.H., Lanchbury,J.S.,
Gutin,A., Hunt,S.C. and Shattuck,D.
TITLE TBC1D1 is a candidate for a severe obesity gene and evidence for a
gene/gene interaction in obesity predisposition
JOURNAL Hum. Mol. Genet. 15 (18), 2709-2720 (2006)
PUBMED 16893906
REMARK GeneRIF: coding variant R125W affects obesity susceptibility,
delimits the location of an obesity gene at 4q34-35 and identifies
a gene/gene interaction that influences the risk for obesity
predisposition
REFERENCE 9 (bases 1 to 2990)
AUTHORS Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
TITLE Immunoaffinity profiling of tyrosine phosphorylation in cancer
cells
JOURNAL Nat. Biotechnol. 23 (1), 94-101 (2005)
PUBMED 15592455
REFERENCE 10 (bases 1 to 2990)
AUTHORS White,R.A., Pasztor,L.M., Richardson,P.M. and Zon,L.I.
TITLE The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene,
BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4
JOURNAL Cytogenet. Cell Genet. 89 (3-4), 272-275 (2000)
PUBMED 10965142
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK074954.1 and CR996632.1.
Summary: TBC1D1 is the founding member of a family of proteins
sharing a 180- to 200-amino acid TBC domain presumed to have a role
in regulating cell growth and differentiation. These proteins share
significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and
CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied
by OMIM, Mar 2008].
Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
large portion of the 5' coding region and initiates translation at
a downstream, in-frame start codon, compared to variant 1. Variants
3 and 4 encode the same isoform (3), which has a significantly
shorter N-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK074954.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1336 AK074954.1 1-1336
1337-1602 CR996632.1 369-634
1603-2990 AK074954.1 1602-2989
FEATURES Location/Qualifiers
source 1..2990
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p14"
gene 1..2990
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/note="TBC1 (tre-2/USP6, BUB2, cdc16) domain family,
member 1"
/db_xref="GeneID:23216"
/db_xref="HGNC:11578"
/db_xref="MIM:609850"
exon 1..200
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/inference="alignment:Splign:1.39.8"
variation 98
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:74432580"
variation 103
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:184292039"
variation 119
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:17497866"
misc_feature 167..169
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/note="upstream in-frame stop codon"
exon 201..445
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/inference="alignment:Splign:1.39.8"
variation 220
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369492733"
variation 290
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372955287"
CDS 353..1150
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/note="isoform 3 is encoded by transcript variant 4; TBC1
domain family member 1"
/codon_start=1
/product="TBC1 domain family member 1 isoform 3"
/protein_id="NP_001240843.1"
/db_xref="GI:359807051"
/db_xref="GeneID:23216"
/db_xref="HGNC:11578"
/db_xref="MIM:609850"
/translation="
MSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
"
misc_feature <356..685
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
Rab-GAPs; Region: TBC; smart00164"
/db_xref="CDD:197550"
variation 353
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139639988"
variation 407
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190882933"
variation 418
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369737635"
exon 446..605
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/inference="alignment:Splign:1.39.8"
variation 520
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369138939"
variation 545
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200460442"
variation 548
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="t"
/db_xref="dbSNP:78153714"
variation 560
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201262200"
variation 574
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:144280377"
variation 590
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150619808"
variation 605
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374399526"
exon 606..775
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/inference="alignment:Splign:1.39.8"
variation 642
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149746733"
variation 678
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:191311030"
variation 729
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145666066"
variation 730
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374150933"
exon 776..949
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/inference="alignment:Splign:1.39.8"
variation 793
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185429602"
variation 852
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141434035"
variation 907
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200211276"
variation 913
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145258995"
variation 915
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376683121"
exon 950..2990
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/inference="alignment:Splign:1.39.8"
variation 953
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147610055"
variation 960
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199769631"
variation 1033
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="t"
/db_xref="dbSNP:142082982"
variation 1050
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:13110318"
variation 1068
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:151143743"
variation 1069
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375379532"
variation 1074
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="t"
/db_xref="dbSNP:140049928"
variation 1083
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150295101"
variation 1089
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138981524"
variation 1109
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142224285"
variation 1110
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145834587"
variation 1140
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375094591"
variation 1178
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:180778179"
variation 1218
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:9852"
variation 1219
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:187612705"
STS 1250..1421
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/standard_name="D4S2507E"
/db_xref="UniSTS:28882"
variation 1252
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:190339487"
variation 1268
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:182167537"
STS 1281..1430
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/standard_name="SHGC-59210"
/db_xref="UniSTS:27409"
variation 1319
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12644032"
variation 1329..1330
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace=""
/replace="t"
/db_xref="dbSNP:140473695"
variation 1330..1331
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace=""
/replace="t"
/db_xref="dbSNP:71751139"
variation 1339
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="t"
/db_xref="dbSNP:2882"
variation 1341
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="c"
/db_xref="dbSNP:15275"
variation 1352
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:15276"
variation 1404
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:186099739"
variation 1496
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:190469420"
variation 1498
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="c"
/db_xref="dbSNP:181354169"
variation 1516
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:185625994"
variation 1531
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:16994264"
variation 1575
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:75695278"
variation 1681
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="c"
/db_xref="dbSNP:368725051"
variation 1700
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148588413"
variation 1745
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11941514"
variation 1770
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:191175689"
variation 1946..1947
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace=""
/replace="a"
/db_xref="dbSNP:368675910"
variation 1980
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:75566567"
variation 2091
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143013479"
variation 2107
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182546614"
variation 2178
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375227250"
variation 2236
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="c"
/db_xref="dbSNP:189248409"
variation 2275..2276
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace=""
/replace="a"
/db_xref="dbSNP:371391694"
variation 2276
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace=""
/replace="a"
/db_xref="dbSNP:11330073"
variation 2317
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="c"
/db_xref="dbSNP:368299523"
variation 2355
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:62297301"
variation 2370
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371752989"
variation 2402
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:78069747"
variation 2552
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140112639"
variation 2556
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143776110"
variation 2557
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:16994266"
variation 2599
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:199682170"
variation 2599
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace=""
/replace="g"
/db_xref="dbSNP:3839162"
STS 2696..2906
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/standard_name="WI-22198"
/db_xref="UniSTS:12477"
STS 2698..2820
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/standard_name="RH47722"
/db_xref="UniSTS:67692"
variation 2700
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:191975309"
STS 2710..2804
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/standard_name="D4S2540E"
/db_xref="UniSTS:150969"
variation 2727
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146830672"
variation 2771
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374944172"
variation 2790
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="t"
/db_xref="dbSNP:77368662"
variation 2835
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:77698656"
variation 2911
/gene="TBC1D1"
/gene_synonym="TBC; TBC1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371533159"
ORIGIN
acagctgttccccagcctggtagtgaacccagaggcctgtcttgctgtgcagtgggacaggaagttgcatttgggagtctcatagaacacactggaagatgtgttttagcttggccagtttcatgcaggacagattttctgcataaagaaaatcaatgacagtttctgaaactgcatcctggaagccttgaccagtttggggcgaacctttcctacacacccatacttctctgcccagcttggagcaggacagctatcgctttacaacattttgaaggcctactcacttctagaccaggaagtgggatattgccaaggtctcagctttgtagcaggcattttgcttcttcatatgagtgaggaagaggcgtttaaaatgctcaagtttctgatgtttgacatggggctgcggaaacagtatcggccagacatgattattttacagatccagatgtaccagctctcgaggttgcttcatgattaccacagagacctctacaatcacctggaggagcacgagatcggccccagcctctacgctgccccctggttcctcaccatgtttgcctcacagttcccgctgggattcgtagccagagtctttgatatgatttttcttcagggaacagaggtcatatttaaagtggctttaagtctgttgggaagccataagcccttgattctgcagcatgaaaacctagaaaccatagttgactttataaaaagcacgctacccaaccttggcttggtacagatggaaaagaccatcaatcaggtatttgaaatggacatcgctaaacagttacaagcttatgaagttgagtaccacgtccttcaagaagaacttatcgattcctctcctctcagtgacaaccaaagaatggataaattagagaaaaccaacagcagcttacgcaaacagaaccttgacctccttgaacagttgcaggtggcaaatggtaggatccaaagccttgaggccaccattgagaagctcctgagcagtgagagcaagctgaagcaggccatgcttaccttagaactggagcggtcggccctgctgcagacggtggaggagctgcggcggcggagcgcagagcccagcgaccgggagcctgagtgcacgcagcccgagcccacgggcgactgacagctctgcaggagagattgcaacaccatcccacactgtccaggccttaactgagagggacagaagacgctggaaggagagaaggaagcgggaagtgtgcttctcagggaggaaaccggcttgccagcaagtagattcttacgaactccaacttgcaattcagggggcatgtcccagtgttttttttgttgtttttagatactaaatcgtcccttctccagtcctgattactgtacacagtagctttagatggcgtggacgtgaataaatgcaacttatgttttcttgttggttcctttttgagtgtcactgtgtttgtaaagagcattcacaatacggtggaatttcaaaagctggaagagctcgagatcatgcctcaggcaaaggcgtgggtccatcgttcttccgagagggtttgtgtggcgactacaccctcagcgtccctggcaaggtgcagttggctctcgcccattcttgttatggaaacctaagatgatcattgggaagatcagtgatcttgggtcattgatccctggctcagaggatagcggtttccatcataaaccaagatgatgagttcagcctttatccctcgtggttccactagatgtaacttaaaggagttaacatttgaggactttgttctacatcagattttactatttgaatgtttaagatcactttattgaatttgaagatcatcaaattaaataaaatgatttatttaatttggatatcctgatcactgtcaagtgaaatggatctctctctttggtatttaaggaagtttgtctttaaaaaaaaaatagagtgttttcatacatttttgcttatcccataagtacagttgatcaaagtcatagtaggtaaatgctttatgggacagctgacaccttttagaccctaccaggtattgctagcatgtgagctgcagttgtggggtctgagatatttctttgtggtagtttcatacccatactatagagtcatgtatttatttttgcctgttgtgtgatgtaatgcaatcatgttcctttgagtctccatcccttggaaatctgacttcttgcagaaggagtaggcacatcaagatattcaggggtgccccaagagtctgggactttcaaaaaaaaaagatcaggctgaaactgcagtcagatttatgacagctgacagtttttcagaggtcgcacacagtgactctcctctctcaggatgacgaggacctgtgccttcaacaagcaaaatgctgctcacggttgtcctgcttgcagccagtcactgtgtaaagcctctctgatgtgcacttaagagtgggttgctttctcacaaagatggggttctgtgcagtcacaggtcacttccttgacaacacaatcatttctgatctttatcactgtaaccacgtcttctattccataggagtttcttttgattctctcagttgcggggggcatctcttaatcctggggtaaaaggagagattgccatacttagactcactgtgagtctccccggccatttcacgaggagaccacagtgctgccaccagtgcctaaacaggtggctggcattcgagacttcctcctgttccctgggtcagaggatagcggtttccatcataaaccaagatgatgagttcagcctttatccctcgtggttccgctagatgtaacttataggagttaacatttgaggactttgttctgcatcagatcttactatttgaatgtttactgttggattttgggcatcttattactgttactcaaaaacattgactctgcatcaagaaagaaacaagaaagcaataaaacaagaaataattcatgctcacatt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23216 -> Molecular function: GO:0005097 [Rab GTPase activator activity] evidence: IEA
GeneID:23216 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
GeneID:23216 -> Biological process: GO:0032880 [regulation of protein localization] evidence: IEA
GeneID:23216 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:23216 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
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