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2025-05-09 18:35:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001164407 5901 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens TLC domain containing 2 (TLCD2), mRNA.
ACCESSION NM_001164407 XM_001126126
VERSION NM_001164407.1 GI:256542292
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5901)
AUTHORS Pewzner-Jung,Y., Ben-Dor,S. and Futerman,A.H.
TITLE When do Lasses (longevity assurance genes) become CerS (ceramide
synthases)?: Insights into the regulation of ceramide synthesis
JOURNAL J. Biol. Chem. 281 (35), 25001-25005 (2006)
PUBMED 16793762
REMARK Review article
REFERENCE 2 (bases 1 to 5901)
AUTHORS Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
TITLE DNA sequence of human chromosome 17 and analysis of rearrangement
in the human lineage
JOURNAL Nature 440 (7087), 1045-1049 (2006)
PUBMED 16625196
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC130343.7.
On Aug 25, 2009 this sequence version replaced gi:239745669.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: CD580337.2, DV111297.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025084 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-302 AC130343.7 159581-159882 c
303-385 AC130343.7 159318-159400 c
386-468 AC130343.7 159013-159095 c
469-5901 AC130343.7 152304-157736 c
FEATURES Location/Qualifiers
source 1..5901
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.3"
gene 1..5901
/gene="TLCD2"
/note="TLC domain containing 2"
/db_xref="GeneID:727910"
/db_xref="HGNC:33522"
exon 1..302
/gene="TLCD2"
/inference="alignment:Splign:1.39.8"
CDS 127..921
/gene="TLCD2"
/codon_start=1
/product="TLC domain-containing protein 2"
/protein_id="NP_001157879.1"
/db_xref="GI:256542293"
/db_xref="CCDS:CCDS45567.1"
/db_xref="GeneID:727910"
/db_xref="HGNC:33522"
/translation="
MAPTGLLVAGASFLAFRGLHWGLRRLPTPESAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTLGKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLLLLSRQAPSLAFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILGIRILVNDVLQSRPHPPSPGHEKTRGTRTRRDNGPVTSNSSTLSLKD
"
misc_feature 133..195
/gene="TLCD2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 250..312
/gene="TLCD2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 313..717
/gene="TLCD2"
/note="TLC domain; Region: TRAM_LAG1_CLN8; cl02759"
/db_xref="CDD:207718"
misc_feature 355..417
/gene="TLCD2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 466..528
/gene="TLCD2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 631..693
/gene="TLCD2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 721..783
/gene="TLCD2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
exon 303..385
/gene="TLCD2"
/inference="alignment:Splign:1.39.8"
exon 386..468
/gene="TLCD2"
/inference="alignment:Splign:1.39.8"
exon 469..5901
/gene="TLCD2"
/inference="alignment:Splign:1.39.8"
STS 1579..2048
/gene="TLCD2"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
STS 1963..2052
/gene="TLCD2"
/standard_name="L18426"
/db_xref="UniSTS:34648"
STS 1972..2048
/gene="TLCD2"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
STS 2165..3732
/gene="TLCD2"
/standard_name="GDB:631813"
/db_xref="UniSTS:158430"
STS 2165..2460
/gene="TLCD2"
/standard_name="GDB:631813"
/db_xref="UniSTS:158430"
STS 2487..2600
/gene="TLCD2"
/standard_name="D10S16"
/db_xref="UniSTS:155756"
STS 2526..3882
/gene="TLCD2"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 2526..2613
/gene="TLCD2"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 2653..4345
/gene="TLCD2"
/standard_name="D3S1673"
/db_xref="UniSTS:148450"
STS 3748..5235
/gene="TLCD2"
/standard_name="sY3084"
/db_xref="UniSTS:515126"
STS 3793..5172
/gene="TLCD2"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 3793..3882
/gene="TLCD2"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 3862..4337
/gene="TLCD2"
/standard_name="GDB:434012"
/db_xref="UniSTS:157204"
STS 4360..5208
/gene="TLCD2"
/standard_name="G35510"
/db_xref="UniSTS:44150"
STS 5130..5212
/gene="TLCD2"
/standard_name="L18426"
/db_xref="UniSTS:34648"
STS 5132..5234
/gene="TLCD2"
/standard_name="D11S2921"
/db_xref="UniSTS:152074"
variation 5726
/gene="TLCD2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3208963"
variation 5743
/gene="TLCD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3208964"
variation 5773
/gene="TLCD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3208965"
ORIGIN
aaaggcgcggcggggaggggagccggggccccagccctgccgggaaacgggttcccagtcccggccgagagcgcgggcgccgaggggaccgacccggactccccgcaaccccccaaccgccaggccatggcgcccacggggctcctggtggccggcgcctccttcctcgcgttccgggggctgcactgggggttgcggcggctgcccacgccggaatcggccgctcgggaccgctggcagtggtggaacctctgcgtctccctggcgcacagcctgctctcggggaccggggcgctgctcggcctgtcactgtaccctcagatggccgccgaccccatccatggccacccgcgctgggctctggtgctggtggctgtgtctgtgggttacttcctggcagacggagctgacctgctgtggaaccagaccttgggcaagacctgggatcttctctgtcatcatttggtggtggtgagctgcctcagcaccgctgttctgtctggccactacgtgggcttctccatggtgtctctgctcctggaactgaactctgcctgcttgcacctgcggaagctgctgttgctttctcgccaggccccatccctggccttcagcgtgaccagctgggcctccttggccaccttggccctcttccgcctggtcccgctggggtggatgagtctgtggctgttccggcagcaccaccaggttcctcttgctctggtcaccctgggtggaattgggctggtcactgtgggcatcatgagcatcatattggggatccgtattctggtcaatgatgtcctacagtctcgaccccatccacccagccctggccatgagaaaaccagggggaccaggacacgtcgtgacaatggacctgtcaccagcaacagttcgactctcagcctgaaagactagagagaagccatgggcccctcgctgggggaggtggggccaggacaaggagatgagggtcttccatgcacagtcccccatcagggtgagggccagacttgctcatcagaatctcagtttctcttccagctaactcacatcccttccccttcctcggatctaagaagaaatgctgatgttggatgggtgggaacctgggtttctgttcactgaaatccgtcatcagatgagcatcctttccagcaaataaactcaagaggtacagctagagctatcagtaaagggtggcaggaggcatgcagctggaagaaactgccagtggagacagaagctctttgctttaacccagggacagatgggggaaggtgaagtcccactaggatcagagagatctggtatggggcgggtggggacagagagaaaagagatctcacctataaccaaattctggcagtgggaggaaggtagaggaggtgctatctgtagcagcagagatggacgtgatagttgccaagagacagaacctgggccacagcaattgctgctgatgtttctggttctcaaagccacactcctgtttttctttttctttttctttttttttatgagacggaatcttactctgtcacccaggctggagtgtagtggcacgatttcggctcactgcaacctcagcctcctgggttcaagtgattgtcctgccttagcctcccgagtagctgtgacttcaggcatgcaccaccaagcccagctaatttttgtattttttggtggagaggaggtttcaccatgttgcccaggctggtctcgaactcctgacctcaagtaatccacctgcctcggcctcccagagtgctgggattacagacgtgagaacaggcgcacactcctgtttttctccttaaccctggtcctgctgtgtctagccttttatttttatttttatttttagtatcttttgacttttcttttttcttttctttttttttttttttttttgagacaagttcttgctctgttgcccaggatggagtgcagtggcttgatcttggctcactgcaatctctgcctcccaggctcaagcaattctcctgcctcccacctcagcctcccaagtagctgggactacaggtgcacgccactgcaccaggctaatttttgtatttttttgtagagaccaggttttgccatgttgcccaggctggtctcaaacttttgcactcaagtgatccacccacctcagcctcccaaagtgctgggattacagacgtgagccaccgtacccgaccccttttgacttttcaaagacaattcggattcttagaggaatgaacacagggctggtttgtcttcttaggacggcactgaagtctagaattacagaaggaaaggtgcccagtacagagttttcccaggcccaggctttcatggaagaacaagggcagaggtagactgtgtgagagaaggctgcaggaggataaaggaatagctggccctctggctgggcgcagcagctcacgcctgtaatcccagcactttgggaggccgaggcgggaggatcacctgaggtcaggagttcaagaccagcctggtcaacatggtgaaaccctgtctctactaaaaatacaaaattagccgggcatggtggtgcatgcctgtaatcccagctactcaggaggctgaggcaggagaatcgcttgaacccaggaggcagaggttgcagtgagccgaggtcgtgccactgcactccagcctgggcaaacagagtgagactcttgtctctaaagaaaaaaaaaaaaggaagagctgggacttttctgagatacattcataaagtcttcttcctccctgctgcttctgctgcgtttttttctgttgaacaagaccccttccttcccagaacatcgaggtgacgggaagtgcccagcagattaagtctgctgttccactaaacaatggactgagagaggcaacccttagccatccacagaaaagctacatgagcaaaagcaagagacaggaagattgtcttcaaaaaaaaacaaaacaaaacaaaaaccttgctaagaagcggaggtacagaaagatacgaagaatgacagagacagacatacatagattgagtgatagatagaaagagagaaggattattcacatagaggtgacagaggcaaagaaggatggagggcaaaagagacaggccctagcagaaatatggagaaaggctgtcatagatcctgagagacaccaaagtcacagaactgataaaagggttataaacaaaaaggaccagaaaaatagaaatgaaggccgacaagaagagaccccaaggctgaaaggcacagagagtctagacagtgaaatagagtgagtgacaaggagaaacacccaggctcaggagtgatggaggaaatactggcagatagagagatcagaagagcaagaggagaggtgggaacagagaagagcggggacgagtccggggagctgagaagcagaaggcggaggaggcagtcagtgggaagattcactgacagaagagaccaggagatatggggacttggaggcaggcagaaagacaaaggacaaacagctgcagcgcaaaccctaaagacaggctgacagtaaccggtcggcagagactggtaggaagataaggacaagtcagaatcaggggtgtcaactgagatgcaaatataggcaaaggagctgacaaagagaatcacagagagaaaaaaaaggaggagagcacagaacaatttaaatatccaggctgggcatggtgggtcacgcctgtaatcccagcattttgggaggccgaggcaggcggatcacgaggtcaggagatgaccatcctggctaacatggtgaaacaccatctctactaaaaatacaaaaaattggccgggcgtggtggcaggcgcccgtaatcccggctactgaggaggctgaggcaggagaatcgtttgaacctgggaggccgaggttgttataatgagccgagatagtgccactgcagtccagcaggggtgacagagtgagactccgtctcaaaaaaaaaaattgaatatccaaagaacaaagaagaggcaggaacccagaaatgaaaagaggaggaaaaatacaggtgtgaaaaaaaaatgagagggattgtgagaagtctccatcatagagtcataaaaacaggcgcaaaggatgaaaatacatcgagactgaggaaaacacagttggaaggagctaaacacaagcagaaaataagagcagagcatttaaatgtaattagataaaaacccaagaggcaaaggtatagatagtgagctagagaaacaatgcagaattttgtcagagtctgtacttctagaagtcatgtttgctggctgggcatggtggctcacgcctgtaatcccagcactttgggaggccgaggtaggaggagtggttgagctcaggagttcaagaccagtctgggcaacatattgagacctcctctctacaaaaaaaaaaaattttcttttttctttcttttcttctttttttttttttttttttgagacagtttcattcttgctgcccaggctggaatgcagtggcacaatcttggctcactgcaacctccacctcctggactcaagtgattctcctgcctcagcctccctagtagctgggattacaggtacccaccaccacactcggctaatttttgtgtttttagtagagacaggatttcaccatattggccaggctggtctcaaactcctgacctcaggtgatccgcccaccttgggctcccaaactactgggattatatgcgtgagccaacacacccggccaaaaaaaaatttttaattaaaaaaaaaagtcatatctgcaaaactcaatttgccatcttaactgaatgccttgattaacaaaaatgttgtctgccttgagtttttaaagaaaaagaaatatgacaaactcatgtgaggaatctattccttaaatatctgttgaggttgatatgaattgattctaagtcatacaccttttctttggccactggtatacattcatgatggtttgagtgagtgtcccttttggtaatacttgatagtgtctatgaggccgggcgtggtggctcacgcctgtaatcccagcactttgggggaccgaggcaggtgaaatcccatctctactaaaaataaaaaaaattagccgggcgtggtggcgggcgcctgtagtcccagctactcaggaggctgaggcaggagaatggcatgaacccgggaggcggagcttgcagtgagccaagatcgtgccactgcactccagcctgggtgacagagcaagactccgtcttaaaaaataaataaataaataaatagacagatagatagatagatagtgtctatgaaggctgcccaagaacttgaccattagggaaacatggctgtttctgtggattaactagtcaagcccatacaggaagagtgaggtcagctcccaggtggggcaggatgtagtggacgcttggaagaatttgggaccacacacgaattgctaccatggtgagccagtgaaacttgaggaaggcaggactggattgtgattacaactgagtaagtaggcagagaattggagtgtgggcaacataaagatgatgtgaatcaaagaagaatggtcaattaagaccctaaaaaaaggacgttcaaaaatgcagaggttaaaaaaaaaaaaagcagagattgccagatgctccatttggtaggagtctgcttagcacagtggtgcttcgccagactttaccgtggcccagggaaatggtcctcaagacggactccatgtctaccaagctacttgctaatgatttctttgtcctccaggacagggaaggggcttttctggatgggatacattgatattttatggccttgaaacactatcctgattataaattaataaattgctatgcaaataattgcattagttgcatcaatctcttat
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:727910 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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