GGRNA | NR_051953.1

LOCUS       NR_051953               3275 bp    RNA     linear   PRI 17-JUL-2013
DEFINITION  Homo sapiens Meis homeobox 2 (MEIS2), transcript variant e,
            non-coding RNA.
ACCESSION   NR_051953
VERSION     NR_051953.1  GI:388596662
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3275)
  AUTHORS   Bjerke,G.A., Hyman-Walsh,C. and Wotton,D.
  TITLE     Cooperative transcriptional activation by Klf4, Meis2, and Pbx1
  JOURNAL   Mol. Cell. Biol. 31 (18), 3723-3733 (2011)
   PUBMED   21746878
  REMARK    GeneRIF: Klf4 recruits a complex of Meis and Pbx proteins to DNA,
            resulting in Meis2 transcriptional activation domain-dependent
            activation of a subset of Klf4 target genes.
REFERENCE   2  (bases 1 to 3275)
  AUTHORS   Shibata,M., Nakao,H., Kiyonari,H., Abe,T. and Aizawa,S.
  TITLE     MicroRNA-9 regulates neurogenesis in mouse telencephalon by
            targeting multiple transcription factors
  JOURNAL   J. Neurosci. 31 (9), 3407-3422 (2011)
   PUBMED   21368052
  REMARK    GeneRIF: Transgenic mice lacking microRNAs miR-9-2 and miR-9-3
            exhibit multiple defects of telencephalic structures which may be
            brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2
            expression.
REFERENCE   3  (bases 1 to 3275)
  AUTHORS   Adkins,D.E., Aberg,K., McClay,J.L., Bukszar,J., Zhao,Z., Jia,P.,
            Stroup,T.S., Perkins,D., McEvoy,J.P., Lieberman,J.A., Sullivan,P.F.
            and van den Oord,E.J.
  TITLE     Genomewide pharmacogenomic study of metabolic side effects to
            antipsychotic drugs
  JOURNAL   Mol. Psychiatry 16 (3), 321-332 (2011)
   PUBMED   20195266
  REMARK    GeneRIF: The Single Nucleotide Polymorphism in Meis homeobox 2
            (MEIS2) mediated the effects of risperidone on hip circumference
            (q=0.004).
            GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 3275)
  AUTHORS   Larsen,K.B., Lutterodt,M.C., Laursen,H., Graem,N., Pakkenberg,B.,
            Mollgard,K. and Moller,M.
  TITLE     Spatiotemporal distribution of PAX6 and MEIS2 expression and total
            cell numbers in the ganglionic eminence in the early developing
            human forebrain
  JOURNAL   Dev. Neurosci. 32 (2), 149-162 (2010)
   PUBMED   20523026
  REMARK    GeneRIF: Data demonstrate by in situ hybridization and
            immunohistochemistry that the two homeobox genes Pax6 and MEIS2 are
            expressed during early fetal brain development in humans.
REFERENCE   5  (bases 1 to 3275)
  AUTHORS   Hyman-Walsh,C., Bjerke,G.A. and Wotton,D.
  TITLE     An autoinhibitory effect of the homothorax domain of Meis2
  JOURNAL   FEBS J. 277 (12), 2584-2597 (2010)
   PUBMED   20553494
  REMARK    GeneRIF: This work suggests that the transcriptional activity of
            all members of the Meis/Prep Hth protein family is subject to
            autoinhibition by their Hth domains, and that the Meis3.2 splice
            variant encodes a protein that bypasses this autoinhibitory effect.
REFERENCE   6  (bases 1 to 3275)
  AUTHORS   Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G., Hirokawa,K. and Nakamura,T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp. Hematol. 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   7  (bases 1 to 3275)
  AUTHORS   Liu,Y., MacDonald,R.J. and Swift,G.H.
  TITLE     DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b
            trimer and cooperation with a pancreas-specific basic
            helix-loop-helix complex
  JOURNAL   J. Biol. Chem. 276 (21), 17985-17993 (2001)
   PUBMED   11279116
REFERENCE   8  (bases 1 to 3275)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J. Biol. Chem. 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   9  (bases 1 to 3275)
  AUTHORS   Smith,J.E., Afonja,O., Yee,H.T., Inghirami,G. and Takeshita,K.
  TITLE     Chromosomal mapping to 15q14 and expression analysis of the human
            MEIS2 homeobox gene
  JOURNAL   Mamm. Genome 8 (12), 951-952 (1997)
   PUBMED   9383298
REFERENCE   10 (bases 1 to 3275)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res. 7 (2), 142-156 (1997)
   PUBMED   9049632
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK056216.1, DA689122.1,
            AF179899.1, BC050431.1 and BM679305.1.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcription regulators, and several members have been
            shown to be essential contributors to developmental programs.
            Multiple transcript variants encoding distinct isoforms have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (e) lacks an alternate coding exon
            and internal segment compared to variant a, that causes a
            frameshift. The resulting transcript is a candidate for
            nonsense-mediated mRNA decay (NMD) and is therefore not thought to
            be protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AK056216.1         400-734
            336-419             DA689122.1         39-122
            420-2632            AF179899.1         1-2213
            2633-3205           BC050431.1         2361-2933
            3206-3275           BM679305.1         1-70                c
FEATURES             Location/Qualifiers
     source          1..3275
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..3275
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:4212"
                     /db_xref="HGNC:7001"
                     /db_xref="MIM:601740"
     misc_RNA        1..3275
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /product="Meis homeobox 2, transcript variant e"
                     /db_xref="GeneID:4212"
                     /db_xref="HGNC:7001"
                     /db_xref="MIM:601740"
     exon            1..686
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(76)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188283226"
     variation       complement(139)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372166848"
     variation       complement(315)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201211078"
     variation       complement(323..331)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="ctttctttt"
                     /db_xref="dbSNP:150319274"
     variation       complement(323)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200040294"
     variation       complement(327..330)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="cttt"
                     /db_xref="dbSNP:200946390"
     variation       complement(414)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:60314502"
     variation       complement(487)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76458635"
     variation       complement(488)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76348970"
     variation       complement(496..497)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:140248890"
     variation       complement(512)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:185043075"
     variation       complement(525)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182029443"
     variation       complement(543)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112410187"
     variation       complement(589)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:111602525"
     variation       complement(642)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201918475"
     variation       complement(645)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199649371"
     misc_feature    675..1583
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="COORDINATES: ab initio prediction:ORF Finder"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated mRNA decay
                     (NMD)candidate"
     exon            687..919
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(698)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369672617"
     variation       complement(764)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376901048"
     variation       complement(776)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200799360"
     variation       complement(777)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138503850"
     variation       complement(794)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144628203"
     variation       complement(824)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375301418"
     variation       complement(827)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140890748"
     variation       complement(841)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372646327"
     exon            920..1061
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1003..1004)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="ggggggggg"
                     /db_xref="dbSNP:138513608"
     exon            1062..1112
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1074)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200496429"
     exon            1113..1163
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1145)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137952617"
     exon            1164..1313
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1181)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139184400"
     variation       complement(1200)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368930165"
     variation       complement(1214)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149182994"
     variation       complement(1253)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377204162"
     variation       complement(1281)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:185278462"
     variation       complement(1289)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145358549"
     variation       complement(1292)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150470779"
     variation       complement(1304)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141907934"
     exon            1314..1428
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1356)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147874392"
     variation       complement(1406)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61734550"
     variation       complement(1407)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375357305"
     variation       complement(1416)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376747133"
     variation       complement(1424)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370758497"
     exon            1429..1574
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1483)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369609025"
     variation       complement(1484)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183075611"
     exon            1575..1633
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1627)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367563077"
     exon            1634..1723
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     exon            1724..1819
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1729)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201131653"
     variation       complement(1737)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113622091"
     variation       complement(1744)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372540616"
     variation       complement(1781)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201431601"
     variation       complement(1804)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369556038"
     exon            1820..3258
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1846)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151055354"
     variation       complement(1853)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142878520"
     variation       complement(1886)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113747758"
     variation       complement(1905)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57860578"
     variation       complement(1926)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148444214"
     variation       complement(1934)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144548752"
     variation       complement(1935)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199728455"
     variation       complement(1981)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374458760"
     variation       complement(1984)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141054432"
     variation       complement(1986)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200282136"
     variation       complement(1995)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139991974"
     variation       complement(1996)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201588285"
     variation       complement(2013)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145933742"
     variation       complement(2015)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370135711"
     variation       complement(2024)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142325445"
     variation       complement(2026)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377210457"
     variation       complement(2037)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372766056"
     variation       complement(2087)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150313361"
     variation       complement(2099)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369601092"
     variation       complement(2138)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77635771"
     variation       complement(2175)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146614487"
     variation       complement(2360)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144383417"
     variation       complement(2444)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139647839"
     variation       complement(2520..2521)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34412514"
     variation       complement(2532)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72708659"
     variation       complement(2558)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117434306"
     variation       complement(2582..2583)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34654533"
     variation       complement(2594..2595)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35427488"
     variation       complement(2728)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146332496"
     variation       complement(2768)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373295254"
     variation       complement(2822)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369432376"
     variation       complement(2846)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376202599"
     variation       complement(2870)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34362471"
     variation       complement(3033)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:375754667"
     variation       complement(3195..3196)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:79470888"
     variation       complement(3205)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34976538"
     variation       complement(3205)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200863215"
     polyA_signal    3229..3234
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
     polyA_site      3258
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
ORIGIN

tttaaagagagaggatcgtattatagataccgcgggggcaaagctaaaaaaggggggaggggggaggaaaaaattcaagaagcagaaacccctcgcggagttttactggaagaaaaaaacgggtctgaaagattcctcctcttcatcatcatcaaccatcattcattcactaccttgacattccgggctttgattgacagctggagtggcaaaaagccatgaaacacgacagttcggttacatgtgggctgctgacgggccgctcgtaaccttcagttcgggggcttgacaatttttttcttctttttcttctttttcttttctttctttttttttccaactgaggggaagagaagagaaagagggggaaaggaggaccgaagaggaggaggaggggaggggggaggaggaggaggtggaggaggaggaggaagatcaggaggaggaggaagaagaggaaaaaagagaaaaagaagaaatatcacagaaaaaaaaattcttcgttgtctagactgggctttttttcccccctaaaaaatagcatattggagaattgggagaagtctctttggtttggaaaaaaaaaaaaggaatcttcagcctagatcactttcttatccggactgggatattaaatatacgacacatccaggagtttattggagcgcagactgatggcgcaaaggtacgatgagctgccccattacggcgggatggacggagtaggggttcccgcttccatgtacggagaccctcacgcgccgcggccgatccccccggttcaccacctgaaccacgggccgccgctccacgccacacagcactacggcgcgcacgccccgcaccccaatgtcatgccggccagtatgggatccgctgtcaacgacgccttgaagcgggacaaggacgcgatctatgggcacccgttgtttcctctgttagctctggtctttgagaagtgcgagctggcgacctgcactccccgggaacctggagtggctggcggagacgtctgctcctccgactccttcaacgaggacatcgcggtcttcgccaagcaggttcgcgccgaaaagccacttttttcctcaaatccagagctggacaatttgatgatacaagcaatacaagtactaaggtttcatcttttggagttagaaaaggtccacgaactgtgcgataacttctgccaccgatacattagctgtttgaaggggaaaatgcccatcgacctcgtcattgatgaaagagacggcagctccaagtcagatcatgaagaactttcaggctcctccacaaatctcgctgaccataacccttcttcttggcgagaccacgatgatgcaacctcaacccactcagcaggcaccccagggccctccagtgggggccatgcttcccagagcggagacaacagcagtgagcaaggggatggtttagacaacagtgtagcttcacctggtacaggtgacgatgatgatccggataaggacaaaaaacgccagaagaaaagaggcattttccccaaagtagcaacaaatatcatgagagcatggctcttccagcatctcacagtttattaatgccagaagaagaatagtacagcccatgattgaccagtcaaatcgagcagtgagccaaggagcagcatatagtccagagggtcagcccatggggagctttgtgttggatggtcagcaacacatggggatccggcctgcaggacctatgagtggaatgggcatgaatatgggcatggatgggcaatggcactacatgtaaccttcatcatgtaaagcaatcgcaaagcaagggggaagtttgcagagcatgccaggggactacgtttctcagggtggtcctatgggaatgagtatggcacagccaagttacactcctccccagatgaccccacaccctactcaattaagacatggacccccaatgcattcatatttgccaagccatccccaccacccagccatgatgatgcacggaggaccccctacccaccctggaatgactatgtcagcacagagccccacaatgttaaattctgtagatcccaatgttggcggacaggttatggacattcatgcccaatagtataagggaactcaagggaaaaggaaacacacgcaaaaactattttaagactttctgaactttgaccagatgttgacacttaatatgaaattccagacagctgtgattattttttacttttgtcatttttcatcaagcaacagaggaccaatgcaacaagaacacaaatgtgaaatcatgggctgactgagacaattctgtccatgtaaagatcctctggaaaaagactccgagagttataactactgtagtataaatataggaactaagttaaacttgtacatttctgttgatcacgccgttatgttgcctcaaatagttttagaagagaaaaaaaaatatatccttgttttccacactatgtgtgttgttcccaaaagaatgactgttttggttcatcagtgaattcaccatccaggagagactgtggtatatattttaaacctgttgggccaatgagaaaagaaccacactggagatcatgatgaacttttggctgaacctcatcactcgaactccagcttcaagaatgtgttttcatgcccggcctttgttcctccataaatgtgtcctttagtttcaaacagatctttatagttcgtgcttcataagccaattcttattattatttttgggggactcttcttcaaagagcttgccaatgaagatttaaagacagagcaggagcttcttccaggagttctgagccttggttgtggacaaaacaatcttaagttgggcagctttcctcaacacaaaaaaaagttattaatggtcattgaaccataactaggactttatcagaaactcaaagcttgggggataaaaaggagcaagagaatactgtaacaaacttcgtacagagttcggtctattaattgtttcatgttagatattctatgtgtttacctcaattgaaaaaaaaaagaatgtttttgctagtatcagatctgctgtggaattggtattgtatgtccatgaattcttcttttctcagcacgtgttcctcactagaagaaaatgctgttacctttaagctttgtcaaatttacattaaaatacttgtatgaggactgtgacgttatgttaaaaaaaaaaaggtgttaagtcacaaaaagcggtaataaatatttcatttttgattttttgttaaaaaaaaaaaaaaaaaa

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