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2025-05-09 20:20:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_038190 1691 bp RNA linear PRI 16-JUL-2013
DEFINITION Homo sapiens advanced glycosylation end product-specific receptor
(AGER), transcript variant 10, non-coding RNA.
ACCESSION NR_038190
VERSION NR_038190.1 GI:332800989
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1691)
AUTHORS Tang,S.C., Wang,Y.C., Li,Y.I., Lin,H.C., Manzanero,S., Hsieh,Y.H.,
Phipps,S., Hu,C.J., Chiou,H.Y., Huang,Y.S., Yang,W.S.,
Mattson,M.P., Arumugam,T.V. and Jeng,J.S.
TITLE Functional role of soluble receptor for advanced glycation end
products in stroke
JOURNAL Arterioscler. Thromb. Vasc. Biol. 33 (3), 585-594 (2013)
PUBMED 23288172
REMARK GeneRIF: Early poststroke plasma sRAGE may play a protective role
in ischemic stroke by capturing HMGB1.
REFERENCE 2 (bases 1 to 1691)
AUTHORS Djerbi,N., Dziunycz,P.J., Reinhardt,D., Iotzova-Weiss,G.,
Hafner,J., Lauchli,S., French,L.E. and Hofbauer,G.F.
TITLE Influence of cyclosporin and prednisolone on RAGE, S100A8/A9, and
NFkappaB expression in human keratinocytes
JOURNAL JAMA Dermatol 149 (2), 236-237 (2013)
PUBMED 23426492
REMARK GeneRIF: The influence of immunosuppressive drugs on S100A8/A9-RAGE
mRNA expression may suggest a role of these proteins in early-stage
SCC development in immunosuppressed patients
REFERENCE 3 (bases 1 to 1691)
AUTHORS Wei,W., Lampe,L., Park,S., Vangara,B.S., Waldo,G.S., Cabantous,S.,
Subaran,S.S., Yang,D., Lakatta,E.G. and Lin,L.
TITLE Disulfide bonds within the C2 domain of RAGE play key roles in its
dimerization and biogenesis
JOURNAL PLoS ONE 7 (12), E50736 (2012)
PUBMED 23284645
REMARK GeneRIF: RAGE intermolecular disulfide bond
REFERENCE 4 (bases 1 to 1691)
AUTHORS Hancock,D.B., Artigas,M.S., Gharib,S.A., Henry,A., Manichaikul,A.,
Ramasamy,A., Loth,D.W., Imboden,M., Koch,B., McArdle,W.L.,
Smith,A.V., Smolonska,J., Sood,A., Tang,W., Wilk,J.B., Zhai,G.,
Zhao,J.H., Aschard,H., Burkart,K.M., Curjuric,I., Eijgelsheim,M.,
Elliott,P., Gu,X., Harris,T.B., Janson,C., Homuth,G., Hysi,P.G.,
Liu,J.Z., Loehr,L.R., Lohman,K., Loos,R.J., Manning,A.K.,
Marciante,K.D., Obeidat,M., Postma,D.S., Aldrich,M.C.,
Brusselle,G.G., Chen,T.H., Eiriksdottir,G., Franceschini,N.,
Heinrich,J., Rotter,J.I., Wijmenga,C., Williams,O.D., Bentley,A.R.,
Hofman,A., Laurie,C.C., Lumley,T., Morrison,A.C., Joubert,B.R.,
Rivadeneira,F., Couper,D.J., Kritchevsky,S.B., Liu,Y., Wjst,M.,
Wain,L.V., Vonk,J.M., Uitterlinden,A.G., Rochat,T., Rich,S.S.,
Psaty,B.M., O'Connor,G.T., North,K.E., Mirel,D.B., Meibohm,B.,
Launer,L.J., Khaw,K.T., Hartikainen,A.L., Hammond,C.J., Glaser,S.,
Marchini,J., Kraft,P., Wareham,N.J., Volzke,H., Stricker,B.H.,
Spector,T.D., Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R.,
Heckbert,S.R., Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A.,
Strachan,D.P., Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and
London,S.J.
TITLE Genome-wide joint meta-analysis of SNP and SNP-by-smoking
interaction identifies novel loci for pulmonary function
JOURNAL PLoS Genet. 8 (12), E1003098 (2012)
PUBMED 23284291
REFERENCE 5 (bases 1 to 1691)
AUTHORS Hudson,B.I., Carter,A.M., Harja,E., Kalea,A.Z., Arriero,M.,
Yang,H., Grant,P.J. and Schmidt,A.M.
TITLE Identification, classification, and expression of RAGE gene splice
variants
JOURNAL FASEB J. 22 (5), 1572-1580 (2008)
PUBMED 18089847
REMARK GeneRIF: RAGE_v1 variant is the primary secreted soluble isoform of
RAGE. identification of functional splice variants of RAGE
underscores biological diversity of the RAGE gene & will aid in
understanding of the gene in the normal & pathological state.
REFERENCE 6 (bases 1 to 1691)
AUTHORS Nozaki,I., Watanabe,T., Kawaguchi,M., Akatsu,H., Tsuneyama,K.,
Yamamoto,Y., Ohe,K., Yonekura,H., Yamada,M. and Yamamoto,H.
TITLE Reduced expression of endogenous secretory receptor for advanced
glycation endproducts in hippocampal neurons of Alzheimer's disease
brains
JOURNAL Arch. Histol. Cytol. 70 (5), 279-290 (2007)
PUBMED 18431028
REMARK GeneRIF: low expression of endogenous secretory RAGE in the
hippocampus would be associated with the development of Alzheimer's
disease
REFERENCE 7 (bases 1 to 1691)
AUTHORS Ritthaler,U., Deng,Y., Zhang,Y., Greten,J., Abel,M., Sido,B.,
Allenberg,J., Otto,G., Roth,H., Bierhaus,A. et al.
TITLE Expression of receptors for advanced glycation end products in
peripheral occlusive vascular disease
JOURNAL Am. J. Pathol. 146 (3), 688-694 (1995)
PUBMED 7887450
REFERENCE 8 (bases 1 to 1691)
AUTHORS Vissing,H., Aagaard,L., Tommerup,N. and Boel,E.
TITLE Localization of the human gene for advanced glycosylation end
product-specific receptor (AGER) to chromosome 6p21.3
JOURNAL Genomics 24 (3), 606-608 (1994)
PUBMED 7713518
REFERENCE 9 (bases 1 to 1691)
AUTHORS Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
Ando,A., Inoko,H. and Ikemura,T.
TITLE Three genes in the human MHC class III region near the junction
with the class II: gene for receptor of advanced glycosylation end
products, PBX2 homeobox gene and a notch homolog, human counterpart
of mouse mammary tumor gene int-3
JOURNAL Genomics 23 (2), 408-419 (1994)
PUBMED 7835890
REFERENCE 10 (bases 1 to 1691)
AUTHORS Neeper,M., Schmidt,A.M., Brett,J., Yan,S.D., Wang,F., Pan,Y.C.,
Elliston,K., Stern,D. and Shaw,A.
TITLE Cloning and expression of a cell surface receptor for advanced
glycosylation end products of proteins
JOURNAL J. Biol. Chem. 267 (21), 14998-15004 (1992)
PUBMED 1378843
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK298100.1, DQ104254.1 and
BM971899.1.
Summary: The advanced glycosylation end product (AGE) receptor
encoded by this gene is a member of the immunoglobulin superfamily
of cell surface receptors. It is a multiligand receptor, and
besides AGE, interacts with other molecules implicated in
homeostasis, development, and inflammation, and certain diseases,
such as diabetes and Alzheimer's disease. Many alternatively
spliced transcript variants encoding different isoforms, as well as
non-protein-coding variants, have been described for this gene
(PMID:18089847). [provided by RefSeq, May 2011].
Transcript Variant: This variant (10, also known as RAGE_v2) is
alternatively spliced at the 5' end compared to variant 1. It is
represented as non-coding because the use of the 5'-most
translation start codon (with a strong Kozak signal), renders this
transcript a candidate for nonsense-mediated mRNA decay (NMD).
Transfection studies also could not detect expression of any
protein from this variant (PMID:18089847).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-152 AK298100.1 3-154
153-1519 DQ104254.1 63-1429
1520-1671 AK298100.1 1339-1490
1672-1691 BM971899.1 1-20 c
FEATURES Location/Qualifiers
source 1..1691
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.3"
gene 1..1691
/gene="AGER"
/gene_synonym="RAGE"
/note="advanced glycosylation end product-specific
receptor"
/db_xref="GeneID:177"
/db_xref="HGNC:320"
/db_xref="MIM:600214"
misc_RNA 1..1691
/gene="AGER"
/gene_synonym="RAGE"
/product="advanced glycosylation end product-specific
receptor, transcript variant 10"
/db_xref="GeneID:177"
/db_xref="HGNC:320"
/db_xref="MIM:600214"
exon 1..442
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
misc_feature 101..178
/gene="AGER"
/gene_synonym="RAGE"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_172197.2"
/note="primary ORF has stop codon >50 nucleotides from the
terminal splice site; nonsense-mediated decay (NMD)
candidate"
variation 106
/gene="AGER"
/gene_synonym="RAGE"
/replace="a"
/replace="t"
/db_xref="dbSNP:1800684"
variation 173
/gene="AGER"
/gene_synonym="RAGE"
/replace="c"
/replace="t"
/db_xref="dbSNP:17846803"
variation 202
/gene="AGER"
/gene_synonym="RAGE"
/replace="a"
/replace="c"
/db_xref="dbSNP:2555464"
variation 366
/gene="AGER"
/gene_synonym="RAGE"
/replace="c"
/replace="t"
/db_xref="dbSNP:17846804"
exon 443..638
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
variation 527
/gene="AGER"
/gene_synonym="RAGE"
/replace="a"
/replace="g"
/db_xref="dbSNP:2070600"
variation 624
/gene="AGER"
/gene_synonym="RAGE"
/replace="a"
/replace="g"
/db_xref="dbSNP:17846806"
exon 639..703
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
exon 704..791
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
exon 792..974
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
exon 975..1105
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
variation 1004
/gene="AGER"
/gene_synonym="RAGE"
/replace="c"
/replace="g"
/db_xref="dbSNP:17846799"
exon 1106..1247
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
exon 1248..1274
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
exon 1275..1401
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
variation 1389
/gene="AGER"
/gene_synonym="RAGE"
/replace="a"
/replace="g"
/db_xref="dbSNP:3176931"
exon 1402..1673
/gene="AGER"
/gene_synonym="RAGE"
/inference="alignment:Splign:1.39.8"
polyA_signal 1651..1656
/gene="AGER"
/gene_synonym="RAGE"
polyA_site 1673
/gene="AGER"
/gene_synonym="RAGE"
ORIGIN
ctgaaagatgggggctggagagagggtgcaggccccacctagggcggaggccacagcagggagaggggcagacagagccaggaccctggaaggaagcaggatggcagccggaacagcagttggagcctgggtgctggtcctcagtctgtggggtgagccactccctcaaccccactgaccctccctgcagaaagcactttaaccccacaccccagtcgtcctagaacttttcccagaacccgaggaagtgcctttcaaggtccctcacccaccctgtccaaattttgttagccctcattcccttcctacccctctaccatggtgctatctcccaggggcagtagtaggtgctcaaaacatcacagcccggattggcgagccactggtgctgaagtgtaagggggcccccaagaaaccaccccagcggctggaatggaaactgaacacaggccggacagaagcttggaaggtcctgtctccccagggaggaggcccctgggacagtgtggctcgtgtccttcccaacggctccctcttccttccggctgtcgggatccaggatgaggggattttccggtgccaggcaatgaacaggaatggaaaggagaccaagtccaactaccgagtccgtgtctaccagattcctgggaagccagaaattgtagattctgcctctgaactcacggctggtgttcccaataaggtggggacatgtgtgtcagagggaagctaccctgcagggactcttagctggcacttggatgggaagcccctggtgcctaatgagaagggagtatctgtgaaggaacagaccaggagacaccctgagacagggctcttcacactgcagtcggagctaatggtgaccccagcccggggaggagatccccgtcccaccttctcctgtagcttcagcccaggccttccccgacaccgggccttgcgcacagcccccatccagccccgtgtctgggagcctgtgcctctggaggaggtccaattggtggtggagccagaaggtggagcagtagctcctggtggaaccgtaaccctgacctgtgaagtccctgcccagccctctcctcaaatccactggatgaaggatggtgtgcccttgccccttccccccagccctgtgctgatcctccctgagatagggcctcaggaccagggaacctacagctgtgtggccacccattccagccacgggccccaggaaagccgtgctgtcagcatcagcatcatcgaaccaggcgaggaggggccaactgcaggctctgtgggaggatcagggctgggaactctagccctggccctggggatcctgggaggcctggggacagccgccctgctcattggggtcatcttgtggcaaaggcggcaacgccgaggagaggagaggaaggccccagaaaaccaggaggaagaggaggagcgtgcagaactgaatcagtcggaggaacctgaggcaggcgagagtagtactggagggccttgaggggcccacagacagatcccatccatcagctcccttttctttttcccttgaactgttctggcctcagaccaactctctcctgtataatctctctcctgtataaccccaccttgccaagctttcttctacaaccagagccccccacaatgatgattaaacacctgacacatcttgcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:177 -> Molecular function: GO:0004872 [receptor activity] evidence: TAS
GeneID:177 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: TAS
GeneID:177 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:177 -> Molecular function: GO:0044548 [S100 protein binding] evidence: IPI
GeneID:177 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:177 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
GeneID:177 -> Biological process: GO:0009611 [response to wounding] evidence: TAS
GeneID:177 -> Biological process: GO:0031175 [neuron projection development] evidence: IGI
GeneID:177 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:177 -> Biological process: GO:0050930 [induction of positive chemotaxis] evidence: IEA
GeneID:177 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IDA
GeneID:177 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:177 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:177 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
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@meso_cacase at
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