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2025-05-09 19:37:38, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_024122               2669 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens pre-B-cell leukemia homeobox 3 (PBX3), transcript
            variant 3, non-coding RNA.
ACCESSION   NR_024122
VERSION     NR_024122.1  GI:198041758
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Li,Z., Zhang,Z., Li,Y., Arnovitz,S., Chen,P., Huang,H., Jiang,X.,
            Hong,G.M., Kunjamma,R.B., Ren,H., He,C., Wang,C.Z., Elkahloun,A.G.,
            Valk,P.J., Dohner,K., Neilly,M.B., Bullinger,L., Delwel,R.,
            Lowenberg,B., Liu,P.P., Morgan,R., Rowley,J.D., Yuan,C.S. and
            Chen,J.
  TITLE     PBX3 is an important cofactor of HOXA9 in leukemogenesis
  JOURNAL   Blood 121 (8), 1422-1431 (2013)
   PUBMED   23264595
  REMARK    GeneRIF: Collectively, our data suggest that PBX3 is a critical
            cofactor of HOXA9 in leukemogenesis.
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Ho,C.Y., Bar,E., Giannini,C., Marchionni,L., Karajannis,M.A.,
            Zagzag,D., Gutmann,D.H., Eberhart,C.G. and Rodriguez,F.J.
  TITLE     MicroRNA profiling in pediatric pilocytic astrocytoma reveals
            biologically relevant targets, including PBX3, NFIB, and METAP2
  JOURNAL   Neuro-oncology 15 (1), 69-82 (2013)
   PUBMED   23161775
  REMARK    GeneRIF: Increased expression of PBX3 is associated with pilocytic
            astrocytoma.
REFERENCE   3  (bases 1 to 2669)
  AUTHORS   Arrington,C.B., Dowse,B.R., Bleyl,S.B. and Bowles,N.E.
  TITLE     Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes
            are associated with congenital heart defects
  JOURNAL   Eur J Med Genet 55 (4), 235-237 (2012)
   PUBMED   22426282
  REMARK    GeneRIF: The Pbx3 Ala136Val variant is a modifier or risk allele
            for congenital heart defects.
REFERENCE   4  (bases 1 to 2669)
  AUTHORS   Li,Z., Huang,H., Li,Y., Jiang,X., Chen,P., Arnovitz,S.,
            Radmacher,M.D., Maharry,K., Elkahloun,A., Yang,X., He,C., He,M.,
            Zhang,Z., Dohner,K., Neilly,M.B., Price,C., Lussier,Y.A., Zhang,Y.,
            Larson,R.A., Le Beau,M.M., Caligiuri,M.A., Bullinger,L., Valk,P.J.,
            Delwel,R., Lowenberg,B., Liu,P.P., Marcucci,G., Bloomfield,C.D.,
            Rowley,J.D. and Chen,J.
  TITLE     Up-regulation of a HOXA-PBX3 homeobox-gene signature following
            down-regulation of miR-181 is associated with adverse prognosis in
            patients with cytogenetically abnormal AML
  JOURNAL   Blood 119 (10), 2314-2324 (2012)
   PUBMED   22251480
  REMARK    GeneRIF: Data show that up-regulation of the HOXA7, HOXA9, HOXA11,
            and PBX3 resulting from the down-regulation of miR-181 family
            members probably contribute to the poor prognosis of patients with
            nonfavorable cytogenetically abnormal AML (CA-AML).
REFERENCE   5  (bases 1 to 2669)
  AUTHORS   Ramberg,H., Alshbib,A., Berge,V., Svindland,A. and Tasken,K.A.
  TITLE     Regulation of PBX3 expression by androgen and Let-7d in prostate
            cancer
  JOURNAL   Mol. Cancer 10, 50 (2011)
   PUBMED   21548940
  REMARK    GeneRIF: PBX3 is up-regulated in prostate cancer and post-
            transcriptionally regulated by androgen through Let-7d.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2669)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol. Vis. 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2669)
  AUTHORS   Knoepfler,P.S., Sykes,D.B., Pasillas,M. and Kamps,M.P.
  TITLE     HoxB8 requires its Pbx-interaction motif to block differentiation
            of primary myeloid progenitors and of most cell line models of
            myeloid differentiation
  JOURNAL   Oncogene 20 (39), 5440-5448 (2001)
   PUBMED   11571641
REFERENCE   8  (bases 1 to 2669)
  AUTHORS   Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G., Hirokawa,K. and Nakamura,T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp. Hematol. 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   9  (bases 1 to 2669)
  AUTHORS   Shen,W.F., Rozenfeld,S., Kwong,A., Kom ves,L.G., Lawrence,H.J. and
            Largman,C.
  TITLE     HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells
  JOURNAL   Mol. Cell. Biol. 19 (4), 3051-3061 (1999)
   PUBMED   10082572
REFERENCE   10 (bases 1 to 2669)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol. Cell. Biol. 11 (12), 6149-6157 (1991)
   PUBMED   1682799
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X59841.1, AI479638.1, AF355141.1, BC094883.1, CD675622.1,
            CN372830.1 and CN372832.1.
            
            Transcript Variant: This variant (3) omits a coding exon resulting
            in a frameshift and truncated open reading frame. The transcript is
            predicted to be a candidate for nonsense-mediated decay and likely
            does not encode a protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                X59841.1           1-72
            73-116              AI479638.1         37-80
            117-246             AF355141.1         1-130
            247-390             BC094883.1         198-341
            391-841             AF355141.1         275-725
            842-1380            BC094883.1         1035-1573
            1381-1641           CD675622.1         318-578
            1642-2040           CN372830.1         355-753
            2041-2497           CN372832.1         95-551
            2498-2669           BC094883.1         2693-2864
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..2669
                     /gene="PBX3"
                     /note="pre-B-cell leukemia homeobox 3"
                     /db_xref="GeneID:5090"
                     /db_xref="HGNC:8634"
                     /db_xref="MIM:176312"
     misc_RNA        1..2669
                     /gene="PBX3"
                     /product="pre-B-cell leukemia homeobox 3, transcript
                     variant 3"
                     /db_xref="GeneID:5090"
                     /db_xref="HGNC:8634"
                     /db_xref="MIM:176312"
     exon            1..316
                     /gene="PBX3"
                     /inference="alignment:Splign:1.39.8"
     variation       41
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:193112371"
     variation       48..49
                     /gene="PBX3"
                     /replace=""
                     /replace="cgc"
                     /db_xref="dbSNP:370214241"
     misc_feature    117..398
                     /gene="PBX3"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_006195.5"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     variation       138
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370064871"
     variation       231
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142427880"
     variation       243
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74704804"
     variation       278
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150874436"
     exon            317..390
                     /gene="PBX3"
                     /inference="alignment:Splign:1.39.8"
     variation       352
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372548249"
     variation       383
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199866010"
     exon            391..581
                     /gene="PBX3"
                     /inference="alignment:Splign:1.39.8"
     misc_signal     415..423
                     /gene="PBX3"
                     /note="Kozak consensus sequence; degenerate"
     misc_signal     475..483
                     /gene="PBX3"
                     /note="Kozak consensus sequence; alternative"
     variation       525
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1854706"
     misc_feature    577..765
                     /gene="PBX3"
                     /note="homeobox"
     exon            582..717
                     /gene="PBX3"
                     /inference="alignment:Splign:1.39.8"
     variation       645
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117595468"
     exon            718..883
                     /gene="PBX3"
                     /inference="alignment:Splign:1.39.8"
     variation       726
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141969948"
     variation       789
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374198859"
     variation       825
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368535684"
     variation       832
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199830900"
     variation       843
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372253003"
     variation       863
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370710553"
     variation       864
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114208419"
     variation       867
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145537886"
     variation       882
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200644689"
     exon            884..996
                     /gene="PBX3"
                     /inference="alignment:Splign:1.39.8"
     exon            997..1086
                     /gene="PBX3"
                     /inference="alignment:Splign:1.39.8"
     variation       1020
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148844992"
     variation       1028
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143568685"
     variation       1039
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376665042"
     variation       1044
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138039965"
     variation       1053
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058389"
     variation       1057
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144885113"
     variation       1063
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:76165119"
     variation       1064
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138731813"
     variation       1068
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189417832"
     variation       1072
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114191763"
     variation       1077
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369882718"
     exon            1087..2633
                     /gene="PBX3"
                     /inference="alignment:Splign:1.39.8"
     variation       1094
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142803989"
     variation       1128
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:111373780"
     variation       1160
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115431152"
     variation       1200
                     /gene="PBX3"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:33993404"
     variation       1216
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374696590"
     variation       1234
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77899191"
     variation       1372..1373
                     /gene="PBX3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35298105"
     variation       1372
                     /gene="PBX3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:79152930"
     variation       1397
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186361189"
     variation       1436
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11792585"
     variation       1440
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144996442"
     variation       1443
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149098105"
     variation       1531
                     /gene="PBX3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192067546"
     variation       1611
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373063178"
     variation       1622
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376294286"
     variation       1690
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13296162"
     variation       1695
                     /gene="PBX3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113094250"
     variation       1863
                     /gene="PBX3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:151283697"
     variation       1870
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374619196"
     variation       1874
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:73667816"
     variation       1884
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141512258"
     variation       1941
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374738745"
     variation       2024..2026
                     /gene="PBX3"
                     /replace=""
                     /replace="tta"
                     /db_xref="dbSNP:71680715"
     variation       2079
                     /gene="PBX3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113517815"
     variation       2123
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147042624"
     variation       2215
                     /gene="PBX3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368092553"
     variation       2345
                     /gene="PBX3"
                     /replace=""
                     /replace="a"
                     /replace="aa"
                     /db_xref="dbSNP:10543594"
     variation       2354
                     /gene="PBX3"
                     /replace=""
                     /replace="a"
                     /replace="aa"
                     /db_xref="dbSNP:67765417"
     variation       2399
                     /gene="PBX3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:183611167"
     variation       2491
                     /gene="PBX3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186955350"
ORIGIN      





gcggccgcctccccctccccctccccctctttcttctcctccctcgtcgccgccgccgccgccgccgcctcagccttcgcctcagccgccgcccgctcccgcccgcgcgcggcgggatggacgatcaatccaggatgctgcagactctggccggggtgaacctggctggccactcggtgcaggggggcatggccctgccgcctcccccgcacggccacgaaggggcggacggcgacggcaggaagcaggacatcggcgacatcctccaccagatcatgaccatcaccgaccagagcttggacgaggcgcaagcaaagaaacatgccctgaactgtcacagaatgaaaccagcgctcttcagcgtcctgtgtgagatcaaagagaaaacaggcatgtaatgaatttactacacatgtgatgaaccttctccgagaacagagtagaacacgtcccatttctccaaaagagattgaaagaatggtgggcatcatccatcgaaaatttagttccattcagatgcagctcaaacaaagcacttgtgaagcagttatgattttaagatcaaggttccttgatgccagacggaaaaggcgtaacttcagtaaacaggccacagaaatcttgaatgaatatttttactcacacctcagcaacccctaccccagtgaagaagccaaagaggagctggccaagaaatgcagcatcacagtgtcacaggtatccaattggtttggcaacaaacgaatcaggtacaagaagaacattggcaagtttcaggaagaagccaacctctatgctgcaaagacggccgtgacagctgcacacgcagtagcagcagctgtgcagaacaaccagaccaattcgcccaccacaccaaattccggttcttctggttcttttaacctcccaaattctggggacatgttcatgaacatgcagagtctgaatggggattcttaccaagggtcccaagtcggagccaatgtgcaatcacaggtggataccctccgtcatgttatcaatcagacgggaggctacagtgatggccttggaggaaattcactgtacagtccacataatttaaatgctaatggaggctggcaggacgcaacaactccatcttctgtgacttctcctacagaaggcccaggaagtgtgcactcggatacctctaactaatctctggccacacttttccctgagctacatgccttgataagtgcattcagagcaataggaggaaaaggaaagcgtttttgtagcccaccatctacagctttactgtaaaaccttgtcttattcgagaacttggtaaatctgttttttaaggaatcataatcatttgtatttatacttaaaaacacacaatgttaaaaaaaataaagcactttatccaattaggccaagatttaacattgttgacagtcctgtagctattttatcataatttattatcaatattttacattaatggtttcacagttgccaattacttggccttaagggtaaaaagtacaatatacactaaacctcaaccgttaaagcagatgcaaaaattcacctcacctaaattgaacttcttgcatatttccattactgacttggattgtctttctttcatatcactaatggagttggaataaagagctgtttgcctatccctgttaatgatggttgtgtttaagaatcttcctcgtcacgtttgtgttcagatctcttatgttataattagatcagagactggtagcatcgtttctctctctgaaagcaccagtgcccagagtctgctcggtaataaaattatggatccagattgttctgagagacgaagatacttgctgctgatagaggtgaaaacgagattgatccgtctggggttttacggtgtgcactgggtgctgcacagacttgtcaaggtttgctacgtcctctgggcatctgcaaaaggccctgctctctggagtgttgtatatagtgtagcaaaagagtatttatacatcccaccaatcaaaacacagctttattacctcatgcgaactcatacaaaccaatagaatttcaacatgttctgtagcttagagtgctcacttactacctctgaacaatactcacgctgtagtttgtctctttcttatctttttgcatcttgtaattaactctttgtttcccttcataaaatgtaatgtacattgtaatcttttaaaagaaaaatcagggttgcacttgcaacttttaaaaaaccgagtgtggaaacattgggtcttaattcaacacaggatcggtaaaactgttgtaaatactgagaaacattttgaatgttcttcatcttattactaatccatgcaaaaaaaaaaaaaaaagcagcgactaattgtgatgcattcagatttcagtattcagtactgtatatttcaccctgtgtaatggggccccctctcctttctctctttttgtattgtatgcgattctgaaactgattgagtcatgaaaataatttgtggcggtgattctaatgtattaaaaacgtttcgtgttcctttctaactggattacaccctggattgaaaaagtcttcctcgtggtagttatatgtagtttcaaacatgaataaactttttgctttcatgattaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


//





Annotations:
 




ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5090 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:5090 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5090 -> Biological process: GO:0002087 [regulation of respiratory gaseous exchange by neurological system process] evidence: IEA
            GeneID:5090 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:5090 -> Biological process: GO:0007387 [anterior compartment pattern formation] evidence: TAS
            GeneID:5090 -> Biological process: GO:0007388 [posterior compartment specification] evidence: TAS
            GeneID:5090 -> Biological process: GO:0007585 [respiratory gaseous exchange] evidence: IEA
            GeneID:5090 -> Biological process: GO:0008344 [adult locomotory behavior] evidence: IEA
            GeneID:5090 -> Biological process: GO:0021516 [dorsal spinal cord development] evidence: IEA
            GeneID:5090 -> Biological process: GO:0048666 [neuron development] evidence: IEA
            GeneID:5090 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA










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