GGRNA | NM_182894.2

LOCUS       NM_182894               2995 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens visual system homeobox 2 (VSX2), mRNA.
ACCESSION   NM_182894 XM_290610
VERSION     NM_182894.2  GI:156071534
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2995)
  AUTHORS   Reis,L.M., Khan,A., Kariminejad,A., Ebadi,F., Tyler,R.C. and
            Semina,E.V.
  TITLE     VSX2 mutations in autosomal recessive microphthalmia
  JOURNAL   Mol. Vis. 17, 2527-2532 (2011)
   PUBMED   21976963
  REMARK    GeneRIF: Mutations in VSX2 represent an important cause of
            autosomal recessive microphthalmia in consanguineous pedigrees.
REFERENCE   2  (bases 1 to 2995)
  AUTHORS   Gonzalez-Rodriguez,J., Pelcastre,E.L., Tovilla-Canales,J.L.,
            Garcia-Ortiz,J.E., Amato-Almanza,M., Villanueva-Mendoza,C.,
            Espinosa-Mattar,Z. and Zenteno,J.C.
  TITLE     Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50
            unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases
  JOURNAL   Br J Ophthalmol 94 (8), 1100-1104 (2010)
   PUBMED   20494911
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2995)
  AUTHORS   Iseri,S.U., Wyatt,A.W., Nurnberg,G., Kluck,C., Nurnberg,P.,
            Holder,G.E., Blair,E., Salt,A. and Ragge,N.K.
  TITLE     Use of genome-wide SNP homozygosity mapping in small pedigrees to
            identify new mutations in VSX2 causing recessive microphthalmia and
            a semidominant inner retinal dystrophy
  JOURNAL   Hum. Genet. 128 (1), 51-60 (2010)
   PUBMED   20414678
  REMARK    GeneRIF: study identified 3 recessive VSX2 mutations associated
            with isolated congenital anophthalmia or severe microphthalmia;
            also identified a novel inner retinal dystrophy in 2 carrier
            parents suggesting a semidominant effect for this particular VSX2
            mutation
REFERENCE   4  (bases 1 to 2995)
  AUTHORS   Nagel,S., Venturini,L., Marquez,V.E., Meyer,C., Kaufmann,M.,
            Scherr,M., MacLeod,R.A. and Drexler,H.G.
  TITLE     Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating
            ID2 in NK/T-cell lines
  JOURNAL   Mol. Cancer 9, 151 (2010)
   PUBMED   20565746
  REMARK    GeneRIF: major differentiation factors of the NK-cell lineage,
            including HOXA9, HOXA10 and ID2, were (de)regulated via PRC2 which
            therefore contributes to T-cell leukemogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2995)
  AUTHORS   Zhang,X., Li,S., Xiao,X., Jia,X., Wang,P., Shen,H., Guo,X. and
            Zhang,Q.
  TITLE     Mutational screening of 10 genes in Chinese patients with
            microphthalmia and/or coloboma
  JOURNAL   Mol. Vis. 15, 2911-2918 (2009)
   PUBMED   20057906
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2995)
  AUTHORS   Dorval,K.M., Bobechko,B.P., Ahmad,K.F. and Bremner,R.
  TITLE     Transcriptional activity of the paired-like homeodomain proteins
            CHX10 and VSX1
  JOURNAL   J. Biol. Chem. 280 (11), 10100-10108 (2005)
   PUBMED   15647262
  REMARK    GeneRIF: CHX10 and VSX1 may control retinal bipolar cell
            specification or differentiation by repressing genes required for
            the development of other cell types
REFERENCE   7  (bases 1 to 2995)
  AUTHORS   Bar-Yosef,U., Abuelaish,I., Harel,T., Hendler,N., Ofir,R. and
            Birk,O.S.
  TITLE     CHX10 mutations cause non-syndromic microphthalmia/ anophthalmia in
            Arab and Jewish kindreds
  JOURNAL   Hum. Genet. 115 (4), 302-309 (2004)
   PUBMED   15257456
REFERENCE   8  (bases 1 to 2995)
  AUTHORS   Mikkola,I., Bruun,J.A., Holm,T. and Johansen,T.
  TITLE     Superactivation of Pax6-mediated transactivation from paired
            domain-binding sites by dna-independent recruitment of different
            homeodomain proteins
  JOURNAL   J. Biol. Chem. 276 (6), 4109-4118 (2001)
   PUBMED   11069920
REFERENCE   9  (bases 1 to 2995)
  AUTHORS   Ferda Percin,E., Ploder,L.A., Yu,J.J., Arici,K., Horsford,D.J.,
            Rutherford,A., Bapat,B., Cox,D.W., Duncan,A.M., Kalnins,V.I.,
            Kocak-Altintas,A., Sowden,J.C., Traboulsi,E., Sarfarazi,M. and
            McInnes,R.R.
  TITLE     Human microphthalmia associated with mutations in the retinal
            homeobox gene CHX10
  JOURNAL   Nat. Genet. 25 (4), 397-401 (2000)
   PUBMED   10932181
REFERENCE   10 (bases 1 to 2995)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006349.3 and AC005519.4.
            This sequence is a reference standard in the RefSeqGene project.
            On Aug 16, 2007 this sequence version replaced gi:34365782.
            
            Summary: This gene encodes a homeobox protein originally described
            as a retina-specific transcription factor. Mutations in this gene
            are associated with microphthalmia, cataracts and iris
            abnormalities. [provided by RefSeq, Oct 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY336059.1, BC128153.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025095 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AC006349.3         12896-13355         c
            461-545             AC006349.3         11561-11645         c
            546-669             AC006349.3         7539-7662           c
            670-850             AC005519.4         134920-135100       c
            851-2995            AC005519.4         131964-134108       c
FEATURES             Location/Qualifiers
     source          1..2995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2995
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /note="visual system homeobox 2"
                     /db_xref="GeneID:338917"
                     /db_xref="HGNC:1975"
                     /db_xref="HPRD:08852"
                     /db_xref="MIM:142993"
     exon            1..460
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /inference="alignment:Splign:1.39.8"
     variation       34
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373352297"
     variation       45
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:115662253"
     misc_feature    52..54
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /note="upstream in-frame stop codon"
     STS             63..1210
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /db_xref="UniSTS:483569"
     CDS             91..1176
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /note="homeobox protein CHX10; ceh-10
                     homeodomain-containing homolog; ceh-10 homeo domain
                     containing homolog"
                     /codon_start=1
                     /product="visual system homeobox 2"
                     /protein_id="NP_878314.1"
                     /db_xref="GI:34365783"
                     /db_xref="CCDS:CCDS9827.1"
                     /db_xref="GeneID:338917"
                     /db_xref="HGNC:1975"
                     /db_xref="HPRD:08852"
                     /db_xref="MIM:142993"
                     /translation="

MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGHLLAARSVLSPAGVGGMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEGERQALPKLDKMEQDERGPDAQAAISQEELRENSIAVLRAKAQEHSTKVLGTVSGPDSLARSTEKPEEEEAMDEDRPAERLSPPQLEDMA

"
     misc_feature    547..711
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(547..549,553..555,604..606,622..624,661..663,
                     667..672,679..684,688..696,700..705)
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(550..552,670..672,679..684,691..693)
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    985..1041
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /note="OAR domain; Region: OAR; pfam03826"
                     /db_xref="CDD:146451"
     misc_feature    1000..1041
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P58304.1);
                     Region: OAR"
     variation       252
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:61747367"
     variation       261
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201395979"
     variation       312
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200824722"
     variation       334
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375294678"
     variation       357
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369629867"
     variation       359
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190729581"
     variation       389
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:35214083"
     variation       398
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375237762"
     exon            461..545
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /inference="alignment:Splign:1.39.8"
     variation       475
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145866932"
     variation       486
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112923895"
     exon            546..669
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /inference="alignment:Splign:1.39.8"
     variation       561
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35435463"
     variation       573
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143366810"
     variation       607
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375663408"
     variation       612
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78509400"
     variation       622
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143480909"
     variation       629
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147167593"
     variation       637
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113142527"
     variation       654
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201354547"
     variation       669
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182972044"
     exon            670..850
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /inference="alignment:Splign:1.39.8"
     variation       686
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377740442"
     variation       689
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:121912543"
     variation       707
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138619416"
     variation       725
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368725719"
     variation       741
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150792267"
     variation       744
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139224826"
     variation       756
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373242858"
     variation       763
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200389260"
     variation       769
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:121912545"
     variation       789
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141712104"
     variation       804
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377107974"
     variation       840
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192712847"
     exon            851..2995
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /inference="alignment:Splign:1.39.8"
     variation       867
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371707151"
     variation       888
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189139917"
     variation       910
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375155660"
     variation       911
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369647679"
     variation       921
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62006815"
     variation       924..925
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:60106203"
     variation       949
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200256286"
     variation       952
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76055170"
     variation       953
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375426810"
     variation       956
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199473712"
     variation       961
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75395981"
     variation       963
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146821562"
     variation       996
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369042868"
     variation       1006..1007
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34895184"
     variation       1006
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140496487"
     variation       1010
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181704375"
     variation       1029
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372651860"
     variation       1101..1102
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace=""
                     /replace="gag"
                     /db_xref="dbSNP:144220788"
     variation       1113
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144219756"
     variation       1116
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199528979"
     variation       1136
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137872696"
     variation       1155
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370443332"
     variation       1159..1165
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace=""
                     /replace="ctggagg"
                     /db_xref="dbSNP:201981942"
     variation       1184
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373971416"
     variation       1187
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140814896"
     variation       1201
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374436224"
     variation       1215
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117813701"
     variation       1230
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144840915"
     variation       1246
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138760799"
     variation       1332
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141741225"
     variation       1426
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144569223"
     variation       1437
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:115396145"
     variation       1467
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:148109679"
     variation       1494
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184078751"
     variation       1592
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189778670"
     variation       1631
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73309254"
     variation       1651
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180856135"
     variation       1755
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12588074"
     variation       1846
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45556237"
     variation       1850
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185981255"
     variation       1908
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150646795"
     variation       1958
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140678898"
     variation       1995
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74694887"
     variation       2031
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45608043"
     variation       2064..2065
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:201083658"
     variation       2065..2066
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:34203376"
     variation       2138
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367835329"
     variation       2161
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192089790"
     variation       2205
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:45474800"
     variation       2250
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34263984"
     variation       2337
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147524933"
     variation       2388
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117409214"
     variation       2428
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:28441537"
     variation       2477
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111457561"
     variation       2478
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8020424"
     variation       2487
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114889622"
     variation       2553
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150033933"
     variation       2687
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145366747"
     variation       2713
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149197006"
     variation       2721..2722
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:10592020"
     variation       2741
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142543750"
     variation       2761
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:6574170"
     variation       2771
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112115147"
     variation       2782
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146455625"
     variation       2789
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181946575"
     variation       2809
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:59105417"
     variation       2816
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140752449"
     variation       2966
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76257502"
     polyA_signal    2975..2980
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
     variation       2979
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11848458"
     polyA_site      2995
                     /gene="VSX2"
                     /gene_synonym="CHX10; HOX10; MCOP2; MCOPCB3; RET1"
ORIGIN

cctgggaccaacttcgcgaagcgggaagcccggcgggggggtggggggagctaaagacctgcggcctcagcccctccaaagaacagggagatgacggggaaagcaggggaagcgctgagcaagcccaaatccgagacagtggccaagagtacctcggggggcgccccggccaggtgcactgggttcggcatccaggagatcctgggcttgaacaaggagcccccgagctcccacccgcgggcagcgctcgacggcctggcccccgggcacttgctggcggcgcgctcagtgctcagccccgcgggggtgggcggcatggggcttctggggcccggggggctccctggcttctacacgcagcccaccttcctggaagtgctgtccgacccgcagagcgtccacttgcagccattgggcagagcatcggggccgctggacaccagccagacggccagctcggattctgaagatgtttcctccagcgatcgaaaaatgtccaaatctgctttaaaccagaccaagaaacggaagaagcggcgacacaggacaatctttacctcctaccagctagaggagctggagaaggcattcaacgaagcccactacccagacgtctatgcccgggagatgctggccatgaaaacggagctgccggaagacaggatacaggtctggttccagaaccgtcgagccaagtggaggaagcgggagaagtgctggggccggagcagtgtcatggcggagtatgggctctacggggccatggtgcggcactccatccccctgcccgagtccatcctcaagtcagccaaggatggcatcatggactcctgtgccccgtggctactggggatgcacaaaaagtcgctggaggcagcagccgagtcggggaggaagcccgagggggaacgccaggccctgcccaagctcgacaagatggagcaggacgagcggggccccgacgctcaggcggccatctcccaggaggaactgagggagaacagcattgcggtgctccgggccaaagctcaggagcacagcaccaaagtgctggggactgtgtctgggccggacagcctggcccggagtaccgagaagccagaggaggaggaggccatggatgaagacaggccggcggagaggctcagtccaccgcagctggaggacatggcttaggtcaaggcgcgctcagatgccggagccccaagactctgctctcctcgggccctgtggtgctgggagatgctctctgaggcaaggcccagacctggcctctgccatcctccctgttccccacaggtcctccatcacccctggtggctgcaggcaccgctgggttctgactctggaccatgctgagacatccctcatctagtcttgacctctccagcatcccagcctcagaagccttcttgctgcccacaacgtcccctcaagccccttctctcaatccctttgcaacgctcactggttttggccaccccttgctctctgttctcttgctttaaagagtcctccttcccagctctacattctgctctgcccatgcctaaagcccattgctgcaaatgcattgtgaattgcctgccatggctgtgacacagacggaggactggaactgcaactccagcgtcctcagcaccccactcctcagtaaaagtcttctcccaactcagcctgttccttcctgcagacctggctgggcctgggcttccacagtgtgaagacactgtgcaggcccaggcaggcccagcctctgccccacccatcagtggagtccagatggcaggctacagttgggaagtctcagcctgggcccctcagccacccttggtctcatgccccgccatggtcaccctcaggaacccaccctctccacacccagcctgtcccactggctcctcccagcacaggcacctatgtggcatgtggtgatgtacgctgcgtgccatgagtccatgtcctatgcctcacaaatgctgtggttcactgcactgttcaggagtccaaaccttctaccctgggtcctcgggcccctgagcctgtgtcctgaagaatctcgactctcgtgatatgctgcttgtgaccttgacttgccatgaaggcacctgcccccacagctccttgcaaactatgagttcacatgtgccctgccttgaacaacccaatctggctggtaaatgacatctacgaagccacaggcctggcctcaactgagaagccaagcctggagtaggcctggggctatgcatacgcattaagggcctgctggagaaaccttcactccagacagacagggggctaaggggctagggctgagcacctctcagagcaagcctttgacctgttcagaaggatgggaaaaaggctggaaggaaagcaaggcagaaggccaggagtaagcccaagctaagctgcaggcacacacgccttcatgccagtgcatgccaggaagcacgttcactagactaaaacacggtaaccatgatggaataaggagctggggcttctttctgctggctgatgggtggacctgtgtatggtgacctctccggcctggccttttccattcgcatgaacaatgggagcacatagccctgttgacctgcccgatccagattcccaggccaggctcccgaccccatccacctatccaccaccccacccacctttgcagggaatacctcgttagagaatggcctgagacagtgcgttgcaactttttaattccatatcaaaagttgatttcttcttcattccatttatggaacttccctccccctagtccggttcttcttgtctttgtccctgttggtttgaagtgttagactatagcccctggtgtgtaaataatgtacatagagtgagaagaaagaaacttgatattgaggtgtttgaaatatggaactgtaataacttctaggtattcgaaacctgtgatttctgtgccattttctgtaaagatacaagtaagaataaaattgacttaaaaata

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