LOCUS       NM_170675               3277 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens Meis homeobox 2 (MEIS2), transcript variant c, mRNA.
ACCESSION   NM_170675
VERSION     NM_170675.4  GI:388596659
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3277)
  AUTHORS   Bjerke,G.A., Hyman-Walsh,C. and Wotton,D.
  TITLE     Cooperative transcriptional activation by Klf4, Meis2, and Pbx1
  JOURNAL   Mol. Cell. Biol. 31 (18), 3723-3733 (2011)
   PUBMED   21746878
  REMARK    GeneRIF: Klf4 recruits a complex of Meis and Pbx proteins to DNA,
            resulting in Meis2 transcriptional activation domain-dependent
            activation of a subset of Klf4 target genes.
REFERENCE   2  (bases 1 to 3277)
  AUTHORS   Shibata,M., Nakao,H., Kiyonari,H., Abe,T. and Aizawa,S.
  TITLE     MicroRNA-9 regulates neurogenesis in mouse telencephalon by
            targeting multiple transcription factors
  JOURNAL   J. Neurosci. 31 (9), 3407-3422 (2011)
   PUBMED   21368052
  REMARK    GeneRIF: Transgenic mice lacking microRNAs miR-9-2 and miR-9-3
            exhibit multiple defects of telencephalic structures which may be
            brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2
            expression.
REFERENCE   3  (bases 1 to 3277)
  AUTHORS   Adkins,D.E., Aberg,K., McClay,J.L., Bukszar,J., Zhao,Z., Jia,P.,
            Stroup,T.S., Perkins,D., McEvoy,J.P., Lieberman,J.A., Sullivan,P.F.
            and van den Oord,E.J.
  TITLE     Genomewide pharmacogenomic study of metabolic side effects to
            antipsychotic drugs
  JOURNAL   Mol. Psychiatry 16 (3), 321-332 (2011)
   PUBMED   20195266
  REMARK    GeneRIF: The Single Nucleotide Polymorphism in Meis homeobox 2
            (MEIS2) mediated the effects of risperidone on hip circumference
            (q=0.004).
            GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 3277)
  AUTHORS   Larsen,K.B., Lutterodt,M.C., Laursen,H., Graem,N., Pakkenberg,B.,
            Mollgard,K. and Moller,M.
  TITLE     Spatiotemporal distribution of PAX6 and MEIS2 expression and total
            cell numbers in the ganglionic eminence in the early developing
            human forebrain
  JOURNAL   Dev. Neurosci. 32 (2), 149-162 (2010)
   PUBMED   20523026
  REMARK    GeneRIF: Data demonstrate by in situ hybridization and
            immunohistochemistry that the two homeobox genes Pax6 and MEIS2 are
            expressed during early fetal brain development in humans.
REFERENCE   5  (bases 1 to 3277)
  AUTHORS   Hyman-Walsh,C., Bjerke,G.A. and Wotton,D.
  TITLE     An autoinhibitory effect of the homothorax domain of Meis2
  JOURNAL   FEBS J. 277 (12), 2584-2597 (2010)
   PUBMED   20553494
  REMARK    GeneRIF: This work suggests that the transcriptional activity of
            all members of the Meis/Prep Hth protein family is subject to
            autoinhibition by their Hth domains, and that the Meis3.2 splice
            variant encodes a protein that bypasses this autoinhibitory effect.
REFERENCE   6  (bases 1 to 3277)
  AUTHORS   Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G., Hirokawa,K. and Nakamura,T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp. Hematol. 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   7  (bases 1 to 3277)
  AUTHORS   Liu,Y., MacDonald,R.J. and Swift,G.H.
  TITLE     DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b
            trimer and cooperation with a pancreas-specific basic
            helix-loop-helix complex
  JOURNAL   J. Biol. Chem. 276 (21), 17985-17993 (2001)
   PUBMED   11279116
REFERENCE   8  (bases 1 to 3277)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J. Biol. Chem. 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   9  (bases 1 to 3277)
  AUTHORS   Smith,J.E., Afonja,O., Yee,H.T., Inghirami,G. and Takeshita,K.
  TITLE     Chromosomal mapping to 15q14 and expression analysis of the human
            MEIS2 homeobox gene
  JOURNAL   Mamm. Genome 8 (12), 951-952 (1997)
   PUBMED   9383298
REFERENCE   10 (bases 1 to 3277)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res. 7 (2), 142-156 (1997)
   PUBMED   9049632
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK056216.1, DA689122.1,
            AF179897.1, BC050431.1 and BM679305.1.
            On May 30, 2012 this sequence version replaced gi:333805642.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcription regulators, and several members have been
            shown to be essential contributors to developmental programs.
            Multiple transcript variants encoding distinct isoforms have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (c) lacks the exon containing the
            stop codon compared to variant a, that causes a frameshift. The
            resulting isoform (c) contains a longer and distinct C-terminus
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF179897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AK056216.1         400-734
            336-419             DA689122.1         39-122
            420-2634            AF179897.1         1-2215
            2635-3207           BC050431.1         2361-2933
            3208-3277           BM679305.1         1-70                c
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..3277
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:4212"
                     /db_xref="HGNC:7001"
                     /db_xref="HPRD:03443"
                     /db_xref="MIM:601740"
     exon            1..686
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(76)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188283226"
     variation       complement(139)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372166848"
     variation       complement(315)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201211078"
     variation       complement(323..331)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="ctttctttt"
                     /db_xref="dbSNP:150319274"
     variation       complement(323)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200040294"
     variation       complement(327..330)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="cttt"
                     /db_xref="dbSNP:200946390"
     variation       complement(414)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:60314502"
     variation       complement(487)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76458635"
     variation       complement(488)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76348970"
     variation       complement(496..497)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:140248890"
     variation       complement(512)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:185043075"
     variation       complement(525)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182029443"
     variation       complement(543)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112410187"
     variation       complement(589)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:111602525"
     misc_feature    633..635
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /note="upstream in-frame stop codon"
     variation       complement(642)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201918475"
     variation       complement(645)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199649371"
     CDS             675..2108
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /note="isoform c is encoded by transcript variant c; Meis
                     homolog 2; TALE homeobox protein Meis2; Meis1-related gene
                     1; meis1-related protein 1; Meis1, myeloid ecotropic viral
                     integration site 1 homolog 2"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform c"
                     /protein_id="NP_733775.1"
                     /db_xref="GI:24762241"
                     /db_xref="CCDS:CCDS10044.1"
                     /db_xref="GeneID:4212"
                     /db_xref="HGNC:7001"
                     /db_xref="HPRD:03443"
                     /db_xref="MIM:601740"
                     /translation="

MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ

"
     misc_feature    885..1247
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14770.2);
                     Region: Required for interaction with PBX1 (By
                     similarity)"
     misc_feature    1512..1673
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1512..1517,1521..1523,1581..1583,1599..1601,
                     1638..1640,1644..1649,1656..1661,1665..1673)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1518..1520,1647..1649,1656..1661,1668..1670)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1692..2105
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14770.2);
                     Region: Transcriptional activation domain"
     exon            687..919
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(698)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369672617"
     variation       complement(764)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376901048"
     variation       complement(776)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200799360"
     variation       complement(777)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138503850"
     variation       complement(794)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144628203"
     variation       complement(824)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375301418"
     variation       complement(827)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140890748"
     variation       complement(841)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372646327"
     exon            920..1061
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     STS             921..1804
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /standard_name="Mrg1"
                     /db_xref="UniSTS:507072"
     variation       complement(1003..1004)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="ggggggggg"
                     /db_xref="dbSNP:138513608"
     exon            1062..1112
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1074)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200496429"
     exon            1113..1163
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1145)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137952617"
     exon            1164..1313
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1181)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139184400"
     variation       complement(1200)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368930165"
     variation       complement(1214)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149182994"
     variation       complement(1253)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377204162"
     variation       complement(1281)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:185278462"
     variation       complement(1289)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145358549"
     variation       complement(1292)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150470779"
     variation       complement(1304)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141907934"
     exon            1314..1428
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1356)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147874392"
     variation       complement(1406)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61734550"
     variation       complement(1407)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375357305"
     variation       complement(1416)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376747133"
     variation       complement(1424)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370758497"
     exon            1429..1574
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1483)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369609025"
     variation       complement(1484)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183075611"
     exon            1575..1651
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1613)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140793410"
     exon            1652..1710
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1704)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367563077"
     exon            1711..1821
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1720)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368127920"
     exon            1822..3260
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1848)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151055354"
     variation       complement(1855)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142878520"
     variation       complement(1888)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113747758"
     variation       complement(1907)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57860578"
     variation       complement(1928)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148444214"
     variation       complement(1936)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144548752"
     variation       complement(1937)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199728455"
     variation       complement(1983)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374458760"
     variation       complement(1986)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141054432"
     variation       complement(1988)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200282136"
     variation       complement(1997)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139991974"
     variation       complement(1998)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201588285"
     variation       complement(2015)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145933742"
     variation       complement(2017)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370135711"
     variation       complement(2026)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142325445"
     variation       complement(2028)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377210457"
     variation       complement(2039)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372766056"
     variation       complement(2089)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150313361"
     variation       complement(2101)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369601092"
     variation       complement(2140)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77635771"
     variation       complement(2177)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146614487"
     variation       complement(2362)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144383417"
     variation       complement(2446)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139647839"
     variation       complement(2522..2523)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34412514"
     variation       complement(2534)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72708659"
     variation       complement(2560)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117434306"
     variation       complement(2584..2585)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34654533"
     variation       complement(2596..2597)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35427488"
     variation       complement(2730)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146332496"
     variation       complement(2770)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373295254"
     variation       complement(2824)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369432376"
     variation       complement(2848)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376202599"
     variation       complement(2872)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34362471"
     variation       complement(3035)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:375754667"
     STS             3050..3228
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /db_xref="UniSTS:34756"
     variation       complement(3197..3198)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:79470888"
     variation       complement(3207)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34976538"
     variation       complement(3207)
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200863215"
     polyA_signal    3231..3236
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
     polyA_site      3260
                     /gene="MEIS2"
                     /gene_synonym="HsT18361; MRG1"
ORIGIN      

tttaaagagagaggatcgtattatagataccgcgggggcaaagctaaaaaaggggggaggggggaggaaaaaattcaagaagcagaaacccctcgcggagttttactggaagaaaaaaacgggtctgaaagattcctcctcttcatcatcatcaaccatcattcattcactaccttgacattccgggctttgattgacagctggagtggcaaaaagccatgaaacacgacagttcggttacatgtgggctgctgacgggccgctcgtaaccttcagttcgggggcttgacaatttttttcttctttttcttctttttcttttctttctttttttttccaactgaggggaagagaagagaaagagggggaaaggaggaccgaagaggaggaggaggggaggggggaggaggaggaggtggaggaggaggaggaagatcaggaggaggaggaagaagaggaaaaaagagaaaaagaagaaatatcacagaaaaaaaaattcttcgttgtctagactgggctttttttcccccctaaaaaatagcatattggagaattgggagaagtctctttggtttggaaaaaaaaaaaaggaatcttcagcctagatcactttcttatccggactgggatattaaatatacgacacatccaggagtttattggagcgcagactgatggcgcaaaggtacgatgagctgccccattacggcgggatggacggagtaggggttcccgcttccatgtacggagaccctcacgcgccgcggccgatccccccggttcaccacctgaaccacgggccgccgctccacgccacacagcactacggcgcgcacgccccgcaccccaatgtcatgccggccagtatgggatccgctgtcaacgacgccttgaagcgggacaaggacgcgatctatgggcacccgttgtttcctctgttagctctggtctttgagaagtgcgagctggcgacctgcactccccgggaacctggagtggctggcggagacgtctgctcctccgactccttcaacgaggacatcgcggtcttcgccaagcaggttcgcgccgaaaagccacttttttcctcaaatccagagctggacaatttgatgatacaagcaatacaagtactaaggtttcatcttttggagttagaaaaggtccacgaactgtgcgataacttctgccaccgatacattagctgtttgaaggggaaaatgcccatcgacctcgtcattgatgaaagagacggcagctccaagtcagatcatgaagaactttcaggctcctccacaaatctcgctgaccataacccttcttcttggcgagaccacgatgatgcaacctcaacccactcagcaggcaccccagggccctccagtgggggccatgcttcccagagcggagacaacagcagtgagcaaggggatggtttagacaacagtgtagcttcacctggtacaggtgacgatgatgatccggataaggacaaaaaacgccagaagaaaagaggcattttccccaaagtagcaacaaatatcatgagagcatggctcttccagcatctcacacatccgtacccttccgaagagcagaagaaacagttagcgcaagacacaggacttacaattctccaagtaaacaactggtttattaatgccagaagaagaatagtacagcccatgattgaccagtcaaatcgagcaggttttcttcttgatccttcagtgagccaaggagcagcatatagtccagagggtcagcccatggggagctttgtgttggatggtcagcaacacatggggatccggcctgcaggtttgcagagcatgccaggggactacgtttctcagggtggtcctatgggaatgagtatggcacagccaagttacactcctccccagatgaccccacaccctactcaattaagacatggacccccaatgcattcatatttgccaagccatccccaccacccagccatgatgatgcacggaggaccccctacccaccctggaatgactatgtcagcacagagccccacaatgttaaattctgtagatcccaatgttggcggacaggttatggacattcatgcccaatagtataagggaactcaagggaaaaggaaacacacgcaaaaactattttaagactttctgaactttgaccagatgttgacacttaatatgaaattccagacagctgtgattattttttacttttgtcatttttcatcaagcaacagaggaccaatgcaacaagaacacaaatgtgaaatcatgggctgactgagacaattctgtccatgtaaagatcctctggaaaaagactccgagagttataactactgtagtataaatataggaactaagttaaacttgtacatttctgttgatcacgccgttatgttgcctcaaatagttttagaagagaaaaaaaaatatatccttgttttccacactatgtgtgttgttcccaaaagaatgactgttttggttcatcagtgaattcaccatccaggagagactgtggtatatattttaaacctgttgggccaatgagaaaagaaccacactggagatcatgatgaacttttggctgaacctcatcactcgaactccagcttcaagaatgtgttttcatgcccggcctttgttcctccataaatgtgtcctttagtttcaaacagatctttatagttcgtgcttcataagccaattcttattattatttttgggggactcttcttcaaagagcttgccaatgaagatttaaagacagagcaggagcttcttccaggagttctgagccttggttgtggacaaaacaatcttaagttgggcagctttcctcaacacaaaaaaaagttattaatggtcattgaaccataactaggactttatcagaaactcaaagcttgggggataaaaaggagcaagagaatactgtaacaaacttcgtacagagttcggtctattaattgtttcatgttagatattctatgtgtttacctcaattgaaaaaaaaaagaatgtttttgctagtatcagatctgctgtggaattggtattgtatgtccatgaattcttcttttctcagcacgtgttcctcactagaagaaaatgctgttacctttaagctttgtcaaatttacattaaaatacttgtatgaggactgtgacgttatgttaaaaaaaaaaaggtgttaagtcacaaaaagcggtaataaatatttcatttttgattttttgttaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4212 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:4212 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: ISS
            GeneID:4212 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS
            GeneID:4212 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4212 -> Molecular function: GO:0008134 [transcription factor binding] evidence: ISS
            GeneID:4212 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
            GeneID:4212 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:4212 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:4212 -> Biological process: GO:0001654 [eye development] evidence: IEA
            GeneID:4212 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:4212 -> Biological process: GO:0045638 [negative regulation of myeloid cell differentiation] evidence: ISS
            GeneID:4212 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:4212 -> Cellular component: GO:0005634 [nucleus] evidence: IEA