GGRNA | NM_153693.3

LOCUS       NM_153693               2072 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox C6 (HOXC6), transcript variant 2, mRNA.
ACCESSION   NM_153693
VERSION     NM_153693.3  GI:100349242
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2072)
  AUTHORS   Moon,S.M., Kim,S.A., Yoon,J.H. and Ahn,S.G.
  TITLE     HOXC6 is deregulated in human head and neck squamous cell carcinoma
            and modulates Bcl-2 expression
  JOURNAL   J. Biol. Chem. 287 (42), 35678-35688 (2012)
   PUBMED   22896703
  REMARK    GeneRIF: HOXC6 is an important mechanism of the anti-apoptotic
            pathway via regulation of Bcl-2 expression.
REFERENCE   2  (bases 1 to 2072)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat. Genet. 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2072)
  AUTHORS   Ansari,K.I., Hussain,I., Shrestha,B., Kasiri,S. and Mandal,S.S.
  TITLE     HOXC6 Is transcriptionally regulated via coordination of MLL
            histone methylase and estrogen receptor in an estrogen environment
  JOURNAL   J. Mol. Biol. 411 (2), 334-349 (2011)
   PUBMED   21683083
  REMARK    GeneRIF: These studies demonstrated that HOXC6 is an
            estrogen-responsive gene, and that histone methylases MLL2 and
            MLL3, in coordination with ERalpha and ERbeta, transcriptionally
            regulate HOXC6 in an estrogen-dependent manner.
REFERENCE   4  (bases 1 to 2072)
  AUTHORS   Feng,J.Q., Liu,W.J., Chen,H.Y., Guo,Q.L., Chen,A. and Chen,S.Q.
  TITLE     [Effect of human cytomegalovirus infection on the expression of
            hoxc4 and hoxc6 genes in the proliferation of lymphocytic
            progenitor cells]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 17 (1), 141-145 (2009)
   PUBMED   19236766
  REMARK    GeneRIF: Human cytomegalovirus downregulates while all-trans
            retinoic acid upregulates expression of hoxc4 and hoxc6 in
            lymphocytic progenitor cells.
REFERENCE   5  (bases 1 to 2072)
  AUTHORS   Zhang,X., Hamada,J., Nishimoto,A., Takahashi,Y., Murai,T., Tada,M.
            and Moriuchi,T.
  TITLE     HOXC6 and HOXC11 increase transcription of S100beta gene in
            BrdU-induced in vitro differentiation of GOTO neuroblastoma cells
            into Schwannian cells
  JOURNAL   J. Cell. Mol. Med. 11 (2), 299-306 (2007)
   PUBMED   17488478
  REMARK    GeneRIF: HOXC6 increases transcription of S100beta gene in
            BrdU-induced in vitro differentiation of GOTO neuroblastoma cells
            into Schwann cells.
REFERENCE   6  (bases 1 to 2072)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   7  (bases 1 to 2072)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
REFERENCE   8  (bases 1 to 2072)
  AUTHORS   Simeone,A., Pannese,M., Acampora,D., D'Esposito,M. and
            Boncinelli,E.
  TITLE     At least three human homeoboxes on chromosome 12 belong to the same
            transcription unit
  JOURNAL   Nucleic Acids Res. 16 (12), 5379-5390 (1988)
   PUBMED   2898768
REFERENCE   9  (bases 1 to 2072)
  AUTHORS   Simeone,A., Mavilio,F., Acampora,D., Giampaolo,A., Faiella,A.,
            Zappavigna,V., D'Esposito,M., Pannese,M., Russo,G., Boncinelli,E.
            et al.
  TITLE     Two human homeobox genes, c1 and c8: structure analysis and
            expression in embryonic development
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (14), 4914-4918 (1987)
   PUBMED   2885844
REFERENCE   10 (bases 1 to 2072)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA905719.1, AW445186.1,
            M16938.1 and AC012531.11.
            This sequence is a reference standard in the RefSeqGene project.
            On May 24, 2006 this sequence version replaced gi:93141223.
            
            Summary: This gene belongs to the homeobox family, members of which
            encode a highly conserved family of transcription factors that play
            an important role in morphogenesis in all multicellular organisms.
            Mammals possess four similar homeobox gene clusters, HOXA, HOXB,
            HOXC and HOXD, which are located on different chromosomes and
            consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is
            one of several HOXC genes located in a cluster on chromosome 12.
            Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon.
            Transcripts may include the shared exon spliced to the
            gene-specific exons, or they may include only the gene-specific
            exons. Alternatively spliced transcript variants encoding different
            isoforms have been identified for HOXC6. Transcript variant two
            includes the shared exon, and transcript variant one includes only
            gene-specific exons. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR and
            lacks an in-frame portion of the 5' coding region, compared to
            variant 1. The resulting isoform (2) has a shorter N-terminus when
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16938.1, AK314829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               DA905719.1         2-504
            504-937             AW445186.1         1-434               c
            938-1154            M16938.1           671-887
            1155-2072           AC012531.11        167510-168427
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..2072
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="homeobox C6"
                     /db_xref="GeneID:3223"
                     /db_xref="HGNC:5128"
                     /db_xref="HPRD:00858"
                     /db_xref="MIM:142972"
     exon            1..557
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /inference="alignment:Splign:1.39.8"
     variation       288
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74568890"
     variation       360
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3736210"
     variation       361
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4133943"
     variation       376
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4101168"
     variation       510..511
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace=""
                     /replace="ga"
                     /db_xref="dbSNP:375826581"
     misc_feature    543..545
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="upstream in-frame stop codon"
     exon            558..903
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /inference="alignment:Splign:1.39.8"
     variation       572
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201443964"
     variation       583
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377315282"
     variation       585
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75114216"
     variation       598
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200758418"
     variation       633
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370829959"
     variation       640
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:79558505"
     variation       647
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201730816"
     variation       675
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200694174"
     variation       677
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145731630"
     variation       702
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144307645"
     variation       747
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201594434"
     CDS             750..1211
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="isoform 2 is encoded by transcript variant 2; homeo
                     box C6; homeo box C8 protein; homeo box 3C; homeobox
                     protein Hox-C6; homeobox protein CP25; homeobox protein
                     HHO.C8; homeobox protein Hox-3C"
                     /codon_start=1
                     /product="homeobox protein Hox-C6 isoform 2"
                     /protein_id="NP_710160.1"
                     /db_xref="GI:24497544"
                     /db_xref="CCDS:CCDS41792.1"
                     /db_xref="GeneID:3223"
                     /db_xref="HGNC:5128"
                     /db_xref="HPRD:00858"
                     /db_xref="MIM:142972"
                     /translation="

MLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE

"
     misc_feature    927..1103
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(927..941,945..947,996..998,1014..1016,1053..1055,
                     1059..1064,1071..1076,1080..1088,1092..1097)
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(933..935,942..944,1062..1064,1071..1076,1083..1085)
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       782
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111518456"
     STS             795..1004
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /standard_name="MARC_44017-44022:1098368610:3"
                     /db_xref="UniSTS:471619"
     variation       849
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376534127"
     variation       858
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371058976"
     variation       873
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:80157375"
     exon            904..2072
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /inference="alignment:Splign:1.39.8"
     variation       924
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138685629"
     variation       952
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113381644"
     variation       979
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377095092"
     variation       986
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368405993"
     variation       988
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372813456"
     variation       1004
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375750909"
     variation       1028
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151083984"
     variation       1031
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61736613"
     variation       1034
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199717526"
     variation       1041
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139697680"
     variation       1058
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143618403"
     variation       1112
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369084398"
     variation       1114
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148638675"
     variation       1119
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373295522"
     variation       1128
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200427348"
     variation       1134
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202121790"
     variation       1141..1142
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:147247423"
     STS             1150..2038
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /standard_name="Hoxc6"
                     /db_xref="UniSTS:547241"
     variation       1182
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201035626"
     STS             1229..1453
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /standard_name="STS-S82986"
                     /db_xref="UniSTS:9088"
     STS             1333..1512
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /standard_name="STS-M16938"
                     /db_xref="UniSTS:20596"
     variation       1401
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1042245"
     variation       1405
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141463318"
     variation       1456
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1249078"
     variation       1549..1550
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34643568"
     variation       1588
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7308105"
     variation       1695
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35857063"
     variation       1721
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1249077"
     variation       1793
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373542987"
     polyA_signal    2043..2048
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
     polyA_site      2072
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
ORIGIN

ttattgtggtttgtccgttccgagcgctccgcagaacagtcctccctgtaagagcctaaccattgccagggaaacctgccctgggcgctcccttcattagcagtattttttttaaattaatctgattaataattatttttcccccatttaattttttttcctcccaggtggagttgccgaagctgggggcagctggggagggtggggatgggaggggagagacagaagttgagggcatctctctcttccttcccgaccctctggcccccaaggggcaggaggaatgcaggagcaggagttgagcttgggagctgcagatgcctccgcccctcctctctcccaggctcttcctcctgcccccttcttgcaactctccttaattttgtttggcttttggatgattataattatttttatttttgaatttatataaagtatatgtgtgtgtgtgtggagctgagacaggctcggcagcggcacagaatgagggaagacgagaaagagagtgggagagagagaggcagagagggagagagggagagtgacagcagcgctcggacgtcctccccaacgtcgccctcaattccaccgcctatgatccagtgaggcatttctcgacctatggagcggccgttgcccagaaccggatctactcgactcccttttattcgccacaggagaatgtcgtgttcagttccagccgggggccgtatgactatggatctaattccttttaccaggagaaagacatgctctcaaactgcagacaaaacaccttaggacataacacacagacctcaatcgctcaggattttagttctgagcagggcaggactgcgccccaggaccagaaagccagtatccagatttacccctggatgcagcgaatgaattcgcacagtggggtcggctacggagcggaccggaggcgcggccgccagatctactcgcggtaccagaccctggaactggagaaggaatttcacttcaatcgctacctaacgcggcgccggcgcatcgagatcgccaacgcgctttgcctgaccgagcgacagatcaaaatctggttccagaaccgccggatgaagtggaaaaaagaatctaatctcacatccactctctcggggggcggcggaggggccaccgccgacagcctgggcggaaaagaggaaaagcgggaagagacagaagaggagaagcagaaagagtgaccaggactgtccctgccacccctctctccctttctccctcgctccccaccaactctcccctaatcacacactctgtatttatcactggcacaattgatgtgttttgattccctaaaacaaaattagggagtcaaacgtggacctgaaagtcagctctggaccccctccctcaccgcacaactctctttcaccacgcgcctcctcctcctcgctcccttgctagctcgttctcggcttgtctacaggcccttttccccgtccaggccttgggggctcggaccctgaactcagactctacagattgccctccaagtgaggacttggctcccccactccttcgacgcccccacccccgccccccgtgcagagagccggctcctgggcctgctggggcctctgctccagggcctcagggcccggcctggcagccggggagggccggaggcccaaggagggcgcgccttggccccacaccaacccccagggcctccccgcagtccctgcctagcccctctgccccagcaaatgcccagcccaggcaaattgtatttaaagaatcctgggggtcattatggcattttacaaactgtgaccgtttctgtgtgaagatttttagctgtatttgtggtctctgtatttatatttatgtttagcaccgtcagtgttcctatccaatttcaaaaaaggaaaaaaaagagggaaaattacaaaaagagagaaaaaaagtgaatgacgtttgtttagccagtaggagaaaataaataaataaataaatcccttcgtgttaccctcctgtataaatccaacctctgggtccgttctcgaatatttaataaaactgatattatttttaaaacttta

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