LOCUS       NM_153633               1689 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox C4 (HOXC4), transcript variant 2, mRNA.
ACCESSION   NM_153633
VERSION     NM_153633.2  GI:93141221
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat. Genet. 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Auvray,C., Delahaye,A., Pflumio,F., Haddad,R., Amsellem,S.,
            Miri-Nezhad,A., Broix,L., Yacia,A., Bulle,F., Fichelson,S. and
            Vigon,I.
  TITLE     HOXC4 homeoprotein efficiently expands human hematopoietic stem
            cells and triggers similar molecular alterations as HOXB4
  JOURNAL   Haematologica 97 (2), 168-178 (2012)
   PUBMED   22298821
  REMARK    GeneRIF: HOXC4 homeoprotein expands human hematopoietic immature
            cells by 3 to 6 times ex vivo and significantly improves the level
            of in vivo engraftment.
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Mai,T., Zan,H., Zhang,J., Hawkins,J.S., Xu,Z. and Casali,P.
  TITLE     Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to
            potentiate HoxC4-mediated activation-induced cytosine deaminase
            induction, immunoglobulin class switch DNA recombination, and
            somatic hypermutation
  JOURNAL   J. Biol. Chem. 285 (48), 37797-37810 (2010)
   PUBMED   20855884
  REMARK    GeneRIF: Esr1 bind to and activate the HOXC4 promoter to potentiate
            HoxC4-mediated AID induction, immunoglobulin class switch and
            somatic hypermutation.
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   Park,S.R., Zan,H., Pal,Z., Zhang,J., Al-Qahtani,A., Pone,E.J.,
            Xu,Z., Mai,T. and Casali,P.
  TITLE     HoxC4 binds to the promoter of the cytidine deaminase AID gene to
            induce AID expression, class-switch DNA recombination and somatic
            hypermutation
  JOURNAL   Nat. Immunol. 10 (5), 540-550 (2009)
   PUBMED   19363484
  REMARK    GeneRIF: HoxC4 directly activates the Aicda promoter
REFERENCE   5  (bases 1 to 1689)
  AUTHORS   Feng,J.Q., Liu,W.J., Chen,H.Y., Guo,Q.L., Chen,A. and Chen,S.Q.
  TITLE     [Effect of human cytomegalovirus infection on the expression of
            hoxc4 and hoxc6 genes in the proliferation of lymphocytic
            progenitor cells]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 17 (1), 141-145 (2009)
   PUBMED   19236766
  REMARK    GeneRIF: Human cytomegalovirus downregulates while all-trans
            retinoic acid upregulates expression of hoxc4 and hoxc6 in
            lymphocytic progenitor cells.
REFERENCE   6  (bases 1 to 1689)
  AUTHORS   Meazza,R., Faiella,A., Corsetti,M.T., Airoldi,I., Ferrini,S.,
            Boncinelli,E. and Corte,G.
  TITLE     Expression of HOXC4 homeoprotein in the nucleus of activated human
            lymphocytes
  JOURNAL   Blood 85 (8), 2084-2090 (1995)
   PUBMED   7718879
REFERENCE   7  (bases 1 to 1689)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   8  (bases 1 to 1689)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
REFERENCE   9  (bases 1 to 1689)
  AUTHORS   Simeone,A., Pannese,M., Acampora,D., D'Esposito,M. and
            Boncinelli,E.
  TITLE     At least three human homeoboxes on chromosome 12 belong to the same
            transcription unit
  JOURNAL   Nucleic Acids Res. 16 (12), 5379-5390 (1988)
   PUBMED   2898768
REFERENCE   10 (bases 1 to 1689)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050442.1 and AC023794.37.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 21, 2006 this sequence version replaced gi:24497539.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene, HOXC4, is one of several homeobox HOXC genes located in a
            cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6,
            share a 5' non-coding exon. Transcripts may include the shared exon
            spliced to the gene-specific exons, or they may include only the
            gene-specific exons. Two alternatively spliced variants that encode
            the same protein have been described for HOXC4. Transcript variant
            one includes the shared exon, and transcript variant two includes
            only gene-specific exons. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050442.1, BQ720847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               BC050442.1         1-494
            495-1632            AC023794.37        22519-23656
            1633-1689           BC050442.1         1629-1685
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1689
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="homeobox C4"
                     /db_xref="GeneID:3221"
                     /db_xref="HGNC:5126"
                     /db_xref="HPRD:00860"
                     /db_xref="MIM:142974"
     exon            1..485
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /inference="alignment:Splign:1.39.8"
     variation       39
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374709422"
     CDS             47..841
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="homeo box C4; homeo box 3E; homeobox protein CP19;
                     homeobox protein Hox-3E"
                     /codon_start=1
                     /product="homeobox protein Hox-C4"
                     /protein_id="NP_705897.1"
                     /db_xref="GI:24497540"
                     /db_xref="CCDS:CCDS8873.1"
                     /db_xref="GeneID:3221"
                     /db_xref="HGNC:5126"
                     /db_xref="HPRD:00860"
                     /db_xref="MIM:142974"
                     /translation="

MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL

"
     misc_feature    449..466
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09017.2);
                     Region: Antp-type hexapeptide"
     misc_feature    515..691
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(515..529,533..535,584..586,602..604,641..643,
                     647..652,659..664,668..676,680..685)
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(521..523,530..532,650..652,659..664,671..673)
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       79
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377491433"
     variation       86
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370651700"
     variation       91
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201246146"
     variation       108
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375540278"
     variation       221
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201031063"
     variation       234
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368312732"
     variation       252
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148305568"
     variation       271
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200135426"
     variation       303
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369142454"
     STS             307..838
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /standard_name="Hoxc4"
                     /db_xref="UniSTS:143389"
     variation       320
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141526599"
     variation       330
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371650916"
     variation       361
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375090194"
     variation       362
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201787571"
     variation       385
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147020678"
     variation       415
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138201582"
     STS             434..654
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /standard_name="HOX3A"
                     /db_xref="UniSTS:266290"
     STS             441..582
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /standard_name="Hoxc4"
                     /db_xref="UniSTS:536661"
     variation       446
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75256744"
     variation       455
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200182829"
     variation       457
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150564642"
     exon            486..1666
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /inference="alignment:Splign:1.39.8"
     variation       495
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17854635"
     variation       511
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372733424"
     variation       513
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200589330"
     variation       518
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200111255"
     variation       519
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11835301"
     variation       544
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374693094"
     variation       579
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35406888"
     variation       681
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144484338"
     variation       685
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367700740"
     variation       689
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201279056"
     variation       697
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139130458"
     variation       705
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199886486"
     variation       753
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199538004"
     variation       764
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371537421"
     variation       770
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375884273"
     variation       921..922
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:71444831"
     variation       922..923
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:72272573"
     variation       947..948
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="ta"
                     /db_xref="dbSNP:60894549"
     variation       948..949
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="ta"
                     /db_xref="dbSNP:71070803"
     variation       978
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113651547"
     variation       1014
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138869843"
     variation       1099..1100
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:199529607"
     variation       1161
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76297541"
     variation       1274
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:67954156"
     variation       1274
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368226822"
     variation       1280
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="c"
                     /replace="ggatgggatg"
                     /db_xref="dbSNP:11362453"
     variation       1281
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:199756525"
     variation       1383..1384
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:376243618"
     variation       1384
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:11362454"
     variation       1393
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200962735"
     variation       1395
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:201221665"
     variation       1511
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:45448092"
     variation       1545
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117223623"
     variation       1575
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11554014"
     variation       1628
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45625633"
     polyA_signal    1638..1643
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
     polyA_site      1666
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
ORIGIN      

agaaaaacgacaaagcgagaaaaattattttccactccagaaattaatgatcatgagctcgtatttgatggactctaactacatcgatccgaaatttcctccatgcgaagaatattcgcaaaatagctacatccctgaacacagtccggaatattacggccggaccagggaatcgggattccagcatcaccaccaggagctgtacccaccaccgcctccgcgccctagctaccctgagcgccagtatagctgcaccagtctccaggggcccggcaattcgcgaggccacgggccggcccaggcgggccaccaccaccccgagaaatcacagtcgctctgcgagccggcgcctctctcaggcgcctccgcctccccgtccccagccccgccagcctgcagccagccagcccccgaccatccctccagcgccgccagcaagcaacccatagtctacccatggatgaaaaaaattcacgttagcacggtgaaccccaattataacggaggggaacccaagcgctcgaggacagcctatacccggcagcaagtcctggaattagagaaagagtttcattacaaccgctacctgacccgaaggagaaggatcgagatcgcccactcgctgtgcctctctgagaggcagatcaaaatctggttccaaaaccgtcgcatgaaatggaagaaggaccaccgactccccaacaccaaagtcaggtcagcacccccggccggcgctgcgcccagcaccctttcggcagctaccccgggtacttctgaagaccactcccagagcgccacgccgccggagcagcaacgggcagaggacattaccaggttataaaacataactcacacccctgcccccaccccatgcccccaccctcccctcacacacaaattgactcttatttatagaatttaatatatatatatatatatatatatataggttcttttctctcttcctctcaccttgtcccttgtcagttccaaacagacaaaacagataaacaaacaagccccctgccctcctctccctcccactgttaaggacccttttaagcatgtgatgttgtcttagcatggtacctgctgggtgtttttttttaaaaggccattttggggggttatttattttttaagaaaaaaagctgcaaaaattatatattgcaaggtgtgatggtctggcttgggtgaatttcaggggaaatgaggaaaagaaaaaaggaaagaaattttaaagccaattctcatccttctcctcctcctccttccccccctctttccttaggccttttgcattgaaaatgcaccaggggaggttagtgagggggaagtcattttaaggagaacaaagctatgaagttcttttgtattattgttgggggggggtgtgggaggagagggggcgaagacagcagacaaagctaaatgcatctggagagcctctcagagctgttcagtttgaggagccaaaagaaaatcaaaatgaactttcagttcagagaggcagtctataggtagaatctctccccacccctatcgtggttattgtgtttttggactgaatttacttgattattgtaaaacttgcaataaagaattttagtgtcgatgtgaaatgccccgtgatcaataataaaccagtggatgtgaattagttttaaaaaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3221 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
            GeneID:3221 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3221 -> Molecular function: GO:0071837 [HMG box domain binding] evidence: IEA
            GeneID:3221 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3221 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS
            GeneID:3221 -> Biological process: GO:0007275 [multicellular organismal development] evidence: NAS
            GeneID:3221 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3221 -> Biological process: GO:0048562 [embryonic organ morphogenesis] evidence: IEA
            GeneID:3221 -> Biological process: GO:0051216 [cartilage development] evidence: IEA
            GeneID:3221 -> Cellular component: GO:0005634 [nucleus] evidence: NAS