LOCUS       NM_139282                780 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens Rhox homeobox family, member 1 (RHOXF1), mRNA.
ACCESSION   NM_139282 XM_001715156
VERSION     NM_139282.2  GI:429836860
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Li,Q., O'Malley,M.E., Bartlett,D.L. and Guo,Z.S.
  TITLE     Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer
            and stem cells and promotes cancer growth
  JOURNAL   Mol. Cancer 10, 63 (2011)
   PUBMED   21609483
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 780)
  AUTHORS   Li,Q., Bartlett,D.L., Gorry,M.C., O'Malley,M.E. and Guo,Z.S.
  TITLE     Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer
            cells through overlapping and distinct molecular mechanisms
  JOURNAL   Mol. Pharmacol. 76 (5), 1072-1081 (2009)
   PUBMED   19679824
REFERENCE   3  (bases 1 to 780)
  AUTHORS   Zhan,M., Miura,T., Xu,X. and Rao,M.S.
  TITLE     Conservation and variation of gene regulation in embryonic stem
            cells assessed by comparative genomics
  JOURNAL   Cell Biochem. Biophys. 43 (3), 379-405 (2005)
   PUBMED   16244364
REFERENCE   4  (bases 1 to 780)
  AUTHORS   Wayne,C.M., MacLean,J.A., Cornwall,G. and Wilkinson,M.F.
  TITLE     Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2,
            selectively expressed in the testis
  JOURNAL   Gene 301 (1-2), 1-11 (2002)
   PUBMED   12490318
REFERENCE   5  (bases 1 to 780)
  AUTHORS   Geserick,C., Weiss,B., Schleuning,W.D. and Haendler,B.
  TITLE     OTEX, an androgen-regulated human member of the paired-like class
            of homeobox genes
  JOURNAL   Biochem. J. 366 (PT 1), 367-375 (2002)
   PUBMED   11980563
  REMARK    GeneRIF: cloning and characterization of human OTEX
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY099086.1 and BE675048.1.
            On Dec 14, 2012 this sequence version replaced gi:23943885.
            
            Summary: This gene is a member of the PEPP subfamily of paired-like
            homoebox genes. The gene may be regulated by androgens and
            epigenetic mechanisms. The encoded nuclear protein is likely a
            transcription factor that may play a role in human reproduction.
            [provided by RefSeq, Dec 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY099086.1, BC103857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-755               AY099086.1         1-755
            756-780             BE675048.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..780
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="Rhox homeobox family, member 1"
                     /db_xref="GeneID:158800"
                     /db_xref="HGNC:29993"
                     /db_xref="HPRD:15954"
                     /db_xref="HPRD:02345"
                     /db_xref="MIM:300446"
     exon            1..473
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    4..6
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="upstream in-frame stop codon"
     STS             26..680
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /db_xref="UniSTS:481169"
     STS             42..703
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /db_xref="UniSTS:482630"
     variation       complement(66)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369557590"
     CDS             76..630
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="PEPP subfamily gene 1; paired-like homeobox protein
                     PEPP-1; ovary-, testis- and epididymis-expressed gene
                     protein"
                     /codon_start=1
                     /product="rhox homeobox family member 1"
                     /protein_id="NP_644811.1"
                     /db_xref="GI:23943886"
                     /db_xref="CCDS:CCDS14593.1"
                     /db_xref="GeneID:158800"
                     /db_xref="HGNC:29993"
                     /db_xref="HPRD:15954"
                     /db_xref="HPRD:02345"
                     /db_xref="MIM:300446"
                     /translation="

MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGLMGNMNPEGGVNHENGMNRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQPRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANELRADPDDCVYIVVD

"
     misc_feature    385..561
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(385..399,403..405,454..456,472..474,511..513,
                     517..522,529..534,538..546,550..555)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(391..393,400..402,520..522,529..534,541..543)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    538..567
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NHV9.1);
                     Region: Nuclear localization signal"
     variation       complement(81)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376932123"
     variation       complement(87)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144907004"
     variation       complement(104)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149847534"
     variation       complement(115)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201110942"
     variation       complement(119)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202119409"
     variation       complement(180)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200045031"
     variation       complement(184)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:36014613"
     variation       complement(223)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140029775"
     variation       complement(229)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150693893"
     variation       complement(285)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374790558"
     variation       complement(303)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61737035"
     variation       complement(339)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201599692"
     variation       complement(363)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372797512"
     variation       complement(376)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368824826"
     variation       complement(417)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140101792"
     variation       complement(470)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374507906"
     exon            474..519
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(486)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370344070"
     variation       complement(487)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191816066"
     exon            520..769
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(547)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147476615"
     variation       complement(576)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143142811"
     variation       complement(581)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148295665"
     variation       complement(584)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144256540"
     variation       complement(590)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2301977"
     variation       complement(600)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199595044"
     variation       complement(603)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373236335"
     variation       complement(604)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138060880"
     variation       complement(621)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145568775"
     variation       complement(658)
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184584525"
     polyA_signal    749..754
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
     polyA_site      769
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
ORIGIN      

aactagctccaccctctaacccccactccagctgcagacgccacggagtttgtgcaggggcgcagcgctccagccatggcgcgttcgctcgtccacgacaccgtgttctactgcctgagtgtataccaggtaaaaataagccccacacctcagctgggggcagcatcaagcgcagaaggccatgttggccaaggagctccaggcctcatgggtaatatgaaccctgagggcggtgtgaaccacgagaacggcatgaaccgcgatggcggcatgatccccgagggcggcggtggaaaccaggagcctcggcagcagccgcagcccccgccggaggagccggcccaggcggccatggagggtccgcagcccgagaacatgcagccacgaactcggcgcacgaagttcacgctgttgcaggtggaggagctggaaagtgttttccgacacactcaataccctgatgtgcccacaagaagggaacttgccgaaaacttaggtgtgactgaagacaaagtgcgggtttggtttaagaataaaagggccagatgtaggcgacatcagagagaattaatgctcgccaatgaactacgtgctgacccagacgactgtgtctacatcgtcgtggactagccctagaatgccatccttcttcaggagctagtttggagatgggtttttctggtgccactgacacctgggctgcccatgccgctcaggctacccttatctcctctgcacttatgttatcaataaagaggcaaattctcaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:158800 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IEA
            GeneID:158800 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS
            GeneID:158800 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
            GeneID:158800 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:158800 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS
            GeneID:158800 -> Biological process: GO:0007275 [multicellular organismal development] evidence: NAS
            GeneID:158800 -> Biological process: GO:0007276 [gamete generation] evidence: NAS
            GeneID:158800 -> Biological process: GO:0019953 [sexual reproduction] evidence: IEP
            GeneID:158800 -> Biological process: GO:0030518 [intracellular steroid hormone receptor signaling pathway] evidence: NAS
            GeneID:158800 -> Cellular component: GO:0005634 [nucleus] evidence: IDA