LOCUS       NM_033343               1909 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens LIM homeobox 4 (LHX4), mRNA.
ACCESSION   NM_033343
VERSION     NM_033343.3  GI:315013531
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1909)
  AUTHORS   Filges,I., Bischof-Renner,A., Rothlisberger,B., Potthoff,C.,
            Glanzmann,R., Gunthard,J., Schneider,J., Huber,A.R., Zumsteg,U.,
            Miny,P. and Szinnai,G.
  TITLE     Panhypopituitarism presenting as life-threatening heart failure
            caused by an inherited microdeletion in 1q25 including LHX4
  JOURNAL   Pediatrics 129 (2), E529-E534 (2012)
   PUBMED   22232309
  REMARK    GeneRIF: Variably penetrant pituitary insufficiency, including this
            severe and atypical presentation, can be correlated with LHX4
            insufficiency and highlights the role of LHX4 for pituitary
            development.
REFERENCE   2  (bases 1 to 1909)
  AUTHORS   Takagi,M., Ishii,T., Inokuchi,M., Amano,N., Narumi,S., Asakura,Y.,
            Muroya,K., Hasegawa,Y., Adachi,M. and Hasegawa,T.
  TITLE     Gradual loss of ACTH due to a novel mutation in LHX4: comprehensive
            mutation screening in Japanese patients with congenital
            hypopituitarism
  JOURNAL   PLoS ONE 7 (9), E46008 (2012)
   PUBMED   23029363
  REMARK    GeneRIF: This study is the first to describe, a gradual loss of
            ACTH in a patient carrying an LHX4 mutation.
REFERENCE   3  (bases 1 to 1909)
  AUTHORS   Hung,T.M., Hu,R.H., Ho,C.M., Chiu,Y.L., Lee,J.L., Jeng,Y.M.,
            Shih,D.T. and Lee,P.H.
  TITLE     Downregulation of alpha-fetoprotein expression by LHX4: a critical
            role in hepatocarcinogenesis
  JOURNAL   Carcinogenesis 32 (12), 1815-1823 (2011)
   PUBMED   21965270
  REMARK    GeneRIF: data indicate that LHX4 may act as a potential tumor
            suppressor in hepatocarcinogenesis, suggesting that targeting LHX4
            to downregulate AFP might have therapeutic implications
REFERENCE   4  (bases 1 to 1909)
  AUTHORS   Reynaud,R., Albarel,F., Saveanu,A., Kaffel,N., Castinetti,F.,
            Lecomte,P., Brauner,R., Simonin,G., Gaudart,J., Carmona,E.,
            Enjalbert,A., Barlier,A. and Brue,T.
  TITLE     Pituitary stalk interruption syndrome in 83 patients: novel HESX1
            mutation and severe hormonal prognosis in malformative forms
  JOURNAL   Eur. J. Endocrinol. 164 (4), 457-465 (2011)
   PUBMED   21270112
  REMARK    GeneRIF: A novel HESX1 causative mutation was found in a
            consanguineous family, and two LHX4 mutations were present in
            familial Pituitary stalk interruption syndrome.
REFERENCE   5  (bases 1 to 1909)
  AUTHORS   Dateki,S., Fukami,M., Uematsu,A., Kaji,M., Iso,M., Ono,M.,
            Mizota,M., Yokoya,S., Motomura,K., Kinoshita,E., Moriuchi,H. and
            Ogata,T.
  TITLE     Mutation and gene copy number analyses of six pituitary
            transcription factor genes in 71 patients with combined pituitary
            hormone deficiency: identification of a single patient with LHX4
            deletion
  JOURNAL   J. Clin. Endocrinol. Metab. 95 (8), 4043-4047 (2010)
   PUBMED   20534763
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1909)
  AUTHORS   Sobrier,M.L., Attie-Bitach,T., Netchine,I., Encha-Razavi,F.,
            Vekemans,M. and Amselem,S.
  TITLE     Pathophysiology of syndromic combined pituitary hormone deficiency
            due to a LHX3 defect in light of LHX3 and LHX4 expression during
            early human development
  JOURNAL   Gene Expr. Patterns 5 (2), 279-284 (2004)
   PUBMED   15567726
  REMARK    GeneRIF: LHX4 expression is transient, and, at 6 weeks of
            development, is stronger at the caudal than at the cervical level.
REFERENCE   7  (bases 1 to 1909)
  AUTHORS   Kawamata,N., Sakajiri,S., Sugimoto,K.J., Isobe,Y., Kobayashi,H. and
            Oshimi,K.
  TITLE     A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute
            lymphoblastic leukemia involves the LIM homeodomain protein gene,
            Lhx4
  JOURNAL   Oncogene 21 (32), 4983-4991 (2002)
   PUBMED   12118377
REFERENCE   8  (bases 1 to 1909)
  AUTHORS   Liu,Y., Fan,M., Yu,S., Zhou,Y., Wang,J., Yuan,J. and Qiang,B.
  TITLE     cDNA cloning, chromosomal localization and expression pattern
            analysis of human LIM-homeobox gene LHX4
  JOURNAL   Brain Res. 928 (1-2), 147-155 (2002)
   PUBMED   11844481
REFERENCE   9  (bases 1 to 1909)
  AUTHORS   Machinis,K., Pantel,J., Netchine,I., Leger,J., Camand,O.J.,
            Sobrier,M.L., Dastot-Le Moal,F., Duquesnoy,P., Abitbol,M.,
            Czernichow,P. and Amselem,S.
  TITLE     Syndromic short stature in patients with a germline mutation in the
            LIM homeobox LHX4
  JOURNAL   Am. J. Hum. Genet. 69 (5), 961-968 (2001)
   PUBMED   11567216
  REMARK    GeneRIF: germline mutations; phenotype characterized by short
            stature and by pituitary, hindbrain, and skull abnormalities
REFERENCE   10 (bases 1 to 1909)
  AUTHORS   Li,H., Witte,D.P., Branford,W.W., Aronow,B.J., Weinstein,M.,
            Kaur,S., Wert,S., Singh,G., Schreiner,C.M., Whitsett,J.A. et al.
  TITLE     Gsh-4 encodes a LIM-type homeodomain, is expressed in the
            developing central nervous system and is required for early
            postnatal survival
  JOURNAL   EMBO J. 13 (12), 2876-2885 (1994)
   PUBMED   7913017
  REMARK    GeneRIF: In mice, a similar protein plays a critical role in the
            development of respiratory control mechanisms and in the normal
            growth and maturation of the lung.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX954266.1, AF179849.1,
            AL139141.23 and BC011759.2.
            This sequence is a reference standard in the RefSeqGene project.
            On Dec 14, 2010 this sequence version replaced gi:30410786.
            
            Summary: This gene encodes a member of a large protein family which
            contains the LIM domain, a unique cysteine-rich zinc-binding
            domain. The encoded protein is a transcription factor involved in
            the control of differentiation and development of the pituitary
            gland. Mutations in this gene cause combined pituitary hormone
            deficiency 4. [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011759.2, AF179849.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BX954266.1         2-10
            10-31               AF179849.1         14-35
            32-32               AL139141.23        6132-6132
            33-189              AF179849.1         37-193
            190-1909            BC011759.2         1-1720
FEATURES             Location/Qualifiers
     source          1..1909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..1909
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="LIM homeobox 4"
                     /db_xref="GeneID:89884"
                     /db_xref="HGNC:21734"
                     /db_xref="HPRD:03686"
                     /db_xref="MIM:602146"
     exon            1..308
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:1.39.8"
     variation       61
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376657735"
     variation       113
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:355625"
     misc_feature    176..178
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="upstream in-frame stop codon"
     variation       207
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373681851"
     variation       226
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201496412"
     CDS             233..1405
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="LIM homeobox protein 4"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx4"
                     /protein_id="NP_203129.1"
                     /db_xref="GI:15375314"
                     /db_xref="CCDS:CCDS1338.1"
                     /db_xref="GeneID:89884"
                     /db_xref="HGNC:21734"
                     /db_xref="HPRD:03686"
                     /db_xref="MIM:602146"
                     /translation="

MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF

"
     misc_feature    320..475
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="The first LIM domain of Lhx4; Region: LIM1_Lhx4;
                     cd09468"
                     /db_xref="CDD:188852"
     misc_feature    order(320..322,329..331,383..385,392..394,401..403,
                     410..412,461..463,470..472)
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188852"
     misc_feature    497..664
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="The second LIM domain of Lhx3-Lhx4 family; Region:
                     LIM2_Lhx3_Lhx4; cd09376"
                     /db_xref="CDD:188762"
     misc_feature    order(497..499,506..508,563..565,572..574,581..583,
                     590..592,650..652,659..661)
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188762"
     misc_feature    order(533..535,608..610)
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="Isl binding site; other site"
                     /db_xref="CDD:188762"
     misc_feature    704..880
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(704..718,722..724,773..775,791..793,830..832,
                     836..841,848..853,857..865,869..874)
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(710..712,719..721,839..841,848..853,860..862)
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       255
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370108347"
     variation       269
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146664099"
     variation       278
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138103487"
     variation       295
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75857235"
     variation       298
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200544905"
     exon            309..480
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:1.39.8"
     variation       322
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147491286"
     variation       323
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145933198"
     variation       378
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368995644"
     variation       427
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143798020"
     variation       448
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374428382"
     variation       454
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377503336"
     exon            481..683
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:1.39.8"
     variation       482
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:121912642"
     variation       483
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374124070"
     variation       487
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367664877"
     variation       512
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371343131"
     variation       596
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374435549"
     variation       597
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368906861"
     variation       616
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141139762"
     variation       617
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150875319"
     variation       630
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371899398"
     variation       631
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139382707"
     variation       637
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376426884"
     variation       664
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140300978"
     variation       667
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143957546"
     variation       682
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:16855642"
     exon            684..838
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:1.39.8"
     variation       710
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145500874"
     variation       718
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183432227"
     variation       801
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:121912643"
     variation       833
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370041840"
     exon            839..1010
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:1.39.8"
     variation       840
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201275928"
     variation       860
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:121912641"
     variation       891
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35014126"
     variation       892
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370472407"
     variation       917
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373172431"
     variation       922
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111822893"
     variation       953
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374399850"
     variation       1008
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375216188"
     exon            1011..1879
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /inference="alignment:Splign:1.39.8"
     variation       1011
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376766897"
     variation       1014
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:148555694"
     variation       1034
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368040014"
     variation       1054
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140444641"
     variation       1059
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371800371"
     variation       1060
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139155359"
     variation       1069
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150931176"
     variation       1070
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375787650"
     variation       1078
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139479246"
     variation       1081
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373879455"
     variation       1084
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145600753"
     variation       1087
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146970858"
     variation       1111
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375441662"
     variation       1156
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146655496"
     variation       1180
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369378953"
     variation       1201
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202022709"
     variation       1205
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148293290"
     variation       1215
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7536561"
     variation       1216
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201605695"
     variation       1239
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201612374"
     variation       1249
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:28737275"
     variation       1254
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372952844"
     variation       1265
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376977848"
     variation       1284
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200119009"
     variation       1285
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143072371"
     variation       1293
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140154605"
     variation       1348
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369174314"
     variation       1361
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:143972405"
     variation       1378
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200889836"
     variation       1392
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200187045"
     variation       1393
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142044989"
     variation       1394
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:121912644"
     variation       1397
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145433128"
     variation       1422
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:116482990"
     variation       1431
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138054044"
     variation       1433
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75471724"
     variation       1453
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373806372"
     variation       1502
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145063714"
     variation       1524
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180725260"
     variation       1535
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:59623342"
     variation       1580
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372160683"
     variation       1627
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148288621"
     variation       1650
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113216566"
     variation       1691
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:80203153"
     variation       1694
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74970014"
     variation       1850
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:57069480"
     polyA_signal    1856..1861
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
     polyA_site      1879
                     /gene="LHX4"
                     /gene_synonym="CPHD4"
ORIGIN      

gcaccaaccccggagagcgagatcaaagggactggaaacagactggggactggcggggggagggggccggccagcctgtggagtcctccctgagaagcggagggcccggcttccaccgtgactccagcggcctgcttggggttttaattattattttgaaatttctgaatcgagctagagcgagagagcgagagatctccgtagactgcgactcgctggctttcgctccgagatgatgcagagtgcgactgtccccgcggaaggggctgtcaaggggctcccggagatgctaggtgtgccgatgcaacagattccccagtgcgctggctgcaaccagcacatcctggacaagttcatcctgaaggtcctggacagacactggcacagctcctgcctcaagtgtgcagactgccagatgcagctggcggacaggtgcttctccagggctgggagcgtctactgcaaggaggacttcttcaagcgcttcggcacaaaatgcacggcctgccagcagggtatccccccaacccaggtggtccgcaaggcccaggactttgtctaccacctgcactgctttgcttgcatcatctgcaaccggcagctggccacgggggacgaattctacctcatggaggacgggcggctggtgtgcaaggaagactacgagacagccaagcagaacgatgactcagaggctggagctaagcggccccggaccaccatcacagccaagcagctggagacattaaagaatgcatacaagaactcccccaagcctgcccggcacgtgagggagcagctgtcctcagagacaggcctggacatgagggtcgtacaggtttggtttcagaacagaagggccaaagagaaacgcctgaagaaggatgcagggcggcaccgctgggggcagttctataagagcgtcaagaggagccggggcagcagcaagcaggagaaggagagctctgcagaggactgtggggttagtgacagtgagctgagcttccgagaggatcaaattctctcagaacttggccacaccaataggatttatggcaacgtgggggacgttacaggcggacagttaatgaatgggagcttctccatggacgggacaggacaatcctatcaggacttgagggatgggagcccctatggaatcccccagtctccatcctccatatcgtccctgccatcccacgctcctttgctcaatgggctggattacacggtggacagtaatttgggcatcattgcgcatgcagggcagggagtaagccagacgctgagagccatggctgggggacccacctctgacatctccacaggaagcagtgtaggctatcccgactttccaactagcccaggctcttggctcgatgaaatggatcatcctcctttttaaacttctctcctccccaccctacctgcccccctggcttgagagaatatcttcaaggatcaaaagagacttgccttttaaggatcgaaagtacgccaatgtgaatttccattattttcaatggaagtcctccgctgattcctagaaggctgtgagaccacactagggcattgtttccctggggaagcagtgggagagcagactcatctcagaacacagcacagggggtaatggcctagagctctagggacactggcttgttgggtctctcccctgctgttctgcttaggggcttggctgctcagtgctttggtagcacaaggtgactgtgataggcccccttggcctttgggaactttgctccaactggtgtgtctcacacaatgcctcccaaaacactgctctcaccagaactgagactcctaaggtagaggcctcacagcccttgagtaaaataaaagtgatttctggaccatcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:89884 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:89884 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:89884 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:89884 -> Biological process: GO:0001890 [placenta development] evidence: IEA
            GeneID:89884 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:89884 -> Biological process: GO:0008045 [motor neuron axon guidance] evidence: IEA
            GeneID:89884 -> Biological process: GO:0009887 [organ morphogenesis] evidence: IEA
            GeneID:89884 -> Biological process: GO:0021526 [medial motor column neuron differentiation] evidence: IEA
            GeneID:89884 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:89884 -> Cellular component: GO:0005634 [nucleus] evidence: IEA