GGRNA | NM_025245.2

LOCUS       NM_025245               1747 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens pre-B-cell leukemia homeobox 4 (PBX4), transcript
            variant 1, mRNA.
ACCESSION   NM_025245
VERSION     NM_025245.2  GI:333108277
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Yan,T.T., Yin,R.X., Li,Q., Huang,P., Zeng,X.N., Huang,K.K.,
            Aung,L.H., Wu,D.F., Liu,C.W. and Pan,S.L.
  TITLE     Sex-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4
            and serum lipid levels in the Mulao and Han populations
  JOURNAL   Lipids Health Dis 10, 248 (2011)
   PUBMED   22208664
  REMARK    GeneRIF: Sex (male)-specific association of rs16996148 SNP in the
            NCAN/CILP2/PBX4 and serum lipid levels is observed both the Mulao
            and Han ethnic groups.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Rosales-Avina,J.A., Torres-Flores,J., Aguilar-Lemarroy,A.,
            Gurrola-Diaz,C., Hernandez-Flores,G., Ortiz-Lazareno,P.C.,
            Lerma-Diaz,J.M., de Celis,R., Gonzalez-Ramella,O.,
            Barrera-Chaires,E., Bravo-Cuellar,A. and Jave-Suarez,L.F.
  TITLE     MEIS1, PREP1, and PBX4 are differentially expressed in acute
            lymphoblastic leukemia: association of MEIS1 expression with higher
            proliferation and chemotherapy resistance
  JOURNAL   J. Exp. Clin. Cancer Res. 30, 112 (2011)
   PUBMED   22185299
  REMARK    GeneRIF: up-regulation of PREP1 and PBX genes could be implicated
            in the modulation of the cellular response to
            chemotherapeutic-induced apoptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Tai,E.S., Sim,X.L., Ong,T.H., Wong,T.Y., Saw,S.M., Aung,T.,
            Kathiresan,S., Orho-Melander,M., Ordovas,J.M., Tan,J.T. and
            Seielstad,M.
  TITLE     Polymorphisms at newly identified lipid-associated loci are
            associated with blood lipids and cardiovascular disease in an Asian
            Malay population
  JOURNAL   J. Lipid Res. 50 (3), 514-520 (2009)
   PUBMED   18987386
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Kathiresan,S., Melander,O., Guiducci,C., Surti,A., Burtt,N.P.,
            Rieder,M.J., Cooper,G.M., Roos,C., Voight,B.F., Havulinna,A.S.,
            Wahlstrand,B., Hedner,T., Corella,D., Tai,E.S., Ordovas,J.M.,
            Berglund,G., Vartiainen,E., Jousilahti,P., Hedblad,B.,
            Taskinen,M.R., Newton-Cheh,C., Salomaa,V., Peltonen,L., Groop,L.,
            Altshuler,D.M. and Orho-Melander,M.
  TITLE     Six new loci associated with blood low-density lipoprotein
            cholesterol, high-density lipoprotein cholesterol or triglycerides
            in humans
  JOURNAL   Nat. Genet. 40 (2), 189-197 (2008)
   PUBMED   18193044
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[Nat Genet. 2008 Nov;40(11):1384]
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Laurent,A., Bihan,R., Omilli,F., Deschamps,S. and Pellerin,I.
  TITLE     PBX proteins: much more than Hox cofactors
  JOURNAL   Int. J. Dev. Biol. 52 (1), 9-20 (2008)
   PUBMED   18033668
  REMARK    Review article
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Wagner,K., Mincheva,A., Korn,B., Lichter,P. and Popperl,H.
  TITLE     Pbx4, a new Pbx family member on mouse chromosome 8, is expressed
            during spermatogenesis
  JOURNAL   Mech. Dev. 103 (1-2), 127-131 (2001)
   PUBMED   11335119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC141859.1, AC002306.1 and
            CK300861.1.
            On May 17, 2011 this sequence version replaced gi:15149471.
            
            Summary: This gene encodes a member of the pre-B cell leukemia
            transcription factor family. These proteins are homeobox proteins
            that play critical roles in embryonic development and cellular
            differentiation both as Hox cofactors and through Hox-independent
            pathways. The encoded protein contains a homeobox DNA-binding
            domain, but specific functions of the protein have not been
            determined. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein-coding.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141859.1, AK097427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025091 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               BC141859.1         1-154
            155-155             AC002306.1         29731-29731         c
            156-1724            BC141859.1         156-1724
            1725-1747           CK300861.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..1747
                     /gene="PBX4"
                     /note="pre-B-cell leukemia homeobox 4"
                     /db_xref="GeneID:80714"
                     /db_xref="HGNC:13403"
                     /db_xref="HPRD:16287"
                     /db_xref="MIM:608127"
     exon            1..406
                     /gene="PBX4"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(42)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76080803"
     variation       complement(50)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189130488"
     misc_feature    174..176
                     /gene="PBX4"
                     /note="upstream in-frame stop codon"
     variation       complement(176)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12983838"
     variation       complement(181)
                     /gene="PBX4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:181371144"
     STS             224..1448
                     /gene="PBX4"
                     /db_xref="UniSTS:485630"
     variation       complement(283)
                     /gene="PBX4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112396932"
     STS             287..1462
                     /gene="PBX4"
                     /db_xref="UniSTS:480898"
     CDS             288..1412
                     /gene="PBX4"
                     /note="homeobox protein PBX4"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 4"
                     /protein_id="NP_079521.1"
                     /db_xref="GI:15149472"
                     /db_xref="CCDS:CCDS12406.1"
                     /db_xref="GeneID:80714"
                     /db_xref="HGNC:13403"
                     /db_xref="HPRD:16287"
                     /db_xref="MIM:608127"
                     /translation="

MAAPPRPAPSPPAPRRLDTSDVLQQIMAITDQSLDEAQARKHALNCHRMKPALFSVLCEIKEKTVVSIRGIQDEDPPDAQLLRLDNMLLAEGVCRPEKRGRGGAVARAGTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLQEQSRMRPVSPKEIERMVGAIHGKFSAIQMQLKQSTCEAVMTLRSRLLDARRKRRNFSKQATEVLNEYFYSHLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKKNMGKFQEEATIYTGKTAVDTTEVGVPGNHASCLSTPSSGSSGPFPLPSAGDAFLTLRTLASLQPPPGGGCLQSQAQGSWQGATPQPATASPAGDPGSINSSTSN

"
     misc_feature    339..893
                     /gene="PBX4"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:146435"
     misc_feature    933..1103
                     /gene="PBX4"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(933..935,1062..1064,1071..1076,1083..1085)
                     /gene="PBX4"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    order(936..938,996..998,1014..1016,1053..1055,1059..1064,
                     1071..1076,1080..1088,1092..1097)
                     /gene="PBX4"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     variation       complement(303)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375518457"
     variation       complement(351)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370270980"
     exon            407..480
                     /gene="PBX4"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(416)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191905542"
     variation       complement(429)
                     /gene="PBX4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:151162080"
     variation       complement(450)
                     /gene="PBX4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377677809"
     variation       complement(452)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375684730"
     exon            481..728
                     /gene="PBX4"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(488)
                     /gene="PBX4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148760242"
     variation       complement(498)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202136740"
     variation       complement(507)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147300531"
     variation       complement(511)
                     /gene="PBX4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144094318"
     variation       complement(513)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151268425"
     variation       complement(515)
                     /gene="PBX4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377023999"
     variation       complement(521)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112528821"
     variation       complement(539)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200752601"
     variation       complement(563)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140225945"
     variation       complement(570)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375963844"
     variation       complement(598)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372958240"
     variation       complement(605)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369260221"
     variation       complement(643)
                     /gene="PBX4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200325194"
     variation       complement(660)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200628306"
     variation       complement(706)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375066211"
     exon            729..919
                     /gene="PBX4"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(748)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113788698"
     variation       complement(753)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201625234"
     variation       complement(760)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149342353"
     variation       complement(761)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200663780"
     variation       complement(765)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375549686"
     variation       complement(791)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8108088"
     variation       complement(792)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8108180"
     variation       complement(810)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370646681"
     variation       complement(814)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370844553"
     variation       complement(816)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8108981"
     variation       complement(824)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150208525"
     variation       complement(833)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141893181"
     variation       complement(835)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374756898"
     variation       complement(846)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370372588"
     variation       complement(859)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148245498"
     variation       complement(883)
                     /gene="PBX4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375600193"
     variation       complement(898)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372535392"
     variation       complement(903)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144820446"
     exon            920..1055
                     /gene="PBX4"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(925)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369430064"
     variation       complement(931)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35516996"
     variation       complement(949)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199673541"
     variation       complement(964)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200360885"
     variation       complement(971)
                     /gene="PBX4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:75799973"
     variation       complement(977)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371731150"
     variation       complement(1017)
                     /gene="PBX4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367886261"
     variation       complement(1026)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201537948"
     variation       complement(1031)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145584999"
     variation       complement(1038)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200171479"
     variation       complement(1041)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372436008"
     exon            1056..1212
                     /gene="PBX4"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1064)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371142377"
     variation       complement(1081)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62137777"
     variation       complement(1085)
                     /gene="PBX4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:114083358"
     variation       complement(1087)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148814820"
     variation       complement(1135)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376647012"
     variation       complement(1136)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145467560"
     variation       complement(1145)
                     /gene="PBX4"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200643734"
     variation       complement(1157)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149681009"
     variation       complement(1159)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139542458"
     variation       complement(1160)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147715000"
     variation       complement(1181)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369823420"
     variation       complement(1184)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377739787"
     variation       complement(1185)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:116791423"
     variation       complement(1211)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201219684"
     exon            1213..1319
                     /gene="PBX4"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1232)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372278117"
     variation       complement(1242)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368764630"
     variation       complement(1247)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374485381"
     variation       complement(1251)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370342583"
     variation       complement(1267)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141765874"
     variation       complement(1287)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199666197"
     exon            1320..1730
                     /gene="PBX4"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(1337)
                     /gene="PBX4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377365977"
     variation       complement(1353)
                     /gene="PBX4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35913871"
     variation       complement(1359)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374029974"
     variation       complement(1404)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376094794"
     variation       complement(1416)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371587486"
     variation       complement(1436)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369459162"
     variation       complement(1442)
                     /gene="PBX4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373886682"
     variation       complement(1460)
                     /gene="PBX4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369021002"
     variation       complement(1650)
                     /gene="PBX4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144960029"
     variation       complement(1653)
                     /gene="PBX4"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:184567636"
     polyA_signal    1701..1706
                     /gene="PBX4"
     polyA_site      1730
                     /gene="PBX4"
ORIGIN

agaagtgccgttgcctcggcaaccccaaacccagtccaagcccggagagggggaagttcggggcgagtcccgggggcggtgcgtggcgccggttggctgacggagatgaaggggcgtgtctgtaggcggtgcaatacacgggttggctggcgatagcggcggtgggcgtggcttaggcgcgagcgagagcgggcgcggcgctcaggcagcggcggttggctgcggcgccagtggtagtgctccaggctcgacggcaccctcacagcgcccgcccggccctgccgctcatggccgccccgccgcgccccgcgccatcgccccccgccccgcggcgcctcgacacgagcgacgtcctgcagcagatcatggccatcaccgaccagagcctggacgaggcacaggccagaaagcatgctctgaattgccatcggatgaagcctgctctgttcagcgtgctctgtgagatcaaggaaaagacagtggtaagcatccgtggcattcaagacgaagatccccctgacgcccagctcctgaggctggataacatgctgctggctgagggcgtgtgcaggcccgagaagagaggaagaggaggagcggtggccagggccggcacagcaacaccaggtggctgtccaaatgacaatagcattgagcactctgactacagggccaagctgtcccagatccgacagatttaccactctgagctagagaaatatgaacaggcctgtcgtgagttcaccacgcacgtcaccaacctcctccaggagcagagcaggatgaggcctgtctcccctaaggagattgagcgcatggtcggcgccattcacggcaagttcagcgccatccagatgcagttgaagcagagcacctgtgaggcagtgatgaccctgcgttcgcggctgctcgatgccaggcgcaagcggcggaatttcagcaagcaggcgacggaagtgctgaatgagtatttttactcccatctgaacaacccttaccccagcgaagaagccaaagaagagctggccaggaagggcggcctcaccatctcccaggtctctaactggtttggcaacaaaagaatccggtataaaaagaacatggggaagtttcaagaagaggctaccatttacacgggtaaaacggctgtggataccacggaagttggggtcccagggaaccacgccagctgcctgtcaacacctagctccggctcctctggacccttcccgctgcccagcgctggggacgccttcctcaccctgcggactctggcctctctccagcctcctcctgggggaggctgcctgcagtcccaggcccagggtagctggcagggggccaccccccaacctgcaactgcctcacctgctggagaccctggcagcatcaactccagtacatctaattaagtttgggggataagcaggaaagagcgctgcgtgagctgccatgtatcgccagccgttgctttgttactgaacgtgccgccgacgacctcagaaaacccagatgggtggtggtgcccatgagcccctgctcctcagccaggcccgtggcgccggctcatgtgtctgctgcgactcgagatggcctgaaacgccactcattctcccacttcagttcgtttttttgacagtaattttatggtaacgctatgaattgaattgtctgttctaggactgggcacagattttcccattaaaatttttgacttattttaattccgaaaaaaaaaaaaaaaaaa

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