LOCUS       NM_024567               3233 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens homeobox containing 1 (HMBOX1), transcript variant 1,
            mRNA.
ACCESSION   NM_024567
VERSION     NM_024567.3  GI:209180432
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3233)
  AUTHORS   Gong,J., Liu,R., Zhuang,R., Zhang,Y., Fang,L., Xu,Z., Jin,L.,
            Wang,T., Song,C., Yang,K., Wei,Y., Yang,A., Jin,B. and Chen,L.
  TITLE     miR-30c-1* promotes natural killer cell cytotoxicity against human
            hepatoma cells by targeting the transcription factor HMBOX1
  JOURNAL   Cancer Sci. 103 (4), 645-652 (2012)
   PUBMED   22320217
  REMARK    GeneRIF: our results revealed a novel regulatory mechanism:
            miR-30c-1(*) promoted NK cell cytotoxicity against hepatoma cells
            by targeting HMBOX1.
REFERENCE   2  (bases 1 to 3233)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 3233)
  AUTHORS   Wu,L., Zhang,C., Zheng,X., Tian,Z. and Zhang,J.
  TITLE     HMBOX1, homeobox transcription factor, negatively regulates
            interferon-gamma production in natural killer cells
  JOURNAL   Int. Immunopharmacol. 11 (11), 1895-1900 (2011)
   PUBMED   21839858
  REMARK    GeneRIF: HMBOX1 may function as a negative regulator of IFN-gamma
            in NK cells.
REFERENCE   4  (bases 1 to 3233)
  AUTHORS   Wu,L., Zhang,C. and Zhang,J.
  TITLE     HMBOX1 negatively regulates NK cell functions by suppressing the
            NKG2D/DAP10 signaling pathway
  JOURNAL   Cell. Mol. Immunol. 8 (5), 433-440 (2011)
   PUBMED   21706044
  REMARK    GeneRIF: HMBOX1 negatively regulates the expression of NKG2D and
            the activation of the NKG2D/DAP10 signaling pathway in NK cells.
REFERENCE   5  (bases 1 to 3233)
  AUTHORS   Aghai,Z.H., Saslow,J.G., Meniru,C., Porter,C., Eydelman,R.,
            Bhat,V., Stahl,G., Sannoh,S., Pyon,K., Hewitt,C. and Bhandari,V.
  TITLE     High-mobility group box-1 protein in tracheal aspirates from
            premature infants: relationship with bronchopulmonary dysplasia and
            steroid therapy
  JOURNAL   J Perinatol 30 (9), 610-615 (2010)
   PUBMED   20182437
  REMARK    GeneRIF: higher HMGB1(homeobox containing 1) levels in Tracheal
            aspirates are associated with the development of bronchopulmonary
            dysplasia or death in ventilated premature infants.
REFERENCE   6  (bases 1 to 3233)
  AUTHORS   Zhang,M., Chen,S., Li,Q., Ling,Y., Zhang,J. and Yu,L.
  TITLE     Characterization of a novel human HMBOX1 splicing variant lacking
            the homeodomain and with attenuated transcription repressor
            activity
  JOURNAL   Mol. Biol. Rep. 37 (6), 2767-2772 (2010)
   PUBMED   19757162
  REMARK    GeneRIF: These findings suggest a distinct role of HMBOX1b, and the
            control of mRNA splicing might be involved in homeobox genes
            regulation.
REFERENCE   7  (bases 1 to 3233)
  AUTHORS   Dai,J., Wu,L., Zhang,C., Zheng,X., Tian,Z. and Zhang,J.
  TITLE     Recombinant expression of a novel human transcriptional repressor
            HMBOX1 and preparation of anti-HMBOX1 monoclonal antibody
  JOURNAL   Cell. Mol. Immunol. 6 (4), 261-268 (2009)
   PUBMED   19728927
  REMARK    GeneRIF: decreased expression in hepatic carcinoma
REFERENCE   8  (bases 1 to 3233)
  AUTHORS   De Marco,A., Biancotto,C., Knezevich,A., Maiuri,P., Vardabasso,C.
            and Marcello,A.
  TITLE     Intragenic transcriptional cis-activation of the human
            immunodeficiency virus 1 does not result in allele-specific
            inhibition of the endogenous gene
  JOURNAL   Retrovirology 5, 98 (2008)
   PUBMED   18983639
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3233)
  AUTHORS   Chen,S., Saiyin,H., Zeng,X., Xi,J., Liu,X., Li,X. and Yu,L.
  TITLE     Isolation and functional analysis of human HMBOX1, a homeobox
            containing protein with transcriptional repressor activity
  JOURNAL   Cytogenet. Genome Res. 114 (2), 131-136 (2006)
   PUBMED   16825764
  REMARK    GeneRIF: Hmbox1 is widely expressed in pancreas and the expression
            of this gene can also be detected in pallium, hippocampus and
            hypothalamus
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC069242.1 and AC108449.5.
            On Oct 9, 2008 this sequence version replaced gi:47059039.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069242.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1883              BC069242.1         1-1883
            1884-3233           AC108449.5         53313-54662
FEATURES             Location/Qualifiers
     source          1..3233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..3233
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="homeobox containing 1"
                     /db_xref="GeneID:79618"
                     /db_xref="HGNC:26137"
                     /db_xref="HPRD:07964"
     exon            1..312
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       96
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117901466"
     variation       174
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371954919"
     variation       288
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144108418"
     exon            313..343
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     exon            344..423
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       356
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190364776"
     variation       386
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375170302"
     misc_feature    395..397
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="upstream in-frame stop codon"
     variation       396
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143238324"
     CDS             401..1663
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="homeobox telomere-binding protein 1;
                     homeobox-containing protein PBHNF"
                     /codon_start=1
                     /product="homeobox-containing protein 1"
                     /protein_id="NP_078843.2"
                     /db_xref="GI:47059040"
                     /db_xref="CCDS:CCDS6071.1"
                     /db_xref="GeneID:79618"
                     /db_xref="HGNC:26137"
                     /db_xref="HPRD:07964"
                     /translation="

MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDKFGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPSNSYDTSPQPCTTNQNGRENNERLSTSNGKMSPTRYHANSMGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRPAPIPIEDPEWRQTPPPVSATSGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIEAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDDSTSHSDHQDPISLAVEMAAVNHTILALARQGANEIKTEALDDD

"
     misc_feature    1202..1420
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1202..1216,1220..1222,1271..1273,1289..1291,
                     1373..1375,1379..1384,1391..1396,1400..1408,1412..1417)
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1208..1210,1217..1219,1382..1384,1391..1396,
                     1403..1405)
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     variation       415
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369410329"
     exon            424..900
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       513
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372949481"
     variation       534
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377394078"
     variation       535
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368975966"
     variation       538
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150056601"
     variation       553
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145379672"
     variation       596
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375109128"
     variation       622
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376798312"
     variation       670
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370727503"
     variation       685
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374107196"
     variation       697
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148768782"
     variation       819
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113918455"
     variation       824
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111980547"
     variation       856
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367563195"
     variation       894
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201679029"
     exon            901..986
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     exon            987..1097
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1002
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374483267"
     variation       1055
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144731490"
     variation       1069
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147891204"
     exon            1098..1251
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1099
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372681580"
     variation       1127
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376040742"
     variation       1133
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370049630"
     variation       1147
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373691508"
     variation       1169
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371498035"
     variation       1195
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201671682"
     exon            1252..1334
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1307
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372399969"
     exon            1335..1430
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1337
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57483862"
     exon            1431..1525
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     exon            1526..3233
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1600
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377441971"
     variation       1617
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371243883"
     variation       1630
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202238043"
     variation       1631
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141568231"
     variation       1645
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370641360"
     variation       1667
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376300184"
     variation       1748
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142408867"
     variation       1752
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185761956"
     variation       1756
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11831"
     variation       1814
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150865526"
     variation       1865..1866
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="ggtt"
                     /db_xref="dbSNP:3830316"
     variation       1866..1867
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="aacc"
                     /db_xref="dbSNP:35389793"
     variation       1867..1868
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="ccaa"
                     /db_xref="dbSNP:146960848"
     variation       1875..1876
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="acca"
                     /replace="ccaa"
                     /db_xref="dbSNP:5890436"
     variation       1876..1877
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="ccaa"
                     /db_xref="dbSNP:34303559"
     variation       1877..1878
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="caac"
                     /db_xref="dbSNP:72378921"
     variation       1881..1882
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="aacc"
                     /db_xref="dbSNP:34984916"
     variation       1884
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:73669467"
     variation       1992
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139785494"
     variation       1995
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374383298"
     variation       2021
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144497394"
     STS             2067..2312
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /standard_name="WI-20805"
                     /db_xref="UniSTS:52353"
     variation       2085
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14015"
     variation       2201..2203
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="tat"
                     /db_xref="dbSNP:373733278"
     variation       2238
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14118"
     STS             2249..2389
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /standard_name="D8S2113"
                     /db_xref="UniSTS:57588"
     variation       2267
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146433919"
     variation       2360
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140779972"
     variation       2373
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187475748"
     variation       2401..2406
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="gtcatt"
                     /db_xref="dbSNP:375419031"
     variation       2406..2407
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:372815934"
     variation       2406
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1128136"
     variation       2407..2414
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="aaaaaaaa"
                     /db_xref="dbSNP:200587602"
     variation       2407
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="a"
                     /replace="aaaaaaaa"
                     /db_xref="dbSNP:11356150"
     variation       2407
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:78932143"
     variation       2415
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="a"
                     /replace="aaaaaaaa"
                     /db_xref="dbSNP:34577722"
     variation       2426
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74597687"
     variation       2429
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:62502811"
     variation       2455
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:79251998"
     variation       2456
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:80024799"
     variation       2514
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10088428"
     variation       2618
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149659731"
     STS             3072..3210
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /standard_name="RH103807"
                     /db_xref="UniSTS:98132"
     variation       3149
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373069277"
     variation       3152
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192657387"
ORIGIN      

cctcaagtctctttcctcacttctttctcttcacttaaaacaatttttttggaggggttttggggaggaagtgagcggacgctggggatgggtctcgtaagcggccggattgagaggagggaggaagcagggggcttccgagtgggtgacccagacgcgggctgtggggtggggcagttcgtggggtccggtcctggaaaggcgtcgactgccccccaactcttctggtttcctctacgatgagcggaaggtttgaatcctggaggtggggtctccggtgtggagttctggaaactgtgaggtgatttgcagctggtggaatggaacagtgaagaagcattggaatggtagataacgcagatcatctctggaaaggatattgatccgcctcatgtaaagtatgcttagttcctttccagtggttttgctggaaaccatgtctcattatacagatgaacccagatttaccatagagcagatagatctgcttcagcgacttcggcgtactggaatgactaaacatgaaattctccatgccttggaaactttggaccgtcttgatcaagagcatagtgacaagtttggaagaaggtccagctatggaggaagttcatatgggaatagtactaacaatgtcccagcatcttcctctacagctacagcttccacacagacgcagcattcgggaatgtccccgtcacctagcaacagttatgatacttccccacagccttgcactaccaatcaaaatgggagggagaataatgagcgattatctacatccaatggaaagatgtcaccaactcgctaccatgcaaacagcatgggtcagaggtcatacagttttgaagcctcagaagaggacctagatgtagatgataaagtggaagaattaatgaggagggacagcagtgtgataaaagaggaaatcaaagcctttcttgccaatcggaggatttcccaagcagttgttgcacaggtaacaggtatcagtcagagccggatctctcattggctgttgcagcagggatcagacctgagtgaacagaagaaaagagcattttaccgatggtatcaacttgagaagacaaaccctggcgctacactaagtatgagaccagcccccattccaatagaggaccctgaatggagacaaacgcctcccccagtctctgccacatctggtactttccgactgcgacgagggagtcgatttacctggagaaaggagtgcctggctgttatggaaagttacttcaatgagaatcaatacccagatgaagcaaagagggaagaaattgcaaacgcttgcaatgcagttatacagaagccaggcaaaaagctgtcagatctggaaagagttacctccctgaaagtatataattggtttgctaacagaaggaaggagatcaagaggagagccaatattgaagcagcaatcctggagagtcatgggatagatgtgcagagtccaggaggccactcaaacagtgatgatgtcgacgggaatgactactctgagcaggatgacagtacgagccatagtgaccaccaagaccccatctcattagctgtggaaatggcagcagtcaaccacactatcttggcattggcccgacaaggagccaacgaaatcaagacagaggccctggatgatgactgatcagggaggttaaacatgacaagttaacttagtttagacgtagcaccttagcagactttcctcggtccttaacatgtgttcttacagtataacttgcagtttcttgtatgtcaggtagctgttagggtcttgttctgtgaagatggcatggtgccctcagcctttgcatatactctctcagtattaactcccagtaaataataaccaaccaaccaaccaaacttccctctcccagcccccgaggctagaaaatcttgctgctccgtcttagcattccaagaaagtgcttccaggtatttagatagccctcagttctcaaatattagactacgtgtaaaatcttgggtacctttagattcttgtaacactagtctgtactcccttttccttccccaagactgataggatgcaagctgaggtcgtggcacaggaatgacagacaccatttggggagtatccacagagtcaaaggaacactagaatccccacctcagcgtgaggataattgatttccagctgcaataagccgtgcctcattatagccacactgtggctagattatacttctttgggtgctgtgctaagaatgtcaatggaaaaagccgatctcagattttgtttgaagttaacatgcctgacacagacatcctttcctctcacaagctgtgtgacttagtagataaaatactgccttctgcctttgggaccatgattaaaaacaaagacaaaaaccaaaagtcattaaaaaaaaaaaaaaaaaaaacccagcttgagagcattggaaaaaaaaaatatgagctgaatgtctaatggatgctaagtccagttttcagaaccactgtacattccacggcacagttagcagtgcctgcctggaaaagttttggaggtcatcgtggaagttgctttgcctcctgtcagtgtcccctttccctgctaccaaaaaagtctttcaaggatggagctaaggtcaaaaatgagtgaaaaaacttgcagtgtttgtatccattaaacggaagccccctcactctgagaggtcactagaggacttcatagtggggttgtgctgcttatcacagatgcagacacttgcccagataggagcagagaaaagcaggggacgtttcctactcacattgtggctgtatgagaacacgatgggactgctttgctgttctctttactctgtccttggagaggtgtgaaaagctgtattgctacaggcaatttatttaataattggaagccatattgataatggatgtggtaatatttgtaaagtttaatctactttaagcggcagtaactaatggaatttttttccttgatcacatatgtagcacttttgttactttttaaagatatttatatttgataaatctttttttcattttgagaactcaaaataccaaacagtgaacttgcattctaaagtcaccctgtgatcaccttgtcatctagtagcaaaatgatgaactattcatgcatcaaagaaaattacatctgctggccttgtatgaaaatgatctcttggcatcccgattaaatgacacactgtcactgtgggtaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:79618 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:79618 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:79618 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:79618 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:79618 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:79618 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:79618 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA