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2025-05-09 20:15:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_024422 5211 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2a, mRNA.
ACCESSION NM_024422
VERSION NM_024422.3 GI:189163543
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5211)
AUTHORS Knosel,T., Chen,Y., Hotovy,S., Settmacher,U., Altendorf-Hofmann,A.
and Petersen,I.
TITLE Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are
associated with tumor progression and survival in colorectal
carcinoma
JOURNAL Int J Colorectal Dis 27 (11), 1391-1399 (2012)
PUBMED 22438068
REMARK GeneRIF: High expression of desmocollin 1 (DSC1) was observed in
41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in
58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in
42.5%, and MDM2 in 0.2% of colorectal carcinomas.
REFERENCE 2 (bases 1 to 5211)
AUTHORS Nekrasova,O.E., Amargo,E.V., Smith,W.O., Chen,J., Kreitzer,G.E. and
Green,K.J.
TITLE Desmosomal cadherins utilize distinct kinesins for assembly into
desmosomes
JOURNAL J. Cell Biol. 195 (7), 1185-1203 (2011)
PUBMED 22184201
REMARK GeneRIF: The Dsc2 exhibit microtubule-dependent transport in
epithelial cells but use distinct motors to traffic to the plasma
membrane.
Erratum:[J Cell Biol. 2012 Jan 23;196(2):297]
REFERENCE 3 (bases 1 to 5211)
AUTHORS Hayashi,T., Sentani,K., Oue,N., Anami,K., Sakamoto,N., Ohara,S.,
Teishima,J., Noguchi,T., Nakayama,H., Taniyama,K., Matsubara,A. and
Yasui,W.
TITLE Desmocollin 2 is a new immunohistochemical marker indicative of
squamous differentiation in urothelial carcinoma
JOURNAL Histopathology 59 (4), 710-721 (2011)
PUBMED 22014052
REMARK GeneRIF: DSC2 is a useful immunohistochemical marker for separation
of Urothelial carcinoma with squamous differentiation from pure
Urothelial carcinoma
REFERENCE 4 (bases 1 to 5211)
AUTHORS Gehmlich,K., Lambiase,P.D., Asimaki,A., Ciaccio,E.J., Ehler,E.,
Syrris,P., Saffitz,J.E. and McKenna,W.J.
TITLE A novel desmocollin-2 mutation reveals insights into the molecular
link between desmosomes and gap junctions
JOURNAL Heart Rhythm 8 (5), 711-718 (2011)
PUBMED 21220045
REMARK GeneRIF: At the molecular level, altered binding properties of the
desmocollin-2a mutant may contribute to the changes in connexin43
REFERENCE 5 (bases 1 to 5211)
AUTHORS Kolegraff,K., Nava,P., Helms,M.N., Parkos,C.A. and Nusrat,A.
TITLE Loss of desmocollin-2 confers a tumorigenic phenotype to colonic
epithelial cells through activation of Akt/beta-catenin signaling
JOURNAL Mol. Biol. Cell 22 (8), 1121-1134 (2011)
PUBMED 21325624
REMARK GeneRIF: Loss of Desmocollin2 promotes cell proliferation and
enables tumor growth in vivo through the activation of
Akt/beta-catenin signaling.
REFERENCE 6 (bases 1 to 5211)
AUTHORS Amagai,M., Wang,Y., Minoshima,S., Kawamura,K., Green,K.J.,
Nishikawa,T. and Shimizu,N.
TITLE Assignment of the human genes for desmocollin 3 (DSC3) and
desmocollin 4 (DSC4) to chromosome 18q12
JOURNAL Genomics 25 (1), 330-332 (1995)
PUBMED 7774948
REFERENCE 7 (bases 1 to 5211)
AUTHORS Nuber,U.A., Schafer,S., Schmidt,A., Koch,P.J. and Franke,W.W.
TITLE The widespread human desmocollin Dsc2 and tissue-specific patterns
of synthesis of various desmocollin subtypes
JOURNAL Eur. J. Cell Biol. 66 (1), 69-74 (1995)
PUBMED 7750520
REFERENCE 8 (bases 1 to 5211)
AUTHORS Arnemann,J., Spurr,N.K., Wheeler,G.N., Parker,A.E. and Buxton,R.S.
TITLE Chromosomal assignment of the human genes coding for the major
proteins of the desmosome junction, desmoglein DGI (DSG),
desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and
plakoglobin DPIII (JUP)
JOURNAL Genomics 10 (3), 640-645 (1991)
PUBMED 1889810
REFERENCE 9 (bases 1 to 5211)
AUTHORS Parker,A.E., Wheeler,G.N., Arnemann,J., Pidsley,S.C., Ataliotis,P.,
Thomas,C.L., Rees,D.A., Magee,A.I. and Buxton,R.S.
TITLE Desmosomal glycoproteins II and III. Cadherin-like junctional
molecules generated by alternative splicing
JOURNAL J. Biol. Chem. 266 (16), 10438-10445 (1991)
PUBMED 2037591
REFERENCE 10 (bases 1 to 5211)
AUTHORS Garrod,D.R. and Fleming,S.
TITLE Early expression of desmosomal components during kidney tubule
morphogenesis in human and murine embryos
JOURNAL Development 108 (2), 313-321 (1990)
PUBMED 2112455
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC382631.1, BC063291.1,
X56807.1 and BU735677.1.
On May 29, 2008 this sequence version replaced gi:40806177.
Summary: The protein encoded by this gene is a calcium-dependent
glycoprotein that is a member of the desmocollin subfamily of the
cadherin superfamily. These desmosomal family members, along with
the desmogleins, are found primarily in epithelial cells where they
constitute the adhesive proteins of the desmosome cell-cell
junction and are required for cell adhesion and desmosome
formation. The desmosomal family members are arranged in two
clusters on chromosome 18, occupying less than 650 kb combined.
Mutations in this gene are associated with arrhythmogenic right
ventricular dysplasia-11. Alternative splicing results in two
transcript variants encoding distinct isoforms. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (Dsc2a, also known as DGII)
encodes the longer isoform (Dsc2a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC063291.1, AK290313.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-576 DC382631.1 8-583
577-3161 BC063291.1 566-3150
3162-3570 X56807.1 2794-3202
3571-5134 BC063291.1 3560-5123
5135-5211 BU735677.1 1-77 c
FEATURES Location/Qualifiers
source 1..5211
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q12.1"
gene 1..5211
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="desmocollin 2"
/db_xref="GeneID:1824"
/db_xref="HGNC:3036"
/db_xref="HPRD:00512"
/db_xref="MIM:125645"
exon 1..523
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
misc_feature 353..355
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="upstream in-frame stop codon"
CDS 455..3160
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="isoform Dsc2a preproprotein is encoded by
transcript variant Dsc2a; desmosomal glycoprotein II/III;
cadherin family member 2"
/codon_start=1
/product="desmocollin-2 isoform Dsc2a preproprotein"
/protein_id="NP_077740.1"
/db_xref="GI:13435364"
/db_xref="CCDS:CCDS11892.1"
/db_xref="GeneID:1824"
/db_xref="HGNC:3036"
/db_xref="HPRD:00512"
/db_xref="MIM:125645"
/translation="
MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMKR
"
sig_peptide 455..535
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
proprotein 536..3157
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/product="desmocollin-2 isoform Dsc2a proprotein"
misc_feature 545..787
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Cadherin prodomain like; Region: Cadherin_pro;
smart01055"
/db_xref="CDD:198123"
mat_peptide 860..3157
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/product="desmocollin-2 isoform Dsc2a"
misc_feature <938..1171
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1058..1060,1064..1066,1157..1159,1163..1168)
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1217..1507
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1217..1219,1388..1390,1394..1396,1493..1495,
1499..1504)
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1529..1855
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1550..1555,1724..1726,1730..1732,1844..1846,
1850..1855)
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1883..2173
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1898..1903,2054..2056,2060..2062,2159..2161,
2165..2170)
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 2537..2599
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q02487.1);
transmembrane region"
misc_feature 2816..3157
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/note="Cadherin cytoplasmic region; Region: Cadherin_C;
pfam01049"
/db_xref="CDD:163601"
misc_feature 2921..2923
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 524..608
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 609..808
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 809..928
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 929..1084
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 1085..1229
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 1230..1396
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 1397..1531
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 1532..1717
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 1718..1974
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 1975..2117
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 2118..2342
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 2343..2579
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 2580..2704
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
exon 2705..2962
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
variation 2780
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1893963"
variation 2835
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1617629"
exon 2963..5199
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/inference="alignment:Splign:1.39.8"
STS 2976..3845
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/standard_name="DSC2_v370"
/db_xref="UniSTS:277170"
STS 3039..3155
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/standard_name="GDB:185730"
/db_xref="UniSTS:155457"
STS 3374..3521
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/standard_name="RH18110"
/db_xref="UniSTS:91110"
polyA_signal 3458..3463
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
polyA_site 3478
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
variation 3944
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1613246"
STS 4948..5114
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
/standard_name="RH93906"
/db_xref="UniSTS:90687"
polyA_signal 5114..5119
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
polyA_site 5135
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
polyA_signal 5181..5186
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
polyA_site 5199
/gene="DSC2"
/gene_synonym="ARVD11; CDHF2; DG2; DGII/III; DSC3"
ORIGIN
gtgcagtcagggcttctgctgggcagggccggctgttaatctcgcctggcggagcggacaccggggcgtggtgggggagatgggccttataggtggcgtccgctggtgagaaacaccttgcgcaggtaaaagggtggcggcgagagggagttcccacccgtggctttcttagagaaatgaagtcttaagtcttaaatagacaacaaggaggggccgatcggtgtcttttggacgcgtctggagcccctccctccgccaaaggaaaagccccttggatgagaggcaggcgcttcagagaagctaagaaaagcacctctccgcgcgccccacctcctccgcctcgcgctcctcctgagcagcgggcccagactgcgctccggccgcggccctcgccccgcggagccctcctaccccggcccgacgctcggcccgcgacctgccccgagccctctccatggaggcagcccgcccctccggctcctggaacggagccctctgccggctgctcctgctgaccctcgcgatcttaatatttgccagtgatgcctgcaaaaatgtgacattacatgttccctccaaactagatgccgagaaacttgttggtagagttaacctgaaagagtgctttacagctgcaaatctaattcattcaagtgatcctgacttccaaattttggaggatggttcagtctatacaacaaatactattctattgtcctcggagaagagaagttttaccatattactttccaacactgagaaccaagaaaagaagaaaatatttgtctttttggagcatcaaacaaaggtcctaaagaaaagacatactaaagaaaaagttctaaggcgcgccaagagaagatgggctccaattccttgttcgatgctagaaaactccttgggtccttttccacttttccttcaacaggttcaatctgacacggcccaaaactataccatatactattccataagaggtcctggagttgaccaagaacctcggaatttattttatgtggagagagacactggaaacttgtattgtactcgtcctgtagatcgtgagcagtatgaatcttttgagataattgcctttgcaacaactccagatgggtatactccagaacttccactgcccctaataatcaaaatagaggatgaaaatgataactacccaatttttacagaagaaacttatacttttacaatttttgaaaattgcagagtgggcactactgtgggacaagtgtgtgctactgacaaagatgagcctgacacgatgcacacacgcctgaagtactccatcattgggcaggtgccaccatcacccaccctattttctatgcatccaactacaggcgtgatcaccacaacatcatctcagctagacagagagttaattgacaagtaccagttgaaaataaaagtacaagacatggatggtcagtattttggtctacagacaacttcaacttgtatcattaacattgatgatgtaaatgaccacttgccaacatttactcgtacttcttatgtgacatcagtggaagaaaatacagttgatgtggaaatcttacgagttactgttgaggataaggacttagtgaatactgctaactggagagctaattataccattttaaagggcaatgaaaatggcaattttaaaattgtaacagatgccaaaaccaatgaaggagttctttgtgtagttaagcctttgaattatgaagaaaagcaacagatgatcttgcaaattggtgtagttaatgaagctccattttccagagaggctagtccaagatcagccatgagcacagcaacagttactgttaatgtagaagatcaggatgagggccctgagtgtaaccctccaatacagactgttcgcatgaaagaaaatgcagaagtgggaacaacaagcaatggatataaagcatatgacccagaaacaagaagtagcagtggcataaggtataagaaattaactgatccaacagggtgggtcaccattgatgaaaatacaggatcaatcaaagttttcagaagcctggatagagaggcagagaccatcaaaaatggcatatataatattacagtccttgcatcagaccaaggagggagaacatgtacggggacactgggcattatacttcaagacgtgaatgataacagcccattcatacctaaaaagacagtgatcatctgcaaacccaccatgtcatctgcggagattgttgcggttgatcctgatgagcctatccatggcccaccctttgactttagtctggagagttctacttcagaagtacagagaatgtggagactgaaagcaattaatgatacagcagcacgtctttcctatcagaatgatcctccatttggctcatatgtagtacctataacagtgagagatagacttggcatgtctagtgtcacttcattggatgttacactgtgtgactgcattaccgaaaatgactgcacacatcgtgtagatccaaggattggcggtggaggagtacaacttggaaagtgggccatccttgcaatattgttgggcatagcattgctcttttgcatcctgtttacgctggtctgtggggcttctgggacgtctaaacaaccaaaagtaattcctgatgatttagcccagcagaacctaattgtatcaaacacagaagctcctggagatgacaaagtgtattctgcgaatggcttcacaacccaaactgtgggcgcttctgctcagggagtttgtggcaccgtgggatcaggaatcaaaaacggaggtcaggagaccatcgaaatggtgaaaggaggacaccagacctcggaatcctgccggggggctggccaccatcacaccctggactcctgcaggggaggacacacggaggtggacaactgcagatacacttactcggagtggcacagttttactcagccccgtcttggtgaaaaagtgtatctgtgtaatcaagatgaaaatcacaagcatgcccaagactatgtcctgacatataactatgaaggaagaggatcggtggctgggtctgtaggttgttgcagtgaacgacaagaagaagatgggcttgaatttttggataatttggagcccaaatttaggacactagcagaagcatgcatgaagagatgagtgtgttctaataagtctctgaaagccagtggctttatgacttttaaaaaaaattacaaaccaagaattttttaaagcagaagatgctatttgtgggggtttttctctcattatttggatggaatctctttggtcaaatgcacatttacagagagacactataaacaagtacacaaatttttcaatttttacatatttttaaattacttatcttctatccaaggaggtctacagagaaattaaagtctgccttatttgttacatttgggtataatgacaacagccaatttatagtgcaataaaatgtaattaattcaagtccttattatagactatttgaagcacaacctaatggaaaattgtagagaccttgctttaacattatctccagttaattaagtgttcatgtggtgcttggaaactgttgttttcctgaacatctaaagtgtgtagactgcattcttgctattattttattcttgtaatgtgaccttttcactgtgcaaagggagatttctagccaggcattgactattacaatttcattttggtggagtttagttttaggttttattgtatataaaatcctgcactgaatctgtgtctcctctgttacctacttttgccagtgaaatttaagttttaaaatactttcagaatgtatttttactactgcaagtttttggtctttaaaatgtcaagtagcatctctctctttctctctgtctctttctgtttctctctccagttttttttttttttttaatttccatatgggctaaagaatccaaatattttaaaaatctgtctctcttttcttctctcataaagtgaattattccttttttttgttttatgtaagtgtatatattcttagtttttcttgaaatcattgtaatgttaactttgttgtttcaaatatcttggtgattgcttcattatctcttcaacaaaaaaaacctttaattttgccattgaaactgtagaactatgccatgcttttattagaagcagtgctctgtgttaacaacaagaatggtgtaattagaattgggatgtggatatttactgtatgacaacacatttacagttctgtaatgcaaggatgcagtttaaaaatgtgaagtagtgatggtttttgaaataagctttaaaatatagggatcttgaaggctccctggggtaactattttataacttagataaaatggctagtcatatctgtgtgtttgtaaagttatttttttaatattttaagattacaattttaacaaatgtagaaatgagccaaactatttaaattttaaaacagtaaaacaaaatgaaacttaatagctcacaaaattccagtccatgtttcatgacttattttagtcaatgaattttctatttatactaaacatatggacattttaaatgtgtttctaatatttttgattatctataatgtgcctgtcttcaattcacaagattgggttataacaattatttgccagattaacactagggaattatttgataaccagcttatcttatcagtagttttattgctgatcaggcaaaaatagttttccaaagttatttttaataaagtatatacaaaattcttatatattactagtcatgataaagtaaattaagcagtttttaaaacttagtgtgagtttgttcatcacaggtctgatatgagtttaagggatttcgcactccctgaatcagagaagtaagaccccttccttagattcctgttatacattttttaaaatgtagagtttgttttggagacattttcagtgcattgttattgccatatttatataatatgactattctaaaggctgtgaggccatggggtattggttaagttgcttgcttttgctttgtccattttcatcattttaaaatgggggataataacagaacttgtttcctagggccattgtaagtcacttgaataaaaaatagttttgaagcatgagagtcatacagagcggtccacctaaaaggcactcctgataataataaatgattttaaacaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1824 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:1824 -> Biological process: GO:0007155 [cell adhesion] evidence: TAS
GeneID:1824 -> Biological process: GO:0007156 [homophilic cell adhesion] evidence: IEA
GeneID:1824 -> Biological process: GO:0086005 [regulation of ventricular cardiac muscle cell action potential] evidence: IMP
GeneID:1824 -> Biological process: GO:0086069 [bundle of His cell to Purkinje myocyte communication] evidence: IMP
GeneID:1824 -> Biological process: GO:0086091 [regulation of heart rate by cardiac conduction] evidence: IMP
GeneID:1824 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:1824 -> Cellular component: GO:0005913 [cell-cell adherens junction] evidence: IEA
GeneID:1824 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:1824 -> Cellular component: GO:0030057 [desmosome] evidence: IDA
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