LOCUS       NM_022658               2290 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox C8 (HOXC8), mRNA.
ACCESSION   NM_022658
VERSION     NM_022658.3  GI:45580721
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Adwan,H., Zhivkova-Galunska,M., Georges,R., Eyol,E., Kleeff,J.,
            Giese,N.A., Friess,H., Bergmann,F. and Berger,M.R.
  TITLE     Expression of HOXC8 is inversely related to the progression and
            metastasis of pancreatic ductal adenocarcinoma
  JOURNAL   Br. J. Cancer 105 (2), 288-295 (2011)
   PUBMED   21712827
  REMARK    GeneRIF: HOXC8 expression is inversely related to pancreatic ductal
            adenocarcinoma progression and metastasis.
REFERENCE   2  (bases 1 to 2290)
  AUTHORS   Axlund,S.D., Lambert,J.R. and Nordeen,S.K.
  TITLE     HOXC8 inhibits androgen receptor signaling in human prostate cancer
            cells by inhibiting SRC-3 recruitment to direct androgen target
            genes
  JOURNAL   Mol. Cancer Res. 8 (12), 1643-1655 (2010)
   PUBMED   21047772
  REMARK    GeneRIF: a complex role for HOXC8 in prostate cancer, promoting
            invasiveness while inhibiting AR-mediated gene induction at
            androgen response element-regulated genes associated with
            differentiated function of the prostate
REFERENCE   3  (bases 1 to 2290)
  AUTHORS   Li,Y., Zhang,M., Chen,H., Dong,Z., Ganapathy,V., Thangaraju,M. and
            Huang,S.
  TITLE     Ratio of miR-196s to HOXC8 messenger RNA correlates with breast
            cancer cell migration and metastasis
  JOURNAL   Cancer Res. 70 (20), 7894-7904 (2010)
   PUBMED   20736365
  REMARK    GeneRIF: Ratio of microRNA to HOXC8 mRNA may be an indicator of the
            metastatic capability of breast tumors.
REFERENCE   4  (bases 1 to 2290)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   5  (bases 1 to 2290)
  AUTHORS   Kikugawa,T., Kinugasa,Y., Shiraishi,K., Nanba,D., Nakashiro,K.,
            Tanji,N., Yokoyama,M. and Higashiyama,S.
  TITLE     PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to
            androgen-independent prostate cancer proliferation
  JOURNAL   Prostate 66 (10), 1092-1099 (2006)
   PUBMED   16637071
  REMARK    GeneRIF: Androgen-independent cell line DU145 cells lack PLZF gene
            expression, resulting in the upregulation of Pbx1 and HoxC8
            expression. The Pbx1-HoxC8 heterocomplex may lead to
            androgen-independent growth in prostate cancer.
REFERENCE   6  (bases 1 to 2290)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   7  (bases 1 to 2290)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
REFERENCE   8  (bases 1 to 2290)
  AUTHORS   Cannizzaro,L.A., Croce,C.M., Griffin,C.A., Simeone,A.,
            Boncinelli,E. and Huebner,K.
  TITLE     Human homeo box-containing genes located at chromosome regions
            2q31----2q37 and 12q12----12q13
  JOURNAL   Am. J. Hum. Genet. 41 (1), 1-15 (1987)
   PUBMED   2886047
REFERENCE   9  (bases 1 to 2290)
  AUTHORS   Simeone,A., Mavilio,F., Acampora,D., Giampaolo,A., Faiella,A.,
            Zappavigna,V., D'Esposito,M., Pannese,M., Russo,G., Boncinelli,E.
            et al.
  TITLE     Two human homeobox genes, c1 and c8: structure analysis and
            expression in embryonic development
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (14), 4914-4918 (1987)
   PUBMED   2885844
REFERENCE   10 (bases 1 to 2290)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC053898.1 and BU618342.1.
            On Mar 18, 2004 this sequence version replaced gi:24497545.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXC genes located in a cluster on
            chromosome 12. The product of this gene may play a role in the
            regulation of cartilage differentiation. It could also be involved
            in chondrodysplasias or other cartilage disorders. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053898.1, AK290959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-935               BC053898.1         1-935
            936-1866            BC053898.1         937-1867
            1867-2290           BU618342.1         3-426               c
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..2290
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="homeobox C8"
                     /db_xref="GeneID:3224"
                     /db_xref="HGNC:5129"
                     /db_xref="HPRD:00856"
                     /db_xref="MIM:142970"
     exon            1..615
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /inference="alignment:Splign:1.39.8"
     variation       21
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371701559"
     variation       28..29
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:737219"
     variation       28
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:737220"
     variation       101
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377555061"
     variation       134
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370052189"
     variation       136
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200420679"
     misc_feature    138..140
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="upstream in-frame stop codon"
     variation       143
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376707431"
     variation       145
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:12818817"
     CDS             180..908
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="homeo box C8; homeo box 3A; Hox-3.1, mouse, homolog
                     of; homeobox protein Hox-3A"
                     /codon_start=1
                     /product="homeobox protein Hox-C8"
                     /protein_id="NP_073149.1"
                     /db_xref="GI:12056969"
                     /db_xref="CCDS:CCDS8870.1"
                     /db_xref="GeneID:3224"
                     /db_xref="HGNC:5129"
                     /db_xref="HPRD:00856"
                     /db_xref="MIM:142970"
                     /translation="

MSSYFVNPLFSKYKAGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD

"
     misc_feature    591..608
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P31273.2);
                     Region: Antp-type hexapeptide"
     misc_feature    627..803
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(627..641,645..647,696..698,714..716,753..755,
                     759..764,771..776,780..788,792..797)
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(633..635,642..644,762..764,771..776,783..785)
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       224
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142847294"
     variation       227
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147408410"
     variation       244
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373994805"
     variation       245
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139631619"
     variation       290
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367879548"
     variation       294
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371713562"
     variation       299
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376375995"
     variation       306
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368462442"
     variation       413
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369825482"
     variation       416
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372655410"
     variation       431
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145158234"
     STS             433..662
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /standard_name="MARC_41665-41666:1086710236:1"
                     /db_xref="UniSTS:471605"
     variation       482
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377312910"
     variation       495
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2083837"
     variation       500
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201495324"
     variation       514
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373026625"
     variation       542
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180837385"
     variation       551
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199563805"
     variation       572
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139484223"
     STS             579..661
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /standard_name="Hoxc8"
                     /db_xref="UniSTS:536664"
     variation       611
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149665546"
     exon            616..2290
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /inference="alignment:Splign:1.39.8"
     variation       619
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201628503"
     variation       637
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369363687"
     variation       638
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183205906"
     variation       806
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35198366"
     variation       821
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372905494"
     STS             851..1793
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /standard_name="MARC_43876-43875:1099078210:3"
                     /db_xref="UniSTS:471614"
     STS             861..964
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /standard_name="Hoxc8"
                     /db_xref="UniSTS:143391"
     variation       882
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367728182"
     variation       905
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145144648"
     variation       922
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:375908300"
     variation       923
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:375330102"
     variation       931
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200035305"
     variation       932
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201173990"
     variation       933..935
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35378573"
     variation       933
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4142680"
     variation       936..937
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:71068198"
     variation       955
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370624442"
     variation       976
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116334238"
     variation       1060
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11170784"
     variation       1114
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376723569"
     variation       1115
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371009456"
     variation       1222
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146077521"
     variation       1380
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139313620"
     variation       1482
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:12814340"
     STS             1607..2207
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /standard_name="HOXC8_2494"
                     /db_xref="UniSTS:280762"
     variation       1664
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73313182"
     variation       1705
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144078770"
     variation       1839
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192449987"
     variation       1866..1868
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace=""
                     /replace="a"
                     /replace="tc"
                     /db_xref="dbSNP:368097239"
     variation       1867..1868
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11444199"
     variation       1867
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:77729302"
     variation       1881
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77153785"
     variation       1882
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79679701"
     variation       1968
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182733929"
     variation       2024
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146523694"
     variation       2035
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148698267"
     variation       2072
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142212620"
     variation       2118
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187964390"
     variation       2220
                     /gene="HOXC8"
                     /gene_synonym="HOX3; HOX3A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61921780"
ORIGIN      

gccgagctcagcaccgaggcgccccccaacctgcccagcccccagcccaccagcccagcccagtcccggggagccagctggcctggggttcggtcccggggggaggggagtttcgggggtactgggcggggtactcgtgagccagaggggagggggccgcgggttttcatgtacccagcatgagctcctacttcgtcaaccccctgttctccaaatacaaagccggcgagtccctggaaccggcctattacgactgccggttccctcagagcgtgggcaggagccatgcgctggtgtacgggcccggcggctcggcgcccggcttccagcacgcttcgcaccacgttcaagacttcttccaccacggcacctccggcatctccaactcaggctaccagcagaacccgtgctcgcttagctgccacggagacgcctccaaattctatggctacgaggcgctccccagacagtccctttatggggctcagcaagaggcgagcgtggtgcaatatcccgactgtaaatcctccgccaacactaacagtagcgaaggacaaggccacttaaatcaaaactcgtctcccagcctcatgtttccatggatgagaccccacgctccggggaggcgcagtggacggcaaacttacagccggtatcagaccttggaactagaaaaggagtttctctttaatccttatttgacacgaaaacgtcggattgaagtctctcatgccctgggactgaccgagagacaagtgaagatctggttccagaaccgaaggatgaagtggaaaaaggagaacaacaaggataaactgccgggagcccgagatgaggagaaggtggaggaagaaggaaatgaggaagaggagaaagaagaggaggaaaaggaagaaaacaaggactaagcaaaaaagaaagacccccccccccttagcaactcccttgaagtttcgttttatggtagcagataaattgagaagtttacgactgtcatttgcttttatagagaatagaatgacactcacaactctaactacctgtcagatacttgcagctctggttttattacctttggacttcccccactctttatttgtttgggggctggaggggggagacggagaaacagtgaaaagttcggactctctgtctcactccttgccccacacacacttgtccctgcccccacccttctgagtccttcctggattttaaggtctgagacctggcctccgtgctcctcggtctgtctctcaccacactcccacctccctgcttctctggtatttattttagaggggagccccctcgaaatgcagaaaaggacttgtggttttgtttttatgctaaggctagtgtactagatgtactttttctaaaaaggaaaggacagaaaaaaatgaagaaaggaaaggaagacaaatgtaaagaaataaggaaaaaagcaaggaatatcccctccccctccccctccccctccccagggctccctgcttagaaaaacccccttgactttctctaggaacctgatggaaacctgaaggagatgtgggtctttcccctccccccatttccagaagggtagataggagcctgcagtcgcctctaaaatcctacctaaccatcccatggtcactcgggcccatgccttcctctccttcgctgtttgatttctattctgttgggcccgccttcctctgagctgcattagtgttagtgctcagaaatcaccataatcacgaaaataataataataaatctttaacatactacctaaagggaacctgcaataatcttgaaaaagaaaaagagaaaaattttaaaatcctgctataggagaaaaaaagagaaaaaaataaaaatcaaaaaaaaaaaaaagaaagaaagaaacctccagcgtattttatcactacctatagaaagaaatcctgctttgagagtatttgtaatgcggttttgttgtcgtttgttgctgcttatttcactaagaaaacccaacaactgagactgcctagcccgccggtcctgtgcgcttttattgtgcttctaaccccagtagagtagaactaaattgcactgaatgtatagttaactctgtcttgaattctctgtttatgcaatgtgctcgaaagaaaaaaatgttaaaaatatatctataataataattttttgtcatttgtctttatgtccagctatgaatgtagattttgtgtcccgacagccctgttcctggtccaagtactttgtattgtatacgtgagtcataataataaaaagaagaagaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3224 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IEA
            GeneID:3224 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
            GeneID:3224 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:3224 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3224 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS
            GeneID:3224 -> Biological process: GO:0007275 [multicellular organismal development] evidence: NAS
            GeneID:3224 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3224 -> Biological process: GO:0030182 [neuron differentiation] evidence: IEA
            GeneID:3224 -> Biological process: GO:0048705 [skeletal system morphogenesis] evidence: IEA
            GeneID:3224 -> Cellular component: GO:0005634 [nucleus] evidence: NAS