GGRNA | NM_022062.2

LOCUS       NM_022062               3730 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens PBX/knotted 1 homeobox 2 (PKNOX2), mRNA.
ACCESSION   NM_022062
VERSION     NM_022062.2  GI:116812643
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3730)
  AUTHORS   Bergen,S.E., O'Dushlaine,C.T., Ripke,S., Lee,P.H., Ruderfer,D.M.,
            Akterin,S., Moran,J.L., Chambert,K.D., Handsaker,R.E., Backlund,L.,
            Osby,U., McCarroll,S., Landen,M., Scolnick,E.M., Magnusson,P.K.,
            Lichtenstein,P., Hultman,C.M., Purcell,S.M., Sklar,P. and
            Sullivan,P.F.
  TITLE     Genome-wide association study in a Swedish population yields
            support for greater CNV and MHC involvement in schizophrenia
            compared with bipolar disorder
  JOURNAL   Mol. Psychiatry 17 (9), 880-886 (2012)
   PUBMED   22688191
REFERENCE   2  (bases 1 to 3730)
  AUTHORS   Wang,K.S., Zhang,Q., Liu,X., Wu,L. and Zeng,M.
  TITLE     PKNOX2 is associated with formal thought disorder in schizophrenia:
            a meta-analysis of two genome-wide association studies
  JOURNAL   J. Mol. Neurosci. 48 (1), 265-272 (2012)
   PUBMED   22648509
  REMARK    GeneRIF: We identified four new loci (PKNOX2, MYH13, PHF2, and
            GPC6) associated with formal thought disorder in schizophrenia.
REFERENCE   3  (bases 1 to 3730)
  AUTHORS   Sanchez-Juan,P., Bishop,M.T., Aulchenko,Y.S., Brandel,J.P.,
            Rivadeneira,F., Struchalin,M., Lambert,J.C., Amouyel,P.,
            Combarros,O., Sainz,J., Carracedo,A., Uitterlinden,A.G., Hofman,A.,
            Zerr,I., Kretzschmar,H.A., Laplanche,J.L., Knight,R.S., Will,R.G.
            and van Duijn,C.M.
  TITLE     Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob
            risk
  JOURNAL   Neurobiol. Aging 33 (7), 1487 (2012)
   PUBMED   22137330
REFERENCE   4  (bases 1 to 3730)
  AUTHORS   Zuo,L., Zhang,F., Zhang,H., Zhang,X.Y., Wang,F., Li,C.S., Lu,L.,
            Hong,J., Lu,L., Krystal,J., Deng,H.W. and Luo,X.
  TITLE     Genome-wide search for replicable risk gene regions in alcohol and
            nicotine co-dependence
  JOURNAL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B (4), 437-444
            (2012)
   PUBMED   22488850
REFERENCE   5  (bases 1 to 3730)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 3730)
  AUTHORS   Chen,X., Cho,K., Singer,B.H. and Zhang,H.
  TITLE     PKNOX2 gene is significantly associated with substance dependence
            in European-origin women
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. (2009) In press
   PUBMED   19721000
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Available-Online prior to print
REFERENCE   7  (bases 1 to 3730)
  AUTHORS   Haller,K., Rambaldi,I., Daniels,E. and Featherstone,M.
  TITLE     Subcellular localization of multiple PREP2 isoforms is regulated by
            actin, tubulin, and nuclear export
  JOURNAL   J. Biol. Chem. 279 (47), 49384-49394 (2004)
   PUBMED   15339927
REFERENCE   8  (bases 1 to 3730)
  AUTHORS   Haller,K., Rambaldi,I., Kovacs,E.N., Daniels,E. and Featherstone,M.
  TITLE     Prep2: cloning and expression of a new prep family member
  JOURNAL   Dev. Dyn. 225 (3), 358-364 (2002)
   PUBMED   12412021
REFERENCE   9  (bases 1 to 3730)
  AUTHORS   Fognani,C., Kilstrup-Nielsen,C., Berthelsen,J., Ferretti,E.,
            Zappavigna,V. and Blasi,F.
  TITLE     Characterization of PREP2, a paralog of PREP1, which defines a
            novel sub-family of the MEINOX TALE homeodomain transcription
            factors
  JOURNAL   Nucleic Acids Res. 30 (9), 2043-2051 (2002)
   PUBMED   11972344
REFERENCE   10 (bases 1 to 3730)
  AUTHORS   Imoto,I., Sonoda,I., Yuki,Y. and Inazawa,J.
  TITLE     Identification and characterization of human PKNOX2, a novel
            homeobox-containing gene
  JOURNAL   Biochem. Biophys. Res. Commun. 287 (1), 270-276 (2001)
   PUBMED   11549286
  REMARK    GeneRIF: This novel PKNOX-related protein may interact with PBX
            proteins and play a role in tissue-specific regulation of
            transcription.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA789677.1, BC045626.1, AJ417081.1 and AP000708.5.
            On Oct 28, 2006 this sequence version replaced gi:11545768.
            
            Summary: Homeodomain proteins are sequence-specific transcription
            factors that share a highly conserved DNA-binding domain and play
            fundamental roles in cell proliferation, differentiation, and
            death. PKNOX2 belongs to the TALE (3-amino acid loop extension)
            class of homeodomain proteins characterized by a 3-amino acid
            extension between alpha helices 1 and 2 within the homeodomain
            (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045626.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DA789677.1         1-46
            47-898              BC045626.1         4-855
            899-2031            AJ417081.1         549-1681
            2032-3730           AP000708.5         13130-14828
FEATURES             Location/Qualifiers
     source          1..3730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..3730
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /note="PBX/knotted 1 homeobox 2"
                     /db_xref="GeneID:63876"
                     /db_xref="HGNC:16714"
                     /db_xref="MIM:613066"
     exon            1..114
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     exon            115..185
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     exon            186..292
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       288
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184874240"
     exon            293..401
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    303..305
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /note="upstream in-frame stop codon"
     CDS             315..1733
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /note="PBX/knotted homeobox 2; homeobox protein PREP-2"
                     /codon_start=1
                     /product="homeobox protein PKNOX2"
                     /protein_id="NP_071345.2"
                     /db_xref="GI:116812644"
                     /db_xref="CCDS:CCDS41730.1"
                     /db_xref="GeneID:63876"
                     /db_xref="HGNC:16714"
                     /db_xref="MIM:613066"
                     /translation="

MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQAMMAAHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEHSDSLE

"
     misc_feature    1179..1349
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1179..1193,1197..1199,1257..1259,1275..1277,
                     1314..1316,1320..1325,1332..1337,1341..1349)
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1185..1187,1194..1196,1323..1325,1332..1337,
                     1344..1346)
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       373
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371091100"
     variation       394
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201426611"
     exon            402..541
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       407
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373748561"
     variation       419
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144404502"
     variation       435
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371722377"
     variation       446
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:57996089"
     variation       464
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199784530"
     variation       483
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372013727"
     variation       492
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371325354"
     variation       495
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201213983"
     variation       529
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369949499"
     variation       533
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373837852"
     exon            542..713
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       548
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377588863"
     variation       565
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201383194"
     variation       566
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375711475"
     variation       621
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199787185"
     variation       622
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371099368"
     variation       642
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34936365"
     variation       678
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368618567"
     variation       678
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34882075"
     variation       689
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371925603"
     variation       690
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373672970"
     exon            714..902
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       746
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141113634"
     variation       752
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113674136"
     variation       758
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372330663"
     variation       810
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376830697"
     variation       825
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187602579"
     variation       830
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369895427"
     variation       845
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143626805"
     variation       855
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201952114"
     variation       865
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373391503"
     variation       875
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377342245"
     variation       891
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369269063"
     exon            903..1032
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       920
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374260796"
     variation       946
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377539931"
     variation       959
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199520187"
     variation       979
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201804321"
     variation       991
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371053622"
     exon            1033..1130
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       1052
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370466867"
     variation       1056
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373902784"
     variation       1060
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368034578"
     exon            1131..1250
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       1164
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200769767"
     variation       1208
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368680997"
     variation       1211
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200326885"
     variation       1217
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373185091"
     exon            1251..1327
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       1265
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375717927"
     variation       1302
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370272772"
     exon            1328..1506
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       1397
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375632728"
     variation       1405
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372781903"
     variation       1422
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374072981"
     variation       1454
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200196787"
     variation       1455
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368519080"
     variation       1457
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371748929"
     variation       1460
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374881222"
     variation       1482
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200590076"
     variation       1486
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372793703"
     variation       1503
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201127515"
     exon            1507..3730
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /inference="alignment:Splign:1.39.8"
     variation       1516
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376543915"
     variation       1523
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370967915"
     variation       1571
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141180751"
     variation       1574
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189283505"
     variation       1584
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370753546"
     variation       1589
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146936477"
     variation       1599
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377536771"
     variation       1638..1640
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="gag"
                     /db_xref="dbSNP:3832749"
     variation       1653
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="gag"
                     /db_xref="dbSNP:79349589"
     variation       1654..1656
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="agc"
                     /db_xref="dbSNP:201311184"
     variation       1654
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144494760"
     variation       1673
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371098213"
     variation       1674
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71474144"
     variation       1683
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375568838"
     variation       1697
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368620035"
     variation       1698
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372201456"
     variation       1716
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201663625"
     variation       1736
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367560539"
     variation       1738
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372145517"
     variation       1765
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375379902"
     variation       1770
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369226023"
     variation       1774
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372011173"
     variation       1798..1799
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:373983112"
     variation       1907
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182170552"
     variation       2032
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1630030"
     variation       2078
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185557835"
     variation       2097
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55782530"
     variation       2195
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147552831"
     variation       2221
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116112817"
     variation       2224
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:181691799"
     variation       2250
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1044314"
     variation       2345
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116580976"
     variation       2518
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372017664"
     STS             2560..2664
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /standard_name="A009E38"
                     /db_xref="UniSTS:11330"
     STS             2560..2664
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /standard_name="G32485"
                     /db_xref="UniSTS:117070"
     variation       2591..2592
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35969676"
     variation       2673
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10466606"
     variation       2894
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12421724"
     variation       2923
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3740893"
     variation       2976..2977
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="agg"
                     /db_xref="dbSNP:376748022"
     variation       3049
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:58726240"
     variation       3062
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186034974"
     variation       3167
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:645172"
     variation       3349
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141943333"
     variation       3413
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146208712"
     STS             3430..3722
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /standard_name="A004A26"
                     /db_xref="UniSTS:54874"
     variation       3455
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148271533"
     STS             3456..3646
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /standard_name="RH11980"
                     /db_xref="UniSTS:8464"
     variation       3467..3468
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:71680915"
     variation       3504
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74949805"
     variation       3517..3518
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:71682182"
     variation       3525
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78631085"
     variation       3535..3536
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace=""
                     /replace="ac"
                     /db_xref="dbSNP:149294918"
     variation       3639
                     /gene="PKNOX2"
                     /gene_synonym="PREP2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190406519"
ORIGIN

gtgtgaagggggggtccggggggcgggtccctgtgccgctgacgtcccgagcagtgctgggaagtataggctgtgttgtcacgccggtgtcagtctgatgaagattggcatcaggtgaagtctggagcaggacttctgaggctttctatcctccatgctgctcactagaaaaggggctgtgaactgtgctttggctctagcagacaggaagaaattctggcccagctggaagtagaaagaggggagtgagtctcctgaggaccatctcagaggccccgggatcacccgaacagtcctccatgtgaatcaatcccatgatgcaacatgcctccccagcccccgctctgacgatgatggccacgcagaatgtcccgcccccaccctaccaggacagcccacagatgacggcaaccgcccagccaccctccaaggcccaggctgtccacatctctgccccctcagctgctgccagcacacctgtgcccagtgcccccatcgacccccaggcccagctggaggctgacaagcgagctgtatacaggcaccctcttttcccgctcctgacgctgctgtttgagaaatgtgaacaggccacccagggctctgagtgcatcacctccgccagctttgatgtggacatcgagaactttgtccaccagcaggaacaggagcacaaacccttcttcagcgatgacccagaactggacaatctgatggtgaaggcaatccaggtcctgagaatccacctgctggagctggagaaagtcaatgaactctgcaaggacttttgtaaccgttacatcacctgcctcaaaaccaagatgcacagcgacaacctgctcaggaatgatctaggggggccctactcccccaaccagccctccatcaaccttcactcacaggacctcctgcagaattcccccaattccatgtccggagtctccaataacccccaggggattgtggtcccagcctcagcgctccagcagggcaacatcgccatgacaaccgtcaactcacaagttgtgtcaggtggagccttataccaaccggttaccatggtaacctcccagggtcaggtggtcacccaagcaatcccccagggagccatccagatccagaacacacaggttaaccttgacctcacctccctcctggacaatgaggataagaagtccaagaacaaacgaggagtcttgcccaagcatgccaccaatataatgcgttcttggctcttccagcatctcatgcacccctaccccacggaggatgagaagaggcagatcgcagcccagaccaacctcaccctcctgcaagtaaacaactggttcatcaatgcccggaggcgcatcctgcagcccatgcttgatgccagcaacccagatcctgcccccaaagccaagaagatcaagtctcagcaccggcccacccaaagattctggcccaactccatcgctgcgggggtgctgcagcagcagggcggtgccccagggacaaaccccgatggttccatcaacttggacaacctgcagtccctgtcctcagacagtgccaccatggccatgcagcaggctatgatggctgcacacgatgactcattggatgggacagaagaagaggatgaggatgagatggaagaggaggaggaggaggagctggaggaggaggtcgacgagctgcagacgacaaatgtcagcgacctgggcttggaacacagtgactccctggagtagtcgggcagcccagatggcactgatcactgagcaggagaggagtgtcgccgggaggccttcagggtgggggggaaggggacatgggcaggaagcaccgagggagttgggccctagcttccccaaatcagtagcttgaagaaaggcaaaggagacacctgttccttcccaaccaccgagcttcaatgaggaccccagccccacttccctggaactgccgaggactctgtttggcggggccagtcgagcagcctgtgtggaaagacaggagtgagatctggactcaccaaatccctgaggatagatggcacccatggcccccacccacggaaggacttgagttgtttacaagccctgcactgaggcagattggtgctgttcgcagagtaggcctttgcccgggggcagacttagaaggaaggggagagacaaagggggactgagtttcatccccagaagtttctcagctcctttgacagacattcaagggcaggagggagccccaaagcataaccagtggccagaggagtgggagggcctgaggcatcacatcttgcagatcagaatgggatggaatccaccaggctccagctcatccctccaaggccctgtctctgcgcacagcaaccatggacatgggagaaagggatgggagccacagtgcccttcactctctcctggaaaccaactgtaagctggtgggctcaacctgtgggaggttaagaggagtcccttctgggttgactccaagagccaaggagatggcagaccctgggctaggaaccatatggaggtgactttgaggccacagctgtccctaggtgatcacagaacttagctcctttaacaacaggacaatggttttttaccctagatgttcccaccttcagtgctccacgccctccatagaccttcagagaaggtgaaaccaggttatctgggaatctttccagcccgcaggtcgccacggccatccctttgctcccagcctggctccatcagcctccagcttcctttcttcattctgtccttcagggaaggcagaagaaacattggaaagcatctagtccagtgggaagccaggggttggagaaggtgctacatccctcttcccatcaatatcctaaatgtgggggagggcccagagaatggcacccaagagcctgcggggatgcccatcccacacaccccacccagctgttctaaccctgctatccacagccctggaggaactggggctcctggaaggaggaggaggctctccactgtccaccctaacacataccctcccacccaccttccagacccccttggttggcaccctctcctccggttccctctcaccccatggctgtgaatgacaggacaggtcacacgtgtgttttccattgggtttaatttaatggacgtgcagtttcatttgtaaattgtgcattggccacctccttcagtggcaggatgtgagtggctacctggctcaactggaggggaccccttgggccctctggggcttcccctcccccacctggttggggtagagcaaaaggatggtcactcttccgaggtctccctgaaatgaatgtatttctcccccaaaagagctgatatttaatgttttaataaggatttttgagaaacaaataaccttatttataatctgggtgatccaatcattttttactcccttttgatgccatacatagaggaaagtctagcttttttggcgtgagacttttgcaatgtgcagtgggataaaatgcatttccttttctggttcgtttttcttgttaacacgcgcacacagacacacacacacaccgttccactcaccacctggacaggcgtcccccagcacggacacactggcacacaggtgcccacatctcttcctctcagcccctccacctgcctaatgttatgcaacctccttctgatgtatccaccaaaccagtactgaatgtggccgagacgttttcagtaaatcttattacctaccgtaa

//

Annotations: