GGRNA | NM_020834.2

LOCUS       NM_020834               3741 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox and leucine zipper encoding (HOMEZ), mRNA.
ACCESSION   NM_020834 NM_001010849 XM_033391
VERSION     NM_020834.2  GI:158631176
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3741)
  AUTHORS   McGregor,T.L., Misri,A., Bartlett,J., Orabona,G., Friedman,R.D.,
            Sexton,D., Maheshwari,S. and Morgan,T.M.
  TITLE     Consanguinity mapping of congenital heart disease in a South Indian
            population
  JOURNAL   PLoS ONE 5 (4), E10286 (2010)
   PUBMED   20422016
  REMARK    GeneRIF: no single gene of major effect could be convincingly
            identified in a sample of Indian CHD cases born to consanguineous
            parents. The possibility that noncoding regions of HOMEZ may harbor
            recessive mutations leading to CHD could not be excluded.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3741)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   3  (bases 1 to 3741)
  AUTHORS   Bayarsaihan,D., Enkhmandakh,B., Makeyev,A., Greally,J.M.,
            Leckman,J.F. and Ruddle,F.H.
  TITLE     Homez, a homeobox leucine zipper gene specific to the vertebrate
            lineage
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (18), 10358-10363 (2003)
   PUBMED   12925734
REFERENCE   4  (bases 1 to 3741)
  AUTHORS   Ceulemans,H., Stalmans,W. and Bollen,M.
  TITLE     Regulator-driven functional diversification of protein
            phosphatase-1 in eukaryotic evolution
  JOURNAL   Bioessays 24 (4), 371-381 (2002)
   PUBMED   11948623
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC398645.1, AF463523.1 and BC045733.1.
            On Oct 24, 2007 this sequence version replaced gi:29789117.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF463523.1, AB037864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DC398645.1         18-93
            77-315              AF463523.1         1-239
            316-1051            BC045733.1         162-897
            1052-1755           AF463523.1         976-1679
            1756-1905           BC045733.1         1601-1750
            1906-3741           AF463523.1         1827-3662
FEATURES             Location/Qualifiers
     source          1..3741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3741
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="homeobox and leucine zipper encoding"
                     /db_xref="GeneID:57594"
                     /db_xref="HGNC:20164"
                     /db_xref="MIM:608119"
     exon            1..188
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /inference="alignment:Splign:1.39.8"
     CDS             149..1801
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="homeodomain leucine zipper-containing factor"
                     /codon_start=1
                     /product="homeobox and leucine zipper protein Homez"
                     /protein_id="NP_065885.2"
                     /db_xref="GI:158631177"
                     /db_xref="CCDS:CCDS45085.1"
                     /db_xref="GeneID:57594"
                     /db_xref="HGNC:20164"
                     /db_xref="MIM:608119"
                     /translation="

MVRGWEPPPGLDCAISEGHKSEGTMPPNKEASGLSSSPAGLICLPPISEELQLVWTQAAQTSELDSNEHLLKTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYRRDQLHFKSLLSFTHHAGRPPEEVPPPPVPAPEQVGIGIGPPTLSKPTQTKGLKVEPEEPSQMPPLPQSHQKLKESLMTPGSGAFPYQSDFWQHLQSSGLSKEQAGRGPNQSHGIGTASWNHSTTVPQPQARDKPPPIALIASSCKEESASSVTPSSSSTSSSFQVLANGATAASKPLQPLGCVPQSVSPSEQALPPHLEPAWPQGLRHNSVPGRVGPTEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYQKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAIPTPPPSTRSLNERAETPPLPIPPPPPDIQPLERYWAAHQQLRETDIPQLSQASRLSTQQVLDWFDSRLPQPAEVVVCLDEEEEEEEEELPEDDEEEEEEEEEDDDDDDDDVIIQD

"
     misc_feature    341..490
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(383..385,401..403,440..442,446..451,458..463,
                     467..475,479..484)
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(449..451,458..463,470..472)
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1220..1237
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX15.2);
                     Region: Nuclear localization signal (Potential)"
     misc_feature    1244..1393
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1286..1288,1304..1306,1343..1345,1349..1354,
                     1361..1366,1370..1378,1382..1387)
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1352..1354,1361..1366,1373..1375)
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    <1547..1675
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /note="Homeodomain leucine-zipper encoding, Homez; Region:
                     Homez; pfam11569"
                     /db_xref="CDD:152005"
     exon            189..3741
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /inference="alignment:Splign:1.39.8"
     variation       1653
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1055061"
     variation       1762
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3208861"
     STS             2556..2645
                     /gene="HOMEZ"
                     /gene_synonym="KIAA1443"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
ORIGIN

ctgggtagaccggcgcgctcccggggacggtggggggggcagtcccggtttcggccatcgctggggtgggctcggagcggccgcaccgggcagcaaccccactcccactcggaggccccctgccctctcccccacttccccccggcccatggtgcgaggctgggagccgccgcccgggctggactgcgctatctctgaagggcacaaatcagaaggcaccatgcctcctaataaagaggccagcggtctcagtagttcaccagcggggctcatctgcctccctccaatctctgaggagctacagcttgtgtggacgcaagcagcccagaccagtgagctagacagcaatgaacacctgctcaaaaccttcagctactttccctatcccagcctagcagacattgcccttctctgcctacgttatgggttgcagatggagaaagtcaagacttggtttatggcccagcgcctccgctgtggtattagctggtcatctgaagaaatagaagagactcgagcccgagtagtctaccgtcgggaccaactccatttcaaatcccttctctcttttactcatcatgcgggacggcccccagaggaggtgcctcctcctccagtgccagctccagagcaagttggtattggaataggtcctccaactcttagcaagcctacccagacgaaaggattgaaggtagagcctgaggagccctctcagatgccaccactgccacagagtcaccagaaattaaaggagtccctgatgacacctggcagtggagcattcccctaccaatcagatttttggcaacatcttcaaagcagtggcctctcaaaggagcaggcaggcaggggtcccaaccagtcacatggcataggtactgcttcctggaaccactccacaaccgtcccccagccacaagctcgggataaacccccaccaattgcattaattgccagtagttgtaaggaggagtcagcatctagtgttactccctcttcttcctctacctcttcttctttccaggtactggctaatggagctactgccgcctctaaacccctccagccactaggctgtgtcccacagtcagtgtcacccagtgaacaggcattacccccacatctggaaccagcctggccccaagggctacggcataactcagtaccaggtagagttggccccacagagtacctttccccagatatgcaacgccagcgaaagaccaagcgcaaaaccaaagagcagctggctatccttaaatccttttttttacagtgccagtgggcacggcgtgaggattaccaaaagttagaacagatcactggtttacctcggcctgagatcattcagtggtttggtgacacacgctatgccttgaagcatgggcaactaaagtggtttcgggacaacgcagtacctggtgcccctagtttccaagacccagcaattcctacaccaccaccatcaacccgctccttgaacgaaagggctgagacaccacctctgccgatccctccacccccaccggatatacaacccttggagaggtactgggcagcccaccaacagctacgggaaactgatatccctcaattgagtcaggcatcaaggcttagcacccagcaggtgctggattggtttgactctcgattacctcagccagctgaggtggtagtttgtctagatgaagaagaggaagaggaggaggaagaactgccagaagatgatgaggaagaggaggaggaggaggaggaagatgatgatgatgatgatgatgatgtgatcatacaagactgagtggggagctgggggaggggaggtctgttactgaaagatgaaccaacttagtaactgtttaaacaaagaaaccacatttttaaaattaccttgtggcagagaactaaaaagctttgtgttcttcagggtgggtggcagggggatatagtgagggtggaccagggagaatgaccatagggcactaagtaaggctgggattggatcagcagaaatccaaccctctaaccttagggtagggagtgctaaggatctggggaaaccatgggctgggaagctgctcttgctctcctcgtgtctgctgtttttttcccttggtgtactatacagaggccagatgttggcaccacctctccaggaggattggaaaggaggagtaaaggattctgatttgattgatgattccagtgcatccccaatcccaccatcttacctggaatataaggctgccttgtaccccttttctgagcacaagtctgtgcgtaatgcaactgactctcttacttttttcttagtaactgatcatttcctagacaaccaagattctcaataagtcccagtctcatcacaaatattaatatttccttttcctcataccaacttgactatgtttcacccgcttcatgactaaatcacaggtggcagaatttttcagttcttttttttttttttgaggtggagtcttgctctgtcgcccaggctgtagtgcaatggcgcaatctcagctcactgcaagctccgcctcccaggttcatgccattctcctgcctcagcctcccgagtagctgggactacaggcacctgccaccacacccggctacttttttatatttttagtagagacgggtttcatcatgttagccaggatggtcttgatctcctgacctcatgatccgcccaccttggcctcccaaagtgctgggattataggcatgagccaccgtgcccggctattttcagttcttatgctgtgaccactttgccttgtagctttttctatctttccaaaatcctcactctgttcattgtttgtctcagggaaaatcttcccccaccgagcttgtaaaaaactttaataattgggtggagaataatttagaatggatatttattggaggtggtaattagggaagatgtccttttaaacagtagaattgtgttacaaaggggtgaaagagagggaatagtttctccttgttgaagggcagtgaaggtaggtttcaggtttggttttacaaacctgttaactacctcctgtccagcttgacagagactaatttttcatctttttgctgtcaatttgtttccagaaaagagacttttccctctcttgataggatctgtcttagggacagagggaccatcgtctttaagtgaattaattattgatgttttagaatggttttcatcagttgggatcagctatatggcaaataggtatcatcaatgagttaaccatctaaaaataaaagagtggaagccctaaaatgctagaataataataaaaaggccaaaaataaaattgtttctctctcaaccactttgccactcctatggtttagggattaatggaaccaaatccattaacattctaactcagcatacttttaacttattgtttggaggggcaggacttattgaggtaaattaaaagaacaaaaactgtaaaaaggaagtagttcagcatctatcgccagccaggttgtttctcagccatcaaatgataatgactaaaatttctgaggcttcaggagtaacagagatacaacagtcttggaggtaactccatttgctacaggacaggcccttgcctaaaagagaaggtatctagaaatgcctttaaaataaattcagagtaccagaaagggtatggggatcctagttcagatacaagatcattcccaagacctaatttatttctggcagatgcctgctattttctg

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