GGRNA | NM_014620.4

LOCUS       NM_014620               2300 bp    mRNA    linear   PRI 15-APR-2013
DEFINITION  Homo sapiens homeobox C4 (HOXC4), transcript variant 1, mRNA.
ACCESSION   NM_014620
VERSION     NM_014620.4  GI:100349236
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2300)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat. Genet. 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2300)
  AUTHORS   Auvray,C., Delahaye,A., Pflumio,F., Haddad,R., Amsellem,S.,
            Miri-Nezhad,A., Broix,L., Yacia,A., Bulle,F., Fichelson,S. and
            Vigon,I.
  TITLE     HOXC4 homeoprotein efficiently expands human hematopoietic stem
            cells and triggers similar molecular alterations as HOXB4
  JOURNAL   Haematologica 97 (2), 168-178 (2012)
   PUBMED   22298821
  REMARK    GeneRIF: HOXC4 homeoprotein expands human hematopoietic immature
            cells by 3 to 6 times ex vivo and significantly improves the level
            of in vivo engraftment.
REFERENCE   3  (bases 1 to 2300)
  AUTHORS   Mai,T., Zan,H., Zhang,J., Hawkins,J.S., Xu,Z. and Casali,P.
  TITLE     Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to
            potentiate HoxC4-mediated activation-induced cytosine deaminase
            induction, immunoglobulin class switch DNA recombination, and
            somatic hypermutation
  JOURNAL   J. Biol. Chem. 285 (48), 37797-37810 (2010)
   PUBMED   20855884
  REMARK    GeneRIF: Esr1 bind to and activate the HOXC4 promoter to potentiate
            HoxC4-mediated AID induction, immunoglobulin class switch and
            somatic hypermutation.
REFERENCE   4  (bases 1 to 2300)
  AUTHORS   Park,S.R., Zan,H., Pal,Z., Zhang,J., Al-Qahtani,A., Pone,E.J.,
            Xu,Z., Mai,T. and Casali,P.
  TITLE     HoxC4 binds to the promoter of the cytidine deaminase AID gene to
            induce AID expression, class-switch DNA recombination and somatic
            hypermutation
  JOURNAL   Nat. Immunol. 10 (5), 540-550 (2009)
   PUBMED   19363484
  REMARK    GeneRIF: HoxC4 directly activates the Aicda promoter
REFERENCE   5  (bases 1 to 2300)
  AUTHORS   Feng,J.Q., Liu,W.J., Chen,H.Y., Guo,Q.L., Chen,A. and Chen,S.Q.
  TITLE     [Effect of human cytomegalovirus infection on the expression of
            hoxc4 and hoxc6 genes in the proliferation of lymphocytic
            progenitor cells]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 17 (1), 141-145 (2009)
   PUBMED   19236766
  REMARK    GeneRIF: Human cytomegalovirus downregulates while all-trans
            retinoic acid upregulates expression of hoxc4 and hoxc6 in
            lymphocytic progenitor cells.
REFERENCE   6  (bases 1 to 2300)
  AUTHORS   Meazza,R., Faiella,A., Corsetti,M.T., Airoldi,I., Ferrini,S.,
            Boncinelli,E. and Corte,G.
  TITLE     Expression of HOXC4 homeoprotein in the nucleus of activated human
            lymphocytes
  JOURNAL   Blood 85 (8), 2084-2090 (1995)
   PUBMED   7718879
REFERENCE   7  (bases 1 to 2300)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   8  (bases 1 to 2300)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
REFERENCE   9  (bases 1 to 2300)
  AUTHORS   Simeone,A., Pannese,M., Acampora,D., D'Esposito,M. and
            Boncinelli,E.
  TITLE     At least three human homeoboxes on chromosome 12 belong to the same
            transcription unit
  JOURNAL   Nucleic Acids Res. 16 (12), 5379-5390 (1988)
   PUBMED   2898768
REFERENCE   10 (bases 1 to 2300)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA905719.1, X07495.1,
            BC050442.1, AC023794.37 and AA331371.1.
            This sequence is a reference standard in the RefSeqGene project.
            On May 24, 2006 this sequence version replaced gi:93141220.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene, HOXC4, is one of several homeobox HOXC genes located in a
            cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6,
            share a 5' non-coding exon. Transcripts may include the shared exon
            spliced to the gene-specific exons, or they may include only the
            gene-specific exons. Two alternatively spliced variants that encode
            the same protein have been described for HOXC4. Transcript variant
            one includes the shared exon, and transcript variant two includes
            only gene-specific exons. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X07495.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               DA905719.1         2-504
            504-1160            X07495.1           431-1087
            1161-1580           BC050442.1         527-946
            1581-2266           AC023794.37        22971-23656
            2267-2300           AA331371.1         193-226
FEATURES             Location/Qualifiers
     source          1..2300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..2300
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="homeobox C4"
                     /db_xref="GeneID:3221"
                     /db_xref="HGNC:5126"
                     /db_xref="MIM:142974"
     exon            1..557
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /inference="alignment:Splign:1.39.8"
     variation       288
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74568890"
     variation       360
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3736210"
     variation       361
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4133943"
     variation       376
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4101168"
     variation       510..511
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="ga"
                     /db_xref="dbSNP:375826581"
     misc_feature    543..545
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="upstream in-frame stop codon"
     exon            558..674
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /inference="alignment:Splign:1.39.8"
     variation       608
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191711164"
     variation       627
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2277372"
     exon            675..1119
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /inference="alignment:Splign:1.39.8"
     CDS             681..1475
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="homeo box C4; homeo box 3E; homeobox protein CP19;
                     homeobox protein Hox-3E"
                     /codon_start=1
                     /product="homeobox protein Hox-C4"
                     /protein_id="NP_055435.2"
                     /db_xref="GI:24497538"
                     /db_xref="CCDS:CCDS8873.1"
                     /db_xref="GeneID:3221"
                     /db_xref="HGNC:5126"
                     /db_xref="MIM:142974"
                     /translation="

MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL

"
     misc_feature    1083..1100
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09017.2);
                     Region: Antp-type hexapeptide"
     misc_feature    1149..1325
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1149..1163,1167..1169,1218..1220,1236..1238,
                     1275..1277,1281..1286,1293..1298,1302..1310,1314..1319)
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1155..1157,1164..1166,1284..1286,1293..1298,
                     1305..1307)
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       713
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377491433"
     variation       720
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370651700"
     variation       725
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201246146"
     variation       742
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375540278"
     variation       855
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201031063"
     variation       868
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368312732"
     variation       886
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148305568"
     variation       905
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200135426"
     variation       937
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369142454"
     STS             941..1472
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /standard_name="Hoxc4"
                     /db_xref="UniSTS:143389"
     variation       954
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141526599"
     variation       964
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371650916"
     variation       995
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375090194"
     variation       996
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201787571"
     variation       1019
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147020678"
     variation       1049
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138201582"
     STS             1068..1288
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /standard_name="HOX3A"
                     /db_xref="UniSTS:266290"
     STS             1075..1216
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /standard_name="Hoxc4"
                     /db_xref="UniSTS:536661"
     variation       1080
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75256744"
     variation       1089
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200182829"
     variation       1091
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150564642"
     exon            1120..2300
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /inference="alignment:Splign:1.39.8"
     variation       1129
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17854635"
     variation       1145
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372733424"
     variation       1147
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200589330"
     variation       1152
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200111255"
     variation       1153
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11835301"
     variation       1178
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374693094"
     variation       1213
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35406888"
     variation       1315
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144484338"
     variation       1319
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367700740"
     variation       1323
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201279056"
     variation       1331
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139130458"
     variation       1339
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199886486"
     variation       1387
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199538004"
     variation       1398
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371537421"
     variation       1404
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375884273"
     variation       1555..1556
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:71444831"
     variation       1556..1557
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:72272573"
     variation       1581..1582
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="ta"
                     /db_xref="dbSNP:60894549"
     variation       1582..1583
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="ta"
                     /db_xref="dbSNP:71070803"
     variation       1612
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113651547"
     variation       1648
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138869843"
     variation       1733..1734
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:199529607"
     variation       1795
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76297541"
     variation       1908
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:67954156"
     variation       1908
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368226822"
     variation       1914
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="c"
                     /replace="ggatgggatg"
                     /db_xref="dbSNP:11362453"
     variation       1915
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:199756525"
     variation       2017..2018
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:376243618"
     variation       2018
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:11362454"
     variation       2027
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200962735"
     variation       2029
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:201221665"
     variation       2145
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:45448092"
     variation       2179
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117223623"
     variation       2209
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11554014"
     variation       2262
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45625633"
     polyA_signal    2272..2277
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
     polyA_site      2300
                     /gene="HOXC4"
                     /gene_synonym="cp19; HOX3; HOX3E"
ORIGIN

ttattgtggtttgtccgttccgagcgctccgcagaacagtcctccctgtaagagcctaaccattgccagggaaacctgccctgggcgctcccttcattagcagtattttttttaaattaatctgattaataattatttttcccccatttaattttttttcctcccaggtggagttgccgaagctgggggcagctggggagggtggggatgggaggggagagacagaagttgagggcatctctctcttccttcccgaccctctggcccccaaggggcaggaggaatgcaggagcaggagttgagcttgggagctgcagatgcctccgcccctcctctctcccaggctcttcctcctgcccccttcttgcaactctccttaattttgtttggcttttggatgattataattatttttatttttgaatttatataaagtatatgtgtgtgtgtgtggagctgagacaggctcggcagcggcacagaatgagggaagacgagaaagagagtgggagagagagaggcagagagggagagagggagagtgacagcagcgctcgcgggggctcaacccccagacctccagaaatgacgtcagaatcatttgcatcccgctgcctctacctgcctggtccagctgggaccctgcctcgccggccgcatggccagagggttggaaattaatgatcatgagctcgtatttgatggactctaactacatcgatccgaaatttcctccatgcgaagaatattcgcaaaatagctacatccctgaacacagtccggaatattacggccggaccagggaatcgggattccagcatcaccaccaggagctgtacccaccaccgcctccgcgccctagctaccctgagcgccagtatagctgcaccagtctccaggggcccggcaattcgcgaggccacgggccggcccaggcgggccaccaccaccccgagaaatcacagtcgctctgcgagccggcgcctctctcaggcgcctccgcctccccgtccccagccccgccagcctgcagccagccagcccccgaccatccctccagcgccgccagcaagcaacccatagtctacccatggatgaaaaaaattcacgttagcacggtgaaccccaattataacggaggggaacccaagcgctcgaggacagcctatacccggcagcaagtcctggaattagagaaagagtttcattacaaccgctacctgacccgaaggagaaggatcgagatcgcccactcgctgtgcctctctgagaggcagatcaaaatctggttccaaaaccgtcgcatgaaatggaagaaggaccaccgactccccaacaccaaagtcaggtcagcacccccggccggcgctgcgcccagcaccctttcggcagctaccccgggtacttctgaagaccactcccagagcgccacgccgccggagcagcaacgggcagaggacattaccaggttataaaacataactcacacccctgcccccaccccatgcccccaccctcccctcacacacaaattgactcttatttatagaatttaatatatatatatatatatatatatataggttcttttctctcttcctctcaccttgtcccttgtcagttccaaacagacaaaacagataaacaaacaagccccctgccctcctctccctcccactgttaaggacccttttaagcatgtgatgttgtcttagcatggtacctgctgggtgtttttttttaaaaggccattttggggggttatttattttttaagaaaaaaagctgcaaaaattatatattgcaaggtgtgatggtctggcttgggtgaatttcaggggaaatgaggaaaagaaaaaaggaaagaaattttaaagccaattctcatccttctcctcctcctccttccccccctctttccttaggccttttgcattgaaaatgcaccaggggaggttagtgagggggaagtcattttaaggagaacaaagctatgaagttcttttgtattattgttgggggggggtgtgggaggagagggggcgaagacagcagacaaagctaaatgcatctggagagcctctcagagctgttcagtttgaggagccaaaagaaaatcaaaatgaactttcagttcagagaggcagtctataggtagaatctctccccacccctatcgtggttattgtgtttttggactgaatttacttgattattgtaaaacttgcaataaagaattttagtgtcgatgtgaaatgccccgtgatcaataataaaccagtggatgtgaattagtttta

//

Annotations: