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2025-05-09 19:35:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_012474 4940 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens uridine-cytidine kinase 2 (UCK2), mRNA.
ACCESSION NM_012474
VERSION NM_012474.4 GI:315360639
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4940)
AUTHORS Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
TITLE Follow-up of a major linkage peak on chromosome 1 reveals
suggestive QTLs associated with essential hypertension: GenNet
study
JOURNAL Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)
PUBMED 19536175
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (bases 1 to 4940)
AUTHORS Smith,A.J., Li,Y. and Houk,K.N.
TITLE Quantum mechanics/molecular mechanics investigation of the
mechanism of phosphate transfer in human uridine-cytidine kinase 2
JOURNAL Org. Biomol. Chem. 7 (13), 2716-2724 (2009)
PUBMED 19532987
REMARK GeneRIF: The mechanism of phosphate transfer in UCK2 is shown to be
concerted, and is accompanied by concerted proton transfer from the
5'-hydroxyl to a conserved active site aspartic acid that serves as
a catalytic base
REFERENCE 3 (bases 1 to 4940)
AUTHORS Rapley,E.A., Turnbull,C., Al Olama,A.A., Dermitzakis,E.T.,
Linger,R., Huddart,R.A., Renwick,A., Hughes,D., Hines,S., Seal,S.,
Morrison,J., Nsengimana,J., Deloukas,P., Rahman,N., Bishop,D.T.,
Easton,D.F. and Stratton,M.R.
CONSRTM UK Testicular Cancer Collaboration
TITLE A genome-wide association study of testicular germ cell tumor
JOURNAL Nat. Genet. 41 (7), 807-810 (2009)
PUBMED 19483681
REFERENCE 4 (bases 1 to 4940)
AUTHORS Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
TITLE Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
genetic association with bone mineral density variation
JOURNAL Hum. Mol. Genet. 18 (4), 679-687 (2009)
PUBMED 19064610
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 4940)
AUTHORS Suzuki,N.N., Koizumi,K., Fukushima,M., Matsuda,A. and Inagaki,F.
TITLE Structural basis for the specificity, catalysis, and regulation of
human uridine-cytidine kinase
JOURNAL Structure 12 (5), 751-764 (2004)
PUBMED 15130468
REFERENCE 6 (bases 1 to 4940)
AUTHORS Suzuki,N.N., Koizumi,K., Fukushima,M., Matsuda,A. and Inagaki,F.
TITLE Crystallization and preliminary X-ray analysis of human
uridine-cytidine kinase 2
JOURNAL Acta Crystallogr. D Biol. Crystallogr. 59 (PT 8), 1477-1478 (2003)
PUBMED 12876357
REFERENCE 7 (bases 1 to 4940)
AUTHORS Kashuba,E., Kashuba,V., Sandalova,T., Klein,G. and Szekely,L.
TITLE Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel
human uridine kinase/uracil phosphoribosyltransferase
JOURNAL BMC Cell Biol. 3, 23 (2002)
PUBMED 12199906
REMARK GeneRIF: Increased intranuclear levels of UK may contribute to the
metabolic build-up that is needed for Epstein-Barr virus nuclear
protein EBNA-3-mediated B-cell blast transformation and rapid
proliferation.
REFERENCE 8 (bases 1 to 4940)
AUTHORS Koizumi,K., Shimamoto,Y., Azuma,A., Wataya,Y., Matsuda,A.,
Sasaki,T. and Fukushima,M.
TITLE Cloning and expression of uridine/cytidine kinase cDNA from human
fibrosarcoma cells
JOURNAL Int. J. Mol. Med. 8 (3), 273-278 (2001)
PUBMED 11494055
REFERENCE 9 (bases 1 to 4940)
AUTHORS Van Rompay,A.R., Norda,A., Linden,K., Johansson,M. and Karlsson,A.
TITLE Phosphorylation of uridine and cytidine nucleoside analogs by two
human uridine-cytidine kinases
JOURNAL Mol. Pharmacol. 59 (5), 1181-1186 (2001)
PUBMED 11306702
REFERENCE 10 (bases 1 to 4940)
AUTHORS Ozaki,K., Kuroki,T., Hayashi,S. and Nakamura,Y.
TITLE Isolation of three testis-specific genes (TSA303, TSA806, TSA903)
by a differential mRNA display method
JOURNAL Genomics 36 (2), 316-319 (1996)
PUBMED 8812458
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DR762696.1, BC002906.2,
AL358115.18 and BM714864.1.
On Dec 22, 2010 this sequence version replaced gi:20357519.
Summary: This gene encodes a pyrimidine ribonucleoside kinase. The
encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine
and cytidine to uridine monophosphate (UMP) and cytidine
monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC002906.2, AF236637.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-160 DR762696.1 1-160
161-1342 BC002906.2 1-1182
1343-4448 AL358115.18 74751-77856
4449-4940 BM714864.1 1-492
FEATURES Location/Qualifiers
source 1..4940
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q23"
gene 1..4940
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/note="uridine-cytidine kinase 2"
/db_xref="GeneID:7371"
/db_xref="HGNC:12562"
/db_xref="HPRD:01882"
/db_xref="MIM:609329"
exon 1..438
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/inference="alignment:Splign:1.39.8"
variation 120
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:190341677"
misc_feature 121..123
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/note="upstream in-frame stop codon"
variation 175
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:115230060"
variation 303
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:368846066"
CDS 340..1125
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/EC_number="2.7.1.48"
/note="uridine monophosphate kinase; uridine kinase;
uridine monophosphokinase 2; cytidine monophosphokinase 2;
testis-specific protein TSA903"
/codon_start=1
/product="uridine-cytidine kinase 2"
/protein_id="NP_036606.2"
/db_xref="GI:18699734"
/db_xref="CCDS:CCDS1252.1"
/db_xref="GeneID:7371"
/db_xref="HGNC:12562"
/db_xref="HPRD:01882"
/db_xref="MIM:609329"
/translation="
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNGCLNGYTPSRKRQASESSSRPH
"
misc_feature 397..1029
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/note="Uridine kinase [Nucleotide transport and
metabolism]; Region: Udk; COG0572"
/db_xref="CDD:30917"
misc_feature 403..1023
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/note="Uridine monophosphate kinase (UMPK, EC 2.7.1.48),
also known as uridine kinase or uridine-cytidine kinase
(UCK), catalyzes the reversible phosphoryl transfer from
ATP to uridine or cytidine to yield UMP or CMP. In the
primidine nucleotide-salvage pathway; Region: UMPK;
cd02023"
/db_xref="CDD:30196"
misc_feature order(439..441,832..834,976..978)
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:30196"
misc_feature order(523..525,595..597,835..837)
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/note="Sugar specificity; other site"
/db_xref="CDD:30196"
misc_feature order(532..534,586..588,673..675,679..681,688..690,
859..861)
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/note="Pyrimidine base specificity; other site"
/db_xref="CDD:30196"
misc_feature 1099..1101
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9BZX2.1); phosphorylation site"
misc_feature 1099..1101
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1105..1107
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 345
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:373091415"
variation 357
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200215834"
exon 439..598
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/inference="alignment:Splign:1.39.8"
variation 480
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:145654595"
variation 516
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:141107003"
variation 547
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:202192250"
variation 597
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:201530212"
exon 599..695
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/inference="alignment:Splign:1.39.8"
variation 634
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="c"
/db_xref="dbSNP:371392087"
variation 661
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="g"
/db_xref="dbSNP:143841296"
variation 669
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:145861792"
variation 672
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:142685133"
variation 682
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:368137874"
exon 696..838
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/inference="alignment:Splign:1.39.8"
variation 705
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:148472193"
variation 729
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:201608728"
variation 747
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553301"
variation 772
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:376379718"
variation 790
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:202146527"
variation 826
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:371214695"
variation 828
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:374202462"
exon 839..936
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/inference="alignment:Splign:1.39.8"
variation 869
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:74547287"
variation 876
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:143431109"
variation 888
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="t"
/db_xref="dbSNP:139644703"
variation 899
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:36009659"
variation 900
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:372509507"
exon 937..985
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/inference="alignment:Splign:1.39.8"
variation 963
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:142462793"
exon 986..4920
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/inference="alignment:Splign:1.39.8"
variation 1068
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:113225450"
variation 1070
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:369193672"
STS 1098..1198
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/standard_name="SHGC-35183"
/db_xref="UniSTS:56221"
variation 1119
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:181344751"
variation 1133
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="c"
/db_xref="dbSNP:373729839"
variation 1137
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:376173567"
variation 1174
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:371155276"
variation 1211
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:186355028"
variation 1299
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:372660120"
variation 1315
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1803412"
variation 1322
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:375892713"
variation 1393..1394
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace=""
/replace="at"
/db_xref="dbSNP:373607708"
variation 1401
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:190810296"
variation 1404
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="t"
/db_xref="dbSNP:149714727"
variation 1421
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:369163617"
variation 1455
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:372943164"
variation 1619
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:182607978"
variation 1626
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:145546186"
variation 1640
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:536109"
variation 1725
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:140354224"
variation 1730
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:377214990"
variation 1736
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace=""
/replace="t"
/db_xref="dbSNP:56051802"
variation 1816
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:3748699"
variation 1854
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:36046806"
variation 2020
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="g"
/db_xref="dbSNP:188945704"
variation 2053
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:375766144"
variation 2055
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:75605140"
variation 2127
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:376980450"
variation 2134
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:190979239"
variation 2152
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:370280739"
variation 2182
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:200883761"
variation 2268
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:140792557"
variation 2290
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:117653364"
variation 2340
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="c"
/db_xref="dbSNP:3748700"
variation 2485
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:77487347"
variation 2563
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:506813"
variation 2631
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:374616971"
variation 2634
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:183143838"
variation 2792
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="g"
/db_xref="dbSNP:187599811"
variation 2804
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:192020974"
variation 2866
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace=""
/replace="c"
/db_xref="dbSNP:149291837"
variation 2868
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:184810328"
variation 2904
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:188082190"
variation 2905
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:41268534"
variation 2976
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:73031476"
variation 3027
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:41268536"
variation 3068
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:75772084"
variation 3085
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:480813"
variation 3127
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:480050"
variation 3237
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:148214528"
variation 3323
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="g"
/db_xref="dbSNP:192513246"
variation 3344
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:117267370"
variation 3414
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="g"
/replace="t"
/db_xref="dbSNP:11553299"
STS 3473..3605
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/standard_name="RH64600"
/db_xref="UniSTS:72824"
variation 3500
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:11553300"
variation 3687
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="c"
/db_xref="dbSNP:6426943"
variation 3732..3735
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace=""
/replace="ccct"
/db_xref="dbSNP:201881487"
variation 3797
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:184430213"
variation 3869
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:114492158"
variation 3872
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:140232724"
variation 3886
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:74118943"
variation 3910
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:79405236"
variation 3950
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="g"
/db_xref="dbSNP:150328003"
variation 3956
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:3748701"
variation 4052
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:41268540"
variation 4096
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:512542"
variation 4176
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:526374"
variation 4217
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:189453779"
variation 4244
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:372833836"
variation 4259
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:76050847"
variation 4287
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="g"
/db_xref="dbSNP:181809069"
variation 4322..4323
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace=""
/replace="c"
/db_xref="dbSNP:35083147"
variation 4353
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="c"
/db_xref="dbSNP:184597139"
variation 4386
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="g"
/db_xref="dbSNP:115416192"
variation 4474
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:143219806"
variation 4490
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:374957170"
variation 4495
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:73031485"
STS 4569..4733
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/standard_name="RH79046"
/db_xref="UniSTS:33434"
variation 4734
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:520858"
variation 4749
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:138594097"
variation 4767
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:188988603"
STS 4771..4872
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/standard_name="A002B18"
/db_xref="UniSTS:40975"
STS 4771..4872
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/standard_name="G19886"
/db_xref="UniSTS:40974"
variation 4781
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:149556199"
variation 4792
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace=""
/replace="t"
/db_xref="dbSNP:377475662"
variation 4799
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="c"
/replace="t"
/db_xref="dbSNP:3209564"
variation 4864
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="g"
/db_xref="dbSNP:181622462"
polyA_signal 4900..4905
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
variation 4907
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="c"
/db_xref="dbSNP:1132125"
polyA_site 4920
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
variation 4920
/gene="UCK2"
/gene_synonym="TSA903; UK; UMPK"
/replace="a"
/replace="c"
/db_xref="dbSNP:3180503"
ORIGIN
cggggcccgggaggggcggaggctggggccagacgcctcgccgcctccgcctcggcgaatagcagcgcgctgcccgcccggattggagcagcagcatcacgctgacctctgcctgggatgtaaaccggaccagccgctgcgggcaaaggaaggctcttggctccttcgggaaacccagccccgtcaccgggctccgagcggctcgcaggcgagcgacagcggcctcagccccggcagcgcccagcggcggctgcggaaagcggagggagtccgacgcgggcgcgggcggggagcgtgcgtccgttcgcacaggcagcgggaggaggggcggcgcgaaccatggccggggacagcgagcagaccctgcagaaccaccagcagcccaacggcggcgagcccttccttataggcgtcagcgggggaacagctagcggcaagtcttccgtgtgtgctaagatcgtgcagctcctggggcagaatgaggtggactatcgccagaagcaggtggtcatcctgagccaggatagcttctaccgtgtccttacctcggagcagaaggccaaagccctgaagggccagttcaactttgaccacccggatgcctttgacaatgaactcattctcaaaacactcaaagaaatcactgaagggaaaacagtccagatccccgtgtatgactttgtctcccattcccggaaggaggagacagttactgtctatcccgcagacgtggtgctctttgaagggatcctggccttctactcccaggaggtacgagacctgttccagatgaagctttttgtggatacagatgcggacacccggctctcacgcagagtattaagggacatcagcgagagaggcagggatcttgagcagattttatctcagtacattacgttcgtcaagcctgcctttgaggaattctgcttgccaacaaagaagtatgctgatgtgatcatccctagaggtgcagataatctggtggccatcaacctcatcgtgcagcacatccaggacatcctgaatggagggccctccaaacggcagaccaatggctgtctcaacggctacaccccttcacgcaagaggcaggcatcggagtccagcagcaggccgcattgacccgtctccatcggaccccagcccctatctccaagagacagaggaggggtcaggaggcactgctcatctgtacatactgtttcctatgacattactgtatttaagaaaacaccatggagatgaaatgcctttgattttttttttctttttgtactttggaacgacaaaatgaaacagaacttgaccctgagcttaaataacaaaactgtgccaactactactggtgatgcctaattatgaatccaacgtgtaaccagttataaatacatatatatataaaaaaggatctatttttgtgtaaatgtacaaatactgtaaagctgtttgccataagtattttgcaggagggtctgtacttgagtgttttaggactggagctggaatttcaccaaggggaaattgcctgttgtgtcccagggtggggaggctcgggcatctgtgagagacagggagggtggctaaggtccagttgcttttgagtgccccgtggaacttgatgggaatggggttggaaaaccttgattgcctcctctgtcacatgccactcttggagctggagcttagtgatatgtcaatgagagatactcttgtcttttttttttttcttttcttttttttttttgagttgaaattaggtaaaatctcaactcaaaaatcaaactcagggaagaggcccactgaggagaacaagtcttctgcattttcttcctgccctgctcccaccttctcgcctctggctgcttggatagcttggtgactccttcctcaccctcctgcttctctgtctctccaagaagccagagctgcctctttccttccctggaagagattttatgggatcgcttcctgatagaagatgggaaggagagggcagaactttgcctgctgtcatatctgaagaatcactggttctttctgcatcccaggggcgtaactgatctgactccttgggctttttcctgtattgtggaatatagagtggaccattgcaggctgggtgtgggtgagggcttcggtaactgatgccggcagcagcgcctcatggagtggcaggggagctctgtctgtggaggggtagtagtttccgcttcctggaggtttgcagtgaggtgaggagagtaactttggtcagggattctcactagcagcgtcatggccaggatgctttacttatttgcaataccacctagtggatatggcaactgcagagcataaaaggggctcggaaaagcagtttttacaaagtatttaaaaggagagtatttaaatcataggtacctaagttggagcctgaggttgaaatatttggggtggagatttctagctttcctgagagctgctgcttggtggtagtgttttctctggaagtacagattcctgacattctgggtggaggggagcccaagtgagcctgaaggagttctgattatagagtcccgagcctcagtttctgactgcagaagagccagagatgttcatttcattgttgaccaccctagtgcttggtggactgtgcccttagctatcccactgtggctgccattgccagaaacattttggagaaccttttcttcccattgctctcagagcctgttcgagccattcaggtaaattggtctccattattacctggtcacaccagattttcccccagactcagcaccatccagtctgattccccgtttctgggctcagtttgactctaaatctgttttgctattttaaaaagtcaaacctggtccccagcagagcttgccacccggagactttcaggagaccgtgcaggctctgaagggagctcccagtcacagcagccgcctacttggagcaagggaaggctcccaagatgcctcctttgaaagccggtgctcaccaagatcagttcaggatcaatcattatccttgtagtcatgccttgatcagttctgagatgaagcagggaatgcaggcctgggttagtatcctgaggacacagggcccctggccttgatggcactgggctgtgctcaggtgaagcccacccgtgtctgggagagccttggcttttcagtgggcagcatgctcaactttacttgaagctcccaggtgccaaaccatttagtgccttggctgtttatcccactgccttggaagatggactcctctcatctctgagcctttacctagctgcttcctcatctacctgtggtgttgggaccaagcctccaatatctctgaatagcccactcctagcttggaaacagctataagggctgccctgccccttgtcaaatgatcaccaattcttggtggcttggctggggacaatgaacagtgtctgctggggtctgtgacacactgtttctggaacaaggaagggatggaaggctctacccctccgtggcagcccagcatttggccaactctgtatctgaacttgagctttctatggaacaaacaatggtcttagttttttaagagcctctgggtctctgattccatggagagtcaggagtagaattagtggaccagaaaccatgacatttgccatctaggtactctgctgttcagggtggaggcacagatgagcagagtggggtgatgttggttgtatgtgcatagaagtcccctggctccagagccatccagtggtgcttggttctctcttcctgcccaggtattgtgtgtggaccaagtgtttaggaaacaagcatagaagcattatgtcacaggaaggcctggcctctcactccttcacactaatgagccttctactgacccaagtttctttttctcgggcagcctgggaccactatgagcagagagatgggagtctgtgtaagaaggatgcaagtatcctttgatttggagtggacagagcaggtccttgcaaaggcagtgggttaaacaacgggatgtctgtgggacaggccagggaaggagggcagagacagggtctccagttcaccttgccgcagaactagcctaatcatccctgcttctggtcttggccacttggcaatcatggggaagttgactccccgcctcacttgggcttggagctggatacttgtggccacgcccaggataggttgccagagtttcattaggccgctgggtcgggctggaggcttgtgtacacctcggagcagtcgggcagcaggagggccggaagcctggttggtttgtatatgacctctcttgcccttgtgcactttccttgatttagcaaccttgacctgcactggccctcacagctgttggagggaagtagcctcttgcagggaaatattttcccctgccctggaatctcctatgtgcctgttaaagattccagggccaagaactcggcaggctgaggagcagctaggtaggtgggttatgcggttcaggactgcttctggaagggactgcctgtacttctgtaccaccgttgccctttacactttgctcagggcggggtgggggaagcattcaaacaaaacaaggaagggaactgtctggcaaagcataagtggatgcatccagagctcagtcccctttaatcttttgtctctgggcgttctgctgccttcctcataccggggactggcattccaggtcagcttggctgtggtcttagaggcagggagtgcctacccagtcctgcctcaggagcagggtgagtagctaaatacagacttaggcttttttttccccccttttaagatgcttgctcctctcccttttctttttaccaccctacctttattgttagtggttacaaagtgaccacatattatgtactttgctgtaaataaagacagacaaaaaggcaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7371 -> Molecular function: GO:0004849 [uridine kinase activity] evidence: IEA
GeneID:7371 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:7371 -> Molecular function: GO:0016773 [phosphotransferase activity, alcohol group as acceptor] evidence: IEA
GeneID:7371 -> Molecular function: GO:0019206 [nucleoside kinase activity] evidence: EXP
GeneID:7371 -> Biological process: GO:0006206 [pyrimidine nucleobase metabolic process] evidence: TAS
GeneID:7371 -> Biological process: GO:0007631 [feeding behavior] evidence: IEA
GeneID:7371 -> Biological process: GO:0043097 [pyrimidine nucleoside salvage] evidence: TAS
GeneID:7371 -> Biological process: GO:0044206 [UMP salvage] evidence: IEA
GeneID:7371 -> Biological process: GO:0044211 [CTP salvage] evidence: IEA
GeneID:7371 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:7371 -> Biological process: GO:0048678 [response to axon injury] evidence: IEA
GeneID:7371 -> Biological process: GO:0055086 [nucleobase-containing small molecule metabolic process] evidence: TAS
GeneID:7371 -> Biological process: GO:0071453 [cellular response to oxygen levels] evidence: IEA
GeneID:7371 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:7371 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:7371 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_036606 -> EC 2.7.1.48
by
@meso_cacase at
DBCLS
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