LOCUS       NM_006898               2319 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox D3 (HOXD3), mRNA.
ACCESSION   NM_006898
VERSION     NM_006898.4  GI:23510372
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2319)
  AUTHORS   Shaoqiang,C., Yue,Z., Yang,L., Hong,Z., Lina,Z., Da,P. and
            Qingyuan,Z.
  TITLE     Expression of HOXD3 correlates with shorter survival in patients
            with invasive breast cancer
  JOURNAL   Clin. Exp. Metastasis 30 (2), 155-163 (2013)
   PUBMED   22935821
  REMARK    GeneRIF: High expression of HOXD3 correlates with invasive breast
            cancer.
REFERENCE   2  (bases 1 to 2319)
  AUTHORS   Liu,L., Kron,K.J., Pethe,V.V., Demetrashvili,N., Nesbitt,M.E.,
            Trachtenberg,J., Ozcelik,H., Fleshner,N.E., Briollais,L., van der
            Kwast,T.H. and Bapat,B.
  TITLE     Association of tissue promoter methylation levels of APC, TGFbeta2,
            HOXD3 and RASSF1A with prostate cancer progression
  JOURNAL   Int. J. Cancer 129 (10), 2454-2462 (2011)
   PUBMED   21207416
  REMARK    GeneRIF: quantitative increase in promoter methylation levels of
            HOXD3 is associated with prostate cancer progression
REFERENCE   3  (bases 1 to 2319)
  AUTHORS   Goode,E.L., Chenevix-Trench,G., Song,H., Ramus,S.J., Notaridou,M.,
            Lawrenson,K., Widschwendter,M., Vierkant,R.A., Larson,M.C.,
            Kjaer,S.K., Birrer,M.J., Berchuck,A., Schildkraut,J., Tomlinson,I.,
            Kiemeney,L.A., Cook,L.S., Gronwald,J., Garcia-Closas,M., Gore,M.E.,
            Campbell,I., Whittemore,A.S., Sutphen,R., Phelan,C.,
            Anton-Culver,H., Pearce,C.L., Lambrechts,D., Rossing,M.A.,
            Chang-Claude,J., Moysich,K.B., Goodman,M.T., Dork,T.,
            Nevanlinna,H., Ness,R.B., Rafnar,T., Hogdall,C., Hogdall,E.,
            Fridley,B.L., Cunningham,J.M., Sieh,W., McGuire,V., Godwin,A.K.,
            Cramer,D.W., Hernandez,D., Levine,D., Lu,K., Iversen,E.S.,
            Palmieri,R.T., Houlston,R., van Altena,A.M., Aben,K.K.,
            Massuger,L.F., Brooks-Wilson,A., Kelemen,L.E., Le,N.D.,
            Jakubowska,A., Lubinski,J., Medrek,K., Stafford,A., Easton,D.F.,
            Tyrer,J., Bolton,K.L., Harrington,P., Eccles,D., Chen,A.,
            Molina,A.N., Davila,B.N., Arango,H., Tsai,Y.Y., Chen,Z.,
            Risch,H.A., McLaughlin,J., Narod,S.A., Ziogas,A., Brewster,W.,
            Gentry-Maharaj,A., Menon,U., Wu,A.H., Stram,D.O., Pike,M.C.,
            Beesley,J., Webb,P.M., Chen,X., Ekici,A.B., Thiel,F.C.,
            Beckmann,M.W., Yang,H., Wentzensen,N., Lissowska,J., Fasching,P.A.,
            Despierre,E., Amant,F., Vergote,I., Doherty,J., Hein,R.,
            Wang-Gohrke,S., Lurie,G., Carney,M.E., Thompson,P.J., Runnebaum,I.,
            Hillemanns,P., Durst,M., Antonenkova,N., Bogdanova,N., Leminen,A.,
            Butzow,R., Heikkinen,T., Stefansson,K., Sulem,P., Besenbacher,S.,
            Sellers,T.A., Gayther,S.A. and Pharoah,P.D.
  CONSRTM   Wellcome Trust Case-Control Consortium; Australian Cancer Study
            (Ovarian Cancer); Australian Ovarian Cancer Study Group; Ovarian
            Cancer Association Consortium (OCAC); Ovarian Cancer Association
            Consortium (OCAC)
  TITLE     A genome-wide association study identifies susceptibility loci for
            ovarian cancer at 2q31 and 8q24
  JOURNAL   Nat. Genet. 42 (10), 874-879 (2010)
   PUBMED   20852632
REFERENCE   4  (bases 1 to 2319)
  AUTHORS   Kron,K.J., Liu,L., Pethe,V.V., Demetrashvili,N., Nesbitt,M.E.,
            Trachtenberg,J., Ozcelik,H., Fleshner,N.E., Briollais,L., van der
            Kwast,T.H. and Bapat,B.
  TITLE     DNA methylation of HOXD3 as a marker of prostate cancer progression
  JOURNAL   Lab. Invest. 90 (7), 1060-1067 (2010)
   PUBMED   20212450
  REMARK    GeneRIF: HOXD3 methylation distinguishes low-grade prostate cancers
            from intermediate and high-grade ones.
REFERENCE   5  (bases 1 to 2319)
  AUTHORS   Ester,A.R., Weymouth,K.S., Burt,A., Wise,C.A., Scott,A.,
            Gurnett,C.A., Dobbs,M.B., Blanton,S.H. and Hecht,J.T.
  TITLE     Altered transmission of HOX and apoptotic SNPs identify a potential
            common pathway for clubfoot
  JOURNAL   Am. J. Med. Genet. A 149A (12), 2745-2752 (2009)
   PUBMED   19938081
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 2319)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2319)
  AUTHORS   Taniguchi,Y., Fujii,A. and Moriuchi,T.
  TITLE     Cloning and sequencing of the human homeobox gene HOX4A
  JOURNAL   Biochim. Biophys. Acta 1132 (3), 332-334 (1992)
   PUBMED   1358204
REFERENCE   8  (bases 1 to 2319)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   9  (bases 1 to 2319)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   10 (bases 1 to 2319)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005124.2.
            On Oct 7, 2002 this sequence version replaced gi:19923390.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, located on different
            chromosomes, consisting of 9 to 11 genes arranged in tandem. This
            gene is one of several homeobox HOXD genes located at 2q31-2q37
            chromosome regions. Deletions that removed the entire HOXD gene
            cluster or 5' end of this cluster have been associated with severe
            limb and genital abnormalities. The protein encoded by this gene
            may play a role in the regulation of cell adhesion processes.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005124.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..2319
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /note="homeobox D3"
                     /db_xref="GeneID:3232"
                     /db_xref="HGNC:5137"
                     /db_xref="HPRD:00863"
                     /db_xref="MIM:142980"
     exon            1..92
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /inference="alignment:Splign:1.39.8"
     variation       25
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2113562"
     variation       37..38
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:142263809"
     variation       37
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201023251"
     exon            93..717
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /inference="alignment:Splign:1.39.8"
     variation       113
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72927183"
     variation       130
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370796757"
     misc_feature    171..173
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /note="upstream in-frame stop codon"
     CDS             177..1475
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /note="homeo box D3; Hox-4.1, mouse, homolog of; homeobox
                     protein Hox-4A"
                     /codon_start=1
                     /product="homeobox protein Hox-D3"
                     /protein_id="NP_008829.3"
                     /db_xref="GI:19923391"
                     /db_xref="CCDS:CCDS2270.1"
                     /db_xref="GeneID:3232"
                     /db_xref="HGNC:5137"
                     /db_xref="HPRD:00863"
                     /db_xref="MIM:142980"
                     /translation="

MLFEQGQQALELPECTMQKAAYYENPGLFGGYGYSKTTDTYGYSTPHQPYPPPAAASSLDTDYPGSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPPPPPPTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGGNFVESMAPASGPVFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLTHL

"
     misc_feature    624..986
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:35135"
     misc_feature    654..671
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P31249.3);
                     Region: Antp-type hexapeptide"
     misc_feature    759..935
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(759..773,777..779,828..830,846..848,885..887,
                     891..896,903..908,912..920,924..929)
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(765..767,774..776,894..896,903..908,915..917)
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1278..1466
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /note="Domain of unknown function (DUF4074); Region:
                     DUF4074; pfam13293"
                     /db_xref="CDD:205473"
     variation       184
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200641637"
     variation       186
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201061047"
     variation       190
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200129595"
     variation       260
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140952976"
     variation       274
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373609882"
     variation       281
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199964353"
     variation       289
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75250034"
     variation       290
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373537603"
     variation       299
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201012462"
     variation       300
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138422926"
     variation       327
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143404265"
     variation       329
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141168805"
     variation       350
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143525922"
     variation       397
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372175551"
     variation       448
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147184232"
     variation       449
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145664108"
     variation       455
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:34729309"
     variation       464
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77818566"
     variation       533
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375537887"
     variation       535
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190587708"
     variation       541
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368322060"
     variation       547
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140883088"
     variation       550
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74698314"
     variation       562
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1051932"
     variation       598
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199953096"
     variation       650
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371779084"
     STS             683..1035
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /standard_name="Hoxd3"
                     /db_xref="UniSTS:158733"
     variation       698
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376541904"
     exon            718..2299
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /inference="alignment:Splign:1.39.8"
     variation       739
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:137915443"
     variation       757
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369217663"
     variation       785
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373952633"
     variation       801
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373433353"
     variation       854
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201297341"
     variation       956
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147174389"
     variation       974
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376325506"
     variation       1013
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141288498"
     variation       1047
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202241409"
     variation       1094
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371230694"
     variation       1135
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374139731"
     variation       1155
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199832736"
     variation       1227
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1051929"
     variation       1247
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201412033"
     variation       1249
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368898563"
     variation       1259
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372195235"
     variation       1282
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374967073"
     variation       1299
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200410001"
     variation       1305
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199829552"
     variation       1313
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146292581"
     variation       1337
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374894451"
     variation       1358
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368978061"
     variation       1399
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374462578"
     variation       1430
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200844846"
     variation       1484
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201134562"
     variation       1535..1536
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:71409074"
     variation       1540
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369109077"
     variation       1584
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75081700"
     variation       1608
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369602867"
     variation       1630
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35746949"
     variation       1656
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112414246"
     variation       1657..1658
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace=""
                     /replace="ctt"
                     /replace="tct"
                     /db_xref="dbSNP:34952493"
     variation       1658..1659
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace=""
                     /replace="ttc"
                     /db_xref="dbSNP:60794848"
     variation       1659..1660
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace=""
                     /replace="ttc"
                     /db_xref="dbSNP:72050501"
     variation       1659
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186345984"
     variation       1733
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1051928"
     variation       1734
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1051927"
     variation       1738
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143449156"
     variation       1784
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:711830"
     variation       1789
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75690576"
     variation       1901
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148367105"
     variation       2036
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376448993"
     variation       2132
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182114564"
     variation       2184..2185
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2857536"
     variation       2184
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:966800"
     variation       2193
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115537830"
     variation       2196
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141586867"
     polyA_signal    2280..2285
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
     polyA_site      2299
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /experiment="experimental evidence, no additional details
                     recorded"
     variation       2300
                     /gene="HOXD3"
                     /gene_synonym="Hox-4.1; HOX1D; HOX4; HOX4A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:966801"
ORIGIN      

gcctccacagatatcaaaagaaacctgaagagcctacaaaaaaaaaagagataaagacaaaattcaagaaaacacacacatacataattgtggtcacctggagcctgggggccggcccagctctctcaggattcagcagacattggaggtggcagtgaaggatacagtggtagtcaatgttatttgagcagggtcagcaggccctggagcttcctgagtgcacaatgcagaaggctgcttactatgaaaacccaggactgtttggaggctatggctacagcaaaactacggacacttacggctacagcaccccccaccagccctacccaccccctgctgctgccagctccctggacactgactatccaggttctgcctgctccatccagagctctgcccctctgagagccccagcccacaaaggagctgaactcaatggcagctgcatgcggccgggcactgggaacagccagggtgggggtggtggcagccagcctcctggtctgaactcagagcagcagccaccacaaccccctcctccaccaccgaccctgcccccatcttcacccaccaatcctggaggtggagtgcctgccaagaagcccaaaggtgggcccaatgcttctagctcctcagccaccatcagcaagcagatcttcccctggatgaaagagtctcgacagaactccaagcagaagaacagctgtgccactgcaggagagagctgcgaggacaagagcccgccaggcccagcatccaagcgggtacgcacggcatacacgagcgcgcagctggtggaattggaaaaggaattccacttcaaccgctacttgtgccggccgcgccgcgtggagatggccaacctgctgaatctcacggaacgccagatcaagatctggttccagaaccggcgcatgaagtacaagaaggaccagaaggccaagggcatcctgcactcgccggctagccagtcccctgagcgcagcccaccgctcggcggcgccgctggccacgtggcctactccggccagctgccgccagtgcccggcctggcctacgacgcgccctcgccgcctgctttcgccaaatcacagcccaatatgtacggcctggccgcctacacggcgccactcagcagctgcctgccacaacagaagcgctacgcagcgccggagttcgagccccatcccatggcgagcaacggcggcggcttcgccagcgccaacttgcagggcagcccggtgtacgtgggcggcaacttcgtcgagtccatggcgcccgcgtccgggcctgtcttcaacctgggccacctctcgcacccgtcgtcggccagcgtggactacagttgcgccgcgcagattccaggcaaccaccaccatggaccttgcgaccctcatcccacctacacagatctctcggcccaccactcgtctcagggacgactgccggaggctcccaaactgacgcatctgtagcggccgccgccagcccgaactcgcggcaaaattacctctcttgctgtagtggtggggtagagggtggggcccgcggggcagttcgggaacccccttccccgctcttgccctgccgccgcctcccgggtctcaggcctccagcggcggaggcgcaggcgaccgggcctcccctccatgggcgtcctttgggtgactcgccataaatcagccgcaaggatccttccctgtaaatttgacagtgccacatactgcggaccaagggactccaatctggtaatggtgtcccaaaggtaagtctgagacccatcagcggcgcgccctgcagagggaccagagcttggagagtcttgggcctggcccgcgtctagcttagtttcagagaccttaatttatattctccttcctgtgccgtaaggattgcatcggactaaactatctgtatttattatttgaagcgagtcatttcgttccctgattatttatccttgtctgaatgtatttatgtgtatatttgtagatttatccagccgagcttaggaattcgcttccaggccgtgggggccacatttcacctccttagtccccctggtctgaactagttgagagagtagttttgaacagtcgtaaccgtggctggtgtttgtagttgacataaaggattaagaccgcaaattgtccttcatgggtagagtcaggaagcccggtggcgtggcacaacacactttggtcatttctcaaaaaccacagtcctcaccacagtttattgatttcaaattgtctggtactattggaacaaatatttagaataaaaaaatttcccagtcaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3232 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3232 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3232 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3232 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IMP
            GeneID:3232 -> Biological process: GO:0007160 [cell-matrix adhesion] evidence: IDA
            GeneID:3232 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: IMP
            GeneID:3232 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: ISS
            GeneID:3232 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
            GeneID:3232 -> Biological process: GO:0021615 [glossopharyngeal nerve morphogenesis] evidence: IEA
            GeneID:3232 -> Biological process: GO:0030878 [thyroid gland development] evidence: ISS
            GeneID:3232 -> Biological process: GO:0045666 [positive regulation of neuron differentiation] evidence: ISS
            GeneID:3232 -> Biological process: GO:0048704 [embryonic skeletal system morphogenesis] evidence: ISS
            GeneID:3232 -> Biological process: GO:0051216 [cartilage development] evidence: ISS
            GeneID:3232 -> Cellular component: GO:0005634 [nucleus] evidence: IC