GGRNA | NM_006896.3

LOCUS       NM_006896               2018 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox A7 (HOXA7), mRNA.
ACCESSION   NM_006896
VERSION     NM_006896.3  GI:84105267
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Li,Z., Huang,H., Li,Y., Jiang,X., Chen,P., Arnovitz,S.,
            Radmacher,M.D., Maharry,K., Elkahloun,A., Yang,X., He,C., He,M.,
            Zhang,Z., Dohner,K., Neilly,M.B., Price,C., Lussier,Y.A., Zhang,Y.,
            Larson,R.A., Le Beau,M.M., Caligiuri,M.A., Bullinger,L., Valk,P.J.,
            Delwel,R., Lowenberg,B., Liu,P.P., Marcucci,G., Bloomfield,C.D.,
            Rowley,J.D. and Chen,J.
  TITLE     Up-regulation of a HOXA-PBX3 homeobox-gene signature following
            down-regulation of miR-181 is associated with adverse prognosis in
            patients with cytogenetically abnormal AML
  JOURNAL   Blood 119 (10), 2314-2324 (2012)
   PUBMED   22251480
  REMARK    GeneRIF: Data show that up-regulation of the HOXA7, HOXA9, HOXA11,
            and PBX3 resulting from the down-regulation of miR-181 family
            members probably contribute to the poor prognosis of patients with
            nonfavorable cytogenetically abnormal AML (CA-AML).
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Jo,S., Lee,H., Kim,S., Hwang,E.M., Park,J.Y., Kang,S.S. and
            Chung,H.
  TITLE     Inhibition of PCGF2 enhances granulocytic differentiation of acute
            promyelocytic leukemia cell line HL-60 via induction of HOXA7
  JOURNAL   Biochem. Biophys. Res. Commun. 416 (1-2), 86-91 (2011)
   PUBMED   22085718
  REMARK    GeneRIF: Taken together, these results support the notion that
            down-regulation of PCGF2 is sufficient to induce granulocytic
            differentiation of HL-60 cells via de-repression of HOXA7 gene
            expression.
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Orlovsky,K., Kalinkovich,A., Rozovskaia,T., Shezen,E., Itkin,T.,
            Alder,H., Ozer,H.G., Carramusa,L., Avigdor,A., Volinia,S.,
            Buchberg,A., Mazo,A., Kollet,O., Largman,C., Croce,C.M.,
            Nakamura,T., Lapidot,T. and Canaani,E.
  TITLE     Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged
            acute leukemia impairs engraftment and reduces proliferation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (19), 7956-7961 (2011)
   PUBMED   21518888
  REMARK    GeneRIF: Several targets of MLL fusions, MEIS1, HOXA7, HOXA9, and
            HOXA10 are functionally related and have been implicated in
            leukemias. Each of the four genes was knocked down separately in
            the precursor B-cell leukemic line RS4;11 expressing MLL-AF4.
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Liborio,T.N., Acquafreda,T., Matizonkas-Antonio,L.F.,
            Silva-Valenzuela,M.G., Ferraz,A.R. and Nunes,F.D.
  TITLE     In situ hybridization detection of homeobox genes reveals distinct
            expression patterns in oral squamous cell carcinomas
  JOURNAL   Histopathology 58 (2), 225-233 (2011)
   PUBMED   21323949
  REMARK    GeneRIF: HOXA7, PIXT1 and PRRX1 homeobox genes have different
            patterns of expression in oral squamous cell carcinomas depending
            on its histological features.
REFERENCE   5  (bases 1 to 2018)
  AUTHORS   Jugessur,A., Shi,M., Gjessing,H.K., Lie,R.T., Wilcox,A.J.,
            Weinberg,C.R., Christensen,K., Boyles,A.L., Daack-Hirsch,S.,
            Nguyen,T.T., Christiansen,L., Lidral,A.C. and Murray,J.C.
  TITLE     Maternal genes and facial clefts in offspring: a comprehensive
            search for genetic associations in two population-based cleft
            studies from Scandinavia
  JOURNAL   PLoS ONE 5 (7), E11493 (2010)
   PUBMED   20634891
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2018)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2018)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   8  (bases 1 to 2018)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 2018)
  AUTHORS   Balling,R., Mutter,G., Gruss,P. and Kessel,M.
  TITLE     Craniofacial abnormalities induced by ectopic expression of the
            homeobox gene Hox-1.1 in transgenic mice
  JOURNAL   Cell 58 (2), 337-347 (1989)
   PUBMED   2568891
REFERENCE   10 (bases 1 to 2018)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004080.2 and AF026397.1.
            On Dec 30, 2005 this sequence version replaced gi:24497555.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            For example, the encoded protein represses the transcription of
            differentiation-specific genes during keratinocyte proliferation,
            but this repression is then overcome by differentiation signals.
            This gene is highly similar to the antennapedia (Antp) gene of
            Drosophila. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF026397.1, BC061916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC004080.2         29816-30047         c
            233-953             AF026397.1         233-953
            954-2018            AC004080.2         27086-28150         c
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2018
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="homeobox A7"
                     /db_xref="GeneID:3204"
                     /db_xref="HGNC:5108"
                     /db_xref="MIM:142950"
     exon            1..511
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /inference="alignment:Splign:1.39.8"
     STS             11..235
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="REN100580"
                     /db_xref="UniSTS:425377"
     STS             15..970
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /db_xref="UniSTS:489818"
     misc_feature    97..99
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="upstream in-frame stop codon"
     CDS             133..825
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="homeo box A7; homeobox protein HOX-1A; homeobox
                     protein Hox 1.1"
                     /codon_start=1
                     /product="homeobox protein Hox-A7"
                     /protein_id="NP_008827.2"
                     /db_xref="GI:24497556"
                     /db_xref="CCDS:CCDS5408.1"
                     /db_xref="GeneID:3204"
                     /db_xref="HGNC:5108"
                     /db_xref="MIM:142950"
                     /translation="

MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGAGAGAFASTVPGLYNVNSPLYQSPFASGYGLGADAYGNLPCASYDQNIPGLCSDLAKGACDKTDEGALHGAAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKDEGPTAAAAPEGAVPSAAATAAADKADEEDDDEEEEDEEE

"
     misc_feature    487..504
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P31268.3);
                     Region: Antp-type hexapeptide"
     misc_feature    523..699
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(523..537,541..543,592..594,610..612,649..651,
                     655..660,667..672,676..684,688..693)
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(529..531,538..540,658..660,667..672,679..681)
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     STS             155..231
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="Hoxa7"
                     /db_xref="UniSTS:536645"
     STS             196..497
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="Hoxa7"
                     /db_xref="UniSTS:143372"
     STS             222..496
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="REN100579"
                     /db_xref="UniSTS:425376"
     exon            512..2018
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /inference="alignment:Splign:1.39.8"
     STS             642..807
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="RH48711"
                     /db_xref="UniSTS:37664"
     STS             659..807
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="RH47950"
                     /db_xref="UniSTS:37665"
     STS             698..968
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="REN100573"
                     /db_xref="UniSTS:425370"
     STS             958..1185
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="REN100572"
                     /db_xref="UniSTS:425369"
     STS             959..1500
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="ECD12537"
                     /db_xref="UniSTS:293570"
     STS             1164..1428
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="REN100571"
                     /db_xref="UniSTS:425368"
     STS             1423..1672
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="REN100570"
                     /db_xref="UniSTS:425367"
     STS             1653..1911
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /standard_name="REN100569"
                     /db_xref="UniSTS:425366"
     variation       1750
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1057512"
     polyA_signal    1991..1996
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
     polyA_site      2018
                     /gene="HOXA7"
                     /gene_synonym="ANTP; HOX1; HOX1.1; HOX1A"
ORIGIN

gtgctgcggcgagctccgtccaaaagaaaatggggtttggtgtaaatctgggggtgtaatgttatcatatatcactctacctcgtaaaaccgacactgaaagctgccggacaacaaatcacaggtcaaaattatgagttcttcgtattatgtgaacgcgctttttagcaaatatacggcgggggcttctctgttccaaaatgccgagccgacttcttgctcctttgctcccaactcacagagaagcggctacggggcgggcgccggcgccttcgcctcgaccgttccgggcttatacaatgtcaacagccccctttatcagagcccctttgcgtccggctacggcctgggcgccgacgcctacggcaacctgccctgcgcctcctacgaccaaaacatccccgggctctgcagtgacctcgccaaaggcgcctgcgacaagacggacgagggcgcgctgcatggcgcggctgaggccaatttccgcatctacccctggatgcggtcttcaggacctgacaggaagcggggccgccagacctacacgcgctaccagacgctggagctggagaaggagttccacttcaaccgctacctgacgcggcgccgccgcattgaaatcgcccacgcgctctgcctcaccgagcgccagattaagatctggttccagaaccgccgcatgaagtggaagaaagagcataaggacgaaggtccgactgccgccgcagctcccgagggcgccgtgccctctgccgccgccactgctgccgcggacaaggccgacgaggaggacgatgatgaagaagaggaagacgaggaggaatgaggggccgatccggggccctctctgcaccggacagtcggaaaagcgtctttaagagactcactggttttacttacaaaaatgggaaaaataaaagaaaatgtaaaaaacaaaaacaaaaacaaaaaagcaacccagtccccaacctgcactctacccacccccatcacctactccagctcccaacttttgtggactgagcggccgcagagactgggtcgccttggattccctctgcctccgaggaccccaaaagacacccccaaccccaggccagccggccctgctctggcgcgtccaaaatactacctagcacaggcctctgctcgaggcacccccaaactacctatgtatccagccccagagggcctccattcccaggaagtccctatgtatcccaacactggcagacacccagcaccaccctcccagacccgcaagaaagtgaatctcactactacctactcccctaaaactacctattttgtgctggctggcttgcctgctacctagtgccgactgctcccaggcaagtcccctgctgcttacagcccgcagcttttggggtccctgaggctgccctgagaatgtgctgaggtccaggatcagggtattggcatctatttaaatcgaaaaataatatatttattccaaaaagcatcctaagtgcttgcaccctagaatcaatccctccttctctggcttggcacccacagctcaggcccatcaacccccacttctggaggggaatgttcctgagctggctgcagatctgtgggttagcttctgcttagcaggactgtggagatgcttccagcttcgctgtcctttcctctggctcctgtatcttactgttcagctgtgttaaatatgtacgccctgatgtttcctataatagcagatactgtatatttgaacaagatttttttttatcatttctatagtcttggagttcatttgtaaggcagtgtcttgacttggaaaggatgtgttaatggggtgactttgtagcatggtatgttgtcttgagttaactgtagtgggtggggaggtccaatgccctccgcaatgcccttcatctcctgtgttgtcctgtaccctgctcagctccatcctggggttcagggaaggcacacttcccagcccagctgtgttttatgtaaccgaaaataaagatgcgtggtgacaaagaaaaa

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