LOCUS       NM_005523               2653 bp    mRNA    linear   PRI 08-JUN-2013
DEFINITION  Homo sapiens homeobox A11 (HOXA11), mRNA.
ACCESSION   NM_005523
VERSION     NM_005523.5  GI:84105266
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2653)
  AUTHORS   Li,Z., Huang,H., Li,Y., Jiang,X., Chen,P., Arnovitz,S.,
            Radmacher,M.D., Maharry,K., Elkahloun,A., Yang,X., He,C., He,M.,
            Zhang,Z., Dohner,K., Neilly,M.B., Price,C., Lussier,Y.A., Zhang,Y.,
            Larson,R.A., Le Beau,M.M., Caligiuri,M.A., Bullinger,L., Valk,P.J.,
            Delwel,R., Lowenberg,B., Liu,P.P., Marcucci,G., Bloomfield,C.D.,
            Rowley,J.D. and Chen,J.
  TITLE     Up-regulation of a HOXA-PBX3 homeobox-gene signature following
            down-regulation of miR-181 is associated with adverse prognosis in
            patients with cytogenetically abnormal AML
  JOURNAL   Blood 119 (10), 2314-2324 (2012)
   PUBMED   22251480
  REMARK    GeneRIF: Data show that up-regulation of the HOXA7, HOXA9, HOXA11,
            and PBX3 resulting from the down-regulation of miR-181 family
            members probably contribute to the poor prognosis of patients with
            nonfavorable cytogenetically abnormal AML (CA-AML).
REFERENCE   2  (bases 1 to 2653)
  AUTHORS   Szczepanska,M., Wirstlein,P., Skrzypczak,J. and Jagodzinski,P.P.
  TITLE     Expression of HOXA11 in the mid-luteal endometrium from women with
            endometriosis-associated infertility
  JOURNAL   Reprod. Biol. Endocrinol. 10, 1 (2012)
   PUBMED   22233680
  REMARK    GeneRIF: reduced HOXA11 expression may contribute to
            endometriosis-associated infertility
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2653)
  AUTHORS   Alizadeh,Z., Shokrzadeh,N., Saidijam,M. and Sanoee,M.F.
  TITLE     Semi-quantitative analysis of HOXA11, leukemia inhibitory factor
            and basic transcriptional element binding protein 1 mRNA expression
            in the mid-secretory endometrium of patients with endometriosis
  JOURNAL   Iran. Biomed. J. 15 (3), 66-72 (2011)
   PUBMED   21987111
  REMARK    GeneRIF: Endometrial HOXA11 and LIF mRNA expression levels
            (normalized to beta-actin expression) were significantly decreased
            in endometrium of infertile patients with endometriosis compared
            with healthy fertile controls
REFERENCE   4  (bases 1 to 2653)
  AUTHORS   Szczepanska,M., Wirstlein,P., Luczak,M., Jagodzinski,P. and
            Skrzypczak,J.
  TITLE     Expression of HOXA-10 and HOXA-11 in the endometria of women with
            idiopathic infertility
  JOURNAL   Folia Histochem. Cytobiol. 49 (1), 111-118 (2011)
   PUBMED   21526497
  REMARK    GeneRIF: The result suggest that HOXA-11 gene expression in the
            endometrium during the implantation window may not be altered in
            patients with idiopathic infertility.
REFERENCE   5  (bases 1 to 2653)
  AUTHORS   Szczepanska,M., Wirstlein,P. and Skrzypczak,J.
  TITLE     [HOXA11 gene expression in women with and without impaired
            infertility]
  JOURNAL   Ginekol. Pol. 81 (6), 414-421 (2010)
   PUBMED   20695189
  REMARK    GeneRIF: Our results suggest that altered HOXA11 gene expression in
            the endometrium during a menstrual cycle may be a common phenomenon
            among patients with endometriosis and may cause infertility in this
            group of patients
REFERENCE   6  (bases 1 to 2653)
  AUTHORS   Miano,J.M., Firulli,A.B., Olson,E.N., Hara,P., Giachelli,C.M. and
            Schwartz,S.M.
  TITLE     Restricted expression of homeobox genes distinguishes fetal from
            adult human smooth muscle cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (2), 900-905 (1996)
   PUBMED   8570656
REFERENCE   7  (bases 1 to 2653)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet. Cell Genet. 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   8  (bases 1 to 2653)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   9  (bases 1 to 2653)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   10 (bases 1 to 2653)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC040948.1 and AC004080.2.
            This sequence is a reference standard in the RefSeqGene project.
            On Dec 30, 2005 this sequence version replaced gi:24497552.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            This gene is involved in the regulation of uterine development and
            is required for female fertility. Mutations in this gene can cause
            radio-ulnar synostosis with amegakaryocytic thrombocytopenia.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040948.1, AL551705.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-781               BC040948.1         1-781
            782-2653            AC004080.2         54527-56398         c
FEATURES             Location/Qualifiers
     source          1..2653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2653
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /note="homeobox A11"
                     /db_xref="GeneID:3207"
                     /db_xref="HGNC:5101"
                     /db_xref="HPRD:00846"
                     /db_xref="MIM:142958"
     exon            1..781
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    34..36
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /note="upstream in-frame stop codon"
     STS             64..323
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100706"
                     /db_xref="UniSTS:425503"
     CDS             73..1014
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /note="homeo box 1I; homeobox protein HOXA11; homeobox
                     protein Hox-1I"
                     /codon_start=1
                     /product="homeobox protein Hox-A11"
                     /protein_id="NP_005514.1"
                     /db_xref="GI:5031759"
                     /db_xref="CCDS:CCDS5411.1"
                     /db_xref="GeneID:3207"
                     /db_xref="HGNC:5101"
                     /db_xref="HPRD:00846"
                     /db_xref="MIM:142958"
                     /translation="

MDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKSAEKGPPAATATSAAAAAAATGAPATSSSDSGGGGGCRETAAAAEEKERRRRPESSSSPESSSGHTEDKAGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL

"
     misc_feature    145..573
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /note="Protein of unknown function (DUF3528); Region:
                     DUF3528; pfam12045"
                     /db_xref="CDD:152480"
     misc_feature    796..966
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(796..810,814..816,865..867,883..885,922..924,
                     928..933,940..945,949..957,961..966)
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(802..804,811..813,931..933,940..945,952..954)
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     STS             147..220
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="Hoxa11"
                     /db_xref="UniSTS:536638"
     STS             303..563
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100705"
                     /db_xref="UniSTS:425502"
     STS             529..762
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100704"
                     /db_xref="UniSTS:425501"
     exon            782..2653
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /inference="alignment:Splign:1.39.8"
     STS             805..2022
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="stSG609385"
                     /db_xref="UniSTS:449470"
     STS             854..1105
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100696"
                     /db_xref="UniSTS:425493"
     STS             1090..1318
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100695"
                     /db_xref="UniSTS:425492"
     STS             1299..1543
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100694"
                     /db_xref="UniSTS:425491"
     variation       1307
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3210747"
     STS             1450..2059
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="ECD10174"
                     /db_xref="UniSTS:291214"
     STS             1521..1763
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100693"
                     /db_xref="UniSTS:425490"
     STS             1745..1995
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100692"
                     /db_xref="UniSTS:425489"
     STS             1976..2214
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100691"
                     /db_xref="UniSTS:425488"
     STS             2147..2276
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="SHGC-33814"
                     /db_xref="UniSTS:76593"
     STS             2178..2435
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /standard_name="REN100690"
                     /db_xref="UniSTS:425487"
     polyA_signal    2276..2281
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
     polyA_site      2295
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_site      2300
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_signal    2632..2637
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
     polyA_site      2653
                     /gene="HOXA11"
                     /gene_synonym="HOX1; HOX1I"
ORIGIN      

cttcaaagaggcagctgcagtggagaatcatgttaagctcggctactgcggagagcccaaggtagcccaataatggattttgatgagcgtggtccctgctcctctaacatgtatttgccaagttgtacttactacgtctcgggtccagatttctccagcctcccttcttttctgccccagaccccgtcttcgcgcccaatgacatactcctactcctccaacctgccccaggtccaacccgtgcgcgaagtgaccttcagagagtacgccattgagcccgccactaaatggcacccccgcggcaatctggcccactgctactccgcggaggagctcgtgcacagagactgcctgcaggcgcccagcgcggccggcgtgcctggcgacgtgctggccaagagctcggccaacgtctaccaccaccccacccccgcagtctcgtccaatttctatagcaccgtgggcaggaacggcgtcctgccacaggctttcgaccagtttttcgagacagcctacggcaccccggaaaacctcgcctcctccgactaccccggggacaagagcgccgagaaggggcccccggcggccacggcgacctccgcggcggcggcggcggctgcaacgggcgcgccggcaacttcaagttcggacagcggcggcggcggcggctgccgggagacggcggcggcagcagaggagaaagagcggcggcggcgccccgagagcagcagcagccccgagtcgtcttccggccacactgaggacaaggccggcggctccagtggccaacgcacccgcaaaaagcgctgcccctataccaagtaccagatccgagagctggaacgggagttcttcttcagcgtctacattaacaaagagaagcgcctgcaactgtcccgcatgctcaacctcactgatcgtcaagtcaaaatctggtttcagaacaggagaatgaaggaaaaaaaaattaacagagaccgtttacagtactactcagcaaatccactcctctaagactccagcggctggaattgggtggggggcttcatacacatgagataatatgcagattttgcccttgacaaagtcaagccacatggtgacttttgaaaagaggtgtgcaagagagggatgcatggagatagccccacaggaggtggtctgggactctcttgattaagatctcagtggttaagattcctaataatcattggattctgagagctgtgcatcagctagaatgacaggtttgggacccctggtggttcactcttggagcctgcagagctgcgggctgggtgtggtctccactggggattgggcccctgccagaccccctggagactaaccccaccacaccctccctctactgggagcctacccacccccaggacccctgagtaaaaaagctgtgtgctctccaagcccagttcagcttggggacaggggcaggaggaaggggtaggattactaggtgcccagaatgaggctgctttccaaagccaatgtgaacagcggctggacttggaggtagctttgaggtggaagagggctgcaaatccttgtgggaaaagaaatctatgattccaggtggcatcagtgtctttccactcctcctagccacccaccacactgatccagccctgagttcctagccaccgcctcctacagcccacctggcttttctttctaccaaatgagggtcttggttccagcctgccactcaggcccaaagcctcgacacagagtggactgttccctgaggtgggagatgtggaaaagccaagaggctgcagccaggccactggcccctgagatctctgcaggaaatggctgtggagtgtggcagtttggcaaactctccaccacacgtaatgaaacttggatttgctcagtgtctggctgcagagcagtgggcctggccagcaggtccccagctttggctatgagggccttgagtcccccaaaacaccgggttccagcaccacactcagccctcattggctcttgaactgagcttggaagcttctggtgaccttccaagagcctgagagtgaggtggaattattttaaaagataaatattatattatatatatatatatttccctgaaggaaccaaagcgaattttaaaagatgcaatgtagaggggaaaagagatgatgaaaatatttaaaggccctatctgtttacagtgttccgtggttaaactcgctcactgctaagaatatttgaatgtatgcttcatacagggatggtgttcaaaaaacttgtaaataaaggaaccataatcaattttcttttctttctttctctttttcttttttcttttgccattagttgatttcctttagggtgttggagggggtggaaaaggtattgagaatggtctttttaatctcttgcaacatttggaaagagttagggaaatgctcagaggcagtcggcctggccggcctggggatctcatctgggaaagccaggcaccctcccattgaatctcctttgcctccctgtgttaagaaatgtctgttggctccatttgtactgggagtgttggcctgtcctcaattctggttcttacccaccgtgtgtgttgcagcacttatacaggcaactgggcacaaggaaaataaagacggtggaaatttga

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3207 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3207 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3207 -> Biological process: GO:0001501 [skeletal system development] evidence: ISS
            GeneID:3207 -> Biological process: GO:0001656 [metanephros development] evidence: IEA
            GeneID:3207 -> Biological process: GO:0001658 [branching involved in ureteric bud morphogenesis] evidence: ISS
            GeneID:3207 -> Biological process: GO:0001759 [organ induction] evidence: IEA
            GeneID:3207 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3207 -> Biological process: GO:0007275 [multicellular organismal development] evidence: ISS
            GeneID:3207 -> Biological process: GO:0007501 [mesodermal cell fate specification] evidence: ISS
            GeneID:3207 -> Biological process: GO:0009653 [anatomical structure morphogenesis] evidence: TAS
            GeneID:3207 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3207 -> Biological process: GO:0009953 [dorsal/ventral pattern formation] evidence: ISS
            GeneID:3207 -> Biological process: GO:0009954 [proximal/distal pattern formation] evidence: IEA
            GeneID:3207 -> Biological process: GO:0010720 [positive regulation of cell development] evidence: ISS
            GeneID:3207 -> Biological process: GO:0030326 [embryonic limb morphogenesis] evidence: ISS
            GeneID:3207 -> Biological process: GO:0032332 [positive regulation of chondrocyte differentiation] evidence: ISS
            GeneID:3207 -> Biological process: GO:0035115 [embryonic forelimb morphogenesis] evidence: IEA
            GeneID:3207 -> Biological process: GO:0042733 [embryonic digit morphogenesis] evidence: IEA
            GeneID:3207 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: ISS
            GeneID:3207 -> Biological process: GO:0048589 [developmental growth] evidence: ISS
            GeneID:3207 -> Biological process: GO:0060272 [embryonic skeletal joint morphogenesis] evidence: IEA
            GeneID:3207 -> Biological process: GO:0060351 [cartilage development involved in endochondral bone morphogenesis] evidence: ISS
            GeneID:3207 -> Cellular component: GO:0005667 [transcription factor complex] evidence: ISS
            GeneID:3207 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:3207 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:3207 -> Cellular component: GO:0032993 [protein-DNA complex] evidence: ISS
            GeneID:3207 -> Cellular component: GO:0043234 [protein complex] evidence: ISS