LOCUS       NM_004789               2416 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens LIM homeobox 2 (LHX2), mRNA.
ACCESSION   NM_004789
VERSION     NM_004789.3  GI:30795195
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Perez,C., Dastot-Le Moal,F., Collot,N., Legendre,M., Abadie,I.,
            Bertrand,A.M., Amselem,S. and Sobrier,M.L.
  TITLE     Screening of LHX2 in patients presenting growth retardation with
            posterior pituitary and ocular abnormalities
  JOURNAL   Eur. J. Endocrinol. 167 (1), 85-91 (2012)
   PUBMED   22535646
  REMARK    GeneRIF: These results suggest that if LHX2 is involved in
            pituitary hormone deficiency associated with posterior pituitary
            and ocular defects, it would be a rare cause of this disease
            condition.
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Mellado,C., Poduri,A., Gleason,D., Elhosary,P.C., Barry,B.J.,
            Partlow,J.N., Chang,B.S., Shaw,G.M., Barkovich,A.J. and Walsh,C.A.
  TITLE     Candidate gene sequencing of LHX2, HESX1, and SOX2 in a large
            schizencephaly cohort
  JOURNAL   Am. J. Med. Genet. A 152A (11), 2736-2742 (2010)
   PUBMED   20949537
  REMARK    GeneRIF: A large cohort of patients with schizencephaly, some with
            features of septo-optic dysplasia, were sequenced for mutations in
            LHX2, HESX1 and SOX2.
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Desmaison,A., Vigouroux,A., Rieubland,C., Peres,C., Calvas,P. and
            Chassaing,N.
  TITLE     Mutations in the LHX2 gene are not a frequent cause of
            micro/anophthalmia
  JOURNAL   Mol. Vis. 16, 2847-2849 (2010)
   PUBMED   21203406
  REMARK    GeneRIF: Mutations in LHX2 do not represent a frequent cause of
            micro/anophthalmia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Glenn,D.J. and Maurer,R.A.
  TITLE     MRG1 binds to the LIM domain of Lhx2 and may function as a
            coactivator to stimulate glycoprotein hormone alpha-subunit gene
            expression
  JOURNAL   J. Biol. Chem. 274 (51), 36159-36167 (1999)
   PUBMED   10593900
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Bach,I., Rodriguez-Esteban,C., Carriere,C., Bhushan,A., Krones,A.,
            Rose,D.W., Glass,C.K., Andersen,B., Izpisua Belmonte,J.C. and
            Rosenfeld,M.G.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat. Genet. 22 (4), 394-399 (1999)
   PUBMED   10431247
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Rincon-Limas,D.E., Lu,C.H., Canal,I., Calleja,M.,
            Rodriguez-Esteban,C., Izpisua-Belmonte,J.C. and Botas,J.
  TITLE     Conservation of the expression and function of apterous orthologs
            in Drosophila and mammals
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (5), 2165-2170 (1999)
   PUBMED   10051612
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Bendall,A.J., Rincon-Limas,D.E., Botas,J. and Abate-Shen,C.
  TITLE     Protein complex formation between Msx1 and Lhx2 homeoproteins is
            incompatible with DNA binding activity
  JOURNAL   Differentiation 63 (3), 151-157 (1998)
   PUBMED   9697309
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Wu,H.K., Heng,H.H., Siderovski,D.P., Dong,W.F., Okuno,Y., Shi,X.M.,
            Tsui,L.C. and Minden,M.D.
  TITLE     Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed
            in chronic myelogenous leukaemia and located on 9q33-34.1
  JOURNAL   Oncogene 12 (6), 1205-1212 (1996)
   PUBMED   8649822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK027597.1.
            On May 16, 2003 this sequence version replaced gi:28077086.
            
            Summary: This gene encodes a protein belonging to a large protein
            family, members of which carry the LIM domain, a unique
            cysteine-rich zinc-binding domain. The encoded protein may function
            as a transcriptional regulator. The protein can recapitulate or
            rescue phenotypes in Drosophila caused by a related protein,
            suggesting conservation of function during evolution. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027597.1, U11701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..2416
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="LIM homeobox 2"
                     /db_xref="GeneID:9355"
                     /db_xref="HGNC:6594"
                     /db_xref="HPRD:04786"
                     /db_xref="MIM:603759"
     exon            1..859
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /inference="alignment:Splign:1.39.8"
     variation       51
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370200195"
     variation       137
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112507291"
     variation       391
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:185294494"
     variation       627
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:7868184"
     STS             661..1980
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /db_xref="UniSTS:484345"
     misc_feature    677..679
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="upstream in-frame stop codon"
     CDS             740..1960
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="LIM HOX gene 2; LIM homeobox protein 2; homeobox
                     protein LH-2"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx2"
                     /protein_id="NP_004780.3"
                     /db_xref="GI:30795196"
                     /db_xref="CCDS:CCDS6853.1"
                     /db_xref="GeneID:9355"
                     /db_xref="HGNC:6594"
                     /db_xref="HPRD:04786"
                     /db_xref="MIM:603759"
                     /translation="

MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF

"
     misc_feature    866..1057
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="The first LIM domain of Lhx2; Region: LIM1_Lhx2;
                     cd09469"
                     /db_xref="CDD:188853"
     misc_feature    order(896..898,905..907,959..961,968..970,977..979,
                     986..988,1043..1045,1052..1054)
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188853"
     misc_feature    1070..1246
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="The second LIM domain of Lhx2 and Lhx9 family;
                     Region: LIM2_Lhx2_Lhx9; cd09377"
                     /db_xref="CDD:188763"
     misc_feature    order(1082..1084,1091..1093,1148..1150,1157..1159,
                     1166..1168,1175..1177,1232..1234,1241..1243)
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188763"
     misc_feature    1538..1711
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1538..1552,1556..1558,1607..1609,1625..1627,
                     1664..1666,1670..1675,1682..1687,1691..1699,1703..1708)
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1544..1546,1553..1555,1673..1675,1682..1687,
                     1694..1696)
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1658..1708
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P50458.2);
                     Region: Nuclear localization signal (Potential)"
     variation       848
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368708873"
     exon            860..1062
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /inference="alignment:Splign:1.39.8"
     variation       887
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113895098"
     variation       892
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149553241"
     variation       901
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201094464"
     variation       915
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370570070"
     variation       961
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373557738"
     variation       1030
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144291200"
     exon            1063..1466
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1075
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371648637"
     variation       1090
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370825161"
     variation       1105
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148731127"
     variation       1114
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186488928"
     variation       1123
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144871925"
     variation       1246
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375687666"
     variation       1260
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368805518"
     variation       1342
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201206386"
     variation       1354
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373482464"
     variation       1388
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189601606"
     variation       1438
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376893872"
     exon            1467..1672
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1504
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61734362"
     variation       1515
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140229756"
     variation       1522
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1042486"
     variation       1609
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367850838"
     exon            1673..2416
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1732
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373941963"
     variation       1736
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151109428"
     variation       1756
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138022431"
     variation       1771..1772
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34002135"
     variation       1779
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369099431"
     variation       1786
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3739828"
     variation       1792
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149656598"
     variation       1828
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368045815"
     variation       1876
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145536168"
     variation       1906
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140281616"
     variation       1912
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371809737"
     variation       1981
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369641402"
     variation       2030
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370577629"
     variation       2093..2094
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:147636766"
     variation       2100..2101
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:78148114"
     variation       2111
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182696516"
     variation       2124
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187764355"
     variation       2159
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146019691"
     variation       2244
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192376887"
     variation       2288
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138733410"
     variation       2317
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184610929"
     variation       2368
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199684038"
     variation       2369..2370
                     /gene="LHX2"
                     /gene_synonym="hLhx2; LH2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:11404693"
ORIGIN      

gactgcagagccggggctgggctaggcgcgcgcttggagagcattgcgcgcggctgggcccgcggccggcggctcctcctcccactctgctcctcctcttttttctcctcctccacctcctcctccgcctcctcctcctcctcttcctcctcctcttcaattctcccggtggctcgactcggctcgcaggcttcggagaaacccctactccagtcgccgactcagcgcccaagagggtcgccttgggctgggggcgcaccccagggaggggaggggtccaggcagctgggccgccgcggacacctagcggcttcagggtgaaccccgaccgcagccgtcgccgcctcgggcagagtttgcgcccttgctttgcgccccgggcgctgaagccgggcgggcgatgcccgcggcgtgaaagcgcccgcggcgggcgccgacctctgtcctagtctcctgctccccccgccccgcttgtcccgtgcccttgtgaccctggctttggcgccgtcgcccaggcgccccgcaatgtagctgcccctgcgcctcggcgggaggcgtcctgccccgcgagcgcccggggcccggagcccggcctgggggctcagccgagctcgggcggggccggggccgcggtggcgatgcaccgggcccgttagcgccaggagcgccaggcagctgaggcggggggcaagccctccctcggaggagccgcgcccccggccccgccggtcccgccgcgatgctgttccacagtctgtcgggccccgaggtgcacggggtcatcgacgagatggaccgcagggccaagagcgaggctcccgccatcagctccgccatcgaccgcggcgacaccgagacgaccatgccgtccatcagcagtgaccgcgccgcgctgtgcgccggctgcgggggcaagatctcggaccgctactacctgctggcggtggacaagcagtggcacatgcgctgcctcaagtgctgcgagtgcaagctcaacctggagtcggagctcacctgtttcagcaaggacggtagcatctactgcaaggaagactactacaggcgcttctctgtgcagcgctgcgcccgctgccacctgggcatctcggcctcggagatggtgatgcgcgctcgggacttggtttatcacctcaactgcttcacgtgcaccacgtgtaacaagatgctgaccacgggcgaccacttcggcatgaaggacagcctggtctactgccgcttgcacttcgaggcgctgctgcagggcgagtaccccgcacacttcaaccatgccgacgtggcagcggcggccgctgcagccgcggcggccaagagcgcggggctgggcgcagcaggggccaaccctctgggtcttccctactacaatggcgtgggcactgtgcagaaggggcggccgaggaaacgtaagagcccgggccccggtgcggatctggcggcctacaacgctgcgctaagctgcaacgaaaacgacgcagagcacctggaccgtgaccagccatacccgagcagccagaagaccaagcgcatgcgcacgtccttcaagcaccaccagcttcggaccatgaagtcttactttgccattaaccacaaccccgacgccaaggacttgaagcagctcgcgcaaaagacgggcctcaccaagcgggtcctccaggtctggttccagaacgcccgagccaagttcaggcgcaacctcttacggcaggaaaacacgggcgtggacaagtcgacagacgcggcgctgcagacagggacgccatcgggcccggcctcggagctctccaacgcctcgctcagcccctccagcacgcccaccaccctgacagacttgactagccccaccctgccaactgtgacgtccgtcttaacttctgtgcctggcaacctggagggccatgagcctcacagcccctcacaaacgactcttaccaaccttttctaatgactcgcaacccctcaccccacaatttctttaaaaaagaaattatctttagttgaattccaagtgtattttaaaatagaggctttgagcaactaactaaccacattttaggatctcgcctggaaacagaggtaaaaaaaagaagtgtgcgcccggctaatgcagcggtgtggaccgaggaacaacttggaagatctacctgcaacacaacatttgtgtcactgtacagttttgtggactgagcgaggaaaaacaacaaataatttaagttggctagagcttctgtattttcaaagactgccacgtgccttaggaatactgttttatctccatactttggatgacttgttcatttttctctccctctttttctctgtatatttatgaccagagcaaaaatgtaaaaaacaaaaaaaacaacaaaaaaagtttgttactttgaatagtcctaaaaag

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9355 -> Molecular function: GO:0001076 [RNA polymerase II transcription factor binding transcription factor activity] evidence: IEA
            GeneID:9355 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:9355 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:9355 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:9355 -> Biological process: GO:0001843 [neural tube closure] evidence: IEA
            GeneID:9355 -> Biological process: GO:0007411 [axon guidance] evidence: IEA
            GeneID:9355 -> Biological process: GO:0007498 [mesoderm development] evidence: IEA
            GeneID:9355 -> Biological process: GO:0009953 [dorsal/ventral pattern formation] evidence: IEA
            GeneID:9355 -> Biological process: GO:0021978 [telencephalon regionalization] evidence: IEA
            GeneID:9355 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: ISS
            GeneID:9355 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:9355 -> Biological process: GO:2000678 [negative regulation of transcription regulatory region DNA binding] evidence: IEA
            GeneID:9355 -> Cellular component: GO:0005634 [nucleus] evidence: IEA