LOCUS       NM_004575               3141 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens POU class 4 homeobox 2 (POU4F2), mRNA.
ACCESSION   NM_004575
VERSION     NM_004575.2  GI:110347454
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3141)
  AUTHORS   Reinert,T., Borre,M., Christiansen,A., Hermann,G.G., Orntoft,T.F.
            and Dyrskjot,L.
  TITLE     Diagnosis of bladder cancer recurrence based on urinary levels of
            EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation
  JOURNAL   PLoS ONE 7 (10), E46297 (2012)
   PUBMED   23056278
  REMARK    GeneRIF: Methylation levels of EOMES, HOXA9, POU4F2, TWIST1, VIM,
            and ZNF154 in urine specimens are promising diagnostic biomarkers
            for bladder cancer recurrence surveillance
REFERENCE   2  (bases 1 to 3141)
  AUTHORS   Fujita,R., Ounzain,S., Wang,A.C., Heads,R.J. and
            Budhram-Mahadeo,V.S.
  TITLE     Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated
            breast cancer cells, whereas phosphorylation alters its cellular
            localisation following drug treatment
  JOURNAL   Cell Stress Chaperones 16 (4), 427-439 (2011)
   PUBMED   21279488
REFERENCE   3  (bases 1 to 3141)
  AUTHORS   Qiu,F., Jiang,H. and Xiang,M.
  TITLE     A comprehensive negative regulatory program controlled by Brn3b to
            ensure ganglion cell specification from multipotential retinal
            precursors
  JOURNAL   J. Neurosci. 28 (13), 3392-3403 (2008)
   PUBMED   18367606
  REMARK    GeneRIF: Brn3b specifies the RGC fate from multipotential
            precursors not only by promoting RGC differentiation but also by
            suppressing non-RGC differentiation programs as a safeguard
            mechanism.
REFERENCE   4  (bases 1 to 3141)
  AUTHORS   Budhram-Mahadeo,V.S., Irshad,S., Bowen,S., Lee,S.A., Samady,L.,
            Tonini,G.P. and Latchman,D.S.
  TITLE     Proliferation-associated Brn-3b transcription factor can activate
            cyclin D1 expression in neuroblastoma and breast cancer cells
  JOURNAL   Oncogene 27 (1), 145-154 (2008)
   PUBMED   17637757
  REMARK    GeneRIF: May act to alter growth properties of breast cancer and
            neuroblastoma cells by enhancing cyclin D1 expression in these
            tumor cells.
REFERENCE   5  (bases 1 to 3141)
  AUTHORS   Calissano,M., Diss,J.K. and Latchman,D.S.
  TITLE     Post-transcriptional regulation of the Brn-3b transcription factor
            in differentiating neuroblastoma cells
  JOURNAL   FEBS Lett. 581 (13), 2490-2496 (2007)
   PUBMED   17490655
  REMARK    GeneRIF: Two different microRNAs that potentially regulate the
            stability of Brn-3b have been identified in neuroblastoma cells.
REFERENCE   6  (bases 1 to 3141)
  AUTHORS   Smith,M.D., Dawson,S.J. and Latchman,D.S.
  TITLE     Inhibition of neuronal process outgrowth and neuronal specific gene
            activation by the Brn-3b transcription factor
  JOURNAL   J. Biol. Chem. 272 (2), 1382-1388 (1997)
   PUBMED   8995448
REFERENCE   7  (bases 1 to 3141)
  AUTHORS   Xiang,M., Zhou,L., Macke,J.P., Yoshioka,T., Hendry,S.H., Eddy,R.L.,
            Shows,T.B. and Nathans,J.
  TITLE     The Brn-3 family of POU-domain factors: primary structure, binding
            specificity, and expression in subsets of retinal ganglion cells
            and somatosensory neurons
  JOURNAL   J. Neurosci. 15 (7 PT 1), 4762-4785 (1995)
   PUBMED   7623109
REFERENCE   8  (bases 1 to 3141)
  AUTHORS   Bhargava,A.K., Li,Z. and Weissman,S.M.
  TITLE     Differential expression of four members of the POU family of
            proteins in activated and phorbol 12-myristate 13-acetate-treated
            Jurkat T cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 90 (21), 10260-10264 (1993)
   PUBMED   8234287
REFERENCE   9  (bases 1 to 3141)
  AUTHORS   Xiang,M., Zhou,L., Peng,Y.W., Eddy,R.L., Shows,T.B. and Nathans,J.
  TITLE     Brn-3b: a POU domain gene expressed in a subset of retinal ganglion
            cells
  JOURNAL   Neuron 11 (4), 689-701 (1993)
   PUBMED   7691107
REFERENCE   10 (bases 1 to 3141)
  AUTHORS   Ring,C.J. and Latchman,D.S.
  TITLE     The human Brn-3b POU transcription factor shows only limited
            homology to the Brn-3a/RDC-1 factor outside the conserved POU
            domain
  JOURNAL   Nucleic Acids Res. 21 (12), 2946 (1993)
   PUBMED   8332509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB082745.1, BY796838.2,
            U06233.1 and X71488.1.
            On Jul 14, 2006 this sequence version replaced gi:4758947.
            
            Summary: The protein encoded by this gene is a member of the
            POU-domain transcription factor family and may be involved in
            maintaining visual system neurons in the retina. The level of the
            encoded protein is also elevated in a majority of breast cancers,
            resulting in accelerated tumor growth. [provided by RefSeq, Sep
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U06233.1, EU439706.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               DB082745.1         1-448
            449-638             BY796838.2         438-627
            639-741             U06233.1           606-708
            742-793             X71488.1           62-113
            794-2552            U06233.1           761-2519
            2553-3141           U06233.1           2522-3110
FEATURES             Location/Qualifiers
     source          1..3141
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.2"
     gene            1..3141
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="POU class 4 homeobox 2"
                     /db_xref="GeneID:5458"
                     /db_xref="HGNC:9219"
                     /db_xref="MIM:113725"
     exon            1..536
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /inference="alignment:Splign:1.39.8"
     variation       21
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143373833"
     variation       97
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370191425"
     variation       112
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372544942"
     variation       155
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35733768"
     variation       194
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369199465"
     variation       200
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369625548"
     STS             202..1531
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /db_xref="UniSTS:482508"
     variation       209
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373501732"
     misc_feature    210..212
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="upstream in-frame stop codon"
     variation       217
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376572394"
     variation       243
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202046663"
     CDS             249..1478
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="Brn3b POU domain transcription factor; POU domain
                     protein; POU domain class 4 transcription factor 2;
                     brain-3B; brain-specific homeobox/POU domain protein 3B"
                     /codon_start=1
                     /product="POU domain, class 4, transcription factor 2"
                     /protein_id="NP_004566.2"
                     /db_xref="GI:110347455"
                     /db_xref="CCDS:CCDS34074.1"
                     /db_xref="GeneID:5458"
                     /db_xref="HGNC:9219"
                     /db_xref="MIM:113725"
                     /translation="

MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI

"
     misc_feature    576..605
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12837.2);
                     Region: POU-IV box"
     misc_feature    996..1229
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    1284..1460
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1284..1298,1302..1304,1353..1355,1371..1373,
                     1410..1412,1416..1421,1428..1433,1437..1445,1449..1454)
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1290..1292,1299..1301,1419..1421,1428..1433,
                     1440..1442)
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       275
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200843721"
     variation       293
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146671454"
     variation       294
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:62327967"
     variation       296
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369358968"
     variation       319
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199899657"
     variation       338
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373682041"
     variation       344
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140261687"
     variation       367
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13152799"
     variation       372
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184591480"
     variation       414..422
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ggcggcggc"
                     /replace="ggcggcggcggc"
                     /db_xref="dbSNP:67907220"
     variation       414..415
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ggc"
                     /db_xref="dbSNP:72269802"
     variation       416
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189899086"
     variation       438..446
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ggcggcggc"
                     /db_xref="dbSNP:67194443"
     variation       438..439
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ggc"
                     /replace="ggcggcggcggcggc"
                     /db_xref="dbSNP:34359247"
     variation       449..450
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="cgg"
                     /db_xref="dbSNP:33986795"
     variation       482
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199600550"
     variation       508
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145352817"
     variation       513
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148020860"
     variation       532
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141725106"
     exon            537..3141
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /inference="alignment:Splign:1.39.8"
     variation       544
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201496393"
     variation       625
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372609971"
     variation       640
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150150229"
     variation       665
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147517729"
     variation       666
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74417037"
     variation       695
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143938073"
     variation       707
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139883264"
     variation       752
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143876216"
     variation       764
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369535679"
     variation       768
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376900695"
     variation       798
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144284868"
     variation       809
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376581460"
     variation       828
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371559221"
     variation       851
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200464919"
     variation       862
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373979098"
     variation       866
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202030431"
     variation       878
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376822201"
     variation       893
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200695260"
     variation       899
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373088055"
     variation       915
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377219455"
     variation       943
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376992021"
     variation       962
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148751103"
     variation       965
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373594627"
     variation       991
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373360428"
     variation       1005
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3827593"
     variation       1059
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200579530"
     variation       1065
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142395313"
     variation       1073
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:151303999"
     variation       1095
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76129457"
     variation       1105
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373485818"
     variation       1107
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376482978"
     variation       1114
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144507526"
     variation       1119
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369337694"
     variation       1122
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372535541"
     variation       1123
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200312228"
     variation       1126
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371120198"
     variation       1172
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3827594"
     variation       1190
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:61733420"
     variation       1209
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145278389"
     variation       1238
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144940288"
     variation       1246
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199979947"
     variation       1275
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377411656"
     variation       1277
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370767940"
     variation       1278
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375025437"
     variation       1298
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371952832"
     variation       1306
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200705430"
     variation       1308
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374901217"
     variation       1310
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367653245"
     variation       1313
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61733419"
     variation       1328
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143117935"
     variation       1334
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148247830"
     variation       1341
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:180935169"
     variation       1344
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142851123"
     variation       1349
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372860552"
     variation       1358
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199813288"
     variation       1374
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147007829"
     variation       1376
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200415873"
     variation       1385
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369917575"
     variation       1409
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138240408"
     variation       1432
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113095745"
     variation       1453
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201841354"
     variation       1466
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370757448"
     variation       1469
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143812023"
     STS             1486..1618
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /standard_name="G34464"
                     /db_xref="UniSTS:80252"
     variation       1489
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3810843"
     variation       1503
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376016201"
     variation       1508
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370553185"
     variation       1613
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368127169"
     variation       1663
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372340520"
     variation       1690
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369146164"
     STS             1765..1859
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /standard_name="D4S3267"
                     /db_xref="UniSTS:76043"
     variation       1840
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376565147"
     variation       1850
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:201294453"
     variation       1989
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:72956271"
     variation       2013
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76180708"
     variation       2091
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186245328"
     variation       2216
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139670347"
     variation       2280
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114364181"
     variation       2423
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7669891"
     variation       2494
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372851210"
     STS             2502..2699
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /standard_name="D4S3346"
                     /db_xref="UniSTS:24323"
     variation       2526..2527
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ac"
                     /replace="acacac"
                     /db_xref="dbSNP:71592457"
     variation       2526
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200297474"
     variation       2527..2528
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ac"
                     /db_xref="dbSNP:375277243"
     variation       2528..2529
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ca"
                     /replace="cacacaca"
                     /db_xref="dbSNP:72274820"
     variation       2541..2542
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ca"
                     /db_xref="dbSNP:10682779"
     variation       2542..2543
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ca"
                     /replace="cacacaca"
                     /db_xref="dbSNP:35584951"
     variation       2543..2544
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace=""
                     /replace="ac"
                     /replace="acac"
                     /replace="acacacac"
                     /db_xref="dbSNP:34459995"
     variation       2590
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6825713"
     variation       2595
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111877076"
     variation       2665
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191340422"
     variation       2777
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183140735"
     variation       2841
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369169254"
     variation       2846
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186059151"
     variation       2919
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144585453"
     variation       2978
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74571172"
     variation       3092
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190835038"
     polyA_site      3141
                     /gene="POU4F2"
                     /gene_synonym="Brn-3b; BRN3.2; BRN3B"
                     /note="19 A residues"
ORIGIN      

agtttcgggtgccgaggtctgcagctagcggcaagcggagtcaggcatccgttcagactgacagcagaggcggcgaaggagcgcgtagccgagatcaggcgtacagagtccggaggcggcggcgggtgagctcaacttcgcacagcccttcccagctccagccccggctggcccggcacttctcggagggtcccggcagccgggaccagtgagtgcctctacggaccagcgccccggcgggcgggaagatgatgatgatgtccctgaacagcaagcaggcgtttagcatgccgcacggcggcagcctgcacgtggagcccaagtactcggcactgcacagcacctcgccgggctcctcggctcccatcgcgccctcggccagctcccccagcagctcgagcaacgctggtggtggcggcggcggcggcggcggcggcggcggcggcggaggccgaagcagcagctccagcagcagtggcagcagcggcggcgggggctcggaggctatgcggagagcctgtcttccaaccccaccgagcaatatattcggcgggctggatgagagtctgctggcccgcgccgaggctctggcagccgtggacatcgtctcccagagcaagagccaccaccaccatccaccccaccacagccccttcaaaccggacgccacctaccacactatgaataccatcccgtgcacgtcggccgcctcttcttcatcggtgcccatctcgcacccttccgcgttggcgggcacgcaccaccaccaccaccatcaccaccaccaccaccaccaaccgcaccaggcgctggagggcgagctgctggagcacctgagtcccgggctggccctgggcgctatggcgggccccgacggcgctgtggtgtccacgccggctcacgcgccgcacatggccaccatgaaccccatgcaccaagcagcgctcagcatggcccacgcgcacgggctgccgtcgcacatgggctgcatgagcgacgtggacgccgacccgcgggacctggaggcattcgccgagcgcttcaagcagcgacgcatcaagctgggggtgacccaggcagatgtgggctccgcgctggccaacctcaagatccccggcgtgggctcgcttagccagagcaccatctgcaggttcgagtccctcacactgtcccacaataatatgatcgcgctcaaacccatcctgcaggcatggctcgaggaggccgagaagtcccaccgcgagaagctcaccaagcctgaactcttcaatggcgcggagaagaagcgcaagcgcacgtccatcgctgcgccagagaagcgctcgctcgaagcctactttgccattcagcctcggccctcctctgaaaagatcgccgccatcgcggagaagctggacctgaagaaaaacgtggtgcgcgtctggttctgcaaccagaggcagaaacagaaaagaatgaaatattccgccggcatttagaagactcttggcctctccagagacgcccctttcctcgtccgctcttttctctcctctcttctgcctcttttcacttttggcgactagaaacaattccagtaaatgtgaatctcgacaaatcgaggactgaagagggagcgaacgagcgaacaactgagcccaagccggtgagaatgtgaaacagtttctcaaaggaaagaataacaaaagatggtatttgtctgttgtagcaaagttgtccctttgaaccccacctcggcttcttcagaggaagtgtggagatggctgtttgcaggaaggcagacgagacagtgtttaaaaagtccacaagaatgatcaagtaagatttgtttttattcttacagacatcacccgtgttcaagtttaaaagtacactttgcaactatttttcagaaatagaaattgattcaggactaaaactttaaactagagttgatgcttaatgtgatagagacatctctaaagtattttgaattttaaaaaaagatggcagattttctgcatttacactgtatattatatatatatttttattgtggttcttacccccttttccttctctgaagtgttaatgcttaagaaaagagttgcgcctgctgtgttcactgatcttgaaagctattattagattattgcagaacaaccctctgtaaattattaatttatctctctagcaacttaattttgtgcacattctaattaattaaacttcttccgtctaaaaaaagtgggggaaatgtatagctagtaacgttcaaaaaattttgtttgatgagtttaccgaatttttacagctttcctcctatactgtgttccttttgacccatttgtatattctcacttgaatgaagattgtttttttctttgtttttactggtagtgttctgatttgtgagtcgacactcagtaatggatgtcttaatcgtgtagacctgattcactgtctgaagtattgtttacttcgttacatatttaatggggattcccacattgtccccatgacacatgagcgctctcacttacccttacacacacacacacacacacacacacctctaacagaagggaagaagcagttggaagcatgaccgatgcaccattttctagttttaggtgcatttgccacttggtgtttgcccttcagattttagatttcaccaaggtatttcagtcttccagttttcaattgctttgttggctacatgttaatatttataggaatacttcagtttttccttttggaggtttgtttgtagaaaaactaatttgaactataagaaagacagtgcactgcttgtaaattcacattgtttggaaaaattcttttggaacaaaaaattaggtacatgataactggtaccttatctactgtaaatatttcattaaaaatgatgcacacatagatatattcttacaaattttgctgtattgctgttctctttgaggctctccaaagtcttgagttctgtatatggcctggtttcttgtttttattaatagatggtttatttactatggtaatgtattaatttatttttggtgttgttcgattgtctttcattgaagagataattttaatgttttattggcaacgtatgctgctttttcattaaaatatgctattaaaattaaatggctttta

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5458 -> Molecular function: GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] evidence: IDA
            GeneID:5458 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IDA
            GeneID:5458 -> Molecular function: GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] evidence: ISS
            GeneID:5458 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
            GeneID:5458 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
            GeneID:5458 -> Biological process: GO:0000165 [MAPK cascade] evidence: IDA
            GeneID:5458 -> Biological process: GO:0007411 [axon guidance] evidence: ISS
            GeneID:5458 -> Biological process: GO:0007605 [sensory perception of sound] evidence: IEA
            GeneID:5458 -> Biological process: GO:0030182 [neuron differentiation] evidence: ISS
            GeneID:5458 -> Biological process: GO:0030520 [intracellular estrogen receptor signaling pathway] evidence: IDA
            GeneID:5458 -> Biological process: GO:0031290 [retinal ganglion cell axon guidance] evidence: IEA
            GeneID:5458 -> Biological process: GO:0045597 [positive regulation of cell differentiation] evidence: ISS
            GeneID:5458 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:5458 -> Biological process: GO:0048675 [axon extension] evidence: IEA
            GeneID:5458 -> Biological process: GO:0050885 [neuromuscular process controlling balance] evidence: IEA
            GeneID:5458 -> Biological process: GO:0060041 [retina development in camera-type eye] evidence: ISS
            GeneID:5458 -> Cellular component: GO:0005634 [nucleus] evidence: IC
            GeneID:5458 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
            GeneID:5458 -> Cellular component: GO:0016607 [nuclear speck] evidence: IEA