GGRNA | NM_004503.3

LOCUS       NM_004503               1681 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox C6 (HOXC6), transcript variant 1, mRNA.
ACCESSION   NM_004503
VERSION     NM_004503.3  GI:93141222
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1681)
  AUTHORS   Moon,S.M., Kim,S.A., Yoon,J.H. and Ahn,S.G.
  TITLE     HOXC6 is deregulated in human head and neck squamous cell carcinoma
            and modulates Bcl-2 expression
  JOURNAL   J. Biol. Chem. 287 (42), 35678-35688 (2012)
   PUBMED   22896703
  REMARK    GeneRIF: HOXC6 is an important mechanism of the anti-apoptotic
            pathway via regulation of Bcl-2 expression.
REFERENCE   2  (bases 1 to 1681)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat. Genet. 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1681)
  AUTHORS   Ansari,K.I., Hussain,I., Shrestha,B., Kasiri,S. and Mandal,S.S.
  TITLE     HOXC6 Is transcriptionally regulated via coordination of MLL
            histone methylase and estrogen receptor in an estrogen environment
  JOURNAL   J. Mol. Biol. 411 (2), 334-349 (2011)
   PUBMED   21683083
  REMARK    GeneRIF: These studies demonstrated that HOXC6 is an
            estrogen-responsive gene, and that histone methylases MLL2 and
            MLL3, in coordination with ERalpha and ERbeta, transcriptionally
            regulate HOXC6 in an estrogen-dependent manner.
REFERENCE   4  (bases 1 to 1681)
  AUTHORS   Feng,J.Q., Liu,W.J., Chen,H.Y., Guo,Q.L., Chen,A. and Chen,S.Q.
  TITLE     [Effect of human cytomegalovirus infection on the expression of
            hoxc4 and hoxc6 genes in the proliferation of lymphocytic
            progenitor cells]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 17 (1), 141-145 (2009)
   PUBMED   19236766
  REMARK    GeneRIF: Human cytomegalovirus downregulates while all-trans
            retinoic acid upregulates expression of hoxc4 and hoxc6 in
            lymphocytic progenitor cells.
REFERENCE   5  (bases 1 to 1681)
  AUTHORS   Zhang,X., Hamada,J., Nishimoto,A., Takahashi,Y., Murai,T., Tada,M.
            and Moriuchi,T.
  TITLE     HOXC6 and HOXC11 increase transcription of S100beta gene in
            BrdU-induced in vitro differentiation of GOTO neuroblastoma cells
            into Schwannian cells
  JOURNAL   J. Cell. Mol. Med. 11 (2), 299-306 (2007)
   PUBMED   17488478
  REMARK    GeneRIF: HOXC6 increases transcription of S100beta gene in
            BrdU-induced in vitro differentiation of GOTO neuroblastoma cells
            into Schwann cells.
REFERENCE   6  (bases 1 to 1681)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   7  (bases 1 to 1681)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
REFERENCE   8  (bases 1 to 1681)
  AUTHORS   Simeone,A., Pannese,M., Acampora,D., D'Esposito,M. and
            Boncinelli,E.
  TITLE     At least three human homeoboxes on chromosome 12 belong to the same
            transcription unit
  JOURNAL   Nucleic Acids Res. 16 (12), 5379-5390 (1988)
   PUBMED   2898768
REFERENCE   9  (bases 1 to 1681)
  AUTHORS   Simeone,A., Mavilio,F., Acampora,D., Giampaolo,A., Faiella,A.,
            Zappavigna,V., D'Esposito,M., Pannese,M., Russo,G., Boncinelli,E.
            et al.
  TITLE     Two human homeobox genes, c1 and c8: structure analysis and
            expression in embryonic development
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (14), 4914-4918 (1987)
   PUBMED   2885844
REFERENCE   10 (bases 1 to 1681)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from S82986.1 and AC012531.11.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 21, 2006 this sequence version replaced gi:24497542.
            
            Summary: This gene belongs to the homeobox family, members of which
            encode a highly conserved family of transcription factors that play
            an important role in morphogenesis in all multicellular organisms.
            Mammals possess four similar homeobox gene clusters, HOXA, HOXB,
            HOXC and HOXD, which are located on different chromosomes and
            consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is
            one of several HOXC genes located in a cluster on chromosome 12.
            Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon.
            Transcripts may include the shared exon spliced to the
            gene-specific exons, or they may include only the gene-specific
            exons. Alternatively spliced transcript variants encoding different
            isoforms have been identified for HOXC6. Transcript variant two
            includes the shared exon, and transcript variant one includes only
            gene-specific exons. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S82986.1, BC074844.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1009              S82986.1           21-1029
            1010-1681           AC012531.11        167756-168427
FEATURES             Location/Qualifiers
     source          1..1681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1681
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="homeobox C6"
                     /db_xref="GeneID:3223"
                     /db_xref="HGNC:5128"
                     /db_xref="HPRD:00858"
                     /db_xref="MIM:142972"
     exon            1..512
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    32..34
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="upstream in-frame stop codon"
     variation       75
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200476091"
     STS             87..856
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /db_xref="UniSTS:482059"
     CDS             113..820
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="isoform 1 is encoded by transcript variant 1; homeo
                     box C6; homeo box C8 protein; homeo box 3C; homeobox
                     protein Hox-C6; homeobox protein CP25; homeobox protein
                     HHO.C8; homeobox protein Hox-3C"
                     /codon_start=1
                     /product="homeobox protein Hox-C6 isoform 1"
                     /protein_id="NP_004494.1"
                     /db_xref="GI:4758554"
                     /db_xref="CCDS:CCDS8871.1"
                     /db_xref="GeneID:3223"
                     /db_xref="HGNC:5128"
                     /db_xref="HPRD:00858"
                     /db_xref="MIM:142972"
                     /translation="

MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAVAQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE

"
     misc_feature    476..493
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09630.3);
                     Region: Antp-type hexapeptide"
     misc_feature    536..712
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(536..550,554..556,605..607,623..625,662..664,
                     668..673,680..685,689..697,701..706)
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(542..544,551..553,671..673,680..685,692..694)
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       155
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:181552044"
     variation       162
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200139629"
     variation       163
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146854412"
     variation       181
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201443964"
     variation       192
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377315282"
     variation       194
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75114216"
     variation       207
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200758418"
     variation       242
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370829959"
     variation       249
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:79558505"
     variation       256
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201730816"
     variation       284
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200694174"
     variation       286
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145731630"
     variation       311
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144307645"
     variation       356
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201594434"
     variation       391
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111518456"
     STS             404..613
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /standard_name="MARC_44017-44022:1098368610:3"
                     /db_xref="UniSTS:471619"
     variation       458
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376534127"
     variation       467
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371058976"
     variation       482
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:80157375"
     exon            513..1681
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /inference="alignment:Splign:1.39.8"
     variation       533
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138685629"
     variation       561
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113381644"
     variation       588
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377095092"
     variation       595
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368405993"
     variation       597
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372813456"
     variation       613
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375750909"
     variation       637
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151083984"
     variation       640
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61736613"
     variation       643
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199717526"
     variation       650
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139697680"
     variation       667
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143618403"
     variation       721
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369084398"
     variation       723
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148638675"
     variation       728
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373295522"
     variation       737
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200427348"
     variation       743
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202121790"
     variation       750..751
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:147247423"
     STS             759..1647
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /standard_name="Hoxc6"
                     /db_xref="UniSTS:547241"
     variation       791
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201035626"
     STS             838..1062
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /standard_name="STS-S82986"
                     /db_xref="UniSTS:9088"
     STS             942..1121
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /standard_name="STS-M16938"
                     /db_xref="UniSTS:20596"
     variation       1010
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1042245"
     variation       1014
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141463318"
     variation       1065
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1249078"
     variation       1158..1159
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34643568"
     variation       1197
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7308105"
     variation       1304
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35857063"
     variation       1330
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1249077"
     variation       1402
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373542987"
     polyA_signal    1652..1657
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
     polyA_site      1681
                     /gene="HOXC6"
                     /gene_synonym="CP25; HHO.C8; HOX3; HOX3C"
ORIGIN

ttttgtctgtcctggattggagccgtccctataaccatctagttccgagtacaaactggagacagaaataaatattaaagaaatcatagaccgaccaggtaaaggcaaagggatgaattcctacttcactaacccttccttatcctgccacctcgccgggggccaggacgtcctccccaacgtcgccctcaattccaccgcctatgatccagtgaggcatttctcgacctatggagcggccgttgcccagaaccggatctactcgactcccttttattcgccacaggagaatgtcgtgttcagttccagccgggggccgtatgactatggatctaattccttttaccaggagaaagacatgctctcaaactgcagacaaaacaccttaggacataacacacagacctcaatcgctcaggattttagttctgagcagggcaggactgcgccccaggaccagaaagccagtatccagatttacccctggatgcagcgaatgaattcgcacagtggggtcggctacggagcggaccggaggcgcggccgccagatctactcgcggtaccagaccctggaactggagaaggaatttcacttcaatcgctacctaacgcggcgccggcgcatcgagatcgccaacgcgctttgcctgaccgagcgacagatcaaaatctggttccagaaccgccggatgaagtggaaaaaagaatctaatctcacatccactctctcggggggcggcggaggggccaccgccgacagcctgggcggaaaagaggaaaagcgggaagagacagaagaggagaagcagaaagagtgaccaggactgtccctgccacccctctctccctttctccctcgctccccaccaactctcccctaatcacacactctgtatttatcactggcacaattgatgtgttttgattccctaaaacaaaattagggagtcaaacgtggacctgaaagtcagctctggaccccctccctcaccgcacaactctctttcaccacgcgcctcctcctcctcgctcccttgctagctcgttctcggcttgtctacaggcccttttccccgtccaggccttgggggctcggaccctgaactcagactctacagattgccctccaagtgaggacttggctcccccactccttcgacgcccccacccccgccccccgtgcagagagccggctcctgggcctgctggggcctctgctccagggcctcagggcccggcctggcagccggggagggccggaggcccaaggagggcgcgccttggccccacaccaacccccagggcctccccgcagtccctgcctagcccctctgccccagcaaatgcccagcccaggcaaattgtatttaaagaatcctgggggtcattatggcattttacaaactgtgaccgtttctgtgtgaagatttttagctgtatttgtggtctctgtatttatatttatgtttagcaccgtcagtgttcctatccaatttcaaaaaaggaaaaaaaagagggaaaattacaaaaagagagaaaaaaagtgaatgacgtttgtttagccagtaggagaaaataaataaataaataaatcccttcgtgttaccctcctgtataaatccaacctctgggtccgttctcgaatatttaataaaactgatattatttttaaaacttta

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