GGRNA | NM_004502.3

LOCUS       NM_004502               1377 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox B7 (HOXB7), mRNA.
ACCESSION   NM_004502
VERSION     NM_004502.3  GI:85068579
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1377)
  AUTHORS   Nguyen Kovochich,A., Arensman,M., Lay,A.R., Rao,N.P., Donahue,T.,
            Li,X., French,S.W. and Dawson,D.W.
  TITLE     HOXB7 promotes invasion and predicts survival in pancreatic
            adenocarcinoma
  JOURNAL   Cancer 119 (3), 529-539 (2013)
   PUBMED   22914903
  REMARK    GeneRIF: HOXB7 is frequently overexpressed in pancreatic
            adenocarcinoma, specifically promotes invasive phenotype, and is
            associated with lymph node metastasis and worse survival outcome.
REFERENCE   2  (bases 1 to 1377)
  AUTHORS   Muller,D., Schreiner,S., Schmid,M., Groitl,P., Winkler,M. and
            Dobner,T.
  TITLE     Functional cooperation between human adenovirus type 5 early region
            4, open reading frame 6 protein, and cellular homeobox protein
            HoxB7
  JOURNAL   J. Virol. 86 (15), 8296-8308 (2012)
   PUBMED   22553335
  REMARK    GeneRIF: the absence of HoxB7 leads to inefficient viral progeny
            production, as HAdV5 gene expression is highly regulated by
            HoxB7-mediated activation of various adenoviral promoters.
REFERENCE   3  (bases 1 to 1377)
  AUTHORS   di Pietro,M., Lao-Sirieix,P., Boyle,S., Cassidy,A., Castillo,D.,
            Saadi,A., Eskeland,R. and Fitzgerald,R.C.
  TITLE     Evidence for a functional role of epigenetically regulated
            midcluster HOXB genes in the development of Barrett esophagus
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (23), 9077-9082 (2012)
   PUBMED   22603795
  REMARK    GeneRIF: HOXB5, HOXB6, and HOXB7 are activated in Barrett
            esophagus, and the midcluster HOXB gene signature in BE most
            resembled the colon rather than other GI epithelia.
REFERENCE   4  (bases 1 to 1377)
  AUTHORS   Nischalke,H.D., Schmitz,V., Luda,C., Aldenhoff,K., Berger,C.,
            Feldmann,G., Sauerbruch,T., Spengler,U. and Nattermann,J.
  TITLE     Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush
            cytology specimens as a new diagnostic tool in patients with
            biliary strictures
  JOURNAL   PLoS ONE 7 (8), E42141 (2012)
   PUBMED   22879911
  REMARK    GeneRIF: Measuring IGF2BP3, HOXB7 and NEK2 mRNA levels by RT-PCR in
            addition to cytology has the potential to improve detection of
            malignant biliary disorders from brush cytology specimens.
REFERENCE   5  (bases 1 to 1377)
  AUTHORS   Wu,X., Ellmann,S., Rubin,E., Gil,M., Jin,K., Han,L., Chen,H.,
            Kwon,E.M., Guo,J., Ha,H.C. and Sukumar,S.
  TITLE     ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional
            activity
  JOURNAL   PLoS ONE 7 (7), E40644 (2012)
   PUBMED   22844406
  REMARK    GeneRIF: a novel mechanism whereby polyADP-ribosylation regulates
            transcriptional activities of HOX proteins such as HOXB7 and HOXA7
REFERENCE   6  (bases 1 to 1377)
  AUTHORS   Baier,L.J., Hannibal,M.C., Hanley,E.W. and Nabel,G.J.
  TITLE     Lymphoid expression and TATAA binding of a human protein containing
            an Antennapedia homeodomain
  JOURNAL   Blood 78 (4), 1047-1055 (1991)
   PUBMED   1678287
REFERENCE   7  (bases 1 to 1377)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   8  (bases 1 to 1377)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 1377)
  AUTHORS   Shen,W.F., Largman,C., Lowney,P., Corral,J.C., Detmer,K.,
            Hauser,C.A., Simonitch,T.A., Hack,F.M. and Lawrence,H.J.
  TITLE     Lineage-restricted expression of homeobox-containing genes in human
            hematopoietic cell lines
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (21), 8536-8540 (1989)
   PUBMED   2573064
REFERENCE   10 (bases 1 to 1377)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG118354.1, BP342702.1,
            BM923808.1 and BQ233410.1.
            On Jan 18, 2006 this sequence version replaced gi:25121962.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded nuclear protein functions as a sequence-specific
            transcription factor that is involved in cell proliferation and
            differentiation. Increased expression of this gene is associated
            with some cases of melanoma and ovarian carcinoma. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG115306.1, AK223249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BG118354.1         5-13
            10-12               BP342702.1         9-11
            13-19               BG118354.1         16-22
            20-803              BM923808.1         21-804
            804-1377            BQ233410.1         122-695
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.3"
     gene            1..1377
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="homeobox B7"
                     /db_xref="GeneID:3217"
                     /db_xref="HGNC:5118"
                     /db_xref="MIM:142962"
     exon            1..503
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /inference="alignment:Splign:1.39.8"
     variation       13
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:16942475"
     misc_feature    68..70
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="upstream in-frame stop codon"
     CDS             104..757
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="homeo box B7; homeo box c1 protein; homeo box 2C;
                     homeobox protein HHO.C1; homeobox protein Hox-2C"
                     /codon_start=1
                     /product="homeobox protein Hox-B7"
                     /protein_id="NP_004493.3"
                     /db_xref="GI:85068580"
                     /db_xref="CCDS:CCDS11532.1"
                     /db_xref="GeneID:3217"
                     /db_xref="HGNC:5118"
                     /db_xref="MIM:142962"
                     /translation="

MSSLYYANTLFSKYPASSSVFATGAFPEQTSCAFASNPQRPGYGAGSGASFAASMQGLYPGGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDSAKAAGAKEQRDSDLAAESNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTAGPGTTGQDRAEAEEEEEE

"
     misc_feature    479..496
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09629.4);
                     Region: Antp-type hexapeptide"
     misc_feature    500..502
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00277"
     misc_feature    515..691
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(515..529,533..535,584..586,602..604,641..643,
                     647..652,659..664,668..676,680..685)
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(521..523,530..532,650..652,659..664,671..673)
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    713..715
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00277"
     variation       247
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35272692"
     variation       283
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34513708"
     variation       336
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35657716"
     variation       454
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2228185"
     variation       489
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1126558"
     exon            504..1367
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /inference="alignment:Splign:1.39.8"
     variation       620
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1042216"
     variation       800
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1042226"
     variation       1032
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:15689"
     polyA_signal    1345..1350
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
     polyA_signal    1356..1361
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
     polyA_site      1367
                     /gene="HOXB7"
                     /gene_synonym="HHO.C1; Hox-2.3; HOX2; HOX2C"
ORIGIN

ggtcctttttggtgtaaatctggactctaattctgtaatatatcaaggaatctcgtaaaaccgacactaaaacgtccctgcctacaaatcatccggccaaattatgagttcattgtattatgcgaatactttattttctaaatatccagcctcaagttcggttttcgctaccggagccttcccagaacaaacttcttgtgcgtttgcttccaacccccagcgcccgggctatggagcgggttcgggcgcttccttcgccgcctcgatgcagggcttgtaccccggcggggggggcatggcgggccagagcgcggccggcgtctacgcggccggctatgggctcgagccgagttccttcaacatgcactgcgcgccctttgagcagaacctctccggggtgtgtcccggcgactccgccaaggcggcgggcgccaaggagcagagggactcggacttggcggccgagagtaacttccggatctacccctggatgcgaagctcaggaactgaccgcaaacgaggccgccagacctacacccgctaccagaccctggagctggagaaagaatttcactacaatcgctacctgacgcggcggcggcgcatcgagatcgcgcacacgctctgcctcacggaaagacagatcaagatttggtttcagaaccggcgcatgaagtggaaaaaggagaacaagaccgcgggcccggggaccaccggccaagacagggctgaagcagaggaggaagaggaagagtgagggatggagaaagggcagaggaagagacatgagaaagggagaggaagagaagcccagctctgggaactgaatcaggaaactcaaatcgaatagggaagtaaaaaaacaaaacaaaaaacaaaaaaaacaaaaaaaaaaccctatttaaatgaaaggagtttaaaaacattttttaaggagggagaaaggagaaattttggtttttcaacactgaaaaaatactacctataggaaagtctgtcaggtttggtttttttgtacaatatgaaaaggatattatctacctgttctgtagctttctggaatttacctccccttttctatgttgctattgtaaggtctttgtaaaatcttgcagttttgtaagccctctttaatgctgtctttgtggactgtgggtctggactaaccctgtggttgcctgccctcctgagcctccgccttcccagcagcggcaccaaggggccttagggagccccaaaacctaccactcgcgtgttccccaagcgcctggctgctgcttcttgcttcccgtcccccagccccatgctcccttttacattctgtgtgtatctaaaggatggaaaaataaaacgcaattaaaaataaaaaaaaaaaaa

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