GGRNA | NM_002146.4

LOCUS       NM_002146               3627 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox B3 (HOXB3), mRNA.
ACCESSION   NM_002146
VERSION     NM_002146.4  GI:84570136
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3627)
  AUTHORS   Chen,J., Zhu,S., Jiang,N., Shang,Z., Quan,C. and Niu,Y.
  TITLE     HoxB3 promotes prostate cancer cell progression by transactivating
            CDCA3
  JOURNAL   Cancer Lett. 330 (2), 217-224 (2013)
   PUBMED   23219899
  REMARK    GeneRIF: HoxB3 promote prostate cancer progression by upregulating
            CDCA3 expression.
REFERENCE   2  (bases 1 to 3627)
  AUTHORS   Palakurthy,R.K., Wajapeyee,N., Santra,M.K., Gazin,C., Lin,L.,
            Gobeil,S. and Green,M.R.
  TITLE     Epigenetic silencing of the RASSF1A tumor suppressor gene through
            HOXB3-mediated induction of DNMT3B expression
  JOURNAL   Mol. Cell 36 (2), 219-230 (2009)
   PUBMED   19854132
  REMARK    GeneRIF: RASSF1A silencing strongly correlates with overexpression
            of HOXB3 and DNMT3B.
REFERENCE   3  (bases 1 to 3627)
  AUTHORS   Ferrai,C., Naum-Ongania,G., Longobardi,E., Palazzolo,M.,
            Disanza,A., Diaz,V.M., Crippa,M.P., Scita,G. and Blasi,F.
  TITLE     Induction of HoxB transcription by retinoic acid requires actin
            polymerization
  JOURNAL   Mol. Biol. Cell 20 (15), 3543-3551 (2009)
   PUBMED   19477923
  REMARK    GeneRIF: Data show that inducible Hox genes are selectively
            sensitive to the inhibition of actin polymerization and that actin
            polymerization is required for the assembly of a transcription
            complex on the regulatory region of the Hox genes.
REFERENCE   4  (bases 1 to 3627)
  AUTHORS   Chung,N., Jee,B.K., Chae,S.W., Jeon,Y.W., Lee,K.H. and Rha,H.K.
  TITLE     HOX gene analysis of endothelial cell differentiation in human bone
            marrow-derived mesenchymal stem cells
  JOURNAL   Mol. Biol. Rep. 36 (2), 227-235 (2009)
   PUBMED   17972163
  REMARK    GeneRIF: HOXA7, HOXB3, HOXA3, and HOXB13 expression levels changed
            during angiogenesis, sugessting these proteins might be involved in
            the angiogenesis of hMSCs.
REFERENCE   5  (bases 1 to 3627)
  AUTHORS   Speleman,F., Cauwelier,B., Dastugue,N., Cools,J., Verhasselt,B.,
            Poppe,B., Van Roy,N., Vandesompele,J., Graux,C., Uyttebroeck,A.,
            Boogaerts,M., De Moerloose,B., Benoit,Y., Selleslag,D., Billiet,J.,
            Robert,A., Huguet,F., Vandenberghe,P., De Paepe,A., Marynen,P. and
            Hagemeijer,A.
  TITLE     A new recurrent inversion, inv(7)(p15q34), leads to transcriptional
            activation of HOXA10 and HOXA11 in a subset of T-cell acute
            lymphoblastic leukemias
  JOURNAL   Leukemia 19 (3), 358-366 (2005)
   PUBMED   15674412
  REMARK    GeneRIF: The HOXb3 was only weakly expressed in the inv(7) positive
            patients.
REFERENCE   6  (bases 1 to 3627)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet. Cell Genet. 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   7  (bases 1 to 3627)
  AUTHORS   Guazzi,S., Lonigro,R., Pintonello,L., Boncinelli,E., Di Lauro,R.
            and Mavilio,F.
  TITLE     The thyroid transcription factor-1 gene is a candidate target for
            regulation by Hox proteins
  JOURNAL   EMBO J. 13 (14), 3339-3347 (1994)
   PUBMED   7913891
REFERENCE   8  (bases 1 to 3627)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 3627)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
REFERENCE   10 (bases 1 to 3627)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA735249.1, CN358294.1,
            AK027609.1, X16667.1, AC103702.3 and AI633956.1.
            On Jan 6, 2006 this sequence version replaced gi:25121960.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a nuclear protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded protein functions as a sequence-specific transcription
            factor that is involved in development. Increased expression of
            this gene is associated with a distinct biologic subset of acute
            myeloid leukemia (AML). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027609.1, X16667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               DA735249.1         40-386
            348-349             CN358294.1         126-127
            350-759             AK027609.1         389-798
            760-761             X16667.1           264-265
            762-1384            AK027609.1         800-1422
            1385-2430           X16667.1           890-1935
            2431-3613           AC103702.3         139442-140624
            3614-3627           AI633956.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..3627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.3"
     gene            1..3627
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="homeobox B3"
                     /db_xref="GeneID:3213"
                     /db_xref="HGNC:5114"
                     /db_xref="MIM:142966"
     exon            1..612
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:1.39.8"
     variation       456
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202142761"
     exon            613..700
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:1.39.8"
     exon            701..1306
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:1.39.8"
     STS             762..2255
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /db_xref="UniSTS:480777"
     misc_feature    805..807
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="upstream in-frame stop codon"
     STS             812..2199
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /db_xref="UniSTS:482026"
     CDS             859..2154
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="homeo box B3; homeo box 2G; homeobox protein
                     Hox-2G; homeobox protein Hox-2.7"
                     /codon_start=1
                     /product="homeobox protein Hox-B3"
                     /protein_id="NP_002137.4"
                     /db_xref="GI:84570137"
                     /db_xref="CCDS:CCDS11528.1"
                     /db_xref="GeneID:3213"
                     /db_xref="HGNC:5114"
                     /db_xref="MIM:142966"
                     /translation="

MQKATYYDNAAAALFGGYSSYPGSNGFGFDVPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLSAPPGSPPPSAAPTSATSNSSNGGGPSKSGPPKCGPGTNSTLTKQIFPWMKESRQTSKLKNNSPGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPMAPSQHHGPCEPHPTYTDLSSHHAPPPQGRIQEAPKLTHL

"
     misc_feature    1243..1260
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P14651.2);
                     Region: Antp-type hexapeptide"
     misc_feature    1423..1599
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1423..1437,1441..1443,1492..1494,1510..1512,
                     1549..1551,1555..1560,1567..1572,1576..1584,1588..1593)
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1429..1431,1438..1440,1558..1560,1567..1572,
                     1579..1581)
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1948..2145
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /note="Domain of unknown function (DUF4074); Region:
                     DUF4074; pfam13293"
                     /db_xref="CDD:205473"
     STS             869..1272
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /standard_name="Hoxb3"
                     /db_xref="UniSTS:143381"
     variation       1102
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2229304"
     exon            1307..3618
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /inference="alignment:Splign:1.39.8"
     variation       1671
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35517955"
     STS             1760..2483
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /standard_name="HOXB3_127"
                     /db_xref="UniSTS:277319"
     variation       1905
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2229303"
     STS             2109..2401
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /standard_name="SHGC-83404"
                     /db_xref="UniSTS:101908"
     STS             2131..2395
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /standard_name="GDB:196132"
                     /db_xref="UniSTS:155815"
     STS             2144..2248
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /standard_name="RH75958"
                     /db_xref="UniSTS:86356"
     variation       3032
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201949561"
     variation       3144
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1057111"
     variation       3186
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200675771"
     polyA_signal    3594..3599
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
     polyA_site      3617
                     /gene="HOXB3"
                     /gene_synonym="Hox-2.7; HOX2; HOX2G"
ORIGIN

ctgggtagggcagggggaaccgacaggccggtgtccccagccgcaaaagagctgctgaactgtccgtttaaatgctgctgggagactcgtaaaaaaatcatcgtggacctggaggatgagaggggcgagctttatttcggtcggattgcggtgtggtggtttagctgcaaggggatgccgcagccccagttgagggggaaaatagttcttaaaaagcatatgcccccctaaggaatgtctctaaagaaccaaatcaaagctgctctttggaaggtatgaatagaatttaaaaaaaaaagatttctatggagcttaaagttcacagccattctgtgtagacaagagctaagaaaaatgtgagaattatacagaaaaccattaatcacttcttttctttaaatacgtatcctctctcctttgttattattcaacagcaaatctccttggaccggctgttgggggaaaaaagtgttagccgtctctcccggatctgcaagggggaaaaaatttggaaccataaagttgaaaacttttttctctcagtttggaagaagcccttcgtcatgaatgggatctgcagagttcgggcgagaggaggcgagaggcgcaaaggaggggagatttgtcgcctgccgctcgctctggggctcgatgtgaatatatattatgtctgcctgttctcccctcgtcggtggctaaggtcagccgcttggaacagaccccggaggaggggggcagagaggggaggtggggggggggggtccggcgtgtcacgtgacccccagggttgccaatgtccggtcctgagggtatcaggcctttccaagttgccacccactgcccaggcctcacccagcgatgcagaaagccacctactacgacaacgccgcggctgctctcttcggaggctattcctcgtaccctggcagcaatggcttcggcttcgatgtccccccccaacccccatttcaggccgccacgcacctggagggcgactaccagcgctcagcttgctcgctgcagtccctgggcaacgctgccccacatgccaagagcaaggagctcaacggcagctgcatgaggccgggtctggcccccgagcccctgtcggccccgcctggctcacccccgcccagtgccgcacctaccagtgccactagcaacagcagtaatgggggcgggcccagcaaaagtggtcccccaaagtgcggtcccggcaccaactccaccctcaccaaacagatattcccctggatgaaagagtcgaggcaaacgtccaagctgaaaaacaactcccccggcacagcagagggctgtggtggcggcggcggtggcggcggcggcggaggcagtggtggcagcgggggcggtggcggcggcggcgggggaggggacaagagccccccggggtcggcggcgtccaagcgggcgcggacggcgtacacgagcgcgcagctggtggagctggagaaggagttccattttaaccgctacctgtgccggcctcgccgtgtagagatggccaacctgctgaacctcagcgagcggcagatcaagatctggttccagaaccggcgcatgaagtacaagaaggaccagaaggccaagggattggcctcgtcgtcggggggcccatctccagccggcagccccccgcagcccatgcagtccacggccggcttcatgaacgccttacactccatgacccccagctacgagagcccgtccccacccgccttcggtaaagcccaccagaatgcctacgcgctgccctccaactaccagccccctctcaaaggctgcggcgccccgcagaagtaccctccgaccccggcgcccgagtatgagccgcacgtcctccaagccaacgggggcgcctacgggacgcccaccatgcagggcagtccggtgtacgtgggcgggggcggctacgcggatccgctgccgccccctgccggcccctccctctatggcctcaaccacctttcccatcacccttccgggaacctggactacaacggggcgccccctatggcgcccagccagcaccacggaccctgcgaaccccaccccacctacacagacctctcctctcaccacgcgcctcctcctcagggtagaatccaagaagcgcccaaattaacacacctgtgatgggaaagggcgaacgaggattaggggatggggaggaagagagagactgtggagctctggggggcaacctggaggtctgaaaagaggagccagagaaggtggtacccaggcttcctggtcagaaccggcctggagctccttcccttccccctggcctgagaggttgcttttaagtcttccaccccttgttccatctgcctgccaacccatcggaaaggaatccacatcatattggagatgaccccatcaaccccagggctccagcactaccaagttggaattccacgcccgggagtggggtagaggaagacgagacaggacgaggcagaaaagcacattttaaaaaccagacaagatggctaggccatcaccaaccaacggacttaccttacatctttgtaggtaattccccccaaatcttgatttttttttttcctcaattatcctttaaaaaataagaaaacacatttcaaacccaaaaggcacaaaacacgttcccttccaactttcccaaaacctcaaatttgttcccatttgaggtttattgaggtacacttctagcccccggtttttctgctctagaacattcatatctatacatcccacccccatcaattacagtttttagagggctcagggatggtgagagatcctgaaagagctgcctatattataaattatatacatttttttttaaggaaaagtgtggaggctagggcaggcaggttgttaggactgaaggtttgcccattctgctgcctccatctcagctccagctccatccccctctccacagaaagcagttggtgacacgaggttctatacttttcttctgttgctctcttgacttaacgtgaaaacagggtatatttgaacaaactgtcccaggcaggggctgggcagggcctgtgtgccttgctcagcctcctgacaggacacttttgttgcacttagaatttacattttaatggatgtaaaaacaactgtgagagatgtctgggcctgcagaagtccagcattgctcaaaaaagcgtgtgttctagtgaacattttcatatatatttattggttatagcctgttaaaatattttcttttttgtattatttatccccctacattatgtatttatatgagggaaaaaaaggaaaaaattgtacttttttagtatttacctgttacaaaggacattgtgtttcctgtcatgtaaaaccagctattttagttactattgtactctagaaaagagctgtagatttatgttaaactcgtacttacgaacaattgtaattagttctaaaaggcatgaactcagctcctaatcgtcactgtatagtcctgaatttgtagaactagagttaattccctcttggaactttctttgttcttcagtagttacttttttccttacctaaaagggttgtctgtcaaacaattcttgaataaactttctgttatcaattttaaaaaaaaaa

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