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2025-05-09 20:01:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001941 6935 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3a, mRNA.
ACCESSION NM_001941
VERSION NM_001941.3 GI:148539845
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6935)
AUTHORS Cui,T., Chen,Y., Yang,L., Knosel,T., Huber,O., Pacyna-Gengelbach,M.
and Petersen,I.
TITLE The p53 target gene desmocollin 3 acts as a novel tumor suppressor
through inhibiting EGFR/ERK pathway in human lung cancer
JOURNAL Carcinogenesis 33 (12), 2326-2333 (2012)
PUBMED 22941060
REMARK GeneRIF: The p53 target gene desmocollin 3 acts as a novel tumor
suppressor through inhibiting EGFR/ERK pathway in human lung
cancer.
REFERENCE 2 (bases 1 to 6935)
AUTHORS Knosel,T., Chen,Y., Hotovy,S., Settmacher,U., Altendorf-Hofmann,A.
and Petersen,I.
TITLE Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are
associated with tumor progression and survival in colorectal
carcinoma
JOURNAL Int J Colorectal Dis 27 (11), 1391-1399 (2012)
PUBMED 22438068
REMARK GeneRIF: High expression of desmocollin 1 (DSC1) was observed in
41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in
58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in
42.5%, and MDM2 in 0.2% of colorectal carcinomas.
REFERENCE 3 (bases 1 to 6935)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 4 (bases 1 to 6935)
AUTHORS Cui,T., Chen,Y., Yang,L., Knosel,T., Zoller,K., Huber,O. and
Petersen,I.
TITLE DSC3 expression is regulated by p53, and methylation of DSC3 DNA is
a prognostic marker in human colorectal cancer
JOURNAL Br. J. Cancer 104 (6), 1013-1019 (2011)
PUBMED 21364582
REMARK GeneRIF: Methylation status of DSC3 DNA is a prognostic marker for
colorectal cancer. P53 appears to have an important role in
regulating DSC3 expression.
REFERENCE 5 (bases 1 to 6935)
AUTHORS Whittock,N.V., Hunt,D.M., Rickman,L., Malhi,S., Vogazianou,A.P.,
Dawson,L.F., Eady,R.A., Buxton,R.S. and McGrath,J.A.
TITLE Genomic organization and amplification of the human desmosomal
cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3
JOURNAL Biochem. Biophys. Res. Commun. 276 (2), 454-460 (2000)
PUBMED 11027496
REFERENCE 6 (bases 1 to 6935)
AUTHORS King,I.A., Sullivan,K.H., Bennett,R. Jr. and Buxton,R.S.
TITLE The desmocollins of human foreskin epidermis: identification and
chromosomal assignment of a third gene and expression patterns of
the three isoforms
JOURNAL J. Invest. Dermatol. 105 (3), 314-321 (1995)
PUBMED 7665906
REFERENCE 7 (bases 1 to 6935)
AUTHORS Amagai,M., Wang,Y., Minoshima,S., Kawamura,K., Green,K.J.,
Nishikawa,T. and Shimizu,N.
TITLE Assignment of the human genes for desmocollin 3 (DSC3) and
desmocollin 4 (DSC4) to chromosome 18q12
JOURNAL Genomics 25 (1), 330-332 (1995)
PUBMED 7774948
REFERENCE 8 (bases 1 to 6935)
AUTHORS Kawamura,K., Watanabe,K., Suzuki,T., Yamakawa,T., Kamiyama,T.,
Nakagawa,H. and Tsurufuji,S.
TITLE cDNA cloning and expression of a novel human desmocollin
JOURNAL J. Biol. Chem. 269 (42), 26295-26302 (1994)
PUBMED 7929347
REFERENCE 9 (bases 1 to 6935)
AUTHORS Buxton,R.S., Wheeler,G.N., Pidsley,S.C., Marsden,M.D., Adams,M.J.,
Jenkins,N.A., Gilbert,D.J. and Copeland,N.G.
TITLE Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely
linked in the proximal region of chromosome 18
JOURNAL Genomics 21 (3), 510-516 (1994)
PUBMED 7959727
REFERENCE 10 (bases 1 to 6935)
AUTHORS Arnemann,J., Spurr,N.K., Wheeler,G.N., Parker,A.E. and Buxton,R.S.
TITLE Chromosomal assignment of the human genes coding for the major
proteins of the desmosome junction, desmoglein DGI (DSG),
desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and
plakoglobin DPIII (JUP)
JOURNAL Genomics 10 (3), 640-645 (1991)
PUBMED 1889810
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC025212.5 and D17427.1.
On Jun 2, 2007 this sequence version replaced gi:13435367.
Summary: The protein encoded by this gene is a calcium-dependent
glycoprotein that is a member of the desmocollin subfamily of the
cadherin superfamily. These desmosomal family members, along with
the desmogleins, are found primarily in epithelial cells where they
constitute the adhesive proteins of the desmosome cell-cell
junction and are required for cell adhesion and desmosome
formation. The desmosomal family members are arranged in two
clusters on chromosome 18, occupying less than 650 kb combined.
Alternative splicing results in two transcript variants encoding
distinct isoforms. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (Dsc3a) is missing exon 16 and
encodes the longer isoform (Dsc3a).
Sequence Note: This RefSeq record was created from transcript and
genome sequence data because no single transcript was available for
the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: D17427.1, X83929.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025083 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-104 AC025212.5 180619-180722 c
105-3108 D17427.1 17-3020
3109-6935 AC025212.5 127993-131819 c
FEATURES Location/Qualifiers
source 1..6935
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q12.1"
gene 1..6935
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="desmocollin 3"
/db_xref="GeneID:1825"
/db_xref="HGNC:3037"
/db_xref="MIM:600271"
exon 1..224
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
CDS 156..2846
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="isoform Dsc3a preproprotein is encoded by
transcript variant Dsc3a; desmocollin-4; cadherin family
member 3"
/codon_start=1
/product="desmocollin-3 isoform Dsc3a preproprotein"
/protein_id="NP_001932.2"
/db_xref="GI:148539846"
/db_xref="CCDS:CCDS32810.1"
/db_xref="GeneID:1825"
/db_xref="HGNC:3037"
/db_xref="MIM:600271"
/translation="
MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR
"
sig_peptide 156..236
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
misc_feature 234..488
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Cadherin prodomain like; Region: Cadherin_pro;
smart01055"
/db_xref="CDD:198123"
proprotein 237..2843
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/product="desmocollin-3 isoform Dsc3a proprotein"
misc_feature 432..434
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
mat_peptide 561..2843
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/product="desmocollin-3 isoform Dsc3a"
misc_feature 573..857
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Cadherin domain; Region: Cadherin; pfam00028"
/db_xref="CDD:200941"
misc_feature order(591..596,759..761,765..767,858..860,864..869)
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206635"
misc_feature 894..1208
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(915..920,1089..1091,1095..1097,1194..1196,
1200..1205)
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1233..1547
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1251..1256,1425..1427,1431..1433,1545..1547)
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature 1584..1874
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Cadherin tandem repeat domain; Region:
Cadherin_repeat; cd11304"
/db_xref="CDD:206637"
misc_feature order(1599..1604,1755..1757,1761..1763,1860..1862,
1866..1871)
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:206637"
misc_feature <1941..2162
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Cadherin repeat-like domain; Region: CA_like;
cl15786"
/db_xref="CDD:211469"
misc_feature 2226..2288
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14574.3);
transmembrane region"
misc_feature 2517..2843
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/note="Cadherin cytoplasmic region; Region: Cadherin_C;
pfam01049"
/db_xref="CDD:163601"
exon 225..309
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 310..509
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
variation 387
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="a"
/replace="t"
/db_xref="dbSNP:276937"
variation 460
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="a"
/replace="g"
/db_xref="dbSNP:276938"
exon 510..629
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 630..785
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
variation 750
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="c"
/replace="t"
/db_xref="dbSNP:276921"
exon 786..930
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 931..1097
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 1098..1232
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 1233..1418
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 1419..1675
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 1676..1818
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 1819..2043
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 2044..2268
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 2269..2390
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
exon 2391..2648
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
STS 2534..2759
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/standard_name="GDB:437227"
/db_xref="UniSTS:157243"
STS 2535..2759
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/db_xref="UniSTS:150383"
variation 2612
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="a"
/replace="g"
/db_xref="dbSNP:2228474"
exon 2649..6935
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/inference="alignment:Splign:1.39.8"
variation 2993
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="a"
/replace="c"
/db_xref="dbSNP:948879"
STS 3074..3323
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/standard_name="RH39274"
/db_xref="UniSTS:85408"
STS 4654..4838
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/standard_name="RH47848"
/db_xref="UniSTS:89662"
variation 4832..4834
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace=""
/replace="c"
/replace="ccc"
/db_xref="dbSNP:66467743"
STS 4879..4982
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/standard_name="D11S2921"
/db_xref="UniSTS:152074"
STS 4934..5036
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/standard_name="D8S2278"
/db_xref="UniSTS:473906"
STS 4942..5031
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 5276..5967
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/standard_name="DSC3_V8"
/db_xref="UniSTS:277171"
variation 5891
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="a"
/replace="c"
/db_xref="dbSNP:3204639"
variation 5904
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="a"
/replace="g"
/db_xref="dbSNP:2850323"
variation 5924
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051487"
polyA_signal 5936..5941
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
polyA_site 5956
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
variation 6336
/gene="DSC3"
/gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
/replace="a"
/replace="g"
/db_xref="dbSNP:8765"
ORIGIN
gaagttgctcccgggcaggcaagcctgagagaggccaaatacacttaaaaacaagcagcggcgagaaaagcacctcccgcgccctgcacctcggcaggtctcgctctcggcaccctcccggcgcccgcgttctcctggccctgcccggcatcccgatggccgccgctgggccccggcgctccgtgcgcggagccgtctgcctgcatctgctgctgaccctcgtgatcttcagtcgtgctggtgaagcctgcaaaaaggtgatacttaatgtaccttctaaactagaggcagacaaaataattggcagagttaatttggaagagtgcttcaggtctgcagacctcatccggtcaagtgatcctgatttcagagttctaaatgatgggtcagtgtacacagccagggctgttgcgctgtctgataagaaaagatcatttaccatatggctttctgacaaaaggaaacagacacagaaagaggttactgtgctgctagaacatcagaagaaggtatcgaagacaagacacactagagaaactgttctcaggcgtgccaagaggagatgggcacctattccttgctctatgcaagagaattccttgggccctttcccattgtttcttcaacaagttgaatctgatgcagcacagaactatactgtcttctactcaataagtggacgtggagttgataaagaacctttaaatttgttttatatagaaagagacactggaaatctattttgcactcggcctgtggatcgtgaagaatatgatgtttttgatttgattgcttatgcgtcaactgcagatggatattcagcagatctgcccctcccactacccatcagggtagaggatgaaaatgacaaccaccctgttttcacagaagcaatttataattttgaagttttggaaagtagtagacctggtactacagtgggggtggtttgtgccacagacagagatgaaccggacacaatgcatacgcgcctgaaatacagcattttgcagcagacaccaaggtcacctgggctcttttctgtgcatcccagcacaggcgtaatcaccacagtctctcattatttggacagagaggttgtagacaagtactcattgataatgaaagtacaagacatggatggccagttttttggattgataggcacatcaacttgtatcataacagtaacagattcaaatgataatgcacccactttcagacaaaatgcttatgaagcatttgtagaggaaaatgcattcaatgtggaaatcttacgaatacctatagaagataaggatttaattaacactgccaattggagagtcaattttaccattttaaagggaaatgaaaatggacatttcaaaatcagcacagacaaagaaactaatgaaggtgttctttctgttgtaaagccactgaattatgaagaaaaccgtcaagtgaacctggaaattggagtaaacaatgaagcgccatttgctagagatattcccagagtgacagccttgaacagagccttggttacagttcatgtgagggatctggatgaggggcctgaatgcactcctgcagcccaatatgtgcggattaaagaaaacttagcagtggggtcaaagatcaacggctataaggcatatgaccccgaaaatagaaatggcaatggtttaaggtacaaaaaattgcatgatcctaaaggttggatcaccattgatgaaatttcagggtcaatcataacttccaaaatcctggatagggaggttgaaactcccaaaaatgagttgtataatattacagtcctggcaatagacaaagatgatagatcatgtactggaacacttgctgtgaacattgaagatgtaaatgataatccaccagaaatacttcaagaatatgtagtcatttgcaaaccaaaaatggggtataccgacattttagctgttgatcctgatgaacctgtccatggagctccattttatttcagtttgcccaatacttctccagaaatcagtagactgtggagcctcaccaaagttaatgatacagctgcccgtctttcatatcagaaaaatgctggatttcaagaatataccattcctattactgtaaaagacagggccggccaagctgcaacaaaattattgagagttaatctgtgtgaatgtactcatccaactcagtgtcgtgcgacttcaaggagtacaggagtaatacttggaaaatgggcaatccttgcaatattactgggtatagcactgctcttttctgtattgctaactttagtatgtggagtttttggtgcaactaaagggaaacgttttcctgaagatttagcacagcaaaacttaattatatcaaacacagaagcacctggagacgatagagtgtgctctgccaatggatttatgacccaaactaccaacaactctagccaaggtttttgtggtactatgggatcaggaatgaaaaatggagggcaggaaaccattgaaatgatgaaaggaggaaaccagaccttggaatcctgccggggggctgggcatcatcataccctggactcctgcaggggaggacacacggaggtggacaactgcagatacacttactcggagtggcacagttttactcaaccccgtctcggtgaaaaattgcatcgatgtaatcagaatgaagaccgcatgccatcccaagattatgtcctcacttataactatgagggaagaggatctccagctggttctgtgggctgctgcagtgaaaagcaggaagaagatggccttgactttttaaataatttggaacccaaatttattacattagcagaagcatgcacaaagagataatgtcacagtgctacaattaggtctttgtcagacattctggaggtttccaaaaataatattgtaaagttcaatttcaacatgtatgtatatgatgatttttttctcaattttgaattatgctactcaccaatttatatttttaaagcaagttgttgcttatcttttccaaaaagtgaaaaatgttaaaacagacaactggtaaatctcaaactccagcactggaattaaggtctctaaagcatctgctcttttttttttttacggatattttagtaataaatatgctggataaatattagtccaacaatagctaagttatgctaatatcacattattatgtattcactttaagtgatagtttaaaaaataaacaagaaatattgagtatcactatgtgaagaaagttttggaaaagaaacaatgaagactgaattaaattaaaaatgttgcagctcataaagaattgggactcacccctactgcactaccaaattcatttgactttggaggcaaaatgtgttgaagtgccctatgaagtagcaattttctataggaatatagttggaaataaatgtgtgtgtgtatattattattaatcaatgcaatatttaaaatgaaatgagaacaaagaggaaaatggtaaaaacttgaaatgaggctggggtatagtttgtcctacaatagaaaaaagagagagcttcctaggcctgggctcttaaatgctgcattataactgagtctatgaggaaatagttcctgtccaatttgtgtaatttgtttaaaattgtaaataaattaaacttttctggtttctgtgggaaggaaatagggaatccaatggaacagtagctttgctttgcagtctgtttcaagatttctgcatccacaagttagtagcaaactggggaatactcgctgcagctggggttccctgctttttggtagcaagggtccagagatgaggtgtttttttcggggagctaataacaaaaacattttaaaacttacctttactgaagttaaatcctctattgctgtttctattctctcttatagtgaccaacatctttttaatttagatccaaataaccatgtcctcctagagtttagaggctagagggagctgaggggaggatcttactgaaagcaccctggggagattgattgtccttaaacctaagccccacaaacttgacacctgatcaggtctgggagctacaaaatttcatttttctcctcactgcccttcttctgagtggcattggcctgaatcaaggaaagccaggccttgtgggcccccttctttcggctttctgctaaagcaacacctccagcagagattcccttaagtgactccaggttttccaccatccttcagcgtgaattaatttttaatcagtttgctttctccagagaaattttaaaataatagaagaaatagaaattttgaatgtataaaagaaaaagatcaagttgtcattttagaacagagggaactttgggagaaagcagcccaagtaggttatttgtacagtcagagggcaacaggaagatgcaggccttcaagggcaaggagaggccacaaggaatatgggtgggagtaaaagcaacatcgtctgcttcatactttttcctaggcttggcactgccttttcctttctcaggccaatggcaactgccatttgagtccggtgagggatcagccaacctcttctctatggctcaccttatttggagtgagaaatcaaggagacagagctgactgcatgatgagtctgaaggcatttgcaggatgagcctgaactggttgtgcagaacaaacaaggcattcatgggaattgttgtattccttctgcagccctccttctgggcactaagaaggtctatgaattaaatgcctatctaaaattctgatttattcctacattttctgttttctaatttgaccctaaaatctatgtgttttagacttagactttttattgccccccccccccccttttttttttgagacggagtctcgctctgacgcacaggctggagtgcagtggctccgatctctgctcactgaaagctccgcctcccgggttcacgccattctcctgcctcagcctcctgagtagctgggactacaggcgcccaccaccacgcccggctaattttttgtatttttaatagagacggggtttcactgtgttagccaggatggtctcgatctcctgacctcgtgatccgcctgcctcggcctcccaaagtgctgggattacaggcatgacccaccgctcccggccttgttttccgtttaaagtcgtcttcttttaatgtaatcattttgaacatgtgtgaaagttgatcatacgaattggatcaatcttgaaatactcaaccaaaagacagtcgagaagccagggggagaaagaactcagggcacaaaatattggtctgagaatggaattctctgtaagcctagttgctgaaatttcctgctgtatccagaagccagttttatctaacggctactgaaacacccactgtgttttgctcactccctcactcaccgatcaaaacctgctacctccccaagactttactagtgccgataaactttctcaaagagcaaccagtatcacttccctgtttataaaacctctaaccatctctttgttctttgaacatgctgaaaaccacctggtctgcatgtatgcccgaatttgtaattcttttctctcaaatgaaaatttaattttagggattcatttctatattttcacatatgtagtattattatttccttatatgtgtaaggtgaaatttatggtatttgagtgtgcaagaaaatatatttttaaagctttcatttttcccccagtgaatgatttagaattttttatgtaaatatacagaatgttttttcttacttttataaggaagcagctgtctaaaatgcagtggggtttgttttgcaatgttttaaacagagttttagtattgctattaaaagaagttactttgcttttaaagaaacttggctgcttaaaataagcaaaaattggatgcgtaaagtaatatttacagatgtggggagatgtaataaaacaatattaacttggtttcttgtttttgctgtatttagagattaaataattctaagatgatcactttgcaaaattatgcttatggctggcatggaaatagaaataattatgtctttgttgtattaatggggaatattttggacaatgtttcattatcaaattgtcgacatcattaatatatattgtaatgttgggaagagatcactattttgaagcacagctttacagatgagtatctatgatacatatgtataataaattttgattgggtattaaaagtattagaaggtggttataattgcagagtattccatgaatagtacactgacacaggggttttactttgaggaccagtgtagtcaagggaaaacatgagttaaaaagaaaagcaggcgatattgcagtcttgattctgccacttacaggatagataacgcctgaactttaatgacaagatgatccaaccataaaggtgctctgtgcttcacagtgaatcttttccccatgcaggagtgtgctcccctacaaacgttaagactgatcatttcaaaaatctattagctatatcaaaagccttacattttaatataggttgaaccaaaatttcaattccagtaacttctattgtaaccattatttttgtgtatgtcttcaagaatgttcattggatttttgtttgtaatagtaaaataccggatacatttcacgtgtccttcagtattgatttggttgaatattgggtcataatggttgagaagcatggacactagagccagaatgcttggatatgaatcctggatctgtcacttacttctgtgtgacctttgaaaggctacttatttcctctcttagctttctcattaaaatcaatgaacaatgccagcctcatggggttgttgaatgattaaatgagttactatacctaaagtacatagaacactgcctgcacatagtaaaagaattataagtgtgaggtagttggtaaaattatgta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1825 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:1825 -> Molecular function: GO:0045295 [gamma-catenin binding] evidence: IPI
GeneID:1825 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:1825 -> Biological process: GO:0007155 [cell adhesion] evidence: TAS
GeneID:1825 -> Biological process: GO:0007156 [homophilic cell adhesion] evidence: IEA
GeneID:1825 -> Biological process: GO:0050821 [protein stabilization] evidence: IDA
GeneID:1825 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:1825 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:1825 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:1825 -> Cellular component: GO:0005911 [cell-cell junction] evidence: TAS
GeneID:1825 -> Cellular component: GO:0016020 [membrane] evidence: TAS
GeneID:1825 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:1825 -> Cellular component: GO:0030057 [desmosome] evidence: IEA
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