LOCUS       NM_001427               3405 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens engrailed homeobox 2 (EN2), mRNA.
ACCESSION   NM_001427
VERSION     NM_001427.3  GI:126090912
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Lin,P.I., Chien,Y.L., Wu,Y.Y., Chen,C.H., Gau,S.S., Huang,Y.S.,
            Liu,S.K., Tsai,W.C. and Chiu,Y.N.
  TITLE     The WNT2 gene polymorphism associated with speech delay inherent to
            autism
  JOURNAL   Res Dev Disabil 33 (5), 1533-1540 (2012)
   PUBMED   22522212
  REMARK    GeneRIF: The WNT2 gene and EN2 gene may act in concert to influence
            the language development in autism.
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Choi,J., Ababon,M.R., Matteson,P.G. and Millonig,J.H.
  TITLE     Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2
            autism spectrum disorder-associated haplotype function
  JOURNAL   Hum. Mol. Genet. 21 (7), 1566-1580 (2012)
   PUBMED   22180456
  REMARK    GeneRIF: The data demonstrates that the autism spectrum
            disorder-associated A-C intronic haplotype of the ENGRAILED2 gene
            is a transcriptional activator, and both CUX1 and NFIB mediate this
            activity.
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Morgan,R., Boxall,A., Bhatt,A., Bailey,M., Hindley,R., Langley,S.,
            Whitaker,H.C., Neal,D.E., Ismail,M., Whitaker,H., Annels,N.,
            Michael,A. and Pandha,H.
  TITLE     Engrailed-2 (EN2): a tumor specific urinary biomarker for the early
            diagnosis of prostate cancer
  JOURNAL   Clin. Cancer Res. 17 (5), 1090-1098 (2011)
   PUBMED   21364037
  REMARK    GeneRIF: findings show EN2 was expressed and secreted by prostate
            cancer (PC) cell lines and PC tissue but not by normal prostate
            tissue or stroma; presence of EN2 in urine was highly predictive of
            PC
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Sen,B., Singh,A.S., Sinha,S., Chatterjee,A., Ahmed,S., Ghosh,S. and
            Usha,R.
  TITLE     Family-based studies indicate association of Engrailed 2 gene with
            autism in an Indian population
  JOURNAL   Genes Brain Behav. 9 (2), 248-255 (2010)
   PUBMED   20050924
  REMARK    GeneRIF: Positive genetic correlation of EN2 with autism in the
            Indian population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Yang,P., Shu,B.C., Hallmayer,J.F. and Lung,F.W.
  TITLE     Intronic single nucleotide polymorphisms of engrailed homeobox 2
            modulate the disease vulnerability of autism in a han chinese
            population
  JOURNAL   Neuropsychobiology 62 (2), 104-115 (2010)
   PUBMED   20523082
  REMARK    GeneRIF: This study demonistrated that in Han chinese the
            association between the EN2 genetic polymorphism and autism.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3405)
  AUTHORS   Kozmik,Z., Sure,U., Ruedi,D., Busslinger,M. and Aguzzi,A.
  TITLE     Deregulated expression of PAX5 in medulloblastoma
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5709-5713 (1995)
   PUBMED   7777574
REFERENCE   7  (bases 1 to 3405)
  AUTHORS   Logan,C., Hanks,M.C., Noble-Topham,S., Nallainathan,D.,
            Provart,N.J. and Joyner,A.L.
  TITLE     Cloning and sequence comparison of the mouse, human, and chicken
            engrailed genes reveal potential functional domains and regulatory
            regions
  JOURNAL   Dev. Genet. 13 (5), 345-358 (1992)
   PUBMED   1363401
REFERENCE   8  (bases 1 to 3405)
  AUTHORS   Joyner,A.L., Herrup,K., Auerbach,B.A., Davis,C.A. and Rossant,J.
  TITLE     Subtle cerebellar phenotype in mice homozygous for a targeted
            deletion of the En-2 homeobox
  JOURNAL   Science 251 (4998), 1239-1243 (1991)
   PUBMED   1672471
REFERENCE   9  (bases 1 to 3405)
  AUTHORS   Poole,S.J., Law,M.L., Kao,F.T. and Lau,Y.F.
  TITLE     Isolation and chromosomal localization of the human En-2 gene
  JOURNAL   Genomics 4 (3), 225-231 (1989)
   PUBMED   2565873
REFERENCE   10 (bases 1 to 3405)
  AUTHORS   Logan,C., Willard,H.F., Rommens,J.M. and Joyner,A.L.
  TITLE     Chromosomal localization of the human homeo box-containing genes,
            EN1 and EN2
  JOURNAL   Genomics 4 (2), 206-209 (1989)
   PUBMED   2567700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008060.5 and H16179.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Feb 23, 2007 this sequence version replaced gi:7710120.
            
            Summary: Homeobox-containing genes are thought to have a role in
            controlling development. In Drosophila, the 'engrailed' (en) gene
            plays an important role during development in segmentation, where
            it is required for the formation of posterior compartments.
            Different mutations in the mouse homologs, En1 and En2, produced
            different developmental defects that frequently are lethal. The
            human engrailed homologs 1 and 2 encode homeodomain-containing
            proteins and have been implicated in the control of pattern
            formation during development of the central nervous system.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-934               AC008060.5         88973-89906
            935-3381            AC008060.5         93215-95661
            3382-3405           H16179.1           1-24                c
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3405
                     /gene="EN2"
                     /note="engrailed homeobox 2"
                     /db_xref="GeneID:2020"
                     /db_xref="HGNC:3343"
                     /db_xref="HPRD:08836"
                     /db_xref="MIM:131310"
     STS             1..1296
                     /gene="EN2"
                     /db_xref="UniSTS:488054"
     exon            1..934
                     /gene="EN2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    97..99
                     /gene="EN2"
                     /note="upstream in-frame stop codon"
     variation       102
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371410446"
     variation       210
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370541113"
     CDS             250..1251
                     /gene="EN2"
                     /note="engrailed homolog 2; engrailed-2; hu-En-2; homeobox
                     protein en-2"
                     /codon_start=1
                     /product="homeobox protein engrailed-2"
                     /protein_id="NP_001418.2"
                     /db_xref="GI:7710121"
                     /db_xref="CCDS:CCDS5940.1"
                     /db_xref="GeneID:2020"
                     /db_xref="HGNC:3343"
                     /db_xref="HPRD:08836"
                     /db_xref="MIM:131310"
                     /translation="

MEENDPKPGEAAAAVEGQRQPESSPGGGSGGGGGSSPGEADTGRRRALMLPAVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAEGGGGAGGSEQLLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDGEGGSKTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDSDSSQAGANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE

"
     misc_feature    976..1155
                     /gene="EN2"
                     /note="Region: homeobox domain"
     misc_feature    994..1152
                     /gene="EN2"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(994..996,1000..1002,1051..1053,1069..1071,
                     1108..1110,1114..1119,1126..1131,1135..1143,1147..1152)
                     /gene="EN2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(997..999,1117..1119,1126..1131,1138..1140)
                     /gene="EN2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1075..1077
                     /gene="EN2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1153..1248
                     /gene="EN2"
                     /note="Engrailed homeobox C-terminal signature domain;
                     Region: Engrail_1_C_sig; pfam10525"
                     /db_xref="CDD:119045"
     variation       277
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:193264681"
     variation       360
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77846527"
     variation       397
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377588499"
     variation       420
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199573836"
     variation       585
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377426405"
     variation       610
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3735653"
     variation       633
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375042010"
     variation       653
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112029171"
     variation       849
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:80239010"
     exon            935..3395
                     /gene="EN2"
                     /inference="alignment:Splign:1.39.8"
     STS             940..1055
                     /gene="EN2"
                     /standard_name="EN2"
                     /db_xref="UniSTS:15616"
     variation       969
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145749730"
     variation       976
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371468430"
     variation       986
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148967146"
     variation       987
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144197066"
     variation       990
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138007513"
     variation       1006
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75103128"
     variation       1032
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373725366"
     variation       1059
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112687347"
     variation       1067
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367902456"
     variation       1083
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146535449"
     variation       1125
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141222652"
     variation       1137
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145531356"
     variation       1149
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34614453"
     variation       1158
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148064651"
     variation       1173
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140822188"
     variation       1179
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:56008230"
     variation       1201
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2361689"
     variation       1209
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142774508"
     variation       1236
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374787499"
     variation       1238
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367924841"
     variation       1245
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149481945"
     variation       1254
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12674067"
     variation       1255
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375061145"
     variation       1284
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369675027"
     variation       1285
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192274449"
     variation       1318
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184624346"
     variation       1344
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374181653"
     variation       1506
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73734533"
     variation       1634
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189436701"
     variation       1660
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181376144"
     variation       1670
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:207468873"
     variation       1770
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:185936495"
     variation       1776
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368761266"
     variation       1825
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372780297"
     variation       1828
                     /gene="EN2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368291486"
     variation       1851
                     /gene="EN2"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:144219267"
     variation       1861
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56651365"
     variation       1874
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143878581"
     variation       1876
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3808330"
     variation       1955
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3808329"
     variation       1964
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189617846"
     variation       1981
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3808328"
     variation       2001
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10234087"
     variation       2019..2022
                     /gene="EN2"
                     /replace=""
                     /replace="cttt"
                     /db_xref="dbSNP:111556743"
     variation       2022..2025
                     /gene="EN2"
                     /replace=""
                     /replace="tctt"
                     /db_xref="dbSNP:371995609"
     variation       2060
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139789685"
     variation       2069
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3808327"
     variation       2075
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55729502"
     variation       2076
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3808326"
     variation       2131
                     /gene="EN2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:57599144"
     variation       2159
                     /gene="EN2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375798987"
     variation       2186
                     /gene="EN2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:113000817"
     variation       2206
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370047096"
     variation       2217
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143914514"
     variation       2235
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368877872"
     variation       2244
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4716597"
     variation       2266
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181828936"
     variation       2267
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369546982"
     variation       2380
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114134796"
     variation       2446
                     /gene="EN2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:67027007"
     variation       2530
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186374442"
     variation       2549
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10949811"
     variation       2559..2560
                     /gene="EN2"
                     /replace=""
                     /replace="ac"
                     /db_xref="dbSNP:113684257"
     variation       2560..2563
                     /gene="EN2"
                     /replace=""
                     /replace="acac"
                     /db_xref="dbSNP:144874127"
     variation       2579..2580
                     /gene="EN2"
                     /replace=""
                     /replace="aca"
                     /db_xref="dbSNP:72022210"
     variation       2580..2581
                     /gene="EN2"
                     /replace=""
                     /replace="cac"
                     /db_xref="dbSNP:72575652"
     variation       2581..2582
                     /gene="EN2"
                     /replace=""
                     /replace="a"
                     /replace="ac"
                     /replace="aca"
                     /db_xref="dbSNP:35869460"
     variation       2581
                     /gene="EN2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:77385528"
     variation       2584
                     /gene="EN2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200149777"
     variation       2711
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190966205"
     variation       2733
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117213382"
     variation       2895
                     /gene="EN2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370953015"
     variation       2925
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182759274"
     variation       3044
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:118079538"
     variation       3124
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146402842"
     STS             3145..3324
                     /gene="EN2"
                     /standard_name="RH102827"
                     /db_xref="UniSTS:97161"
     variation       3222..3223
                     /gene="EN2"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:371338740"
     variation       3238..3239
                     /gene="EN2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34901594"
     variation       3264
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139745969"
     variation       3276
                     /gene="EN2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186998101"
     variation       3299
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115156116"
     variation       3320
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373820948"
     polyA_signal    3362..3367
                     /gene="EN2"
     polyA_signal    3366..3371
                     /gene="EN2"
     variation       3381
                     /gene="EN2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56178493"
     polyA_site      3395
                     /gene="EN2"
ORIGIN      

tctctcatcgtctgggcgagcggggcggctcgtggtgtttctaacccagttcgtggattcaaaggtggctccgcgccgagcgcggccggcgacttgtaggacctcagccctggccgcggccgccgcgcacgccctcggaagactcggcggggtgggggcgcgggggtctccgtgtgcgccgcgggagggccgaaggctgatttggaagggcgtccccggagaaccagtgtgggatttactgtgaacagcatggaggagaatgaccccaagcctggcgaagcagcggcggcggtggagggacagcggcagccggaatccagccccggcggcggctcgggcggcggcggcggtagcagcccgggcgaagcggacaccgggcgccggcgggctctgatgctgcccgcggtcctgcaggcgcccggcaaccaccagcacccgcaccgcatcaccaacttcttcatcgacaacatcctgcggcccgagttcggccggcgaaaggacgcggggacctgctgtgcgggcgcgggaggaggaaggggcggcggagccggcggcgaaggcggcgcgagcggtgcggagggaggcggcggcgcgggcggctcggagcagctcttgggctcgggctcccgagagccccggcagaacccgccatgtgcgcccggcgcgggcgggccgctcccagccgccggcagcgactctccgggtgacggggaaggcggctccaagacgctctcgctgcacggtggcgccaagaaaggcggcgaccccggcggccccctggacgggtcgctcaaggcccgcggcttgggcggcggcgacctgtcggtgagctcggactcggacagctcgcaagccggcgccaacctgggcgcgcagcccatgctctggccggcgtgggtctactgtacgcgctactcggaccggccttcttcaggtcccaggtctcgaaaaccaaagaagaagaacccgaacaaagaggacaagcggccgcgcacggcctttaccgccgagcagctgcagaggctcaaggccgagttccagaccaacaggtacctgacggagcagcggcgccagagcctggcgcaggagctgagcctcaacgagtcacagatcaagatttggttccagaacaagcgcgccaagatcaagaaggccacgggcaacaagaacacgctggccgtgcacctcatggcacagggcttgtacaaccactccaccacagccaaggagggcaagtcggacagcgagtagggcggggggcatggaggccaggtctcagtccgcgctaaacaatgcaataatttaaaatcataaagggccagtgtataaagattataccagcattaatagtgaaaatattgtgtattagctaaggttctgaaatattctatgtatatatcatttacaggtggtataaaatccaaaatatctgactataaaatatttttttgagttttttgtgtttatgagattatgctaattttatgggtttttttcttttttgcgaagggggctgcttagggtttcacctttttttaatcccctaagctccattatatgacattggacacttttttattattccaaaagaagaaaaaattaaaacaacttgctgaagtccaaagattttttattgctgcatttcacacaactgtgaaccgaataaatagctcctatttggtctatgacttctgccactttgtttgtgttggcttggtgaggacagcaggaggggcccacacctcaagcctggaccagccacctcaaggccttggggagcttaggggacctggtgggagagaggggacttccagggtccttgggccagttctgggatttggccctgggaagcagcccagcgtaccccaggcctgctctgggaagtcggctccatgctcaccagcagccgcccaggcccgcagcctcacccggctccctctcctcaccctcctgcacctaactccctcctccttctcctttttcctcctcttcctccttcctccttcctcctgctcctcctttcttcttctttttcttctcctcctcctccttccttcctcctcctccttctctttcctcctcctcctcaccaagggcccaaccgtgtgcatacatcgtctgcgtctgtggtctgtgtcgctgtccccagtcccaccgcagtcctgccgcaggcctaaccctcctgccctgggcactgcctccatgcagaagcgcttcgaggttctggggctaaaggcctggggtgtgtggcctaaagcccaagagcggtggggcgaccctccttttggcttggccccaggaatttcctgtgactccaccagccatcatgggtgccagccagggtcccagaaatgaggccatggctcactgtttctgggcgggcagaaggctctgtagagggagatggcatcatctatcttcctttcctttttcttttcttccctatttttttctttttttcctttatttttttcttttcttggagtggctgcttctgctatagagaacattcttccaagataaatatgtgtgtttacacatatgtctgcatgcatgtgaacacacacacacacacacacacaccaggcgtgtttgagtccacagttctgaaacatgtggctaccttgtctttcaaaagaactcagaatcctccaggatctagaagaaggaagaaagtgtgtaaataatcatttcttatcatcactttttgtcttttcttgttttttaaaatatacattttatttttgaaggtgtggtacagtgtaaattaaatatattcaatatatttcccaccaagtacctatatatgtatataaacaaacacattatctatatataacgccacactgtcttctgtttagtgtatggggaaagaccaatccaactgtccatctgtggctgggacagcccagggggtgtgcccacggctgacccaggggtgtgcacacggctgagctgggagtcccgctggtctccctgaggactgagggtgaacttcgctctttgccttaaacctctttatttcattgcagtaatagttttacgttgtacataatagtgtaaacctttttaaaaaggaaagtataaaaacaaaagttgtaatttaaaagtctgaataaccatctgctgcttaggaaactcaatgaaatgacatgcctttttagcaggaagcaaagttggtttctgttttttgttttctttgttgttttagtttataaaacatgtgcattttacagttccagtatcaaatatttataatcttatgagaaatgaatgaatgtttctatttacaactgtgcttatcaaaattgtgaacacccccacccccgcatttttgtgtgttgaaattcttgaaggttacattaaataaaacaaaatctctttattataaaataaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2020 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:2020 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:2020 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS
            GeneID:2020 -> Biological process: GO:0030901 [midbrain development] evidence: IEA
            GeneID:2020 -> Biological process: GO:0030902 [hindbrain development] evidence: IEA
            GeneID:2020 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:2020 -> Biological process: GO:0048666 [neuron development] evidence: IEA
            GeneID:2020 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:2020 -> Cellular component: GO:0016020 [membrane] evidence: IEA