2025-05-09 20:19:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001272011 1888 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens MOK protein kinase (MOK), transcript variant 2, mRNA. ACCESSION NM_001272011 VERSION NM_001272011.1 GI:436408721 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1888) AUTHORS Cha,H.J., Kim,J., Hong,S.M., Hong,S.J., Park,J.H., Kim,E.S., Wang,H.J., Choi,Y.J., Do,I.G., Joh,J.W., Kim,D.S. and Choi,K.Y. TITLE Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma JOURNAL Ann. Surg. Oncol. 19 (SUPPL 3), S404-S411 (2012) PUBMED 21717246 REMARK GeneRIF: Our results suggest that RAGE may be important in tumor invasion and could be a potential predictor for the prognosis of hepatocellular carcinoma patients. Erratum:[Ann Surg Oncol. 2011 Dec;18 Suppl 3:S321] REFERENCE 2 (bases 1 to 1888) AUTHORS Veloso,C.A., Fernandes,J.S., Volpe,C.M., Fagundes-Netto,F.S., Reis,J.S., Chaves,M.M. and Nogueira-Machado,J.A. TITLE TLR4 and RAGE: similar routes leading to inflammation in type 2 diabetic patients JOURNAL Diabetes Metab. 37 (4), 336-342 (2011) PUBMED 21377387 REMARK GeneRIF: PBMNC from type 2 diabetics were more sensitive to innate immune stimulation with LPS and monoclonal agonist anti-TLR4 than were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE potentiated the production of IL-6 and TNF-alpha in both groups. REFERENCE 3 (bases 1 to 1888) AUTHORS Zhang,L., Liu,W., Alizadeh,D., Zhao,D., Farrukh,O., Lin,J., Badie,S.A. and Badie,B. TITLE S100B attenuates microglia activation in gliomas: possible role of STAT3 pathway JOURNAL Glia 59 (3), 486-498 (2011) PUBMED 21264954 REMARK GeneRIF: The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B. REFERENCE 4 (bases 1 to 1888) AUTHORS Kelley,J.L., Turkheimer,K., Haney,M. and Swanson,W.J. TITLE Targeted resequencing of two genes, RAGE and POLL, confirms findings from a genome-wide scan for adaptive evolution and provides evidence for positive selection in additional populations JOURNAL Hum. Mol. Genet. 18 (4), 779-784 (2009) PUBMED 19060005 REMARK GeneRIF: POLL is under genetic selection in Sub-Saharan African populations. REFERENCE 5 (bases 1 to 1888) AUTHORS Uesaka,T. and Kageyama,N. TITLE Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells JOURNAL FEBS Lett. 573 (1-3), 147-154 (2004) PUBMED 15327990 REMARK GeneRIF: identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2 REFERENCE 6 (bases 1 to 1888) AUTHORS Eichmuller,S., Usener,D., Jochim,A. and Schadendorf,D. TITLE mRNA expression of tumor-associated antigens in melanoma tissues and cell lines JOURNAL Exp. Dermatol. 11 (4), 292-301 (2002) PUBMED 12190937 REFERENCE 7 (bases 1 to 1888) AUTHORS Gotte,K., Usener,D., Riedel,F., Hormann,K., Schadendorf,D. and Eichmuller,S. TITLE Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes JOURNAL Acta Otolaryngol. 122 (5), 546-552 (2002) PUBMED 12206267 REFERENCE 8 (bases 1 to 1888) AUTHORS Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R., Cain,S., Leventhal,C., Thornton,M., Ramachandran,R., Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S., Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K., Offenbacher,J., Danzig,J. and Ducar,M. TITLE Creation of genome-wide protein expression libraries using random activation of gene expression JOURNAL Nat. Biotechnol. 19 (5), 440-445 (2001) PUBMED 11329013 REFERENCE 9 (bases 1 to 1888) AUTHORS Miyata,Y., Akashi,M. and Nishida,E. TITLE Molecular cloning and characterization of a novel member of the MAP kinase superfamily JOURNAL Genes Cells 4 (5), 299-309 (1999) PUBMED 10421840 REFERENCE 10 (bases 1 to 1888) AUTHORS Gaugler,B., Brouwenstijn,N., Vantomme,V., Szikora,J.P., Van der Spek,C.W., Patard,J.J., Boon,T., Schrier,P. and Van den Eynde,B.J. TITLE A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma JOURNAL Immunogenetics 44 (5), 323-330 (1996) PUBMED 8781117 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB037795.1, AK302349.1, AL359402.3, AB022694.1 and DB517173.1. Summary: This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302349.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-15 DB037795.1 1-15 16-790 AK302349.1 1-775 791-791 AL359402.3 115847-115847 c 792-1554 AK302349.1 777-1539 1555-1850 AB022694.1 1639-1934 1851-1888 DB517173.1 164-201 FEATURES Location/Qualifiers source 1..1888 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="14" /map="14q32" gene 1..1888 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /note="MOK protein kinase" /db_xref="GeneID:5891" /db_xref="HGNC:9833" /db_xref="MIM:605762" exon 1..239 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" misc_feature 89..91 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /note="upstream in-frame stop codon" CDS 233..1402 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /EC_number="2.7.11.22" /note="isoform 2 is encoded by transcript variant 2; MAPK/MAK/MRK overlapping kinase; renal tumor antigen 1; renal cell carcinoma antigen" /codon_start=1 /product="MAPK/MAK/MRK overlapping kinase isoform 2" /protein_id="NP_001258940.1" /db_xref="GI:436408722" /db_xref="GeneID:5891" /db_xref="HGNC:9833" /db_xref="MIM:605762" /translation="
MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPASKKTDPQKDLKPAPQQCRLPTIVRKGGR
" misc_feature 242..997 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /note="Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; Region: STKc_MOK; cd07831" /db_xref="CDD:173735" misc_feature 242..997 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature order(260..271,284..286,323..325,329..331,386..397, 404..406,410..415,524..526,530..532,536..541,545..547, 575..577,584..586,617..619,623..634,638..640,752..754) /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /note="active site" /db_xref="CDD:173735" misc_feature order(260..271,284..286,323..325,329..331,386..397, 404..406,413..415,536..541,545..547,575..577) /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173735" misc_feature order(410..412,524..526,530..532,584..586,617..619, 623..634,638..640,752..754) /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173735" misc_feature 572..640 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /note="activation loop (A-loop); other site" /db_xref="CDD:173735" exon 240..354 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 355..425 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 426..504 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 505..553 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 554..732 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 733..834 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 835..1008 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 1009..1123 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 1124..1324 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" exon 1325..1870 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /inference="alignment:Splign:1.39.8" variation 1465 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /replace="c" /replace="t" /db_xref="dbSNP:3087686" variation 1616 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /replace="c" /replace="t" /db_xref="dbSNP:201440332" variation 1622 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /replace="c" /replace="t" /db_xref="dbSNP:1052780" STS 1682..1830 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" /standard_name="SGC32568" /db_xref="UniSTS:17065" polyA_signal 1829..1834 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" polyA_site 1866 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" polyA_site 1870 /gene="MOK" /gene_synonym="RAGE; RAGE-1; RAGE1" ORIGIN
atcttgcgcatgcgcaggcgacagctcatggcgttcagggcctgacggttgctagggtgacagggacacaacatggcggcgggatctctaacgctctccttcgagggaccaccacggagatcctagtgcgggaccccgcctcagggaagtggaaagcagggggacaaccttcctgcttctttcttttccgtccagtgtcggcaaggggttgtcaccggcttccgcatccaagatgaagaactataaagcaattggcaaaataggagagggaacgttttctgaagttatgaagatgcaaagcctgagagatggaaactactatgcatgtaaacaaatgaagcagcgctttgaaagtgacagaaaatctggttctcttgcactaatatgtgaacttatggacatgaatatttatgagctaatacgagggagaagatacccattatcagaaaaaaaaattatgcactatatgtaccagttatgtaagtccctggatcatattcacagaaatggaatatttcacagagatgtaaaaccagaaaatatactaataaagcaggatgtcctgaaattaggggactttggctcctgccggagtgtctattccaagcagccgtacacggaatacatctccacccgctggtaccgggccccggagtgtctcctcactgatgggttctacacgtacaagatggacctgtggagcgccggctgtgtgttctacgagatcgccagtctgcagcccctctttcctggagtaaatgaactggaccaaatctcaaaaatccacgatgtcatcggcacacccgctcagaagatcctcaccaagttcaaacagtcgagagctatgaattttgattttccttttaaaaagggatcaggaatacctctactaacaaccaatttgtccccacaatgcctctccctcctgcacgcaatggtggcctatgatcccgatgagagaatcgccgcccaccaggccctgcagcacccctacttccaagaacagaggaaaacagagaagcgggctctgggcagccacagaaaagctggctttccggagcaccctgtggcaccggaaccactcagtaacagctgccagatttccaaggagggcagaaagcagaaacagtccctaaagcaagaggaggaccgtcccaagagacgaggaccggcctatgtcatggaactgcccaaactaaagctttcgggagtggtcagactgtcgtcttactccagccccacgctgcagtccgtgcttggatctggaacaaatggaagagtgccggtgctgagacccttgaagtgcatccctgcgagcaagaagacagatccgcagaaggaccttaagcctgccccgcagcagtgtcgcctgcccaccatagtgcggaaaggcggaagataactgagcagcaccgtcgtctcgacttcggaggcaacaccaagcccgaccgggccaggcctgggtgatctgctgctgagacgccacggagggctggggatgcgcctgcgtccgtttcgcgctggccggggctctgggtgctgccctgcgccctgccgcacccgcggcccgcgcagctgcctaggatgttctgggctaatatacttgtaaaaccaccgcattctagggttttctttcattttcgttaagaatttggggcaggaaatactttgtaactttgtatatgaatcaaaacaaacgagcaggcatttctgtgatgtgttgggcgtggttggaaggtgggttctgcgtgtcccttcccagcgctgctggtcagtcgtggagcgccatcatgtcttaccagtgacgctgctgacacccctgacttttattaaagaataagctgtcgttacagtattgcattttaatgttaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5891 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS GeneID:5891 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS GeneID:5891 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: IEA GeneID:5891 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:5891 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS GeneID:5891 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:5891 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
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