LOCUS       NM_001270616            8505 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens prospero homeobox 1 (PROX1), transcript variant 1,
            mRNA.
ACCESSION   NM_001270616
VERSION     NM_001270616.1  GI:397174761
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8505)
  AUTHORS   Lecompte,S., Pasquetti,G., Hermant,X., Grenier-Boley,B.,
            Gonzalez-Gross,M., De Henauw,S., Molnar,D., Stehle,P., Beghin,L.,
            Moreno,L.A., Amouyel,P., Dallongeville,J. and Meirhaeghe,A.
  TITLE     Genetic and molecular insights into the role of PROX1 in glucose
            metabolism
  JOURNAL   Diabetes 62 (5), 1738-1745 (2013)
   PUBMED   23274905
  REMARK    GeneRIF: genetic association studies in adolescent populations in
            Europe: Data suggest that 3 SNPs in PROX1 (rs340838; rs340837;
            rs340836) are associated with fasting plasma insulin levels and may
            play a role in regulation of insulin secretion.
REFERENCE   2  (bases 1 to 8505)
  AUTHORS   Zhou,B., Si,W., Su,Z., Deng,W., Tu,X. and Wang,Q.
  TITLE     Transcriptional activation of the Prox1 gene by HIF-1alpha and
            HIF-2alpha in response to hypoxia
  JOURNAL   FEBS Lett. 587 (6), 724-731 (2013)
   PUBMED   23395615
  REMARK    GeneRIF: Prox1 gene transcription is regulated by HIF-1alpha and
            HIF-2alpha in hypoxia.
REFERENCE   3  (bases 1 to 8505)
  AUTHORS   Lu,M.H., Huang,C.C., Pan,M.R., Chen,H.H. and Hung,W.C.
  TITLE     Prospero homeobox 1 promotes epithelial-mesenchymal transition in
            colon cancer cells by inhibiting E-cadherin via miR-9
  JOURNAL   Clin. Cancer Res. 18 (23), 6416-6425 (2012)
   PUBMED   23045246
  REMARK    GeneRIF: PROX1 promotes epithelial-mesenchymal transition and colon
            cancer progression.
REFERENCE   4  (bases 1 to 8505)
  AUTHORS   Cimpean,A.M., Mazuru,V., Saptefrati,L., Ceausu,R. and Raica,M.
  TITLE     Prox 1, VEGF-C and VEGFR3 expression during cervical neoplasia
            progression as evidence of an early lymphangiogenic switch
  JOURNAL   Histol. Histopathol. 27 (12), 1543-1550 (2012)
   PUBMED   23059885
  REMARK    GeneRIF: The presence of Prox1 nuclear expression was detected
            starting from CIN2 and CIN3 lesions to microinvasive carcinoma, in
            the nuclei of lymphatic and venous endothelial cells and scattered
            stromal cells.
REFERENCE   5  (bases 1 to 8505)
  AUTHORS   Elsir,T., Smits,A., Lindstrom,M.S. and Nister,M.
  TITLE     Transcription factor PROX1: its role in development and cancer
  JOURNAL   Cancer Metastasis Rev. 31 (3-4), 793-805 (2012)
   PUBMED   22733308
  REMARK    Review article
REFERENCE   6  (bases 1 to 8505)
  AUTHORS   Wilting,J., Papoutsi,M., Christ,B., Nicolaides,K.H., von
            Kaisenberg,C.S., Borges,J., Stark,G.B., Alitalo,K., Tomarev,S.I.,
            Niemeyer,C. and Rossler,J.
  TITLE     The transcription factor Prox1 is a marker for lymphatic
            endothelial cells in normal and diseased human tissues
  JOURNAL   FASEB J. 16 (10), 1271-1273 (2002)
   PUBMED   12060670
REFERENCE   7  (bases 1 to 8505)
  AUTHORS   Chen,Q., Dowhan,D.H., Liang,D., Moore,D.D. and Overbeek,P.A.
  TITLE     CREB-binding protein/p300 co-activation of crystallin gene
            expression
  JOURNAL   J. Biol. Chem. 277 (27), 24081-24089 (2002)
   PUBMED   11943779
REFERENCE   8  (bases 1 to 8505)
  AUTHORS   Duncan,M.K., Cui,W., Oh,D.J. and Tomarev,S.I.
  TITLE     Prox1 is differentially localized during lens development
  JOURNAL   Mech. Dev. 112 (1-2), 195-198 (2002)
   PUBMED   11850194
  REMARK    GeneRIF: Prox1 is differentially localized during lens development
REFERENCE   9  (bases 1 to 8505)
  AUTHORS   Mouta Carreira,C., Nasser,S.M., di Tomaso,E., Padera,T.P.,
            Boucher,Y., Tomarev,S.I. and Jain,R.K.
  TITLE     LYVE-1 is not restricted to the lymph vessels: expression in normal
            liver blood sinusoids and down-regulation in human liver cancer and
            cirrhosis
  JOURNAL   Cancer Res. 61 (22), 8079-8084 (2001)
   PUBMED   11719431
  REMARK    GeneRIF: Prox 1 is expressed in both quiescent and proliferating
            lymphatic endothelial cells in the liver. Unlike the putative
            lymphatic marker LYVE-1, Prox 1 is not expressed in liver
            sinusoidal endothelial cells.
            GeneRIF: Prox 1 is expressed in both quiescent and proliferating
            lymphatic endothelial cells in the adult human and mouse liver.
            Unlike the putative lymphatic marker LYVE-1, Prox 1 is not
            expressed in liver sinusoidal endothelial cells.
REFERENCE   10 (bases 1 to 8505)
  AUTHORS   Zinovieva,R.D., Duncan,M.K., Johnson,T.R., Torres,R.,
            Polymeropoulos,M.H. and Tomarev,S.I.
  TITLE     Structure and chromosomal localization of the human homeobox gene
            Prox 1
  JOURNAL   Genomics 35 (3), 517-522 (1996)
   PUBMED   8812486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB086260.1, DA802102.1,
            U44060.1, BC024201.2 and AL606537.10.
            
            Summary: The protein encoded by this gene is a member of the
            homeobox transcription factor family. Members of this family
            contain a homeobox domain that consists of a 60-amino acid
            helix-turn-helix structure that binds DNA and RNA. The protein
            encoded by this gene is conserved across vertebrates and may play
            an essential role during development. Altered levels of this
            protein have been reported in cancers of different organs, such as
            colon, brain, blood, breast, pancreas, liver and esophagus.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U44060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB086260.1         1-2
            3-558               DA802102.1         1-556
            559-824             U44060.1           550-815
            825-3418            BC024201.2         482-3075
            3419-8505           AL606537.10        97690-102776
FEATURES             Location/Qualifiers
     source          1..8505
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..8505
                     /gene="PROX1"
                     /note="prospero homeobox 1"
                     /db_xref="GeneID:5629"
                     /db_xref="HGNC:9459"
                     /db_xref="MIM:601546"
     exon            1..548
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       98
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375265407"
     variation       195
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113383864"
     variation       196
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185755196"
     variation       197
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190606359"
     variation       197
                     /gene="PROX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:66880995"
     variation       418
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140934310"
     variation       477
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367821012"
     variation       477
                     /gene="PROX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:66760546"
     variation       478
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368254622"
     variation       522..523
                     /gene="PROX1"
                     /replace=""
                     /replace="agag"
                     /db_xref="dbSNP:71842982"
     variation       542
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:340839"
     exon            549..2340
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       576
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34584886"
     variation       581
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185136406"
     misc_feature    589..591
                     /gene="PROX1"
                     /note="upstream in-frame stop codon"
     CDS             616..2829
                     /gene="PROX1"
                     /note="prospero-related homeobox 1; homeobox prospero-like
                     protein PROX1"
                     /codon_start=1
                     /product="prospero homeobox protein 1"
                     /protein_id="NP_001257545.1"
                     /db_xref="GI:397174762"
                     /db_xref="CCDS:CCDS31021.1"
                     /db_xref="GeneID:5629"
                     /db_xref="HGNC:9459"
                     /db_xref="MIM:601546"
                     /translation="

MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE

"
     misc_feature    616..2820
                     /gene="PROX1"
                     /note="Homeobox prospero-like protein (PROX1); Region:
                     Prox1; pfam05044"
                     /db_xref="CDD:203159"
     misc_feature    2521..2826
                     /gene="PROX1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92786.2);
                     Region: Prospero-like"
     variation       650
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372646482"
     variation       675
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192143344"
     variation       694
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199560210"
     variation       710
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189248628"
     variation       714
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144507992"
     variation       723
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71635949"
     variation       771
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192517068"
     variation       791
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375594682"
     variation       798
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148422967"
     variation       815
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74404045"
     variation       871
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201731499"
     variation       879
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140658485"
     variation       916
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201187008"
     variation       936
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372904856"
     variation       986
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147839309"
     variation       989..990
                     /gene="PROX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34468319"
     variation       1026
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373902403"
     variation       1038
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377531255"
     variation       1098
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368974011"
     variation       1110
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372599303"
     variation       1125
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140311564"
     variation       1171
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149162531"
     variation       1200
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372925105"
     variation       1216
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200548077"
     variation       1289
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146788962"
     variation       1293
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376859063"
     variation       1313
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371118740"
     variation       1315
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199834333"
     variation       1389
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:184188363"
     variation       1428
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140471005"
     variation       1454
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112763420"
     variation       1516
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200543978"
     variation       1517
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141960216"
     variation       1527
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188226653"
     variation       1557
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:117278964"
     variation       1574
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200966732"
     variation       1622
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144228107"
     variation       1623
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199970427"
     variation       1652
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376783773"
     variation       1661
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370674000"
     variation       1697
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374118696"
     variation       1711
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370676590"
     variation       1713
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201837366"
     variation       1744
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368029419"
     variation       1832
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201339853"
     variation       1857
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370313551"
     variation       1896
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373721879"
     variation       1922
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200387223"
     variation       1953
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369633751"
     variation       1963
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201989339"
     variation       2031
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367596069"
     variation       2051
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78142452"
     variation       2163
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200358560"
     variation       2167
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376676769"
     variation       2204
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148478012"
     variation       2223
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369562605"
     variation       2246
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201873517"
     variation       2249
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201147907"
     variation       2265
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35176368"
     variation       2268
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115772074"
     variation       2321
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138867261"
     exon            2341..2448
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       2366
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12121210"
     variation       2368
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181080355"
     variation       2439
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369204553"
     exon            2449..2643
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       2517
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150983193"
     variation       2529
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369040874"
     variation       2547
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373493766"
     exon            2644..8505
                     /gene="PROX1"
                     /inference="alignment:Splign:1.39.8"
     variation       2769
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369927365"
     variation       2775
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201543962"
     variation       2777..2778
                     /gene="PROX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:5780753"
     variation       2826
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370883938"
     variation       2833
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149049354"
     variation       2865
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368745894"
     variation       2878
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199685959"
     variation       2954
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111991025"
     STS             2977..3580
                     /gene="PROX1"
                     /standard_name="PROX1_8568"
                     /db_xref="UniSTS:467846"
     STS             3093..3223
                     /gene="PROX1"
                     /standard_name="RH78799"
                     /db_xref="UniSTS:80708"
     variation       3094
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13375798"
     variation       3112
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145877478"
     variation       3113
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188707422"
     variation       3183
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:180781567"
     variation       3190..3191
                     /gene="PROX1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:150012554"
     STS             3252..3401
                     /gene="PROX1"
                     /standard_name="SHGC-31006"
                     /db_xref="UniSTS:19930"
     variation       3252
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116007960"
     variation       3267
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115808633"
     variation       3383
                     /gene="PROX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:201452230"
     polyA_signal    3410..3415
                     /gene="PROX1"
     polyA_site      3418
                     /gene="PROX1"
                     /note="The 3' most polyA site has not been determined.
                     This is an internal site."
     variation       3470
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138598878"
     variation       3542
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369285090"
     variation       3556
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185181391"
     variation       3636
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142722706"
     variation       3666
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192168652"
     variation       3701
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182175922"
     variation       3736..3737
                     /gene="PROX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:369511554"
     variation       3883..3884
                     /gene="PROX1"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:138905375"
     variation       4005
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113692924"
     variation       4088
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377064485"
     variation       4141
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116305529"
     variation       4234
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76793602"
     variation       4289
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148386217"
     variation       4332
                     /gene="PROX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:376394115"
     variation       4471
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11810156"
     variation       4540
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41277174"
     variation       4569
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116790107"
     variation       4651
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186795261"
     variation       4655
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75626032"
     variation       4669
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41277176"
     variation       4739
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373216743"
     variation       4765..4766
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:148112013"
     variation       4895
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376529172"
     variation       5129
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77615530"
     variation       5137
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191582069"
     variation       5187..5188
                     /gene="PROX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:11392258"
     variation       5199
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183187936"
     variation       5275
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150871232"
     STS             5342..5489
                     /gene="PROX1"
                     /standard_name="D1S3515"
                     /db_xref="UniSTS:33852"
     variation       5388
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78844498"
     variation       5516
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:376893125"
     variation       5525
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77393206"
     variation       5526
                     /gene="PROX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76087254"
     variation       5538
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2241674"
     variation       5829
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:79969811"
     variation       5861
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139366939"
     variation       5901
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3170994"
     variation       6047
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115083933"
     variation       6103..6104
                     /gene="PROX1"
                     /replace=""
                     /replace="at"
                     /db_xref="dbSNP:142188045"
     variation       6159
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:185654155"
     variation       6179
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190365755"
     variation       6242
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149999134"
     variation       6283
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371386813"
     variation       6317
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113250721"
     variation       6355
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182171369"
     variation       6452..6453
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:71712287"
     variation       6475
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186860877"
     variation       6482
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:193214656"
     STS             6513..6646
                     /gene="PROX1"
                     /standard_name="SHGC-76346"
                     /db_xref="UniSTS:21354"
     variation       6583
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183903818"
     variation       6626
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79936119"
     variation       6670
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:7529248"
     variation       6768
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189248252"
     variation       6784
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12091447"
     variation       6792
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192884838"
     variation       6795..6798
                     /gene="PROX1"
                     /replace=""
                     /replace="ac"
                     /db_xref="dbSNP:34477510"
     variation       6796..6797
                     /gene="PROX1"
                     /replace=""
                     /replace="ac"
                     /db_xref="dbSNP:66667661"
     variation       6825..6826
                     /gene="PROX1"
                     /replace=""
                     /replace="ca"
                     /db_xref="dbSNP:57174976"
     variation       6826..6827
                     /gene="PROX1"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:71165945"
     variation       6827
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74139094"
     variation       6881
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76316620"
     variation       7061
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184458341"
     variation       7182..7183
                     /gene="PROX1"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:71677617"
     variation       7283
                     /gene="PROX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140023441"
     variation       7349
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188458481"
     variation       7381
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201348452"
     variation       7387
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114760027"
     variation       7419..7420
                     /gene="PROX1"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:141470586"
     variation       7493
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191767387"
     variation       7501
                     /gene="PROX1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74719846"
     variation       7510
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79560889"
     variation       7514
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1053283"
     variation       7613
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143625407"
     variation       7621
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370810692"
     variation       7670
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189203361"
     variation       7677
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182199286"
     variation       7754
                     /gene="PROX1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1053284"
     variation       8050
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187163705"
     variation       8283
                     /gene="PROX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190786076"
     STS             8339..8465
                     /gene="PROX1"
                     /standard_name="SHGC-76335"
                     /db_xref="UniSTS:12571"
     variation       8389
                     /gene="PROX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142704534"
     variation       8497..8499
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35052233"
     variation       8498
                     /gene="PROX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:200801369"
ORIGIN      

gtgtcttaaagtaaatcttgttgtggagcggagccctcagctgagggagcgctctgaaataatacaccattgcagccggggaaagcagagcggcgcaaaagagctctcgccgggtccgcctgctccctctccgcttcgctcctcttctcttctttacccttctcctctctcctcctctgctgctctctcctctcctccgctcttctctctcctcctctcctgctctctcctcttcccttagctcctcttcttttcttctcctcttcttccctctcctcgcctctcccctgctcctcttctctcgtctcccctcccctcccgcctctctctcccctctccctctcccactcgccccgctcgctcgctcgctgtcgcacagactcaccgtcccttgtccaattatcatattcatcacccgcaagatatcaccgtgtgtgcactcgcgtgttttcctctctctgccgggggaaaaaaaagagagagagagagatagagagagagagagagagagagagagagaggctcggtcccactgctccctgcaccgcggtcccgggattcttgagctgtgcccagctgacgagcttttgaagatggcacaataaccgtccagtgatgcctgaccatgacagcacagccctcttaagccggcaaaccaagaggagaagagttgacattggagtgaaaaggacggtagggacagcatctgcattttttgctaaggcaagagcaacgttttttagtgccatgaatccccaaggttctgagcaggatgttgagtattcagtggtgcagcatgcagatggggaaaagtcaaatgtactccgcaagctgctgaagagggcgaactcgtatgaagatgccatgatgccttttccaggagcaaccataatttcccagctgttgaaaaataacatgaacaaaaatggtggcacggagcccagtttccaagccagcggtctctctagtacaggctccgaagtacatcaggaggatatatgcagcaactcttcaagagacagccccccagagtgtctttccccttttggcaggcctactatgagccagtttgatatggatcgcttatgtgatgagcacctgagagcaaagcgcgcccgggttgagaatataattcggggtatgagccattcccccagtgtggcattaaggggcaatgaaaatgaaagagagatggccccgcagtctgtgagtccccgagaaagttacagagaaaacaaacgcaagcaaaagcttccccagcagcagcaacagagtttccagcagctggtttcagcccgaaaagaacagaagcgagaggagcgccgacagctgaaacagcagctggaggacatgcagaaacagctgcgccagctgcaggaaaagttctaccaaatctatgacagcactgattcggaaaatgatgaagatggtaacctgtctgaagacagcatgcgctcggagatcctggatgccagggcccaggactctgtcggaaggtcagataatgagatgtgcgagctagacccaggacagtttattgaccgagctcgagccctgatcagagagcaggaaatggctgaaaacaagccgaagcgagaaggcaacaacaaagaaagagaccatgggccaaactccttacaaccggaaggcaaacatttggctgagaccttgaaacaggaactgaacactgccatgtcgcaagttgtggacactgtggtcaaagtcttttcggccaagccctcccgccaggttcctcaggtcttcccacctctccagatcccccaggccagatttgcagtcaatggggaaaaccacaatttccacaccgccaaccagcgcctgcagtgctttggcgacgtcatcattccgaaccccctggacacctttggcaatgtgcagatggccagttccactgaccagacagaagcactgcccctggttgtccgcaaaaactcctctgaccagtctgcctccggccctgccgctggcggccaccaccagcccctgcaccagtcgcctctctctgccaccacgggcttcaccacgtccaccttccgccaccccttcccccttcccttgatggcctatccatttcagagcccattaggtgctccctccggctccttctctggaaaagacagagcctctcctgaatccttagacttaactagggataccacgagtctgaggaccaagatgtcatctcaccacctgagccaccacccttgttcaccagcacacccgcccagcaccgccgaagggctctccttgtcgctcataaagtccgagtgcggcgatcttcaagatatgtctgaaatatcaccttattcgggaagtgcaatgcaggaaggattgtcacccaatcacttgaaaaaagcaaagctcatgtttttttatacccgttatcccagctccaatatgctgaagacctacttctccgacgtaaagttcaacagatgcattacctctcagctcatcaagtggtttagcaatttccgtgagttttactacattcagatggagaagtacgcacgtcaagccatcaacgatggggtcaccagtactgaagagctgtctataaccagagactgtgagctgtacagggctctgaacatgcactacaataaagcaaatgactttgaggttccagagagattcctggaagttgctcagatcacattacgggagtttttcaatgccattatcgcaggcaaagatgttgatccttcctggaagaaggccatatacaaggtcatctgcaagctggatagtgaagtccctgagattttcaaatccccgaactgcctacaagagctgcttcatgagtagaaatttcaacaactctttttgaatgtatgaagagtagcagtcccctttggatgtccaagttatatgtgtctagattttgatttcatatatatgtgtatgggaggcatggatatgttatgaaatcagctggtaattcctcctcatcacgtttctctcattttcttttgttttccattgcaaggggatggttgttttctttctgcctttagtttgcttttgcccaaggcccttaacatttggacacttaaaatagggttaattttcagggaaaaagaatgttggcgtgtgtaaagtctctattagcaatgaagggaatttgttaacgatgcatccacttgattgatgacttattgcaaatggcggttggctgaggaaaacccatgacacagcacaactctacagacagtgatgtgtctcttgtttctactgctaagaaggtctgaaaatttaatgaaaccacttcatacatttaagtattttgtttggtttgaactcaatcagtagcttttccttacatgtttaaaaataattccaatgacagatgagcagctcacttttccaaagtaccccaaaaggccaaattaaaaaagaaaaataatcactctcaagccttgtctaagaaaagaggcaaactctgaaagtcgtaccagtttcttctggaggcaaagcaattttgcacaaaaccagctctctcaagatgagactagaaattcatacctggtcttgtagccacctctctaaacttgaaaataggttcttcttcataagtgagcttacatcattcttcataaagaaaaatcctataacttgttatcatttttgcttcagatactaaaaggcactaagtttccaatttacgctgctcaactttgtttatatgcttaaaaggattctgtttacttaacaattttttcccctaaaatactattttctgaatacttccttccagtaaggaataaaggaaagcccaacttggccataaaattcttgcctacactagaagtttgttgacagccattagctgacttgatcgtcatctcctaagaggaacacatatattttcacaagcaattccacactatcctgatgggtatgcaaagtggtgacagtctaactcagtgtttcttcattttaggtataacattttaaagcaattgataatgcctcttccaattcagaagctagtattgaccaaaatgtgagaagagtgtatagcataggaaaatttggggttaacccaaaagacacaattccagcacacataagaaagctagctgctattttatgctttcttccatggttctcctcttttttcccttttatttttccctgtttttcaatgatgtacagtgttccctacttgcattgaaaaaactcgtatggcattcacactttttttcttaggtgggtttttgtgtccagatgcagtaagaattcattgttcatcctaaaactgttttccagacccttccttccccttaggtaatttgatatacacctcctaaaatgacacagtaacaaatctggtatttagaacatatagaacataaatgccattttttaattcaactttaataagaattacatttgactttggagaatacaggtcttgacccatgtgactgactagctgacccgatcgctgtaatttaacgtcatttataaattctgctgatggacaggaatgtatgaactcaattattgtcagcacaaagccttaaaacctgctgactttaaattaaatggtgcagtcctatgatgccctgcaccatccaggggactaacagggcctcgcagtgtagacagagggtgcagccacacgggcgggggcaccagccacctcactctgcacccgcggcctcacacatctcccagctcacactctactaatgcacagagtcattagatccaatttgttatttttctcacttgctttaaaaaaaagcagtttggataatcatgacattggaataaagtgggaaggaaaaattccatcagcacaaaatagggaagtaatcccaacttgtagtcacagttttctgactggctttgttttaaaagaggatggcagtccttgttcgtgtcagtgtgccactgggtttttgctgttccgtgtaattcatatcaactttgtgttgccatttgcaaggtaaaaggcaaagctgtagtgtattcacctatgtagacagattgctagatatctttttgatctggggcgagttcaatattgattccagacttatttggatttttttagtattattttcccctccctttctaatttaaatagacaaattaagcaaaagtgtgtgttcacaaccaaatgttgatgcccttatctactgataatatcctctcaatgttcactgaggcatagaaattatttcagagtagaaattgcagcatgaggataaactcacctctttgttctgaaaatagaactttatcactatgctttccggtggttttcccttttacaatcgaaatcttgtgcctcccaagtgcattggaaaatgacaaaagcctgtctctccaaattcctatttaacagtttgattttttttttttaatcaccatctttcaaatcttagctcaactctcaccaagtgaaaattggctacttgggagaaagttaactttctatggtgggatggtgaaggatgagggacagtttacataggaaaagaaaaaaaaaagtctaaagtccatgttgaaaaaccacactaccacttattttctgctaaccctaaattatttttgcgtatacgcttgaggttatagtctgtgcctagacctaaaatgcaccagcgggggggattttaaaaaatccttcaaaataccagttttttcccaacaagtacaattgttcttgtgccttctgtggctttcgatttcatctttttgactttatttccaattactacagctgcaataaacactagattttttttctggctgtttgacataacgttgatagctatgcatattttgtgtctttttaaaacaaagcgggagaatacgtttttgaagaagagaatttttagaacagtttgataccgcaaattattttttcctcaattgtttgagcagcattcgagttttgaaaattcttgtagaagccaattttttgtaactgtggtgcaaatcttgtgttttcttagcctaatgaaaagtagtatagaagcaatatttcataccatgtgctatatatgtgtgcgcagatgtgtgaacataaaatcacatacacacatatacacacatgtaaaaatatacatatatatatatgcgtgtgaagtggaaagcttaccttttcctatctagatttaagaacctattttagacatttgttatgttttgtgaaaagaatgttctatttgcaacaaaacatttaattcttactgtatctctggctgtttaatgaggacgtttcacattaaatggtaaaacacatggaagatgttagaatgtagtaattatttaagtaaacgttcacccacatattcctgaagtttgctttgtgcctccgagtattatttaattaaagaagtgttttatgtttgcagaatctttgtcactgtactagggatgtgggtgaatatcatttaaaaaaatttaaaacaacaaaaaaaaagcaaaacagaaacactaaagcaagaggggaacttttataaagcaatgtaaatatttaacctcatggctgtcattatgtaagacatgagattttaataaataactacattctcacgacatctgttgaatttactaggaacactacagtgactgtatagacagttgaaagcattcttgaaaatcctgctctctccttttaaaagttaacaatctcttttatcagatgtcaagggcaagggtaatgcagtttctgtaaatttatgaaatttctttttctatgtacatgaagacatttagtaagtaacacccccccttcccatgcgcacatgtgcgcatacacacacacacacacacacacacacacacaaacacacacactgtcataaagctaatgatttggggactttaaaaaataggatgtcctccaggaacaatcataaatttatgaaagaaagagtagtttacagactcccctgaaagaagcagtgtatatgtgaagacagtgcaaaaatctctttgccatgtatattatagcgtattcattggtgtgaatagtacaaatgtttccttctggtacaaactctgtgtttgcaaatttacaagaagcattgttttcaaaaagctccccttaaaaaatgtaactggtttatatgagtaagcagttaccgtattgcacttaaatgttatgttgaaggaaatgcagttttgttttctgtagatctgttggttgtaaaccatctataaaactaaagctaaaatgctcatattcagagctgggatcaaaactggtatttaacctttgcatcttcttataattatccttctaagaatataacagaatgtggaagtgtctggactttgagtcttttcaactgagccttctctcaaatctgacaccccctcagaatgcacaaacataagcagaaaaggcaaacaagcttaccttcttttgtgaaaacgtattcattctgtatttttttaaatattcaattcccctaaaaatggggagaaaatattttaaaattgtatattacgacttcaaatttagaactaagaaaaaaatgtatttgggattggtctcagcgctacctagaagaatcaaaggtcatggcttccctcaatattgtcccagccatttctcatatgtatatagtataaaccgtgacaaaacactgcctttatattatttagcaatatgttgtaaatagcattattaagctcttttttgtaataaagaccctttgatttgaatatagtacaataactgaactgataaagtcaatttttgatttttgtttgttttttttagctagaggcaatttcaattgtgaatttttgttgttgtctattgttctgaagactttgcataatttattggtttaatttatcctaatttatttgatgaaggtgtacaattttgtattaccaaggatgtactgtaatattaattgatatgataaacacaatgagactccctgtccatattaaaaagaaaataaaaaggtgcagtagacaattgattttaaaggaaaagttaaaaaaattagtttggcagctactaaattttaaaacaggaaaaaaaaaagttgttgtggggagggtgggaaaggggttttactttgtgtgttttaagcttttgtatactctccaaacttttaccttttgctttgtaccacttaaaggatacagtagtccaattgccttgtgtgccttccatctcctcttaaactgaatgtatgtgcagtatatatgcaagcttgtgcaaaataaaatatacattacaagctcagtgccgtttgattttcttaaagaaagagtgacttttaatttttggacctgtatccaattgtaggacagtaggctagttgtgccagtaatgtcaagtatggagattttctttcactacaattcttcattctgttagcctaacgtgcagctcctagaaacaacctcttttactttagatgcttggaataattgcttggatttctctctctgaaacatctttcaggcttaactttatttagccctgaaacttaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5629 -> Molecular function: GO:0003677 [DNA binding] evidence: IMP
            GeneID:5629 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IC
            GeneID:5629 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: ISS
            GeneID:5629 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IDA
            GeneID:5629 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5629 -> Molecular function: GO:0016922 [ligand-dependent nuclear receptor binding] evidence: IPI
            GeneID:5629 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5629 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
            GeneID:5629 -> Molecular function: GO:0050692 [DBD domain binding] evidence: IPI
            GeneID:5629 -> Molecular function: GO:0050693 [LBD domain binding] evidence: IPI
            GeneID:5629 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:5629 -> Biological process: GO:0001709 [cell fate determination] evidence: IEA
            GeneID:5629 -> Biological process: GO:0001822 [kidney development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0001889 [liver development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0001938 [positive regulation of endothelial cell proliferation] evidence: IDA
            GeneID:5629 -> Biological process: GO:0001946 [lymphangiogenesis] evidence: IDA
            GeneID:5629 -> Biological process: GO:0002088 [lens development in camera-type eye] evidence: IEP
            GeneID:5629 -> Biological process: GO:0002194 [hepatocyte cell migration] evidence: IEA
            GeneID:5629 -> Biological process: GO:0007420 [brain development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
            GeneID:5629 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IMP
            GeneID:5629 -> Biological process: GO:0010468 [regulation of gene expression] evidence: IDA
            GeneID:5629 -> Biological process: GO:0010595 [positive regulation of endothelial cell migration] evidence: IDA
            GeneID:5629 -> Biological process: GO:0021516 [dorsal spinal cord development] evidence: ISS
            GeneID:5629 -> Biological process: GO:0021542 [dentate gyrus development] evidence: ISS
            GeneID:5629 -> Biological process: GO:0021707 [cerebellar granule cell differentiation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0021915 [neural tube development] evidence: ISS
            GeneID:5629 -> Biological process: GO:0030240 [skeletal muscle thin filament assembly] evidence: ISS
            GeneID:5629 -> Biological process: GO:0030324 [lung development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0030910 [olfactory placode formation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0031016 [pancreas development] evidence: IEP
            GeneID:5629 -> Biological process: GO:0031667 [response to nutrient levels] evidence: IEA
            GeneID:5629 -> Biological process: GO:0043049 [otic placode formation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:5629 -> Biological process: GO:0045071 [negative regulation of viral genome replication] evidence: IDA
            GeneID:5629 -> Biological process: GO:0045737 [positive regulation of cyclin-dependent protein kinase activity] evidence: IDA
            GeneID:5629 -> Biological process: GO:0045787 [positive regulation of cell cycle] evidence: ISS
            GeneID:5629 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:5629 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IMP
            GeneID:5629 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IMP
            GeneID:5629 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:5629 -> Biological process: GO:0046619 [optic placode formation involved in camera-type eye formation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0048845 [venous blood vessel morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0055005 [ventricular cardiac myofibril assembly] evidence: ISS
            GeneID:5629 -> Biological process: GO:0055009 [atrial cardiac muscle tissue morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0055010 [ventricular cardiac muscle tissue morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060042 [retina morphogenesis in camera-type eye] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060059 [embryonic retina morphogenesis in camera-type eye] evidence: IEP
            GeneID:5629 -> Biological process: GO:0060214 [endocardium formation] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060298 [positive regulation of sarcomere organization] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060412 [ventricular septum morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060414 [aorta smooth muscle tissue morphogenesis] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060421 [positive regulation of heart growth] evidence: ISS
            GeneID:5629 -> Biological process: GO:0060836 [lymphatic endothelial cell differentiation] evidence: IDA
            GeneID:5629 -> Biological process: GO:0060849 [regulation of transcription involved in lymphatic endothelial cell fate commitment] evidence: IMP
            GeneID:5629 -> Biological process: GO:0070309 [lens fiber cell morphogenesis] evidence: IEP
            GeneID:5629 -> Biological process: GO:0070365 [hepatocyte differentiation] evidence: IEP
            GeneID:5629 -> Biological process: GO:0070858 [negative regulation of bile acid biosynthetic process] evidence: IMP
            GeneID:5629 -> Biological process: GO:0072574 [hepatocyte proliferation] evidence: IEA
            GeneID:5629 -> Biological process: GO:0097150 [neuronal stem cell maintenance] evidence: ISS
            GeneID:5629 -> Biological process: GO:1901978 [positive regulation of cell cycle checkpoint] evidence: IEA
            GeneID:5629 -> Biological process: GO:2000179 [positive regulation of neural precursor cell proliferation] evidence: ISS
            GeneID:5629 -> Biological process: GO:2000979 [positive regulation of forebrain neuron differentiation] evidence: ISS
            GeneID:5629 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5629 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA