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2025-05-09 19:50:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001267612 7771 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens G protein-coupled receptor 161 (GPR161), transcript
variant 5, mRNA.
ACCESSION NM_001267612
VERSION NM_001267612.1 GI:390190208
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7771)
AUTHORS Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
TITLE Follow-up of a major linkage peak on chromosome 1 reveals
suggestive QTLs associated with essential hypertension: GenNet
study
JOURNAL Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)
PUBMED 19536175
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (bases 1 to 7771)
AUTHORS Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
TITLE Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
genetic association with bone mineral density variation
JOURNAL Hum. Mol. Genet. 18 (4), 679-687 (2009)
PUBMED 19064610
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 7771)
AUTHORS Matteson,P.G., Desai,J., Korstanje,R., Lazar,G., Borsuk,T.E.,
Rollins,J., Kadambi,S., Joseph,J., Rahman,T., Wink,J., Benayed,R.,
Paigen,B. and Millonig,J.H.
TITLE The orphan G protein-coupled receptor, Gpr161, encodes the
vacuolated lens locus and controls neurulation and lens development
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 105 (6), 2088-2093 (2008)
PUBMED 18250320
REFERENCE 4 (bases 1 to 7771)
AUTHORS Small,K.M., Seman,C.A., Castator,A., Brown,K.M. and Liggett,S.B.
TITLE False positive non-synonymous polymorphisms of G-protein coupled
receptor genes
JOURNAL FEBS Lett. 516 (1-3), 253-256 (2002)
PUBMED 11959142
REMARK GeneRIF: False positive non-synonymous polymorphisms of G-protein
coupled receptor genes.
REFERENCE 5 (bases 1 to 7771)
AUTHORS Schoneberg,T., Schulz,A. and Gudermann,T.
TITLE The structural basis of G-protein-coupled receptor function and
dysfunction in human diseases
JOURNAL Rev. Physiol. Biochem. Pharmacol. 144, 143-227 (2002)
PUBMED 11987825
REMARK Review article
REFERENCE 6 (bases 1 to 7771)
AUTHORS Raming,K., Konzelmann,S. and Breer,H.
TITLE Identification of a novel G-protein coupled receptor expressed in
distinct brain regions and a defined olfactory zone
JOURNAL Recept. Channels 6 (2), 141-151 (1998)
PUBMED 9932290
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL033532.36, AK056040.1 and AA662800.1.
Summary: Upon ligand binding, G protein-coupled receptors, such as
GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320),
allowing the receptors to transduce extracellular signals across
the plasma membrane into the cell. Phosphorylation of the receptor
attenuates signaling (Matteson et al., 2008 [PubMed
18250320]).[supplied by OMIM, Aug 2008].
Transcript Variant: This variant (5) differs in the 5' UTR and
lacks a portion of the 5' coding region. These differences cause
translation initiation at a downstream AUG and result in a protein
(isoform 4) with a shorter N-terminus compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK056040.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-53 AL033532.36 65221-65273 c
54-2036 AK056040.1 1-1983
2037-7594 AL033532.36 8548-14105 c
7595-7771 AA662800.1 1-177 c
FEATURES Location/Qualifiers
source 1..7771
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q24.2"
gene 1..7771
/gene="GPR161"
/gene_synonym="RE2"
/note="G protein-coupled receptor 161"
/db_xref="GeneID:23432"
/db_xref="HGNC:23694"
/db_xref="MIM:612250"
exon 1..427
/gene="GPR161"
/gene_synonym="RE2"
/inference="alignment:Splign:1.39.8"
exon 428..558
/gene="GPR161"
/gene_synonym="RE2"
/inference="alignment:Splign:1.39.8"
misc_feature 524..526
/gene="GPR161"
/gene_synonym="RE2"
/note="upstream in-frame stop codon"
exon 559..1283
/gene="GPR161"
/gene_synonym="RE2"
/inference="alignment:Splign:1.39.8"
CDS 581..1774
/gene="GPR161"
/gene_synonym="RE2"
/note="isoform 4 is encoded by transcript variant 5;
G-protein coupled receptor 161; G-protein coupled receptor
RE2"
/codon_start=1
/product="G-protein coupled receptor 161 isoform 4"
/protein_id="NP_001254541.1"
/db_xref="GI:390190209"
/db_xref="CCDS:CCDS58042.1"
/db_xref="GeneID:23432"
/db_xref="HGNC:23694"
/db_xref="MIM:612250"
/translation="
MVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR
"
misc_feature <587..1156
/gene="GPR161"
/gene_synonym="RE2"
/note="7 transmembrane receptor (rhodopsin family);
Region: 7tm_1; pfam00001"
/db_xref="CDD:200918"
exon 1284..1388
/gene="GPR161"
/gene_synonym="RE2"
/inference="alignment:Splign:1.39.8"
exon 1389..1508
/gene="GPR161"
/gene_synonym="RE2"
/inference="alignment:Splign:1.39.8"
exon 1509..7763
/gene="GPR161"
/gene_synonym="RE2"
/inference="alignment:Splign:1.39.8"
STS 1933..2684
/gene="GPR161"
/gene_synonym="RE2"
/standard_name="GPR161_2270"
/db_xref="UniSTS:280714"
variation 2270
/gene="GPR161"
/gene_synonym="RE2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1051426"
variation 2376
/gene="GPR161"
/gene_synonym="RE2"
/replace="a"
/replace="t"
/db_xref="dbSNP:1051428"
STS 2434..2573
/gene="GPR161"
/gene_synonym="RE2"
/standard_name="RH98556"
/db_xref="UniSTS:92344"
STS 3674..3806
/gene="GPR161"
/gene_synonym="RE2"
/standard_name="pchcms1"
/db_xref="UniSTS:539559"
variation 5869
/gene="GPR161"
/gene_synonym="RE2"
/replace="c"
/replace="g"
/db_xref="dbSNP:3202895"
STS 6164..6268
/gene="GPR161"
/gene_synonym="RE2"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 6206..6376
/gene="GPR161"
/gene_synonym="RE2"
/standard_name="D1S1425"
/db_xref="UniSTS:149621"
STS 7570..7740
/gene="GPR161"
/gene_synonym="RE2"
/standard_name="A004N15"
/db_xref="UniSTS:18315"
STS 7637..7771
/gene="GPR161"
/gene_synonym="RE2"
/standard_name="WI-13488"
/db_xref="UniSTS:83528"
ORIGIN
tttctccggcgccgcccgaagcccctaaacagtccgctggatgggagggcgtaggtgcgtgcccgggactctgccgatgcgggccgcgccccctggggccaagagactccacgtcccgctcagggcaaagggtgtggggagaagcggtcacgcccctcggctggaatccgtgaggaccaggtgagcagccttctcccagccgggactcagggcgctgtctccccgagcctgggcgggcggcgggtggcgcgcccagaagtggcccggcgccgccggatgggcggctctgcccctcagatctgcgggagggagattcggctggttcttggaaaggggagaactcgaccagccctcggcgccttctgggccaagcttaacccccgtgcaacctttggacaaaggcatatgggatgagaacgtctgttggcctggtgcactgtgcgtcctctgagaggtgaaggagcactgtgtggtcagagggctgcgagctctctgtttgggttccgaggaagacagaatgggctgaactggaactgacctaaatgtcagcaagaggagctactatgctgtcctgtaccccatggtgtaccccatgaagatcacagggaaccgggctgtgatggcacttgtctacatctggcttcactcgctcatcggctgcctgccacccctgtttggttggtcatccgtggagtttgacgagttcaaatggatgtgtgtggctgcttggcaccgggagcctggctacacggccttctggcagatctggtgtgccctcttcccctttctggtcatgctggtgtgctatggcttcatcttccgcgtggccagggtcaaggcacgcaaggtgcactgtggcacagtcgtcatcgtggaggaggatgctcagaggaccgggaggaagaactccagcacctccacctcctcttcaggcagcaggaggaatgcctttcagggtgtggtctactcggccaaccagtgcaaagccctcatcaccatcctggtggtcctcggtgccttcatggtcacctggggcccctacatggttgtcatcgcctctgaggccctctgggggaaaagctccgtctccccgagcctggagacttgggccacatggctgtcctttgccagcgctgtctgccaccccctgatctatggactctggaacaagacagttcgcaaagaactactgggcatgtgctttggggaccggtattatcgggaaccatttgtgcaacgacagaggacttccaggctcttcagcatttccaacaggatcacagacctgggcctgtccccacacctcactgcgctcatggcaggtggacagcccctggggcacagcagcagcacgggggacactggcttcagctgctcccaggactcagggacagatatgatgctgcttgaggactacacgtctgatgacaaccctccctctcactgcacttgcccacccaagagaaggagctcggtgacatttgaggatgaagtggaacaaatcaaagaagctgccaagaactcgattcttcatgtgaaagctgaagtacacaagtccttggacagttacgcagcaagcttggccaaagccattgaggccgaagccaaaatcaacttatttggggaggaggctttgccaggggtcttggttacagcacggactgtcccggggggcggcttcgggggccgccgaggcagcagaactcttgtgagccagaggctgcagttgcagagcatcgaagaaggagatgttttagctgccgagcagagatgagggcctcagggtgccgtggggctgcagcctgagaggctggcccggggaggagttcccatcaccgcctgtgccgcggccttgggagcatgtcactgtgtacagctggccacacacagggaaggagcagcatctggtatgcagccaccaggacaaggactgaaaataatgtctacagtccacagcttcagcatttccagagaccacatgtgagcttcttttaggtcccagtgatgggaccagaagcatctaaagcaaaaaaaaaaccaaaaaaaaatctagagatgtggctgtggctttttgggaggtggggcatgggaggaccagagacgaagggcttggaaggagacccccacatgcatcatttcctcctcttcacagtgtgctgggagtccagccgtgcactgtgccagatgcctcaggaggagaaccctccccagtgtactgtgaaggatgacacagcacttcttcctaatgacacgcgaccgtcctggtgcctctacatggttgatgcgggcagtgtgggaccctcagttctaggactggtccgcagagaaagcacccaggagcagagcgcttcggagcggtcctcagtggcgccacctgctggtgctaatagggacagccacaggcctcttgcagactggcccaccctgcctacttccctactgacaagttctttggtatttcaaaagggagaaaccactataaaagacaagaggaagggcaggtactaggtgtttcatttccagaattaaaaaaaaaatccatttaagacgtaccactgttttaccggactgaatgggactgtagtgccaagcacagccaggaaatagagaaactgttattatggaagggaatttgttcacatgggaaagcctcattaaatagattctatgtgtgatgtttgagtgaccaatgaaaatagctggcctcagttctgcatggcacactcccaagagcaacagttactattatcacaagcctggtataaataagatagaagcagccctggacccacagccagcaacctgggttattggcccagctctgtctttgtgtgcacatgtcatttggacatcttgtcacctttctaggtcctctgtaaagtgggaaaacagagtggagttggattgaatggtctccaagatcatttccagctctgacctttggtgttctcaggatttgtaaagcagagataggtaaaacacaaaagcagacccacggaccgacctttgtataactttggagtgtggttgctcatgcacatgtgaagtgcaggcagatcaaggttctgtggctttgtctgccctgtccattagagcacaatctggatagaatgccagccaccaagatgcatgaggggcagggtcaccatctcagaaggggaagcacaggaatgtgattgggatggttaaacctctcttctcctccctttgtgctggaacagcagttgaagtttggtcctggagtaattgctgtgatgacttgggaagccactgatctcctcttgcgtctgcccttggcctgcatcatgactaaataagttcaggacttctctgctttggttggcagaaggtagattccaaggagatcttgctggttgctgagaggcagctgttctagaaagtgaattacccttgtggttttttctttggggcccagctagctcctggtgaggttgtgtttttgtgttgtgtggcagaaaccaatggttagctggtcccctggtctgcagtttgtaaaagacctttcatgaggcctggagtcttgctacctgtggtgattgaactcaactattctgggtcacctggatgccaggcgctggcctagcttctggatgggagtgggaaggagcagagggcaggttcacctgtgcaggtcagacactctgcttccatcactggatggcattcctacgtctgcgtgtggttcacgttttctatatatattccctgtatatatttttttctagcacttgtctactttctgaagggaccatattcctgatcaactagtgtgcacagaggtggaacagggcagagagacctttatctctaggatgggttgctggttaggtgtaggcattcttgagtgcagcagcttggctttgaaacgcaagggttggagaatgttcccctgactgtactagactgggctctagggaaagaatcctgagacagccccccactcccccactgaccccacactagctgggctattatagaatttaatctaaatctagaaatactgcatttcacaaaatgattcactgtgtttccctttttttactgaggtccaattcatttagtcgtctaccagacactgcacatccagtgtatgcgaagcaccaggctaggctctgtaggcaataccactaaagtgtgcactctgatttagggagcaggacctgtggataccgattctaataactagcaaagtcaagtcgtggttatagaaagaagtgtggcttcagagggaggtgggtatttccaaatatggagttagggatggctccatgaggtaagtgacagtttgagctaagtcttgaaggatgcttggcagctagaaccatattttccatattcaggaattcaaatttgcctttattcagctagagagaaagagagaagggggtgtgggggagaaggaaaagagaattttcacacattttgaagttcctgagagcatttctgaggatatctgccgttagtgcagaaggtcgaaaccccaagtgcccccactaaacccaggctctttagctgtaaactgccatgcagtggcaggcctgcagccttcctgatgggaccacatggacagtggcacatgggacatttggctactcgttagcttaaacaactcagtcctgtgtcttctggttttgacaagaccacatttaggactgctgcccacctctgcctctttcattgagatttccgccttattgggtccctgtgctatgccacagataccaggtttggggttgttttgacccagaaggcattgggagtcccacattacagagcacacacacagctcaacacagccatttccctggccagaggcaccaagactgaagttcaggcccttagacactaggtggcagcggtgtggctgtgcagagccaaggatgaacctgagagcttgtttgcctctggctgggcactcttgttttgaattcctttgcccttatcgtgtagtccacggccttggtgaccaaggaccacctggctagcctgcttacatgcatgaccccatccaggttcacaggtattgccactgagtgatcttaggtagatcactgctcctggagaagcagagttgaggagtgtaagacaagggccatctagtgccaatgttccttgattcttatttgaggagctactatgtggtctttctgtaaacaagtgaacaaccaatgagactaaatatttgcaatagataggctaaggaatttgggttgagacaggagacggaggaaaaatgctttgatacaatgacagatggttagtctcttcagatttccctgaatattttccatcccgacaatatgcctcttagatacttgcagattagacatgtctctggatggaccacaagatacattcacaacatgtgttcagccttgagccctggctgtgtcctgtctggaaggaactgaggatgatgtggctataaagaggaggcagtgagctggcatgtgactgccttctgtgggcctgacctgtttgacatttgagggcctatgatgtgctaggtgctgtgttaggtacttccaaatgctttatctcattttaccccagtgcaagtgtgatatagtgaggatggtgaagacgtgggtatggttaagtcatgagttcagatcccgtgcttccaattacatgggtgttttcaaacaagtcactacttatgagtttcctcatctgtgaagggaagtttagtcatctgtttcaatgtggagacacacaggattgagggagtcctccgtcacagggtgactgtctggattctatgaggaaatacttggaaagcatgcagcacaatgcctggggtgcagctgaagctgagccactggtgtttcttcacagtatctctgtggggagggtgtattattcctttttatagggatctctataatgaagtgagaatcttgaaaatataagtgttatcctagatgggaggtgttaaaggtttttgccttgggaattttgtcatatttgttgcacagcaaggaaggactttcagaaaagcagggatgtggtgaggaagagcaggcaatagagagcagggaggaaaggctaagtagcatctggaacttgagaagtctaagggagccaaaatgagattttctattaaaaatgtctatcctcagccgggcgtggtagctcacgcctgtaatcccagcactttggggggtcgagatgggcagatcacctgaggtcaggagttcgagaccagcctgaccaatatggagaaaccccgtctctactaaaaatacaaaattagttgcgcgtggtggtgggcgcctgtaatcccagctactcaggagcctgaggcaggagaatcacttaaacccaggaggcggaggttgcagtgagccgagatcgcgccattgcactccagcctgggcaacaagagcgaaaccccgcctaaaaaaagaaaaaaaagaaaaagtctatcctctatgctactggcctgtttgtacaaagataaaatcattctaatttgtccggaatgactatcaaagatgatcaaatccccagggcctggtgtaacgttccaaatcatagcacaaatacagcttgaccttccttacagtccagaaaggacattctccctgagaaatgcccttggttgctgaggacagctctgtcctgtagtgacagagtgactgcctggctgtggctcttgggttcacagaatccctaatcctccaagcccctaagaggcagggcagggatgctacccacaatatatgcagaaccccagatggagcctgtgggagagagaggaaattaccgtcttcactgtaggcaaaggagaatggctgtgattagccatatatgcctataagaaggagcagagccatactgtccttgtgggttgggagaggggacacagaatccagggcaattgtctgaggtctcaaagtaagttaagccagagtcaaagccaaactccaagtcttggccaaggggatgagaaaagcaaggagctagtcttataggtcaaggaagatgaggtatagttaagagtcatcagtatcacagaacaggccagcagggctttattaggtatgtagaactattataaaccaaggatcttgggagatattaatatctgctggccagacctaaaaaaaactgaaggcccaaggaaagtgactggactcactggaaagtatctaacaaatactttggattccaaagtatttccaataccttgaagattcctttgaaaacatcaaagcacaaactcaaatctgcacaagattacaaaagcacaattttggtgttatttttagaatgcaatacacaaagctatgttcatttctctcagcaagcattttcctgggtagtagtaatagcttaggaatcaaatgccacttttgtttttccttttttcactagtttgaaataccacaaatcacaggtgagtcagtcctcccagaggaaaagacagtcctagggagaatcacaggcctggcagacaagaccacactgagagcagtagaaggaacctgcatgcttaagggacagaggactgtgttgtgttctcataatagaccgctggatgaagaagtggttaaaaaccaaccctcgaaaaacaaaaatccctggctaatcctgaaatatatttaacttgaagtctttggatgatttttttaaggttaaaaaaaagtttaggattattataaatcaatatttataaataagcaacaatgtatttggaatttttgtttacctgattaaatatgtttttggtatgtgtaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23432 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: ISS
GeneID:23432 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: ISS
GeneID:23432 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
GeneID:23432 -> Biological process: GO:0030819 [positive regulation of cAMP biosynthetic process] evidence: ISS
GeneID:23432 -> Biological process: GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] evidence: ISS
GeneID:23432 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:23432 -> Cellular component: GO:0055037 [recycling endosome] evidence: ISS
GeneID:23432 -> Cellular component: GO:0060170 [cilium membrane] evidence: IEA
GeneID:23432 -> Cellular component: GO:0072372 [primary cilium] evidence: ISS
by
@meso_cacase at
DBCLS
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