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2025-05-09 20:27:24, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001252120 4741 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens PAS domain containing serine/threonine kinase (PASK),
transcript variant 3, mRNA.
ACCESSION NM_001252120
VERSION NM_001252120.1 GI:355477263
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4741)
AUTHORS Hao,Y., Liu,X., Lu,X., Yang,X., Wang,L., Chen,S., Li,H., Li,J.,
Cao,J., Chen,J., Li,Y., Zhao,L., Shi,Y., Shen,C., Yan,W., He,J.,
Huang,J. and Gu,D.
TITLE Genome-wide association study in Han Chinese identifies three novel
loci for human height
JOURNAL Hum. Genet. 132 (6), 681-689 (2013)
PUBMED 23456168
REFERENCE 2 (bases 1 to 4741)
AUTHORS Semplici,F., Vaxillaire,M., Fogarty,S., Semache,M., Bonnefond,A.,
Fontes,G., Philippe,J., Meur,G., Diraison,F., Sessions,R.B.,
Rutter,J., Poitout,V., Froguel,P. and Rutter,G.A.
TITLE Human mutation within Per-Arnt-Sim (PAS) domain-containing protein
kinase (PASK) causes basal insulin hypersecretion
JOURNAL J. Biol. Chem. 286 (51), 44005-44014 (2011)
PUBMED 22065581
REMARK GeneRIF: Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK)
has a role in insulin hypersecretion
REFERENCE 3 (bases 1 to 4741)
AUTHORS MacDonald,P.E. and Rorsman,P.
TITLE Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon
secretion
JOURNAL Diabetologia 54 (4), 719-721 (2011)
PUBMED 21327866
REFERENCE 4 (bases 1 to 4741)
AUTHORS da Silva Xavier,G., Farhan,H., Kim,H., Caxaria,S., Johnson,P.,
Hughes,S., Bugliani,M., Marselli,L., Marchetti,P., Birzele,F.,
Sun,G., Scharfmann,R., Rutter,J., Siniakowicz,K., Weir,G.,
Parker,H., Reimann,F., Gribble,F.M. and Rutter,G.A.
TITLE Per-arnt-sim (PAS) domain-containing protein kinase is
downregulated in human islets in type 2 diabetes and regulates
glucagon secretion
JOURNAL Diabetologia 54 (4), 819-827 (2011)
PUBMED 21181396
REMARK GeneRIF: PASK is involved in the regulation of glucagon secretion
by glucose and may be a useful target for the treatment of type 2
diabetes.
REFERENCE 5 (bases 1 to 4741)
AUTHORS Grose,J.H. and Rutter,J.
TITLE The role of PAS kinase in PASsing the glucose signal
JOURNAL Sensors (Basel) 10 (6), 5668-5682 (2010)
PUBMED 22219681
REMARK GeneRIF: The role of PAS kinase in PASsing the glucose signal.
Review article
REFERENCE 6 (bases 1 to 4741)
AUTHORS Wilson,W.A., Skurat,A.V., Probst,B., de Paoli-Roach,A., Roach,P.J.
and Rutter,J.
TITLE Control of mammalian glycogen synthase by PAS kinase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 102 (46), 16596-16601 (2005)
PUBMED 16275910
REFERENCE 7 (bases 1 to 4741)
AUTHORS da Silva Xavier,G., Rutter,J. and Rutter,G.A.
TITLE Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of
preproinsulin and pancreatic duodenum homeobox 1 gene expression by
glucose
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (22), 8319-8324 (2004)
PUBMED 15148392
REMARK GeneRIF: Results suggest that elevated glucose concentrations
rapidly increase Per-Arnt-Sim kinase activity in pancreatic islet
beta cells, followed by up-regulation by glucose of preproinsulin
and pancreatic duodenum homeobox 1 gene expression.
REFERENCE 8 (bases 1 to 4741)
AUTHORS Amezcua,C.A., Harper,S.M., Rutter,J. and Gardner,K.H.
TITLE Structure and interactions of PAS kinase N-terminal PAS domain:
model for intramolecular kinase regulation
JOURNAL Structure 10 (10), 1349-1361 (2002)
PUBMED 12377121
REFERENCE 9 (bases 1 to 4741)
AUTHORS Hofer,T., Spielmann,P., Stengel,P., Stier,B., Katschinski,D.M.,
Desbaillets,I., Gassmann,M. and Wenger,R.H.
TITLE Mammalian PASKIN, a PAS-serine/threonine kinase related to
bacterial oxygen sensors
JOURNAL Biochem. Biophys. Res. Commun. 288 (4), 757-764 (2001)
PUBMED 11688972
REMARK GeneRIF: molecular cloning, gene expression, and comparison with
mouse protein
REFERENCE 10 (bases 1 to 4741)
AUTHORS Rutter,J., Michnoff,C.H., Harper,S.M., Gardner,K.H. and
McKnight,S.L.
TITLE PAS kinase: an evolutionarily conserved PAS domain-regulated
serine/threonine kinase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (16), 8991-8996 (2001)
PUBMED 11459942
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CR749231.1, AC005237.2 and
BC063585.1.
Summary: This gene encodes a member of the serine/threonine kinase
family that contains two PAS domains. Expression of this gene is
regulated by glucose, and the encoded protein plays a role in the
regulation of insulin gene expression. Downregulation of this gene
may play a role in type 2 diabetes. Alternatively spliced
transcript variants encoding multiple isoforms have been observed
for this gene. [provided by RefSeq, Nov 2011].
Transcript Variant: This variant (3) differs in the 5' UTR and uses
an alternate splice site in the 3' coding region, but maintains the
reading frame, compared to variant 1. Variants 2 and 3 encode the
same isoform (2), which is shorter than isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CR749231.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-22 CR749231.1 2-23
23-23 AC005237.2 117924-117924 c
24-1504 CR749231.1 25-1505
1505-4741 BC063585.1 1295-4531
FEATURES Location/Qualifiers
source 1..4741
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q37.3"
gene 1..4741
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="PAS domain containing serine/threonine kinase"
/db_xref="GeneID:23178"
/db_xref="HGNC:17270"
/db_xref="MIM:607505"
exon 1..23
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 24..244
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
misc_feature 233..235
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="upstream in-frame stop codon"
variation 238
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="g"
/replace="t"
/db_xref="dbSNP:36123792"
exon 245..482
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
CDS 287..4258
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/EC_number="2.7.11.1"
/note="isoform 2 is encoded by transcript variant 3; PAS
domain-containing serine/threonine-protein kinase;
per-arnt-sim (PAS) domain kinase"
/codon_start=1
/product="PAS domain-containing serine/threonine-protein
kinase isoform 2"
/protein_id="NP_001239049.1"
/db_xref="GI:355477264"
/db_xref="CCDS:CCDS2545.1"
/db_xref="GeneID:23178"
/db_xref="HGNC:17270"
/db_xref="MIM:607505"
/translation="
MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
"
misc_feature 683..982
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="PAS domain; PAS motifs appear in archaea,
eubacteria and eukarya. Probably the most surprising
identification of a PAS domain was that in EAG-like
K+-channels. PAS domains have been found to bind ligands,
and to act as sensors for light and oxygen in...; Region:
PAS; cd00130"
/db_xref="CDD:29035"
misc_feature 686..955
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="PAS domain; Region: PAS_9; pfam13426"
/db_xref="CDD:205604"
misc_feature order(725..727,737..739,755..757,794..805,893..895,
908..910)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="putative active site [active]"
/db_xref="CDD:29035"
misc_feature order(785..787,797..799,821..823,842..847,929..931,
935..937)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="heme pocket [chemical binding]; other site"
/db_xref="CDD:29035"
misc_feature 1316..1489
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="PAS domain; Region: PAS; smart00091"
/db_xref="CDD:197512"
misc_feature 3281..4039
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 3299..4033
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature order(3299..3313,3323..3325,3362..3364,3368..3370,
3479..3481,3527..3538,3551..3553,3557..3559,3668..3670,
3674..3676,3680..3685,3689..3691,3722..3724,3731..3733,
3776..3787)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(3299..3313,3323..3325,3362..3364,3368..3370,
3479..3481,3527..3538,3551..3553,3668..3670,3674..3676,
3680..3685,3689..3691,3722..3724)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(3311..3313,3551..3553,3557..3559,3668..3670,
3674..3676,3680..3682,3731..3733,3776..3787)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(3719..3739,3776..3787)
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 3767..3769
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q96RG2.3); phosphorylation site"
misc_feature 3779..3781
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q96RG2.3); phosphorylation site"
exon 483..715
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 716..886
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 887..1027
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 1028..1162
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
variation 1034
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="a"
/replace="g"
/db_xref="dbSNP:1470414"
exon 1163..1423
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 1424..1592
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 1593..1749
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 1750..3005
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3006..3190
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3191..3358
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3359..3484
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3485..3619
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3620..3819
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3820..3953
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
exon 3954..4100
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
variation 4083
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/replace="g"
/replace="t"
/db_xref="dbSNP:1131293"
exon 4101..4725
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/inference="alignment:Splign:1.39.8"
STS 4270..4415
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/standard_name="RH25358"
/db_xref="UniSTS:92426"
polyA_signal 4506..4511
/gene="PASK"
/gene_synonym="PASKIN; STK37"
polyA_site 4537
/gene="PASK"
/gene_synonym="PASKIN; STK37"
STS 4575..4724
/gene="PASK"
/gene_synonym="PASKIN; STK37"
/standard_name="SHGC-30587"
/db_xref="UniSTS:3455"
polyA_signal 4697..4702
/gene="PASK"
/gene_synonym="PASKIN; STK37"
polyA_site 4725
/gene="PASK"
/gene_synonym="PASKIN; STK37"
ORIGIN
gtccccgcgcggattttacccatcccagtgcggacgctgcagccttcgtctaccctgcggagccacccggcccatgaacgagccgccccgcgtcctccgccttcagaaagaggcctccaagaggcgagctctgcgctactcacccattttgatcgcgagtcgggaggaaaccgcatctgcccggcccgggggcggaggcgcccattattcctttggctcctccgaagcgccgtaggggtgtttgttgttagagttggaagcttggcagttggcctcccttcttcccatggaggacgggggcttaacagcctttgaagaggaccagagatgcctttcccagagcctccccttgccagtgtcagcagagggcccagctgcacagaccactgctgagcccagcaggtcgttttcctcagcccacagacacctgagcagaaggaatgggctttccagactctgccagagcaggacagcgctctctgaagacagatggagctcctattgtctatcatcactggctgcccagaatatttgtacaagtaaactgcactgccctgctgcccctgagcacacggacccgtccgaaccgcggggcagtgtgtcctgctgctccctgctgcggggactgtcctcagggtggtcctcacctctgcttccggcccctgtgtgcaaccctaacaaggccatcttcacggtggatgccaagaccacagagatcctggttgctaacgacaaagcttgcgggctcctggggtacagcagccaggacctgattggccagaagctcacgcagttctttctgaggtcagattctgatgtggtggaggccctcagcgaggagcacatggaggccgacggccacgctgcggtggtgtttggcacggtggtggacatcatcagccgtagtggggagaagattccagtgtctgtgtggatgaagaggatgcggcaggagcgccgcctatgctgcgtggtggtcctggagcccgtggagagggtctcgacctgggtcgctttccagagcgatggcaccgtcacgtcatgtgacagtctctttgctcatcttcacgggtacgtgtctggggaggacgtggctgggcagcatatcacagacctgatcccttctgtgcagctccctccttctggccagcacatcccaaagaatctcaagattcagaggtctgttggaagagccagggacggtaccaccttccctctgagcttaaagctgaaatcccaacccagcagcgaggaggcgaccaccggtgaggcggcccctgtgagcggctaccgggcatctgtctgggtgttctgcaccatcagtggcctcatcaccctcctgccggatgggaccatccacggcatcaaccacagcttcgcgctgacactgtttggttacggaaagacggagctcctgggcaagaatatcactttcctgattcctggtttctacagctacatggaccttgcgtacaacagctcattacagctcccagacctggccagctgcctggacgtcggcaatgagagtgggtgtggggagagaaccttggacccgtggcagggccaggacccagctgaggggggccaggatccaaggattaatgtcgtgcttgctggtggccacgttgtgccccgagatgagatccggaagctgatggaaagccaagacatcttcaccgggactcagactgagctgattgctggaggccagctcctttcctgcctctcacctcagcctgctccaggggtggacaatgtcccagaaggaagcctgccagtgcacggtgaacaggcgctgcccaaggaccagcaaatcactgccttggggagagaggaacctgtggcaatagagagccccggacaggatcttctgggagaaagcaggtctgaaccagtggatgtgaagccatttgcttcctgcgaagattctgaagctccagtcccagctgaggatgggggcagtgatgctggcatgtgtggcctgtgtcagaaggcccagctagagcggatgggagtcagtggtcccagcggttcagacctttgggctggggctgccgtggccaagccccaggccaagggtcagctggcggggggcagcctcctgatgcactgcccttgctatgggagtgaatggggcttgtggtggcgaagccaggacttggcccccagcccctctgggatggcaggcctctcgtttgggacacctactctagatgagccgtggctgggagtggaaaacgaccgagaagagctgcagacctgcttgattaaggagcagctgtcccagttgagccttgcaggagccctggatgtcccccacgccgaactcgttccgacagagtgccaggctgtcaccgctcctgtgtcgtcctgcgatctgggaggcagagacctgtgcggtggctgcacgggcagctcctcagcctgctatgccttggccacggacctccctgggggcctggaagcagtggaggcccaggaggttgatgtgaattcgttttcctggaacctcaaggaactctttttcagtgaccagacagaccaaacgtcatcaaattgttcctgtgctacgtctgaactcagagagacaccctcttccttggcagtgggctccgatccagatgtaggcagtctccaggaacaggggtcgtgtgtcctggatgacagggagctgttactactgaccggcacctgtgttgaccttggccaaggccgacggttccgggagagctgtgtgggacatgatccaacagaaccgcttgaggtttgtttggtgtcctctgagcattatgcagcaagcgacagagaaagcccaggacacgttccttccacgttggatgctggccctgaggacacgtgcccatcagcagaggagccaaggctgaacgtccaggtcacctccacgcccgtgatcgtgatgcgcggggctgctggcctgcagcgggagatccaggagggtgcctactccgggagctgctaccatcgagatggcttacggctgagtatacagtttgaggtgaggcgggtggagctccagggccccacacctctgttctgctgctggctggtgaaagacctcctccacagccaacgcgactcagccgccaggacccgcctgttccttgccagcctgcccggctccacccactctaccgctgctgagctcaccggacccagcctggtggaagtgctcagagccagaccctggtttgaggagccccccaaggctgtggaactggaggggttggcggcctgtgagggcgagtactcccaaaagtacagtaccatgagcccgctgggcagtggggccttcggcttcgtgtggactgctgtggacaaggaaaaaaacaaggaggtggtggtgaagtttattaagaaggagaaggtcttggaggattgttggattgaggatcccaaacttgggaaagttactttagagatcgcaattctatccagggtggagcacgccaatatcatcaaggtattggatatatttgaaaaccaagggttcttccagcttgtgatggagaagcacggctccggcctagacctcttcgctttcatcgaccgccaccccaggctggatgagcccctggcgagctacatcttccgacaactagtgtcagcagtgggatacctgcgcttgaaggacatcatccaccgtgacatcaaggatgagaacatcgtgatcgccgaggacttcacaatcaagctgatagactttggctcggccgcctacttggaaaggggaaaattattttatactttttgtgggaccatcgagtactgtgcaccggaagttctcatggggaatccctacagagggccggagctggagatgtggtctctgggagtcactctgtacacgctggtctttgaggagaaccccttctgtgagctggaggagaccgtggaggctgccatacacccgccatacctggtgtccaaagaactcatgagccttgtgtctgggctgctgcagccagtccctgagagacgcaccaccttggagaagctggtgacagacccgtgggtaacacagcctgtgaatcttgctgactatacatgggaagaggtgtttcgagtaaacaagccagaaagtggagttctgtccgctgcgagcctggagatggggaacaggagcctgagtgatgtggcccaggctcaggagctttgtgggggccccgttccaggcgaggctcctaatggccaaggctgtttgcatcccggggatccccgtctgctgaccagctaaacaccaatttcttcctgcttttctccacttggtttggaaaatcacacagttttcaggctccatctgtttggagaaaatacattctgaagcatccccaattcaccttctaaaaactcatgtgcaggtttgataaacaccagaacagaagacagtgatgctgtattattttagatttattacatagatttggaattcacttttttcatgacctagaaaaaaacattccagtgttcaactgttttatattattaaagggcttttaatttgtgaacttctgaaggcatgagtgttttctctttctacttttgtatatgtgcatgttttgtttcctctgacttggtatatgctcatctgagtgacggatatgtgaaatttgtagaactggttagtcaaatggccagactatttcattaatttatttcctcaaatgcttttcaaattaaagcacctttgttagtaaacagttaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23178 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:23178 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IEA
GeneID:23178 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23178 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:23178 -> Molecular function: GO:0035091 [phosphatidylinositol binding] evidence: IDA
GeneID:23178 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:23178 -> Biological process: GO:0043576 [regulation of respiratory gaseous exchange] evidence: ISS
GeneID:23178 -> Biological process: GO:0045719 [negative regulation of glycogen biosynthetic process] evidence: IDA
GeneID:23178 -> Biological process: GO:0045727 [positive regulation of translation] evidence: TAS
GeneID:23178 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:23178 -> Biological process: GO:0070092 [regulation of glucagon secretion] evidence: ISS
GeneID:23178 -> Biological process: GO:2000505 [regulation of energy homeostasis] evidence: ISS
GeneID:23178 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:23178 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:23178 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001239049 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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