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2025-05-09 20:33:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001198957 3540 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens DDB1 and CUL4 associated factor 6 (DCAF6), transcript
variant 4, mRNA.
ACCESSION NM_001198957
VERSION NM_001198957.1 GI:312176367
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3540)
AUTHORS Chang,S.W., Lu,P.Y., Guo,J.H., Tsai,T.C., Tsao,Y.P. and Chen,S.L.
TITLE NRIP enhances HPV gene expression via interaction with either GR or
E2
JOURNAL Virology 423 (1), 38-48 (2012)
PUBMED 22177699
REMARK GeneRIF: NRIP enhances HPV 16 gene expression via interaction with
either GR or viral E2.
REFERENCE 2 (bases 1 to 3540)
AUTHORS Shi,Y., Li,Z., Xu,Q., Wang,T., Li,T., Shen,J., Zhang,F., Chen,J.,
Zhou,G., Ji,W., Li,B., Xu,Y., Liu,D., Wang,P., Yang,P., Liu,B.,
Sun,W., Wan,C., Qin,S., He,G., Steinberg,S., Cichon,S., Werge,T.,
Sigurdsson,E., Tosato,S., Palotie,A., Nothen,M.M., Rietschel,M.,
Ophoff,R.A., Collier,D.A., Rujescu,D., Clair,D.S., Stefansson,H.,
Stefansson,K., Ji,J., Wang,Q., Li,W., Zheng,L., Zhang,H., Feng,G.
and He,L.
TITLE Common variants on 8p12 and 1q24.2 confer risk of schizophrenia
JOURNAL Nat. Genet. 43 (12), 1224-1227 (2011)
PUBMED 22037555
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3540)
AUTHORS Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
TITLE Follow-up of a major linkage peak on chromosome 1 reveals
suggestive QTLs associated with essential hypertension: GenNet
study
JOURNAL Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)
PUBMED 19536175
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 3540)
AUTHORS Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
TITLE Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
genetic association with bone mineral density variation
JOURNAL Hum. Mol. Genet. 18 (4), 679-687 (2009)
PUBMED 19064610
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 3540)
AUTHORS Han,C.P., Lee,M.Y., Tzeng,S.L., Yao,C.C., Wang,P.H., Cheng,Y.W.,
Chen,S.L., Wu,T.S., Tyan,Y.S. and Kok,L.F.
TITLE Nuclear Receptor Interaction Protein (NRIP) expression assay using
human tissue microarray and immunohistochemistry technology
confirming nuclear localization
JOURNAL J. Exp. Clin. Cancer Res. 27, 25 (2008)
PUBMED 18673574
REMARK GeneRIF: A survey results showed that ten cancer cases were
revealed to express the NRIP in six malignancies, but not all of
these specific tumor types consistently showed positive NRIP
expression.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3540)
AUTHORS Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
TITLE A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
which is required for S phase destruction of the replication factor
Cdt1
JOURNAL Mol. Cell 23 (5), 709-721 (2006)
PUBMED 16949367
REFERENCE 7 (bases 1 to 3540)
AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
Kim,N.S.
TITLE Transcriptome analysis of human gastric cancer
JOURNAL Mamm. Genome 16 (12), 942-954 (2005)
PUBMED 16341674
REFERENCE 8 (bases 1 to 3540)
AUTHORS Tsai,T.C., Lee,Y.L., Hsiao,W.C., Tsao,Y.P. and Chen,S.L.
TITLE NRIP, a novel nuclear receptor interaction protein, enhances the
transcriptional activity of nuclear receptors
JOURNAL J. Biol. Chem. 280 (20), 20000-20009 (2005)
PUBMED 15784617
REMARK GeneRIF: NRIP interacts with either androgen or glucocorticoid
receptors
REFERENCE 9 (bases 1 to 3540)
AUTHORS Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
Wrana,J.L.
TITLE High-throughput mapping of a dynamic signaling network in mammalian
cells
JOURNAL Science 307 (5715), 1621-1625 (2005)
PUBMED 15761153
REFERENCE 10 (bases 1 to 3540)
AUTHORS Tureci,O., Sahin,U., Koslowski,M., Buss,B., Bell,C., Ballweber,P.,
Zwick,C., Eberle,T., Zuber,M., Villena-Heinsen,C., Seitz,G. and
Pfreundschuh,M.
TITLE A novel tumour associated leucine zipper protein targeting to sites
of gene transcription and splicing
JOURNAL Oncogene 21 (24), 3879-3888 (2002)
PUBMED 12032826
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA128283.1, AK297847.1, AF116725.1 and CA310484.1.
Transcript Variant: This variant (4) lacks an in-frame exon in the
CDS compared to variant 3. The resulting isoform (d) lacks an
internal segment compared to isoform c.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK297847.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025099 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-142 DA128283.1 1-142
143-1582 AK297847.1 3-1442
1583-3333 AF116725.1 1417-3167
3334-3540 CA310484.1 1-207 c
FEATURES Location/Qualifiers
source 1..3540
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q24.2"
gene 1..3540
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/note="DDB1 and CUL4 associated factor 6"
/db_xref="GeneID:55827"
/db_xref="HGNC:30002"
/db_xref="MIM:610494"
exon 1..450
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
misc_feature 279..281
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/note="upstream in-frame stop codon"
CDS 354..3116
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/note="isoform d is encoded by transcript variant 4; IQ
motif and WD repeats 1; androgen receptor
complex-associated protein; DDB1- and CUL4-associated
factor 6; nuclear receptor interaction protein; IQ motif
and WD repeat-containing protein 1"
/codon_start=1
/product="DDB1- and CUL4-associated factor 6 isoform d"
/protein_id="NP_001185886.1"
/db_xref="GI:312176368"
/db_xref="CCDS:CCDS55658.1"
/db_xref="GeneID:55827"
/db_xref="HGNC:30002"
/db_xref="MIM:610494"
/translation="
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRFNIRGTTIGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENEDEE
"
misc_feature 495..>1136
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cl02567"
/db_xref="CDD:207648"
misc_feature order(495..497,534..539,597..599,609..611,627..632,
675..680,732..734,747..749,765..770,807..809,882..884,
897..899,915..920,999..1004,1068..1070,1080..1082,
1098..1103)
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
misc_feature <495..>1085
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/note="FOG: WD40 repeat [General function prediction
only]; Region: COG2319"
/db_xref="CDD:32473"
misc_feature 2667..>2900
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cl02567"
/db_xref="CDD:207648"
variation complement(443)
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/replace="a"
/replace="c"
/db_xref="dbSNP:203788"
exon 451..512
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 513..698
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
STS 514..651
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/standard_name="RH45968"
/db_xref="UniSTS:81976"
exon 699..812
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 813..948
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 949..1163
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 1164..1257
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 1258..1377
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 1378..1638
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
STS 1400..1509
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/standard_name="D1S2526"
/db_xref="UniSTS:92704"
exon 1639..1809
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 1810..1869
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 1870..1987
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 1988..2103
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 2104..2190
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 2191..2518
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
STS 2204..2325
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/standard_name="RH64705"
/db_xref="UniSTS:37862"
exon 2519..2560
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 2561..2699
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 2700..2856
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 2857..2945
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 2946..3051
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
exon 3052..3524
/gene="DCAF6"
/gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
PC326; RP4-745I14.1"
/inference="alignment:Splign:1.39.8"
ORIGIN
atctcgcgagaaagggttggcggggagggtatccaggacgaggagagggaggagtcgccatcgcctccgcctccgcctcctcctgttggaggggggctgagggaggagactgttgctgatctttggatgttctggttagtctaagaaggagagtatgaggcgagctccggcccgggtgcggccgggcttcaggggcccaggcgccgctgctgccaccgccatctaacgctgcgccctggaggcccggcgcgcggatggtgccggtgcggctcgggtgttgaaacgggtgtcccctccccctcctcccctcccccacgcggtggtctcccctcccacccggctcaggcagagccatgtctcggggtggctcctacccacacctgttgtgggacgtgaggaaaaggtccctcgggctggaggacccgtcccggctgcggagtcgctacctgggaagaagagaatttatccaaagattaaaacttgaagcaacccttaatgtgcatgatggttgtgttttgacaacaattcgttcagggcaccgagcaaacatatttagtgcaaagttcttaccttgtacaaatgataaacagattgtatcctgctctggagatggagtaatattttataccaacgttgagcaagatgcagaaaccaacagacaatgccaatttacgtgtcattatggaactacttatgagattatgactgtacccaatgacccttacacttttctctcttgtggtgaagatggaactgttaggtggtttgatacacgcatcaaaactagctgcacaaaagaagattgtaaagatgatattttaattaactgtcgacgtgctgccacgtctgttgctatttgcccaccaataccatattaccttgctgttggttgttctgacagctcagtacgaatatatgatcggcgaatgctgggcacaagagctacagggaattatgcaggtcgagggactactggaatggttgcccgttttattccttcccatcttaataataagtcctgcagagtgacatctctgtgttacagtgaagatggtcaagagattctcgttagttactcttcagattacatatatctttttgacccgaaagatgatacagcacgagaacttaaaactccttctgcggaagagagaagagaagagttgcgacaaccaccagttaagcgtttgagacttcgtggtgattggtcagatactggacccagagcaaggccggagagtgaacgagaacgagatggagagcagagtcccaatgtgtcattgatgcagagaatgtctgatatgttatcaagatggtttgaagaagcaagtgaggttgcacaaagcaatagaggacgaggaagatctcgacccagaggtggaacaagtcaatcagatatttcaactcttcctacggtcccatcaagtcctgatttggaagtgagtgaaactgcaatggaagtagatactccagctgaacaatttcttcagccttctacatcctctacaatgtcagctcaggctcattcgacatcatctcccacagaaagccctcattctactcctttgctatcttctccagacagtgaacaaaggcagtctgttgaggcatctggacaccacacacatcatcagtctgaatttttaaggggccctgagatagctttgcttcgtaagcgcctgcaacaactgaggcttaagaaggctgagcagcagaggcagcaagagctagctgcacatacccagcaacagccttccacttctgatcagtcttctcatgagggctcttcacaggaccctcatgcttcagattctccttcttctgtggttaacaaacagctcggatccatgtcacttgacgagcaacaggataacaataatgaaaagctgagccccaaaccagggacaggtgaaccagttttaagtttgcactacagcacagaaggaacaactacaagcacaataaaactgaactttacagatgaatggagcagtatagcatcaagttctagaggaattgggagccattgcaaatctgagggtcaggaggaatctttcgtcccacagagctcagtgcaaccaccagaaggagacagtgaaacaaaagctcctgaagaatcatcagaggatgtgacaaaatatcaggaaggagtatctgcagaaaacccagttgagaaccatatcaatataacacaatcagataagttcacagccaagccattggattccaactcaggagaaagaaatgacctcaatcttgatcgctcttgtggggttccagaagaatctgcttcatctgaaaaagccaaggaaccagaaacttcagatcagactagcactgagagtgctaccaatgaaaataacaccaatcctgagcctcagttccaaacagaagccactgggccttcagctcatgaagaaacatccaccagggactctgctcttcaggacacagatgacagtgatgatgacccagtcctgatcccaggtgcaaggtatcgagcaggacctggtgatagatttaatatcagaggaacaacaataggtgatagaataatgagacgctctgctgttgcccgtattcaggagttcttcagacggagaaaagaaaggaaagaaatggaagaattggatactttgaacattagaaggccgctagtaaaaatggtttataaaggccatcgcaactccaggacaatgataaaagaagccaatttctggggtgctaactttgtaatgagtggttctgactgtggccacattttcatctgggatcggcacactgctgagcatttgatgcttctggaagctgataatcatgtggtaaactgcctgcagccacatccgtttgacccaattttagcctcatctggcatagattatgacataaagatctggtcaccattagaagagtcaaggatttttaaccgaaaacttgctgatgaagttataactcgaaacgaactcatgctggaagaaactagaaacaccattacagttccagcctctttcatgttgaggatgttggcttcacttaatcatatccgagctgaccggttggagggtgacagatcagaaggctctggtcaagagaatgaaaatgaggatgaggaataataaactctttttggcaagcacttaaatgttctgaaatttgtataagacatttattatatttttttctttacagagctttagtgcaattttaaggttatggtttttggagtttttccctttttttgggataacctaacattggtttggaatgattgtgtgcatgaatttgggagattgtataaaacaaaactagcagaatgtttttaaaactttttgccgtgtatgaggagtgctagaaaatgcaaagtgcaatattttccctaaccttcaaatgtgggagcttggatcaatgttgaagaataattttcatcatagtgaaaatgttggttcaaataaatttctacacttgccatttgcatgtttgttgctttctaattaaagaaactggttgttttaagataccctgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55827 -> Molecular function: GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] evidence: IDA
GeneID:55827 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IC
GeneID:55827 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IEA
GeneID:55827 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IGI
GeneID:55827 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:55827 -> Cellular component: GO:0080008 [Cul4-RING ubiquitin ligase complex] evidence: IDA
by
@meso_cacase at
DBCLS
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