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2025-05-09 20:10:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001190737 8507 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens nuclear factor I/B (NFIB), transcript variant 1, mRNA.
ACCESSION NM_001190737
VERSION NM_001190737.1 GI:299758475
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8507)
AUTHORS Ramanan,V.K., Risacher,S.L., Nho,K., Kim,S., Swaminathan,S.,
Shen,L., Foroud,T.M., Hakonarson,H., Huentelman,M.J., Aisen,P.S.,
Petersen,R.C., Green,R.C., Jack,C.R., Koeppe,R.A., Jagust,W.J.,
Weiner,M.W. and Saykin,A.J.
TITLE APOE and BCHE as modulators of cerebral amyloid deposition: a
florbetapir PET genome-wide association study
JOURNAL Mol. Psychiatry (2013) In press
PUBMED 23419831
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 8507)
AUTHORS Ho,C.Y., Bar,E., Giannini,C., Marchionni,L., Karajannis,M.A.,
Zagzag,D., Gutmann,D.H., Eberhart,C.G. and Rodriguez,F.J.
TITLE MicroRNA profiling in pediatric pilocytic astrocytoma reveals
biologically relevant targets, including PBX3, NFIB, and METAP2
JOURNAL Neuro-oncology 15 (1), 69-82 (2013)
PUBMED 23161775
REMARK GeneRIF: Increased expression of NF1B is associated with pilocytic
astrocytoma.
REFERENCE 3 (bases 1 to 8507)
AUTHORS Persson,M., Andren,Y., Moskaluk,C.A., Frierson,H.F. Jr.,
Cooke,S.L., Futreal,P.A., Kling,T., Nelander,S., Nordkvist,A.,
Persson,F. and Stenman,G.
TITLE Clinically significant copy number alterations and complex
rearrangements of MYB and NFIB in head and neck adenoid cystic
carcinoma
JOURNAL Genes Chromosomes Cancer 51 (8), 805-817 (2012)
PUBMED 22505352
REMARK GeneRIF: Explored copy number alterations rearrangements in adenoid
cystic carcinoma. 86% of the tumors expressed MYB-NFIB fusion
transcripts and 97% overexpressed MYB mRNA.
REFERENCE 4 (bases 1 to 8507)
AUTHORS Choi,J., Ababon,M.R., Matteson,P.G. and Millonig,J.H.
TITLE Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2
autism spectrum disorder-associated haplotype function
JOURNAL Hum. Mol. Genet. 21 (7), 1566-1580 (2012)
PUBMED 22180456
REMARK GeneRIF: The data demonstrates that the autism spectrum
disorder-associated A-C intronic haplotype of the ENGRAILED2 gene
is a transcriptional activator, and both CUX1 and NFIB mediate this
activity.
REFERENCE 5 (bases 1 to 8507)
AUTHORS Mitani,Y., Rao,P.H., Futreal,P.A., Roberts,D.B., Stephens,P.J.,
Zhao,Y.J., Zhang,L., Mitani,M., Weber,R.S., Lippman,S.M., Caulin,C.
and El-Naggar,A.K.
TITLE Novel chromosomal rearrangements and break points at the t(6;9) in
salivary adenoid cystic carcinoma: association with MYB-NFIB
chimeric fusion, MYB expression, and clinical outcome
JOURNAL Clin. Cancer Res. 17 (22), 7003-7014 (2011)
PUBMED 21976542
REMARK GeneRIF: study concludes conclude that: t(6;9) results in complex
genetic and molecular alterations in adenoid cystic carcinoma
(ACC); MYB-NFIB gene fusion may not always be associated with
chimeric transcript formation; noncanonical MYB-NFIB gene fusions
occur in a subset of tumors; high MYB expression correlates with
worse patient survival
REFERENCE 6 (bases 1 to 8507)
AUTHORS Mukhopadhyay,S.S. and Rosen,J.M.
TITLE The C-terminal domain of the nuclear factor I-B2 isoform is
glycosylated and transactivates the WAP gene in the JEG-3 cells
JOURNAL Biochem. Biophys. Res. Commun. 358 (3), 770-776 (2007)
PUBMED 17511965
REMARK GeneRIF: C-terminal domain of the nuclear factor I-B2 isoform is
glycosylated and transactivates the WAP gene in tumor cells
REFERENCE 7 (bases 1 to 8507)
AUTHORS Sheeter,D., Du,P., Rought,S., Richman,D. and Corbeil,J.
TITLE Surface CD4 expression modulated by a cellular factor induced by
HIV type 1 infection
JOURNAL AIDS Res. Hum. Retroviruses 19 (2), 117-123 (2003)
PUBMED 12639247
REMARK GeneRIF: expression of NFI-B2 impairs CD4 transcription on
CDd4-positive primary T-lymphocytes and cell lines in HIV-1
infection
REFERENCE 8 (bases 1 to 8507)
AUTHORS Geurts,J.M., Schoenmakers,E.F., Roijer,E., Astrom,A.K., Stenman,G.
and van de Ven,W.J.
TITLE Identification of NFIB as recurrent translocation partner gene of
HMGIC in pleomorphic adenomas
JOURNAL Oncogene 16 (7), 865-872 (1998)
PUBMED 9484777
REFERENCE 9 (bases 1 to 8507)
AUTHORS Liu,Y., Bernard,H.U. and Apt,D.
TITLE NFI-B3, a novel transcriptional repressor of the nuclear factor I
family, is generated by alternative RNA processing
JOURNAL J. Biol. Chem. 272 (16), 10739-10745 (1997)
PUBMED 9099724
REFERENCE 10 (bases 1 to 8507)
AUTHORS Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
TITLE Chromosomal localization of the four genes (NFIA, B, C, and X) for
the human transcription factor nuclear factor I by FISH
JOURNAL Genomics 28 (1), 66-73 (1995)
PUBMED 7590749
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL136366.24, BX648845.1, AL441963.7 and AI140312.1.
Transcript Variant: This variant (1) represents the longest
transcript and it encodes the longest protein (isoform 1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX648845.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-565 AL136366.24 90547-91111 c
566-1097 AL136366.24 84054-84585 c
1098-1341 BX648845.1 1098-1341
1342-1460 AL441963.7 83224-83342 c
1461-2002 BX648845.1 1461-2002
2003-8004 AL441963.7 18860-24861 c
8005-8507 AI140312.1 3-505 c
FEATURES Location/Qualifiers
source 1..8507
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p24.1"
gene 1..8507
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/note="nuclear factor I/B"
/db_xref="GeneID:4781"
/db_xref="HGNC:7785"
/db_xref="MIM:600728"
exon 1..565
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
misc_feature 524..526
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/note="upstream in-frame stop codon"
CDS 536..2020
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/note="isoform 1 is encoded by transcript variant 1;
nuclear factor 1 B-type; nuclear factor 1/B; TGGCA-binding
protein; CCAAT-box-binding transcription factor"
/codon_start=1
/product="nuclear factor 1 B-type isoform 1"
/protein_id="NP_001177666.1"
/db_xref="GI:299758476"
/db_xref="CCDS:CCDS55291.1"
/db_xref="GeneID:4781"
/db_xref="HGNC:7785"
/db_xref="MIM:600728"
/translation="
MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASGTSQANRYVGLSPRDPSFLHQQQSWYLG
"
misc_feature 539..541
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine; propagated from
UniProtKB/Swiss-Prot (O00712.2); acetylation site"
misc_feature 545..676
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/note="Nuclear factor I protein pre-N-terminus; Region:
NfI_DNAbd_pre-N; pfam10524"
/db_xref="CDD:151076"
misc_feature 740..1054
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/note="N-terminal Mad Homology 1 (MH1) domain; Region:
MH1; cl00055"
/db_xref="CDD:206806"
misc_feature 1160..2017
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/note="CTF/NF-I family transcription modulation region;
Region: CTF_NFI; pfam00859"
/db_xref="CDD:144451"
misc_feature 1325..1327
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O00712.2); phosphorylation site"
misc_feature 1469..1471
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O00712.2); phosphorylation site"
misc_feature 1517..1519
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O00712.2); phosphorylation site"
misc_feature 1532..1534
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O00712.2); phosphorylation site"
exon 566..1097
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
variation 954
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/replace="c"
/replace="g"
/db_xref="dbSNP:11543132"
exon 1098..1151
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
exon 1152..1220
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
exon 1221..1341
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
STS 1316..2276
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="Nfib"
/db_xref="UniSTS:527449"
exon 1342..1460
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
exon 1461..1595
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
exon 1596..1780
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
exon 1781..1919
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
exon 1920..2002
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
exon 2003..8486
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/inference="alignment:Splign:1.39.8"
STS 2015..2243
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="RH80854"
/db_xref="UniSTS:89539"
STS 2095..2594
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="MARC_17865-17866:1025013775:1"
/db_xref="UniSTS:268427"
variation 2511
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1804815"
variation 2559
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/replace="a"
/replace="g"
/db_xref="dbSNP:7858"
STS 3285..3486
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="EST12E1"
/db_xref="UniSTS:263076"
variation 3535
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/replace="a"
/replace="c"
/db_xref="dbSNP:199841856"
variation 4745
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/replace="c"
/replace="t"
/db_xref="dbSNP:484555"
STS 5371..5449
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="D8S1564E"
/db_xref="UniSTS:153761"
STS 5396..5551
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="RH78074"
/db_xref="UniSTS:14692"
STS 5554..5811
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="A004O32"
/db_xref="UniSTS:83500"
STS 6362..6546
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="A006V16"
/db_xref="UniSTS:41122"
variation 7120
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/replace="a"
/replace="g"
/db_xref="dbSNP:506115"
STS 7150..7335
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="D9S1065E"
/db_xref="UniSTS:151282"
STS 7524..7650
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="WI-14235"
/db_xref="UniSTS:80885"
variation 8320
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/replace="a"
/replace="c"
/db_xref="dbSNP:1059606"
STS 8340..8465
/gene="NFIB"
/gene_synonym="CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B;
NFI-RED; NFIB2; NFIB3"
/standard_name="D9S2012"
/db_xref="UniSTS:82852"
ORIGIN
gggctgtaaccttgaactttcccagcgcggtgacacattctccccgctctccctcccgcccgcccgctcgccctcctgcgccctcccgcgcccccctccccgccttttttgaaaaagcattttaccaccaaccaccaccccaatccaacccacaccgaaccttcgcgcaccccctacaccccaacaacaacaacaactgcaaaatagaaaacaaatccccaaacccaggcgaaaagcagccaacaccggcggcggcggcggcctcggcaagcacggccagcgcgctcggactgcaagagggttaaaagtgtagattggatttcacccctggaaatctagcacgccgagtgaacttgaatctttggctatttaaggaggactgggtttgttgtgaagttgcggtgatccagcgcagagccccgtcctgattgatcgcatcgcggggctcagatgactgtaaaatgaatagatgaaattcttgcttctcgaagattttcttgggcatctcccggaaagtgcgttttaaggcgaagtcatgatgtattctcccatctgtctcactcaggatgaatttcacccattcatcgaggcacttcttccacatgtccgtgcaattgcctatacttggttcaacctgcaggctcgaaaacgcaagtactttaaaaagcatgagaagcgaatgtcaaaggatgaagaaagagcagtcaaagatgagcttctcagtgaaaagcctgaaatcaaacagaagtgggcatccaggctccttgccaaactgcgcaaagatattcgccaggagtatcgagaggactttgtgctcaccgtgactggcaagaagcacccgtgctgtgtcttatccaatcccgaccagaagggtaagattaggagaatcgactgcctgcgacaggcagacaaagtctggcgtctggatctagtcatggtgatcctgttcaaaggcatccccttggaaagtaccgatggagagcggctcatgaaatccccacattgcacaaacccagcactttgtgtccagccacatcatatcacagtatcagttaaggagcttgatttgtttttggcatactacgtgcaggagcaagattctggacaatcaggaagtccaagccacaatgatcctgccaagaatcctccaggttaccttgaggatagttttgtaaaatctggagtcttcaatgtatcagaacttgtaagagtatccagaacgcccataacccagggaactggagtcaacttcccaattggagaaatcccaagccaaccatactatcatgacatgaactcgggggtcaatcttcagaggtctctgtcttctccaccaagcagcaaaagacccaaaactatatccatagatgaaaatatggaaccaagtcctacaggagacttttacccctctccaagttcaccagctgctggaagtcgaacatggcacgaaagagatcaagatatgtcttctccgactactatgaagaagcctgaaaagccattgttcagctctgcatctccacaggattcttccccaagactgagcactttcccccagcaccaccatcccggaatacctggagttgcacacagtgtcatctcaactcgaactccacctccaccttcaccgttgccatttccaacacaagctatccttcctccagccccatcgagctacttttctcatccaacaatcagatatcctccccacctgaatcctcaggatactctgaagaactatgtaccttcttatgacccatccagtccacaaaccagccagcctaacggcagtggtcaagtagtagggaaagtgcctggccatttcactcctgtcttggcaccctctccccatcccagtgcagtgcgacctgtgaccctgagcatgacagatactaaacccatcactacatccactgaagcctacacagcctcaggcacatctcaagccaatcgatatgtgggactaagcccaagagacccatccttcctacatcagcaacagtcctggtacctgggctagcttggttcctttccaagtgtcaaataggacacccatcttaccggccaatgtccaaaattacggtttgaacataattggagaacctttccttcaagcagaaacaagcaactgagggaaaaagaaacacaacaatagtttaagaaattttttttttaaataaaaaaaaaggaaaagaggaagactggacaaaacaacacaaaggcagaaaggaaagaaactgaagaaagaagataatagaccagcaattgcagcacttacaatcactaattcccttaaggttgaaactgtaatgacataaaaagggtcgatgatatttcactgatggtagatcgcagcccctgcaacgtagcctttgttacatgaagtccgctgggaaatagatgttctgtctctatgacaatatattttaactgactttctagatgccttaatatttgcatgataagctagttttattggtttagtattcttgttgtttacgcatggaatcactattcctggttatctcaccaacgaaggctaggaggcggcgtcagaggtgctgggtgacagagccatgagccagccattttataagcactctgatttctaaaagttaaaaaaaatatatgaaatctctgtagcctttagttatcagtacagatttattaaatttcggcccttaacccagccttttccagtgtgtaacccagtttgaaatcttaaaaaaagaaaaaatgaaaaaaaaaggaaaaaaagaaaaaaggaaaaaaacagtttgaacacaaaggctctatggaagaaatgcctctatgtaggtgaagtgttctctctgcatgcaacagtaaaaattaatataatattttccccacaaaagaaacacttaacagaggcaagtgcaatttataaatttatatctaaaggggaatcatgattataagtccttcagcccttggactctaaattgaggggattaaaaagaatttaaaataattttgaacgaatttattttcccctcagtttttgagggcattaaaaaggcattaaatcaagacaaatcatgtgcttgagaaaaataaaattaatgaaaacacagcacttatgttggtttagctgcagcctccttggaggtagaatttatttatttaaaattactggttgcatcaagaacccatagggtgtacaaaaggttctataaaatctgcattatagagacaaagaggcaggcaaatccatgtcacaagggtaaagcttacagtttacaaactgggaacgccagggtgtaggatataaaaacgcactcttgagaaaacaaatgtaatcagggtgctgaaaacttgcatggtgctttcagacattagccttgttcaacaaatttcttgtattgacagatccatagtgtgcatgggcagacacattttgcctctatgtctcttaaaattttaattaaaaatactctttccagtaatcctaatttgcacgaagatataatgtccacattacgtgccttgccttgaaatctaaaaaacaaaaaacaaaaaaaaaaaaacaaaaaaatacaacaaagtgacatcactacacttgttttgctgcatttattatcattttaaatctttaccatttttatgacaaaatattttgtactccagacgaagaaaaatgtgtgacatcatggattttttagacagttatacctttatctcacatttataaagcatatcatggctgtgtatagttgccgcttaaaaattgtaatcgaccagcaatattttcagtattttggtgtttttttctattaacctttcatgtttttcatcttccaattaatatttgggggggaggggtttcaaatttatacgaattatgcaataccaagttttgcctatgtaggtagtgcttttagctgtattggttattataggtaagtacacagatttaaaaaaaaaataatgtatgcttttttgtttgtttgtttgttttaattgaccaaagtgggtactgctatttttgcagtgtgatgaggtccttttgtgtactgagagatggacaggggattttttttaatatacatatatatatattctggggtgggtgggaggatttttaacactttgcagtgtagctgtgaagcagtgcaccctgagatgggcctgggctgcaaagcgactgttctgcctactgtgacaaacttcaacttacacaggttcccctctctaacttcccacctgggttgcaagctgaactcattactggttttcataacaacacaatagtaagaacaagcaaacacaacaaattctcctggaggcagacttggcttaaaaaggcagacttggcttggtgatagtttttcttgaaagttccagatccacagtggagagtgagcctgtctcatatttggcaaaaatatttgttgaaatgtccacataggggatgttggatgtttaacacttttgagagtttaacacatgaatattctttctcctagaaaacacattagacctgttggagggagtctcccgtattccttttctgccacttttcgtccccatttcatttcattaatgataggatatgatttacctgtgacttactacttcaaatggatggcagtgcacttggatttttttttaatatccagaagattgaacagagggttgctattgttgaatgtatttggactgatagattaaaatcaaagttcaatttttaaggaacaaaaaagtaaatcctgttttcattttatctccccttttaaaactgagaaccagagcagaagggaaatatagaattttaagcaattaatcttcctgtggatgaattaaacccattagatgctgatgggatttttttaaggaatggtaccttaactatatatttgatttcgtttcccctgagggctagaggctgaatggaggctggttttattttgcctttccctcaccgcccagtcccattgagtgtattcattactagaaggaaaatctttcagaattggtgacacatggtaggctgtcttaaggagtcccctggcccccttcccctaggccatggcctaataaaataaactgtcaattgttctcacagcatatcatttaataatgaatactttagaacaatgcttatgggctggagaattgtatttgattagcccattcagtttgatagcccaaatgctgaacagcacagcgggatcctagcagtgcaagttcaaaagtaagtccaatcatttctgtgatactcgccctggtagcaaacagatcatctcagccaagctcttcatgtatctttgacctattaggtgaacaaatgaacctcacaggacacacagtattttttaaaggcagactcgctctcttttttgccagtgagcagttctagctaaccaagttacacactgtgggtattcctgcctgcctcttgaatacaaaggcctagttcaagtgttgctttttttatttcaaatcaattttttcttctttcctttttgagataaaactattaaaagtactactatatatataaaatctcaaatcaacttttcggcctcctcctcgtgtaccaggaagtatattctgacgaagggccccacttttgcaggtcttgcacgcccctcccttacccagaactgcagagcttcaggatggcgaaggtcacccaagggcatgagtagggagtggtgtctccaaccatcagttccgtggcactgttcagcctttgtgtgctgccctgccacccaccactcacagtgcctctgaagcgtgttacccctggagtgacgtgagcatttgaggcttgtctaaggaaaaaaataaaaggcagtgaaggagactgtacataaagacatggcaaaaatcttaattatagcaatatagttatcgggtaatgttcgggtgggcagctccattaaaaaatatgtgaatgaatctgtgaagctgcaagtagcgagaagagcgaaaggtcttcttaatgaaccgcctaccttgtagacagtaatttgtacactgtatagttttgttaagaattttttttaaattaaaattcccatgtttgtaaagctaactttttaacaattataatggaactatatgttgtttccatttttaaagtaaacaagaatattccttgtttagagactggacttgagttaaaactctccagtctcttaagttatgtattaaaaagaaaatctgtccatgttaggagttatttcacagattcctgtgcttgaaaagcataggatactaatcctttaaaaaagtgtaaatggagaaaagttatattttatgaaggttattttgttgtatttagtattggaaaagttggtttccagagcatttcagaatgtcgaagcaccactgtctttttattagtatatacggcctttagcaaaagtttttgtgattgttacgtgatggtatttaaggttaagtttcacagagcattcaggataggcagaaaactaaaacagtgctatgtctcacataacgtgtcctcagggagcagaatcttggatttgtgacttgtagcttcataaggactcaacgaaagagattgcacagggacatcttcagcggtgtgacagcaggacatgttctttacctagattcaaattctatgtactgtgtgaaatgatgaaggctgcagaaagttatcccatattcagtgtacagtattcatttttaatgaaacaactctacaatattgctggcagataggccccaagcatgacattcaatatagtttacatgttcctgtcaaggtcttttgttaacattaaccagctgcatgctttctggactttaagaaattgggtttctatagaaaactttttttttttttttttttttaatgtgcaggctattcaagttcaatagtaaaagctcaaaaatgaatgttctactccatgctgaaggagctgaaagctgccttcttcatattttgcactttctggtagttcccctgttttttctaattccctaaaattgtgtgggtggagtggagccctgcagttggggggtaacatggaccactgattttgccctttgaccctgcacaatgacctttgcatcagccaaactcattgccatgacaactctttgtactgtgtccgtgccacagatctgttggtcacattgttaatagtaaaggggacaagttggagacggtcaatttttacattttttgttgcaattttttcttcaatggttgtaagtagtttttttttttttttaataataaaagggttcactagttaatactctagaaatatctgtgtgttgcaattcaaatgtatgttgagattgtgaaaagcgcttcagtgccactagcttaccggtacactagactaagcccttgatgacttattgcatgatacagtaccaggaacaacaggtggcctaaatacatgaaaagcagtgtaagctagtgacactaaagccagtcttgtattactgtatttttgacagaatggttttgaaaactgtgctacagggactgatgtggcaaatatatctctttatgcagaaggaagtctttttttttcttttttttttttttaagaagtatggctttttatgcatccttcatcgagggcattgaagttgcatggactgataaaagttgatgcaaaacaagaaagaaacaaacaaaaaaaaaaaaccagcaaaatgtttaccaaaaaactcaaacaaatgagcagtgcctgttcaatttcacagtctctgttgagttcagttgtaaatatgtttcaaatgacattttcttgggaaaaaaaatctctacaacattgtagaatgtgaggggtaactacatcccaggcataggtttctcaaagctgcagtagattatgtcttcatcaagctgttaatttgtgcttatatcatatagaacttttagcatcctgggaagagctgcccccacctcaatgatatttctctgagaacaacttttgtaggactgtgtgtttctttagatacatttagtacaactgtaggtgacgagtagtcagttattgcttgctagctacacaccagggttgatccattttaaaacttttggcattttgtcctcatgggccataaatacagaaccttgtattttaattaaatttttttacaaaaggaggcacatgcacaatctccatgtaacaaacctttagcagtaggatgtattatacgacagttacttaatttctagagttcaggcctctgggatcaaccccagactgggccagaatgttagtgaaggttttattgtgcccggttggaggataacgttctttgggtactttttgtgggttgcaaatgaactcaattgccacaagttttaaactggtgtaaatcaagcttgacttaatgtgattgttactgttatatccagcctatactgctagcagctgctcatactgcagtcaattactggaagcggatatatttcctatgcaaaaactgtttaaacaataaaatgagctatgctacagactctgaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4781 -> Molecular function: GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] evidence: IDA
GeneID:4781 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
GeneID:4781 -> Molecular function: GO:0001106 [RNA polymerase II transcription corepressor activity] evidence: IDA
GeneID:4781 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
GeneID:4781 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:4781 -> Biological process: GO:0002062 [chondrocyte differentiation] evidence: ISS
GeneID:4781 -> Biological process: GO:0006260 [DNA replication] evidence: IEA
GeneID:4781 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA
GeneID:4781 -> Biological process: GO:0010001 [glial cell differentiation] evidence: ISS
GeneID:4781 -> Biological process: GO:0021740 [principal sensory nucleus of trigeminal nerve development] evidence: ISS
GeneID:4781 -> Biological process: GO:0021960 [anterior commissure morphogenesis] evidence: ISS
GeneID:4781 -> Biological process: GO:0030902 [hindbrain development] evidence: IEA
GeneID:4781 -> Biological process: GO:0043392 [negative regulation of DNA binding] evidence: IDA
GeneID:4781 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:4781 -> Biological process: GO:0060486 [Clara cell differentiation] evidence: ISS
GeneID:4781 -> Biological process: GO:0060509 [Type I pneumocyte differentiation] evidence: ISS
GeneID:4781 -> Biological process: GO:0060510 [Type II pneumocyte differentiation] evidence: ISS
GeneID:4781 -> Biological process: GO:0061141 [lung ciliated cell differentiation] evidence: ISS
GeneID:4781 -> Biological process: GO:0071679 [commissural neuron axon guidance] evidence: ISS
GeneID:4781 -> Biological process: GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development] evidence: ISS
GeneID:4781 -> Biological process: GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis] evidence: ISS
GeneID:4781 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:4781 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:4781 -> Cellular component: GO:0044300 [cerebellar mossy fiber] evidence: ISS
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