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2025-05-09 20:19:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001174095 5797 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens zinc finger E-box binding homeobox 1 (ZEB1), transcript variant 8, mRNA. ACCESSION NM_001174095 VERSION NM_001174095.1 GI:291575189 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5797) AUTHORS Lemma,S., Karihtala,P., Haapasaari,K.M., Jantunen,E., Soini,Y., Bloigu,R., Pasanen,A.K., Turpeenniemi-Hujanen,T. and Kuittinen,O. TITLE Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma JOURNAL Histopathology 62 (2), 326-333 (2013) PUBMED 23190132 REMARK GeneRIF: In diffuse large B-cell lymphoma, cytoplasmic Slug expression was linked to a favourable disease outcome, whereas nuclear expression of ZEB1 indicated an adverse outcome. REFERENCE 2 (bases 1 to 5797) AUTHORS Lechner,J., Dash,D.P., Muszynska,D., Hosseini,M., Segev,F., George,S., Frazer,D.G., Moore,J.E., Kaye,S.B., Young,T., Simpson,D.A., Churchill,A.J., Heon,E. and Willoughby,C.E. TITLE Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation JOURNAL Invest. Ophthalmol. Vis. Sci. 54 (5), 3215-3223 (2013) PUBMED 23599324 REMARK GeneRIF: Missense substitutions in the ZEB1 protein are associated with FECD6 and keratoconus, whereas protein truncating ZEB1 mutations result in PPCD3. Publication Status: Online-Only REFERENCE 3 (bases 1 to 5797) AUTHORS Guo,S., Li,Y., Tong,Q., Gu,F., Zhu,T., Fu,L. and Yang,S. TITLE deltaEF1 down-regulates ER-alpha expression and confers tamoxifen resistance in breast cancer JOURNAL PLoS ONE 7 (12), E52380 (2012) PUBMED 23285017 REMARK GeneRIF: The expression of deltaEF1 is up-regulated by 17beta-estradiol (E2) in MCF-7 cells in an ER-alpha-dependent manner. REFERENCE 4 (bases 1 to 5797) AUTHORS Mehta,J.S., Vithana,E.N., Tan,D.T., Yong,V.H., Yam,G.H., Law,R.W., Chong,W.G., Pang,C.P. and Aung,T. TITLE Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy JOURNAL Invest. Ophthalmol. Vis. Sci. 49 (1), 184-188 (2008) PUBMED 18172091 REMARK GeneRIF: The identification of a novel missense mutation in only one of the patients implied that TCF8 does not play a significant role in the pathogenesis of FECD in this Chinese population. GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 5 (bases 1 to 5797) AUTHORS Manavella,P.A., Roqueiro,G., Darling,D.S. and Cabanillas,A.M. TITLE The ZFHX1A gene is differentially autoregulated by its isoforms JOURNAL Biochem. Biophys. Res. Commun. 360 (3), 621-626 (2007) PUBMED 17610840 REMARK GeneRIF: The Zfhx1a-1 gene is autoregulated in part by negative feedback on its own promoter which is, in turn, modified by the availability of the negative dominant isoform Zfhx1a-2. REFERENCE 6 (bases 1 to 5797) AUTHORS Liskova,P., Tuft,S.J., Gwilliam,R., Ebenezer,N.D., Jirsova,K., Prescott,Q., Martincova,R., Pretorius,M., Sinclair,N., Boase,D.L., Jeffrey,M.J., Deloukas,P., Hardcastle,A.J., Filipec,M. and Bhattacharya,S.S. TITLE Novel mutations in the ZEB1 gene identified in Czech and British patients with posterior polymorphous corneal dystrophy JOURNAL Hum. Mutat. 28 (6), 638 (2007) PUBMED 17437275 REMARK GeneRIF: Four novel pathogenic mutations were identified in four families; two deletions, one nonsense, and one duplication within exon 7 in the ZEB1 gene at 10p11.2. Czech patients were genotyped for a founder haplotype and lack of 20p11.2 locus segregation. REFERENCE 7 (bases 1 to 5797) AUTHORS Franklin,A.J., Jetton,T.L., Shelton,K.D. and Magnuson,M.A. TITLE BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription JOURNAL Mol. Cell. Biol. 14 (10), 6773-6788 (1994) PUBMED 7935395 REFERENCE 8 (bases 1 to 5797) AUTHORS Watanabe,Y., Kawakami,K., Hirayama,Y. and Nagano,K. TITLE Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene JOURNAL J. Biochem. 114 (6), 849-855 (1993) PUBMED 8138542 REFERENCE 9 (bases 1 to 5797) AUTHORS Williams,T.M., Montoya,G., Wu,Y., Eddy,R.L., Byers,M.G. and Shows,T.B. TITLE The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2 JOURNAL Genomics 14 (1), 194-196 (1992) PUBMED 1427828 REFERENCE 10 (bases 1 to 5797) AUTHORS Williams,T.M., Moolten,D., Burlein,J., Romano,J., Bhaerman,R., Godillot,A., Mellon,M., Rauscher,F.J. III and Kant,J.A. TITLE Identification of a zinc finger protein that inhibits IL-2 gene expression JOURNAL Science 254 (5039), 1791-1794 (1991) PUBMED 1840704 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB442432.1, DC299346.1, AK300830.1, U12170.1, AK314683.1, AL831979.1, AI086650.1, BX111519.1 and BQ003893.1. Summary: This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]. Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks an in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (e) is shorter and has a distinct N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300830.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-24 DB442432.1 1-24 25-50 DC299346.1 1-26 51-392 AK300830.1 1-342 393-1119 U12170.1 555-1281 1120-1823 AK314683.1 1282-1985 1824-3426 U12170.1 1986-3588 3427-4912 AL831979.1 3886-5371 4913-5078 AI086650.1 103-268 c 5079-5212 BX111519.1 1-134 5213-5797 BQ003893.1 8-592 c FEATURES Location/Qualifiers source 1..5797 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10p11.2" gene 1..5797 /gene="ZEB1" /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A" /note="zinc finger E-box binding homeobox 1" /db_xref="GeneID:6935" /db_xref="HGNC:11642" /db_xref="MIM:189909" exon 1..121 /gene="ZEB1" /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A" /inference="alignment:Splign:1.39.8" misc_feature 31..33 /gene="ZEB1" /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A" /note="upstream in-frame stop codon" variation 36 /gene="ZEB1" /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A" /replace="c" /replace="g" /db_xref="dbSNP:367615307" CDS 64..3237 /gene="ZEB1" /gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A" /note="isoform e is encoded by transcript variant 8; zinc finger homeodomain enhancer-binding protein; posterior polymorphous corneal dystrophy 3; transcription factor 8 (represses interleukin 2 expression); delta-crystallin enhancer binding factor 1; negative regulator of IL2" /codon_start=1 /product="zinc finger E-box-binding homeobox 1 isoform e" /protein_id="NP_001167566.1" /db_xref="GI:291575190" /db_xref="CCDS:CCDS53507.1" /db_xref="GeneID:6935" /db_xref="HGNC:11642" /db_xref="MIM:189909" /translation="
MADGPRCKRRKQANPRRNNGKEGQEILGPEAQADEAGCTVKDDECESDAENEQNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA
"
misc_feature 460..528
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
/db_xref="CDD:210117"
misc_feature 580..648
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/note="zinc finger; Region: ZnF_C2H2; smart00355"
/db_xref="CDD:197676"
misc_feature 622..693
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1639..1764
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(1675..1677,1693..1695,1732..1734,1738..1743,
1750..1755,1759..1764)
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(1741..1743,1750..1755,1762..1764)
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 2614..2691
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 2698..2775
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
exon 122..181
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/inference="alignment:Splign:1.39.8"
variation 130
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:12217419"
variation 153
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:11559173"
variation 176
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:367732931"
exon 182..343
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/inference="alignment:Splign:1.39.8"
variation 199
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:369476602"
variation 255
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:189111678"
variation 313
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:202218576"
variation 326
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:369587040"
exon 344..546
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/inference="alignment:Splign:1.39.8"
variation 351
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:142133469"
variation 453
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:150051354"
variation 465
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:79134358"
variation 472
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:201419824"
exon 547..652
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/inference="alignment:Splign:1.39.8"
variation 557
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:370082712"
variation 558
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:149166539"
variation 651
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:143232269"
exon 653..2463
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/inference="alignment:Splign:1.39.8"
variation 738
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:374468151"
variation 743
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:370663355"
variation 804
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:373826858"
variation 820
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:371970352"
variation 828
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:199664973"
variation 913
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:367672138"
variation 920
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:148310638"
variation 943
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:192544989"
variation 984
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:113838847"
variation 1009
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:142232415"
variation 1065
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:145398072"
variation 1066
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:371431986"
variation 1075
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:146384341"
variation 1103
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:138491446"
variation 1111
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:145576217"
variation 1119
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:35238902"
variation 1121
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:75910137"
variation 1126
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:201283071"
variation 1175
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:148867206"
variation 1189
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:150669496"
variation 1283
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:199595565"
variation 1300
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:374398055"
variation 1357
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:139511659"
variation 1388
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:149705490"
variation 1389
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:144430294"
variation 1431
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="a"
/db_xref="dbSNP:35708848"
variation 1468
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:368461324"
variation 1520
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:35753967"
variation 1547
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:140611114"
variation 1563
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:372068000"
variation 1566
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:184880161"
variation 1606
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:143542961"
variation 1614
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:367749817"
variation 1635
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:371536001"
variation 1637
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:375798509"
variation 1656
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:369994958"
variation 1706
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:373879318"
variation 1737
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:142143222"
variation 1761
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201912416"
variation 1765
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:151017318"
variation 1808
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:370211218"
variation 1836
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:151205909"
variation 1839
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:140987489"
variation 1841
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:150228807"
variation 1853
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:141110915"
variation 1896
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:146821579"
variation 1923
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:34846414"
variation 1932
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:35501784"
variation 1941
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:75229306"
variation 2016
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:34111864"
variation 2046
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:200572671"
variation 2057
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:372597335"
variation 2065
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:138456617"
variation 2101
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:117534296"
variation 2113
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:138507868"
variation 2143
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:200667415"
variation 2153
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:376963555"
variation 2178
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:143340752"
variation 2180
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:201927623"
variation 2259..2260
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="c"
/db_xref="dbSNP:35905383"
variation 2269
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:148358382"
variation 2273
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:1577181"
variation 2278
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:141194628"
variation 2291
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:199944415"
variation 2304
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:200125768"
variation 2346
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:201567879"
variation 2381
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:118020901"
variation 2418
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:367685869"
variation 2422
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:139581793"
variation 2450
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:202145455"
exon 2464..2644
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/inference="alignment:Splign:1.39.8"
variation 2479
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:369581136"
variation 2530
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:143370284"
variation 2534
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:369330183"
variation 2552
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:35653460"
variation 2565
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:147142042"
variation 2569
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:184220160"
variation 2576
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:78449005"
exon 2645..5787
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/inference="alignment:Splign:1.39.8"
variation 2656
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:370801976"
variation 2714
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:374536300"
variation 2749
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:149757409"
variation 2760
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:145553237"
variation 2832
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:376922710"
variation 2845
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:371696203"
variation 2893
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:148446855"
variation 2907
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:200948247"
variation 2915
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:200238558"
variation 2923
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:142629102"
variation 2928
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:146803682"
variation 2952
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:140617391"
variation 2954
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:145633572"
variation 3033
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:146561222"
variation 3052..3054
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="gaa"
/db_xref="dbSNP:375988551"
variation 3054..3056
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="aga"
/db_xref="dbSNP:370699695"
variation 3055..3057
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="gag"
/db_xref="dbSNP:369270839"
variation 3089
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:375270538"
variation 3091
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:146672684"
variation 3103
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:140217290"
variation 3119
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:201845244"
variation 3149
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:141086946"
variation 3162
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:34256798"
variation 3170
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:150279725"
variation 3175
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:138952579"
variation 3193
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:143438972"
variation 3250
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:188563673"
variation 3283
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:113977142"
variation 3287
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:374867798"
STS 3295..3445
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/standard_name="D10S1781"
/db_xref="UniSTS:34015"
variation 3306
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:78595841"
STS 3315..3531
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/standard_name="SHGC-31480"
/db_xref="UniSTS:26889"
variation 3385..3386
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="ac"
/db_xref="dbSNP:143911186"
variation 3386..3387
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="ac"
/db_xref="dbSNP:72221464"
variation 3411..3416
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="cacaca"
/db_xref="dbSNP:36207630"
variation 3413..3418
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="cacaca"
/db_xref="dbSNP:5784248"
variation 3414..3417
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="acac"
/db_xref="dbSNP:10610992"
variation 3416..3421
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="acacac"
/db_xref="dbSNP:3086583"
variation 3423..3426
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="caca"
/db_xref="dbSNP:60354357"
variation 3426..3427
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="tg"
/db_xref="dbSNP:71027030"
variation 3503
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:372557668"
variation 3580
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:148015830"
variation 3591
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:372771766"
variation 3623
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:141676377"
variation 3641
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:10490929"
variation 3920..3923
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="actc"
/db_xref="dbSNP:376070628"
variation 4079
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:150246922"
variation 4131..4138
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="gtattttc"
/db_xref="dbSNP:368007808"
variation 4193
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:193087933"
variation 4218
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:139194135"
variation 4546
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:185686910"
variation 4611..4612
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="tg"
/db_xref="dbSNP:149726475"
variation 4794
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="t"
/db_xref="dbSNP:118189529"
variation 4868
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:2839667"
variation 4874
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:191505587"
variation 4950
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:7349"
variation 5018
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:183651581"
variation 5022
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="c"
/db_xref="dbSNP:188702835"
variation 5203
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:77992406"
variation 5255
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:75678706"
variation 5297..5298
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace=""
/replace="t"
/db_xref="dbSNP:201215623"
variation 5376
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="g"
/replace="t"
/db_xref="dbSNP:143336093"
variation 5406
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:75717753"
variation 5450
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:147527127"
variation 5452
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:200534090"
variation 5570
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:181434712"
variation 5608
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="t"
/db_xref="dbSNP:220071"
variation 5652
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="a"
/replace="g"
/db_xref="dbSNP:184147533"
variation 5657
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
/replace="c"
/replace="g"
/db_xref="dbSNP:190131604"
polyA_signal 5756..5761
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
polyA_site 5787
/gene="ZEB1"
/gene_synonym="AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3;
TCF8; ZFHEP; ZFHX1A"
ORIGIN
gggggggaagggggagggagggggaggaggtgactcgagcatttagacacaagcgagaggatcatggcggatggccccaggtgtaagcgcagaaagcaggcgaacccgcggcgcaataacggaaaggaagggcaagaaatcctggggcctgaagctcaggcagatgaagcaggatgtacagtaaaagatgatgaatgcgagtcagatgcagaaaatgagcaaaaccatgatcctaatgttgaagagtttctacaacaacaagacactgctgtcatttttcctgaggcacctgaagaggaccagaggcagggcacaccagaagccagtggtcatgatgaaaatggaacaccagatgcattttcacaattactcacctgtccatattgtgatagaggctataaacgctttacctctctgaaagaacacattaaatatcgtcatgaaaagaatgaagataactttagttgctccctgtgcagttacacctttgcatacagaacccaacttgaacgtcacatgacatcacataaatcaggaagagatcaaagacatgtgacgcagtctgggtgtaatcgtaaattcaaatgcactgagtgtggaaaagctttcaaatacaaacatcacctaaaagagcacttaagaattcacagtggagagaagccatatgaatgcccaaactgcaagaaacgcttttcccattctggctcctatagctcacacataagcagtaagaaatgtatcagcttgatacctgtgaatgggcgaccaagaacaggactcaagacatctcagtgttcttcaccgtctctttcagcatcaccaggcagtcccacacgaccacagatacggcaaaagatagagaataaaccccttcaagaacaactttctgttaaccaaattaaaactgaacctgtggattatgaattcaaacccatagtggttgcttcaggaatcaactgttcaacccctttacaaaatggggttttcactggtggtggcccattacaggcaaccagttctcctcagggcatggtgcaagctgttgttctgccaacagttggtttggtgtctcccataagtatcaatttaagtgatattcagaatgtacttaaagtggcggtagatggtaatgtaataaggcaagtgttggagaataatcaagccaatcttgcatccaaagaacaagaaacaatcaatgcttcacccatacaacaaggtggccattctgttatttcagccatcagtcttcctttggttgatcaagatggaacaaccaaaattatcatcaactacagtcttgagcagcctagccaacttcaagttgttcctcaaaatttaaaaaaagaaaatccagtcgctacaaacagttgtaaaagtgaaaagttaccagaagatcttactgttaagtctgagaaggacaaaagctttgaagggggggtgaatgatagcacttgtcttctgtgtgatgattgtccaggagatattaatgcacttccagaattaaagcactatgacctaaagcagcctactcagcctcctccactccctgcagcagaagctgagaagcctgagtcctctgtttcatcagctactggagatggcaatttgtctcctagtcagccacctttaaagaacctcttgtctctcctaaaagcatattatgctttgaatgcacaaccaagtgcagaagagctctcaaaaattgctgattcagtaaacctaccactggatgtagtaaaaaagtggtttgaaaagatgcaagctggacagatttcagtgcagtcttctgaaccatcttctcctgaaccaggcaaagtaaatatccctgccaagaacaatgatcagcctcaatctgcaaatgcaaatgaaccccaggacagcacagtaaatctacaaagtcctttgaagatgactaactccccagttttaccagtgggatcaaccaccaatggttccagaagtagtacaccatccccatcacctctaaacctttcctcatccagaaatacacagggttacttgtacacagctgagggtgcacaagaagagccacaagtagaacctcttgatctttcactaccaaagcaacagggagaattattagaaaggtcaactatcactagtgtttaccagaacagtgtttattctgtccaggaagaacccttgaacttgtcttgcgcaaaaaaggagccacaaaaggacagttgtgttacagactcagaaccagttgtaaatgtaatcccaccaagtgccaaccccataaatatcgctatacctacagtcactgcccagttacccacaatcgtggccattgctgaccagaacagtgttccatgcttaagagcgctagctgccaataagcaaacgattctgattccccaggtggcatacacctactcaactacggtcagccctgcagtccaagaaccacccttgaaagtgatccagccaaatggaaatcaggatgaaagacaagatactagctcagaaggagtatcaaatgtagaggatcagaatgactctgattctacaccgcccaaaaagaaaatgcggaagacagaaaatggaatgtatgcttgtgatttgtgtgacaagatattccaaaagagtagttcattattgagacataaatatgaacacacaggtaaaagacctcatgagtgtggaatctgtaaaaaggcatttaaacacaaacatcatttgattgaacacatgcgattacattctggagaaaagccctatcaatgtgacaaatgtggaaagcgcttctcacactctgggtcttattctcaacacatgaatcatcgctactcctactgtaagagagaagcggaagaacgtgacagcacagagcaggaagaggcagggcctgaaatcctctcgaatgagcacgtgggtgccagggcgtctccctcacagggcgactcggacgagagagagagtttgacaagggaagaggatgaagacagtgaaaaagaggaagaggaggaggataaagagatggaagaattgcaggaagaaaaagaatgtgaaaaaccacaaggggatgaggaagaggaggaggaggaggaagaagtggaagaagaagaggtagaagaggcagagaatgagggagaagaagcaaaaactgaaggtctgatgaaggatgacagggctgaaagtcaagcaagcagcttaggacaaaaagtaggcgagagtagtgagcaagtgtctgaagaaaagacaaatgaagcctaatcgtttttctagaaggaaaataaattctaattgataatgaatttcgttcaatattatccttgcttttcatggaaacacagtaacctgtatgctgtgattcctgttcactactgtgtaaagtaaaaactaaaaaaatacaaaatacaaaacacacacacacacacacacacacacacacacacacacacaaaataaatccgggtgtgcctgaacctcagacctagtaatttttcatgcagttttcaaagttaggaacaagtttgtaacatgcagcagattagaaaaccttaatgactcagagagcaacaatacaagaggttaaaggaagctgattaattagatatgcatctggcattgttttatcttatcagtattatcactcttatgttggtttattcttaagctgtacaattgggagaaattttataattttttattggtaaacatatgctaaatccgcttcagtattttattatgttttttaaaatgtgagaacttctgcactacaaaattcccttcacagagaagtataatgtagttccaacccgtgctaactaccttttataaattcagtctagaaggtagtaatttctaatatttagatgtcttagtagagcgtattatcatttaaagtgtattgttagccttaagaaagcagctgatagaagaactgaagtttcttactcacgtggtttaaaatggagttcaaaagattgccattgagttctgattgcagggactaacaatgttaatctgataaggacagcaaaatcatcagaatcagtgtttgtgattgtgtttgaatatgtggtaacatatgaaggatatgacatgaagctttgtatctcctttggccttaagcaagacctgtgtgctgtaagtgccatttctcagtattttcaaggctctaacccgccttcatccaatgtgtggcctacaataactagcatttgttgatttgtctcttgtatcaaaattcccaaataaaacttaaaaccactgactctgtcagagaaactgaaacactgggacatttcatccttcaattcctcggtattgattttatgttgattgattttcagaatttctctacagaaacgaaagggaaattttctaatctgctttatccatgtacttgcatttcagacatggacatgctattgttatttggctcataactgtttccaaatgttagttattatggacccaatttattaacaacattagctgatttttacctatcagtattattttatttcttttagtttatagatctgtgcaacatttttgtactgtatgtcttcaaacctggcagtattaatacccttcttactgacatatgtacttttagttttagaaaacttttatatttatgtgtcttatttttatatttctttatttattacacagtgtagtgtataatactgtagtttgtattaatacaataatatattttagtatgaaaatttggaaagttgataagatttaaagtagagatgcaattggttctcctgcattgagatttgatttaacagtgttatgttaacatttatacttgccttggactgtagaacagaacttaaatgggaatgtattagttttacaactacaatcaagtcattttacctttacccagtttttaatataaaacttaaattttgaaattcactgtgtgactaatagcatgatgctctgcagttttattaagaaatcagcctaaccatacaactctcatttccttagtaagccaaattaggattaacttctataaacagtgttgggaacaatgtttaacattttgtgccaatttgttcctgtattcatgtatgtaagttacagatctgactcttcatttttaagttccttgttacatcatggtcattttctagttttttaccagactcccatctcacaataaaatgcatcaacaagcctgaactgctgtcattcttttcatcattatcagtattttctttggaaaactgtgaaatggggtacattgtcatcctgcatttgattcatcttgagctgaatttgggtaacactaaatgttttagacattctccactaaattatggattttcttgtggctaaatgtttctggagaggtcagagttgacaaaacctcttcacaggttgctccttcttcctgaaatccttaatcctccgcatttcatgcttcaggtcatttcagggaagcctgggtttagatgcctttctgactctcagctcctgcacttctgtcatcatacctctgatactattatttatattccttccccactaggaacaggaaccacatttgtcatagtcactctcacattcctcactgcctaacagggtgcctggcataagttgggacaacagatatttgttgaataaaaatataatttgcatgtttatggagctcagctatgttctcactttttttgcttctaattccagaatatatgttaaatgatctaataatttgattattttcttataagtcttattaaacactagtcataatagacacaataaattatgccttctttttctattgccttaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6935 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:6935 -> Molecular function: GO:0003690 [double-stranded DNA binding] evidence: IEA
GeneID:6935 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:6935 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: TAS
GeneID:6935 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS
GeneID:6935 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6935 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IEA
GeneID:6935 -> Molecular function: GO:0008270 [zinc ion binding] evidence: TAS
GeneID:6935 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:6935 -> Molecular function: GO:0070888 [E-box binding] evidence: ISS
GeneID:6935 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:6935 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:6935 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:6935 -> Biological process: GO:0006955 [immune response] evidence: TAS
GeneID:6935 -> Biological process: GO:0007389 [pattern specification process] evidence: IEA
GeneID:6935 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
GeneID:6935 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IEA
GeneID:6935 -> Biological process: GO:0010464 [regulation of mesenchymal cell proliferation] evidence: IEA
GeneID:6935 -> Biological process: GO:0014823 [response to activity] evidence: IEA
GeneID:6935 -> Biological process: GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] evidence: IEA
GeneID:6935 -> Biological process: GO:0030857 [negative regulation of epithelial cell differentiation] evidence: IEA
GeneID:6935 -> Biological process: GO:0030900 [forebrain development] evidence: IEA
GeneID:6935 -> Biological process: GO:0031667 [response to nutrient levels] evidence: IEA
GeneID:6935 -> Biological process: GO:0033081 [regulation of T cell differentiation in thymus] evidence: IEA
GeneID:6935 -> Biological process: GO:0045666 [positive regulation of neuron differentiation] evidence: ISS
GeneID:6935 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:6935 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IMP
GeneID:6935 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:6935 -> Biological process: GO:0048596 [embryonic camera-type eye morphogenesis] evidence: IEA
GeneID:6935 -> Biological process: GO:0048704 [embryonic skeletal system morphogenesis] evidence: IEA
GeneID:6935 -> Biological process: GO:0048752 [semicircular canal morphogenesis] evidence: IEA
GeneID:6935 -> Biological process: GO:0051150 [regulation of smooth muscle cell differentiation] evidence: IEA
GeneID:6935 -> Biological process: GO:0051216 [cartilage development] evidence: IEA
GeneID:6935 -> Biological process: GO:0071230 [cellular response to amino acid stimulus] evidence: IEA
GeneID:6935 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IEA
GeneID:6935 -> Biological process: GO:0090103 [cochlea morphogenesis] evidence: IEA
GeneID:6935 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6935 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:6935 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:6935 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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