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2025-05-09 20:26:35, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001171653 9171 bp mRNA linear PRI 16-JUN-2013 DEFINITION Homo sapiens zinc finger E-box binding homeobox 2 (ZEB2), transcript variant 2, mRNA. ACCESSION NM_001171653 VERSION NM_001171653.1 GI:284413745 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 9171) AUTHORS Cai,J., Schleidt,S., Pelta-Heller,J., Hutchings,D., Cannarsa,G. and Iacovitti,L. TITLE BMP and TGF-beta pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells JOURNAL Dev. Biol. 376 (1), 62-73 (2013) PUBMED 23352789 REMARK GeneRIF: The up-regulation in SMAD-interacting protein 1 (SIP1) results in greater repression of the Wnt antagonist, secreted frizzled related protein 1 (Sfrp1) in stem cells. REFERENCE 2 (bases 1 to 9171) AUTHORS Koopmansch,B., Berx,G., Foidart,J.M., Gilles,C. and Winkler,R. TITLE Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression JOURNAL Biochem. Biophys. Res. Commun. 431 (4), 652-657 (2013) PUBMED 23376074 REMARK GeneRIF: these results suggest that E-cadherin expression in cancer cells is controlled by a balance between ZEB2 and KLF4 expression levels. REFERENCE 3 (bases 1 to 9171) AUTHORS McKinsey,G.L., Lindtner,S., Trzcinski,B., Visel,A., Pennacchio,L.A., Huylebroeck,D., Higashi,Y. and Rubenstein,J.L. TITLE Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons JOURNAL Neuron 77 (1), 83-98 (2013) PUBMED 23312518 REMARK GeneRIF: Zfhx1b zinc finger homeobox gene is required to generate cortical interneurons in the medial ganglionic eminence. REFERENCE 4 (bases 1 to 9171) AUTHORS Usova,E.V., Kopantseva,M.R., Kostina,M.B., Van'kovich,A.N., Egorov,V.I. and Kopantsev,E.P. TITLE Expression of the ZEB2 gene in pancreatic stromal cells in pancreatic ductal adenocarcinoma, pancreatitis, and normal state JOURNAL Dokl. Biol. Sci. 448, 61-64 (2013) PUBMED 23479023 REMARK GeneRIF: Expression of the ZEB2 gene in pancreatic stromal cells in pancreatic ductal adenocarcinoma, pancreatitis, and normal state. REFERENCE 5 (bases 1 to 9171) AUTHORS Meral,C., Malbora,B., Celikel,F., Aydemir,G., Suleymanoglu,S., Zollino,M. and Derbent,M. TITLE A case of Mowat-Wilson syndrome caused by a truncating mutation within exon 8 of the ZEB2 gene JOURNAL Turk. J. Pediatr. 54 (5), 523-527 (2012) PUBMED 23427518 REMARK GeneRIF: The investigation identified a heterozygous complex rearrangement in exon 8 of ZEB2, specifically a 48-nucleotide deletion and a 44-nucleotide insertion that caused a frameshift. REFERENCE 6 (bases 1 to 9171) AUTHORS Cacheux,V., Dastot-Le Moal,F., Kaariainen,H., Bondurand,N., Rintala,R., Boissier,B., Wilson,M., Mowat,D. and Goossens,M. TITLE Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease JOURNAL Hum. Mol. Genet. 10 (14), 1503-1510 (2001) PUBMED 11448942 REFERENCE 7 (bases 1 to 9171) AUTHORS Comijn,J., Berx,G., Vermassen,P., Verschueren,K., van Grunsven,L., Bruyneel,E., Mareel,M., Huylebroeck,D. and van Roy,F. TITLE The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion JOURNAL Mol. Cell 7 (6), 1267-1278 (2001) PUBMED 11430829 REMARK GeneRIF: Conditional expression of SIP1 in E-cadherin-positive cells abrogates E-cadherin-mediated intercellular adhesion and induces invasion. SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors. REFERENCE 8 (bases 1 to 9171) AUTHORS Wakamatsu,N., Yamada,Y., Yamada,K., Ono,T., Nomura,N., Taniguchi,H., Kitoh,H., Mutoh,N., Yamanaka,T., Mushiake,K., Kato,K., Sonta,S. and Nagaya,M. TITLE Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease JOURNAL Nat. Genet. 27 (4), 369-370 (2001) PUBMED 11279515 REFERENCE 9 (bases 1 to 9171) AUTHORS Verschueren,K., Remacle,J.E., Collart,C., Kraft,H., Baker,B.S., Tylzanowski,P., Nelles,L., Wuytens,G., Su,M.T., Bodmer,R., Smith,J.C. and Huylebroeck,D. TITLE SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes JOURNAL J. Biol. Chem. 274 (29), 20489-20498 (1999) PUBMED 10400677 REFERENCE 10 (bases 1 to 9171) AUTHORS Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M. TITLE Selection system for genes encoding nuclear-targeted proteins JOURNAL Nat. Biotechnol. 16 (13), 1338-1342 (1998) PUBMED 9853615 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP218652.1, DA305985.1, AK294928.1, AB056507.1, AC010130.12 and AI341193.1. Summary: The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]. Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294928.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025098 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-62 BP218652.1 1-62 63-631 DA305985.1 21-589 632-2699 AK294928.1 360-2427 2700-5528 AB056507.1 2729-5557 5529-8685 AC010130.12 81024-84180 c 8686-9171 AI341193.1 1-486 c FEATURES Location/Qualifiers source 1..9171 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q22.3" gene 1..9171 /gene="ZEB2" /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B" /note="zinc finger E-box binding homeobox 2" /db_xref="GeneID:9839" /db_xref="HGNC:14881" /db_xref="MIM:605802" exon 1..453 /gene="ZEB2" /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B" /inference="alignment:Splign:1.39.8" variation 35 /gene="ZEB2" /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B" /replace="c" /replace="t" /db_xref="dbSNP:146048066" misc_feature 208..210 /gene="ZEB2" /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B" /note="upstream in-frame stop codon" exon 454..595 /gene="ZEB2" /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B" /inference="alignment:Splign:1.39.8" CDS 523..4095 /gene="ZEB2" /gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B" /note="isoform 2 is encoded by transcript variant 2; zinc finger homeobox 1b; zinc finger E-box-binding homeobox 2; Smad-interacting protein 1; SMAD interacting protein 1" /codon_start=1 /product="zinc finger E-box-binding homeobox 2 isoform 2" /protein_id="NP_001165124.1" /db_xref="GI:284413746" /db_xref="CCDS:CCDS54403.1" /db_xref="GeneID:9839" /db_xref="HGNC:14881" /db_xref="MIM:605802" /translation="
MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM
"
misc_feature 1171..1239
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
/db_xref="CDD:210117"
misc_feature 1297..1362
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
/db_xref="CDD:210117"
misc_feature 1336..1407
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1579..1581
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (O60315.1); acetylation site"
misc_feature 1759..1911
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O60315.1);
Region: SMAD-MH2 binding domain (By similarity)"
misc_feature 2407..2538
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(2518..2520,2527..2532)
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 3487..3564
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 3571..3648
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
exon 596..853
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/inference="alignment:Splign:1.39.8"
STS 776..1673
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/standard_name="Zeb2"
/db_xref="UniSTS:275880"
exon 854..1042
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/inference="alignment:Splign:1.39.8"
exon 1043..1257
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/inference="alignment:Splign:1.39.8"
variation 1248
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/replace="c"
/replace="g"
/db_xref="dbSNP:34961586"
exon 1258..1366
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/inference="alignment:Splign:1.39.8"
exon 1367..3336
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/inference="alignment:Splign:1.39.8"
variation 1860
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/replace="a"
/replace="t"
/db_xref="dbSNP:34890427"
variation 2653
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/replace="c"
/replace="t"
/db_xref="dbSNP:144154908"
variation 2907
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/replace="a"
/replace="g"
/db_xref="dbSNP:144184948"
variation 2931
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/replace="a"
/replace="c"
/db_xref="dbSNP:201574695"
exon 3337..3517
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/inference="alignment:Splign:1.39.8"
exon 3518..9171
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/inference="alignment:Splign:1.39.8"
STS 3759..4901
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/standard_name="Zeb2"
/db_xref="UniSTS:546057"
polyA_signal 5509..5514
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
polyA_site 5530
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
STS 7838..8022
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/standard_name="RH68819"
/db_xref="UniSTS:23373"
variation 7892
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
/replace="a"
/replace="c"
/db_xref="dbSNP:1043719"
polyA_signal 8043..8048
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
polyA_site 8071
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
polyA_signal 8956..8961
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
polyA_site 8982
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
polyA_signal 9026..9031
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
polyA_site 9055
/gene="ZEB2"
/gene_synonym="HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B"
ORIGIN
atttcatttcttccactaaagcgtttgcggagacttcaaggtataatctatcccagatcctttcccagagagaaacttggcgatcacgttttcacatgatgctcacgctcagggcgcttcaattatccctccccacaaagataggtggcgcgtgtttcagggtctctcgtctctctcctacagaaaagaaaaagaaaaaaatgtcattagaagaggcgtaacacgtcagtccgtccccaggtttgtgtttcctggagtggccgaaagagatcagttctaacctgctctgcaggaataacggtcctgcctcccgacactcttggcgaggtttttgtacagtttgctccgggagctgtttcttcgcttccacctttttctcccccacacttcgcggcttcttcatgctttttcttctcaccatttctggccaaaactacaaacaagacttcgcagatcgagcctgcgtgctgccgaagcagggcgccgagtccatgcgaactgccatctgatccgctcttatcaatgaagcagccgatcatggcggatggcccccggtgcaagaggcgcaaacaagccaatcccaggaggaaaaacgtggtgaactatgacaatgtagtggacacaggttctgaaacagatgaggaagacaagcttcatattgctgaggatgacggtattgccaaccctctggaccaggagacgagtccagctagtgtgcccaaccatgagtcctccccacacgtgagccaagctctgttgccaagagaggaagaggaagatgaaataagggagggtggagtggaacacccctggcacaacaacgagattctacaagcctctgtagatggtccagtgaagaatgcaaattgcacatcagattttgaggaatactttgccaaaagaaaactggaggaacgcgatggtcatgcagtcagcatcgaggagtaccttcagcgcagtgacacagccattatttacccagaagcccctgaggagctgtctcgccttggcacgccagaggccaatgggcaagaagaaaatgacctgccacctggaactccagatgcttttgcccaactgctgacctgcccctactgcgaccggggctacaagcgcttgacatcactgaaggagcacatcaagtaccgccacgagaagaatgaagagaacttttcctgccctctctgtagctacacgtttgcctaccgcacccagctcgagcggcatatggtgacacacaagccagggacagatcagcaccaaatgctaacccaaggagcaggtaatcgcaagttcaaatgcacagagtgtggcaaggccttcaaatataaacaccatctgaaagaacacctgcgaattcacagtggtgaaaaaccttacgagtgcccaaactgcaagaaacgtttctcccattctggttcctacagttcgcacatcagcagcaagaaatgtattggtttaatctctgtaaatggccgaatgagaaacaatatcaagacgggttcttcccctaattctgtttcttcttctcctactaattcagccattacccagttaagaaacaagttggagaatggaaaaccacttagtatgtctgaacagacaggcttacttaaaattaaaacagaaccactagacttcaatgactataaagttcttatggctacacacgggtttagtggcactagtccctttatgaatggtgggcttggagccaccagccctttaggagttcatccatctgctcagagtccaatgcagcacttaggtgtagggatggaagcccctttacttgggtttcccaccatgaatagtaatttaagtgaggtacaaaaggttctacagattgtggacaatactgtttccaggcaaaaaatggactgcaaggctgaagaaatttcaaagttgaaaggttatcacatgaaggatccatgctctcaacctgaggaacaaggagttacttctcctaatattccgcctgtcggtcttccggtagtgagtcataatggtgccactaaaagtattattgactatacgttggaaaaagtcaatgaagccaaagcttgcctccagagcttgactactgactcaaggagacagatcagtaatataaagaaagagaagctacgtactttaatagatttggtcactgatgacaaaatgattgagaaccacaacatatccactccattttcatgccagttctgtaaagaaagttttcctggccccatccctttgcatcagcatgaacgttacctttgtaagatgaatgaagagatcaaggcggtcctgcagcctcatgaaaacatagtccccaacaaagccggagtttttgttgataataaagccctcctcttgtcatctgtactttctgagaaaggaatgacaagccccatcaacccatacaaggaccacatgtctgtactcaaagcatactatgctatgaacatggagcccaactccgatgaactgctgaaaatttccattgctgtgggccttcctcaggaatttgtgaaggaatggtttgaacaacgaaaagtctaccagtactcaaattccaggtccccatccctggaaagaagctccaagccgttagctcccaacagtaaccctcccacaaaagactctttattacccaggtctcctgtaaaacctatggactccataacatcaccatctatagcagaactccacaacagtgttacgaattgtgatcctcctctcaggctaacaaaaccttcccattttaccaatattaaaccagttgaaaaattggaccactccaggagtaatactccttctcccttaaatctttcctccacatcttctaaaaactcccacagtagttcatacactccaaacagcttctcttctgaggagctccaggctgagcctttagacttgtcattaccaaaacaaatgaaagaacccaaaagtattatagccacaaagaacaaaacaaaagctagtagcatcagtttagatcataacagtgtttcttcctcatctgaaaactcagatgagcctctgaacttgacttttatcaagaaggaattttcaaattcaaataatctggacaacaaaagcactaacccagtgttcagcatgaacccatttagtgccaaacctttatacacagctcttccacctcaaagcgcatttccccctgctactttcatgccaccagtccagaccagtattcctgggctacgaccatacccaggactggatcagatgagcttcctaccacatatggcctacacctacccaactggagcagctacttttgctgatatgcagcaaaggagaaagtaccagcggaaacaaggatttcagggagaattgcttgatggagcacaagactacatgtcaggcctagatgatatgacagactccgactcctgtctgtctcgcaaaaagatcaagaagacagagagtggcatgtatgcatgtgacttatgtgacaagacattccagaaaagcagttcccttctgcgacataaatacgaacacacaggaaaaagaccacatcagtgtcagatttgtaagaaagcgtttaaacacaagcaccaccttatcgagcactcaaggcttcactcgggcgagaagccctatcagtgtgataaatgtggcaagcgcttctcacactcgggctcgtactcgcagcacatgaatcacaggtattcctactgcaagcgggaggcggaggagcgggaagcggcggagcgcgaggcgcgcgagaaagggcacttggaacccaccgagctgctgatgaaccgggcttacttgcagagcattacccctcaggggtactctgactcggaggagagggagagtatgccgagggatggcgagagcgagaaggagcacgagaaagaaggcgaggatggctacgggaagctgggcagacaggatggcgacgaggagttcgaggaggaagaggaagaaagtgaaaataaaagtatggatacggatcccgaaacgatacgagatgaagaagagactggagatcactccatggacgatagttcggaggatgggaaaatggaaaccaaatcagaccacgaggaagacaatatggaagatggcatgtaataaactactgcattttaagcttcctatttttttttccagtagtattgttacctgcttgaaaacactgctgtgttaagctgttcatgcacgtgcctgacgcttccaggaagctgtagagagggacagaaggggcggttcagccaagacagatgtagacggagttggagctgggtattgttaaaaactgcattatgcaaaaattttgtacagtgttaaggcctaaaaactgtgtggttcagagactaattcctgtgtttaatagcatttatactttaagcacaactagaaaattgtaagaattgcactctacttatgtatcactacaaactttaaaaaactatgtctaatttatattaatacattttaaaaaggtgcccgcactaccatacatcagtatttttattattattattgttattcctttttaatttaatgtgctcgcactacaatgcatcagtattatgattcctctgtactttcctttcgctattcatcaatttcccattttttttttcagcttaagtaaccacacaattttaggcctcaatttttttttttttctgtgaaggaacttgaagtgatgcatgtgtgaatttaagataccgaagtcttaaagtgacctggacgtgaaggaaaaagtaagatgagaaataaagaaagcctttgtaaggtggttttaaaagccttatatgcaaaccttttaatctgtgtttctgcaagtgccatccttgtacagtgttaagagggtaacatgggttacctttgcaccagcttcagtgttaagctcaccctgttctttgaagcacccatgtcagtattagaagaataggcagcagttccttagtttacatatgtttgtgcaattattttctgtacttttttgttcattaattttgtcagtattacaccaaactgtttttgcaacaaaaaaattttttttgcattcatttaattttaggtcaaataacattttatttatgtggctcattttatatttcctaattttatttatttcatactgtagtgtacagtattatagttcttcaatatatagatatattttagtaaaaaaggaacatgacgttgatcatttgggcaaattttacgtaaagagaagagcatttattgtgttttggaacattaattgtgagatgggatttttcaattttattattttatttttgtttttttccaattactggaaattccaaatttgggaacttttgatacgatcttgtgaaaacactgtattttcgactgaaaattccactttcttcatcttgttttttagctaaaaagagggactgttaaatacaatgtatgataccatgacaaaaatctttcctgaattgtctttgtaaaagtattattgaattttcaatttgtaatttcttttgaaaatgaccatgctcgaataaaaatgtagccaaactaagaatgtagttaatgagttctgtacttttagagagttttccttcaatgaccattaacatgtaacatgctttatgcttataataatgctaattatgtttttttcatataattttagtttagcaataattttgactggtaccaataactgttttttaaaattccatacctatgtacagcaattttacagcttttctcaactgatcctgattccagattgtgtatttttatgtgaggttatattattcaaatttagtctatttactttacagacatttctacttttgcattacgagtatttagagattatgtgttaaaaattcacttctctgtccaaggggtctttgtgatttattcaaaaaaaagtctaatttcaaaaagacagctattattcagtgttatttataatatgtaaccttttttaaaggattgggatagtttatctcactttttgaaatgcagacagtagtttaccgtttatctgaaactagaaggcgtgggtgggagaggaaaagctaaaagcaaatgctaacaaaaataaccgtgattttctaagacagtttttcagtttttacaagatgaccctaatattcagaatatgaatgtattcgtaggttttacataatgacttttatcaagaaactagattctgcttcttaaatctaattgccaagtgaagaataacagaaaaaacagattaccttatcaaatttacagctcttgaatatacagaactataatatagtagctgtccatgtattttttctactttagaatcaaagaagaaaagcatcattttgctattaaatttgctaaaattttgagtatgatatttccagttggcaagaacaacatatttatatttattccttagccataataccactttcctaaatttcacaaaagtcattctttgcaacttgaaactcaatagaaagtgtgtatgtgtgtgtgtgtatatatatatatatatacacacacacacatacacagaaaggatgtaatgaagatacagtaatagttgagcagacctttttagaaaaacatgtttttagctctatcttcaaactttctggcagagggggtggggggggcagggggaggagtggcatcaaaatgctatgcctcctgttatccacagcctagagtttttatatttggaaagtttagaaaattctatcctcgtttctccttctttgaatggcacaaataaatacactacataaatttttctggtttgaaaggctctaggcgataactttattaattcaacctgaaaatatcaagccattaaattttgtccgggtagaataaatccctgtggcctcttttaaagcaatgtaggtctctgttgcccatggggcatatctgtgtcccaatccacaagagataggaccaacaaacaatgaatgtgcaacctaactctttctccttggaaagaagaaagtgtgcacgaagtagaggagggtgggcagaccctgccttgcccctcctgttacccccttctctgtcatttgttcctaactccatttcataggcaggctcagaatacctgagtctgaaaatatcaggataacacttgtgaattgtgacaatcactacaatgtcccatatctgaggagttttttttaatgctatttatccgctggacacgattgcacattagggctgcataatcctctaactctagggaaaaataaaaacttttgatttgtcttaagattcttctccaaggtcgcaaacaagaaattcccctccacaaccaagagatgtgcattttagtaacatcagatgtgttcttctgttttatcaactacttactcttcccacacgcttagttctaaatctaacctttcccccctcgaatagggggcaggggaggatgaggaaacactggaacaactgaacacccctgcccattttctccaagagccttttgtattctagcatatctgtgcaatcttttcttttttcttcacatgacactgtaagcttaggcctgaaataactgggaagagagatgcgtatcagaatttctccgcaagagctaaacaaaacatacatcttccttagcatgaattggactgggggcggagtgggagggcttggaggaaaggggaaagaagggactatatttgaataaatatgaataaatgtattagatacttttcacaatcagataacttttaaaaaggtcattttttatctttctaataatgtaagccttaataaaagcaaatcttagtcacaaatttgaggagactgcccaataataagtttacatgtatttgaactgaaaaattgttaaccatgcttttgctccaagatgtgtgaggccattcaggggctgtagggccctggatatacacacaaacaagtgtgtgtatatctggagccccacacattgtaataaacacagctgcatttatttgactatgtgatcccatgtacatgtaaaaacattcaaacaaacacactcagcggatttatttattgtgcaatggggcaattattcaaataaacatgctcaatgcaattatttgaatctcacattgcatgttcatcaatcatagcactaaaaaaagagggggaaaaaacaccaaagaattcacatggggaaaaaatatatatatgaaaaccaccttattatagattttatagggcagctgaggttatggctcccttcttaactgtaactcaactattctgtattcaatgacatttgtttctaatgattaattggttcactcacttgatcatataatagcaaactttataaacctgtattgtgtagagatgtgaaatctctatatttcaagagcagaagagttctttctagacaccttacatcaagggacactggtccaattattatcgcttatataagcactcctataaattctgaaaaattttatacatgcaacaaaacattcctacatttgaagacattaagaaaaatcacaggtgactcatctgatcattctatatattaataaatattatgacatatatgtgaacacatcacaaatcatattggtgtaccaagaggcaatttatgcctctcttaagtatgtactgacataacctaatatactaaaatgggaaggggcttttagtcactgaaatatgcatcgtgtaacaaagatgaagaaaatacatggcttgtgcccatcataaaaaaagattcagactgaaggcttagctttggttttttcaattaaattgttaaactgtgcacagtgatttttttttagaacttgagacatttgtgatgttggctgtttaaatctttgttaccttcgctgtgaattgaaattgtacatatttagtaaatcatgcagacaaaacaaactttttagacaatatttttattggagagttttcttttcctgtatccatgttaaaaaaaaaaaagacctcctttcccaaaataaaaatgtcaatactaaatttaaagaagtataaaggaatgattgcttcctttagagcaaaatatttaaataaacatggagataattggcaacatgttctttttgggctagtaggctgtgtccaattttttgggtctgatgtttcagagggcctctgtttcagggttgaagatgatatattaatctcggaattaaacaaatgctattaaataac
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9839 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:9839 -> Molecular function: GO:0019208 [phosphatase regulator activity] evidence: NAS
GeneID:9839 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:9839 -> Molecular function: GO:0046332 [SMAD binding] evidence: NAS
GeneID:9839 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:9839 -> Molecular function: GO:0070412 [R-SMAD binding] evidence: IEA
GeneID:9839 -> Biological process: GO:0001755 [neural crest cell migration] evidence: IEA
GeneID:9839 -> Biological process: GO:0001756 [somitogenesis] evidence: IEA
GeneID:9839 -> Biological process: GO:0001843 [neural tube closure] evidence: IEA
GeneID:9839 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:9839 -> Biological process: GO:0007399 [nervous system development] evidence: NAS
GeneID:9839 -> Biological process: GO:0021766 [hippocampus development] evidence: IEA
GeneID:9839 -> Biological process: GO:0021846 [cell proliferation in forebrain] evidence: IEA
GeneID:9839 -> Biological process: GO:0030177 [positive regulation of Wnt receptor signaling pathway] evidence: IEA
GeneID:9839 -> Biological process: GO:0043507 [positive regulation of JUN kinase activity] evidence: IEA
GeneID:9839 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:9839 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:9839 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
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