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2025-05-09 20:27:24, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001164766 12778 bp mRNA linear PRI 16-JUN-2013 DEFINITION Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant B, mRNA. ACCESSION NM_001164766 VERSION NM_001164766.1 GI:258613986 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 12778) AUTHORS Li,M., Zhao,D., Ma,G., Zhang,B., Fu,X., Zhu,Z., Fu,L., Sun,X. and Dong,J.T. TITLE Upregulation of ATBF1 by progesterone-PR signaling and its functional implication in mammary epithelial cells JOURNAL Biochem. Biophys. Res. Commun. 430 (1), 358-363 (2013) PUBMED 23159610 REMARK GeneRIF: These findings suggest that ATBF1 plays a crucial role in the Progesterone-progesterone receptors signaling pathway in mammary epithelial cells. REFERENCE 2 (bases 1 to 12778) AUTHORS Bevan,S., Traylor,M., Adib-Samii,P., Malik,R., Paul,N.L., Jackson,C., Farrall,M., Rothwell,P.M., Sudlow,C., Dichgans,M. and Markus,H.S. TITLE Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations JOURNAL Stroke 43 (12), 3161-3167 (2012) PUBMED 23042660 REMARK GeneRIF: 3 loci from related cardiovascular genomewide studies were significant: PHACTR1 in large-vessel disease (P=2.63e(-6)), PITX2 in cardioembolic stroke (P=4.78e(-8)), and ZFHX3 in cardioembolic stroke (P=5.50e(-7)). REFERENCE 3 (bases 1 to 12778) AUTHORS Li,M., Fu,X., Ma,G., Sun,X., Dong,X., Nagy,T., Xing,C., Li,J. and Dong,J.T. TITLE Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling JOURNAL PLoS ONE 7 (12), E51283 (2012) PUBMED 23251482 REMARK GeneRIF: findings indicate that Atbf1 plays a role in the development of pubertal mammary gland likely by modulating the function of estrogen-ER signaling in luminal cells and by modulating gene expression in basal cells REFERENCE 4 (bases 1 to 12778) AUTHORS Minamiya,Y., Saito,H., Ito,M., Imai,K., Konno,H., Takahashi,N., Motoyama,S. and Ogawa,J. TITLE Suppression of Zinc Finger Homeobox 3 expression in tumor cells decreases the survival rate among non-small cell lung cancer patients JOURNAL Cancer Biomark 11 (4), 139-146 (2012) PUBMED 23144151 REMARK GeneRIF: Suppression of ZFHX3 expression in tumor cells decreases the survival rate among patients with NSCLC. REFERENCE 5 (bases 1 to 12778) AUTHORS Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R., Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L., Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S., Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D. TITLE Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q JOURNAL Genomics 60 (3), 295-308 (1999) PUBMED 10493829 REFERENCE 6 (bases 1 to 12778) AUTHORS Kaspar,P., Dvorakova,M., Kralova,J., Pajer,P., Kozmik,Z. and Dvorak,M. TITLE Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein JOURNAL J. Biol. Chem. 274 (20), 14422-14428 (1999) PUBMED 10318867 REFERENCE 7 (bases 1 to 12778) AUTHORS Bedford,M.T., Chan,D.C. and Leder,P. TITLE FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands JOURNAL EMBO J. 16 (9), 2376-2383 (1997) PUBMED 9171351 REFERENCE 8 (bases 1 to 12778) AUTHORS Miura,Y., Tam,T., Ido,A., Morinaga,T., Miki,T., Hashimoto,T. and Tamaoki,T. TITLE Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner JOURNAL J. Biol. Chem. 270 (45), 26840-26848 (1995) PUBMED 7592926 REFERENCE 9 (bases 1 to 12778) AUTHORS Yamada,K., Miura,Y., Scheidl,T., Yoshida,M.C. and Tamaoki,T. TITLE Assignment of the human ATBF1 transcription factor gene to chromosome 16q22.3-q23.1 JOURNAL Genomics 29 (2), 552-553 (1995) PUBMED 8666409 REFERENCE 10 (bases 1 to 12778) AUTHORS Morinaga,T., Yasuda,H., Hashimoto,T., Higashio,K. and Tamaoki,T. TITLE A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers JOURNAL Mol. Cell. Biol. 11 (12), 6041-6049 (1991) PUBMED 1719379 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D10250.1, AC004943.2 and L32832.1. Summary: This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. Transcript Variant: This variant (B) represents use of an alternate promoter and 5' UTR, lacks an alternate coding exon, and uses a downstream start codon, compared to variant A. The resulting isoform (B) has a shorter N-terminus, compared to isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10250.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025084 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1832 D10250.1 1-1832 1833-1833 AC004943.2 68245-68245 1834-8607 L32832.1 5120-11893 8608-12778 AC004943.2 79426-83596 FEATURES Location/Qualifiers source 1..12778 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="16" /map="16q22.3" gene 1..12778 /gene="ZFHX3" /gene_synonym="ATBF1; ATBT; ZNF927" /note="zinc finger homeobox 3" /db_xref="GeneID:463" /db_xref="HGNC:777" /db_xref="MIM:104155" exon 1..106 /gene="ZFHX3" /gene_synonym="ATBF1; ATBT; ZNF927" /inference="alignment:Splign:1.39.8" misc_feature 28..30 /gene="ZFHX3" /gene_synonym="ATBF1; ATBT; ZNF927" /note="upstream in-frame stop codon" exon 107..603 /gene="ZFHX3" /gene_synonym="ATBF1; ATBT; ZNF927" /inference="alignment:Splign:1.39.8" CDS 130..8499 /gene="ZFHX3" /gene_synonym="ATBF1; ATBT; ZNF927" /note="isoform B is encoded by transcript variant B; AT motif-binding factor 1; AT-binding transcription factor 1; zinc finger homeobox protein 3; alpha-fetoprotein enhancer binding protein; ZFH-3; zinc finger homeodomain protein 3; alpha-fetoprotein enhancer-binding protein" /codon_start=1 /product="zinc finger homeobox protein 3 isoform B" /protein_id="NP_001158238.1" /db_xref="GI:258613987" /db_xref="CCDS:CCDS54035.1" /db_xref="GeneID:463" /db_xref="HGNC:777" /db_xref="MIM:104155" /translation="
MRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSEDLGKNILPSASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASGSSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLLSQVPTESVGMPPLGNPIGANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLPVTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSIAQSHSALLQPSQHPEKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKELAPGGGSEPSMLPPRIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTDQGENLEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPPPPPPPPPPPPLPAAPPQPASTPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPPKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAEELATFNSKTEAGDEKPKLAEAPSAQPNQTQEKQGQPKPELQQQEQPEQKTNTPQQKLPQLVSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAMMAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDSGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNTPLQALNLPTAYPALQGIPPVLLPGLNSPSLPGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMGPQQPPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKDSEKVKEKEKAHKGKGEPLPVPKKEKGEAPTATAATISAPLPTMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSLLQQYQQYQQSLQEAIQQQQQRQLQQQQQQKVQQQQPKASQTPVPPGAPSPDKDPAKESPKPEEQKNTPREVSPLLPKLPEEPEAESKSADSLYDPFIVPKVQYKLVCRKCQAGFSDEEAARSHLKSLCFFGQSVVNLQEMVLHVPTGGGGGGSGGGGGGGGGGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAAPSSASPHASRKSWPQVVSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL
"
misc_feature 3823..3999
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(3823..3837,3841..3843,3892..3894,3910..3912,
3949..3951,3955..3960,3967..3972,3976..3984,3988..3993)
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(3829..3831,3838..3840,3958..3960,3967..3972,
3979..3981)
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 4114..4287
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(4114..4128,4132..4134,4183..4185,4201..4203,
4240..4242,4246..4251,4258..4263,4267..4275,4279..4284)
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(4120..4122,4129..4131,4249..4251,4258..4263,
4270..4272)
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 5218..5601
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="Homeodomain-containing transcription factor
[Transcription]; Region: COG5576"
/db_xref="CDD:35135"
misc_feature 5311..5487
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(5311..5325,5329..5331,5380..5382,5398..5400,
5437..5439,5443..5448,5455..5460,5464..5472,5476..5481)
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(5317..5319,5326..5328,5446..5448,5455..5460,
5467..5469)
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 6226..6402
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(6226..6240,6244..6246,6295..6297,6313..6315,
6352..6354,6358..6363,6370..6375,6379..6387,6391..6396)
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(6232..6234,6241..6243,6361..6363,6370..6375,
6382..6384)
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
variation 303
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="a"
/replace="g"
/db_xref="dbSNP:2228200"
variation 376
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="g"
/replace="t"
/db_xref="dbSNP:2213978"
exon 604..835
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/inference="alignment:Splign:1.39.8"
exon 836..916
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/inference="alignment:Splign:1.39.8"
exon 917..1050
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/inference="alignment:Splign:1.39.8"
exon 1051..1251
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/inference="alignment:Splign:1.39.8"
exon 1252..1354
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/inference="alignment:Splign:1.39.8"
exon 1355..6814
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/inference="alignment:Splign:1.39.8"
variation 1833
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="a"
/replace="t"
/db_xref="dbSNP:740178"
variation 2316
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229290"
STS 2797..2994
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/standard_name="RH65127"
/db_xref="UniSTS:37848"
variation 5565
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229286"
variation 5634
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229287"
variation 5664
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="g"
/replace="t"
/db_xref="dbSNP:2229288"
variation 5703
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229289"
exon 6815..12778
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/inference="alignment:Splign:1.39.8"
variation 7266
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="c"
/replace="t"
/db_xref="dbSNP:2228199"
STS 7763..8667
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/standard_name="ATBF1_4388"
/db_xref="UniSTS:463552"
variation 10596..10597
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace=""
/replace="t"
/db_xref="dbSNP:3841241"
variation 11842
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="a"
/replace="c"
/db_xref="dbSNP:3193941"
variation 11980
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="a"
/replace="g"
/db_xref="dbSNP:3812983"
variation 12479
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="a"
/replace="c"
/db_xref="dbSNP:1053410"
variation 12655
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
/replace="a"
/replace="c"
/db_xref="dbSNP:1053412"
polyA_signal 12755..12760
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
polyA_site 12778
/gene="ZFHX3"
/gene_synonym="ATBF1; ATBT; ZNF927"
ORIGIN
cgcggcccgagcgcctcttttcgggattaaaagcgccgccagctcccgccgccgccgccgtcgccagcagcgccgctgcagccgccgccgccggagaagcaaccgctgggcggtgagatccccctagacatgcggctcgggggcgggcagctggtgtcagaggagctgatgaacctgggcgagagcttcatccagaccaacgacccgtcgctgaagctcttccagtgcgccgtctgcaacaagttcacgacggacaacctggacatgctgggcctgcacatgaacgtggagcgcagcctgtcggaggacgagtggaaggcggtgatgggggactcataccagtgcaagctctgccgctacaacacccagctcaaggccaacttccagctgcactgcaagacagacaagcacgtgcagaagtaccagctggtggcccacatcaaggagggcggcaaggccaacgagtggaggctcaagtgtgtggccatcggcaaccccgtgcacctcaagtgcaacgcctgtgactactacaccaacagcctggagaagctgcggctgcacacggtcaactccaggcacgaggccagcctgaagttgtacaagcacctgcagcagcatgagagtggtgtagaaggtgagagctgctactaccactgcgttctgtgcaactactccaccaaggccaagctcaacctcatccagcatgtgcgctccatgaagcaccagcgaagcgagagcctgcgaaagctgcagcggctgcagaagggccttccagaggaggacgaggacctggggcagatcttcaccatccgcaggtgcccctccacggacccagaagaagccattgaagatgttgaaggacccagtgaaacagctgctgatccagaggagcttgctaaggaccaagagggcggagcatcgtccagccaagcagagaaggagctgacagattctcctgcaacctccaaacgcatctccttcccaggtagctcagagtctcccctctcttcgaagcgaccaaaaacagctgaggagatcaaaccggagcagatgtaccagtgtccctactgcaagtacagtaatgccgatgtcaaccggctccgggtgcatgccatgacgcagcactcggtgcaacccatgcttcgctgccccctgtgccaggacatgctcaacaacaagatccacctccagctgcacctcacccacctccacagcgtggcacctgactgcgtggagaagctcattatgacggtgaccacccctgagatggtgatgccaagcagcatgttcctcccagcagctgttccagatcgagatgggaattccaatttggaagaggcaggaaagcagcctgaaacctcagaggatctgggaaagaacatcttgccatccgcaagcacagagcaaagcggagatttgaaaccatcccctgctgacccaggctctgtgagagaagactcaggcttcatctgctggaagaaggggtgcaaccaggttttcaaaacttctgctgcccttcagacgcattttaatgaagtgcatgccaagaggcctcagctgccggtgtcagatcgccatgtgtacaagtaccgctgtaatcagtgtagcctggccttcaagaccattgaaaagttgcagctccattctcagtaccatgtgatcagagctgccaccatgtgctgtctttgtcagcgcagtttccgaactttccaggctctgaagaagcaccttgagacaagccacctggagctgagtgaggctgacatccaacagctttatggtggcctgctggccaatggggacctcctggcaatgggagaccccactctggcagaggaccataccataattgttgaggaagacaaggaggaagagagtgacttggaagataaacagagcccaacgggcagtgactctgggtcagtacaagaagactcgggctcagagccaaagagagctctgcctttcagaaaaggtcccaattttactatggaaaagttcctagacccttctcgcccttacaagtgtaccgtctgcaaggaatctttcactcaaaagaatatcctgctagtacactacaattctgtctcccacctgcataagttaaagagagcccttcaagaatcagcaaccggtcagccagaacccaccagcagcccagacaacaaaccttttaagtgtaacacttgtaatgtggcctacagccagagttccactctggagatccatatgaggtctgtgttacatcaaaccaaggcccgggcagccaagctggaggctgcaagtggcagcagcaatgggactgggaacagcagcagtatttccttgagctcctccacgccaagtcctgtgagcaccagtggcagtaacacctttaccacctccaatccaagcagtgctggcattgctccaagctctaacttactaagccaagtgcccactgagagtgtagggatgccacccctggggaatcctattggtgccaacattgcttccccttcagagcccaaagaggccaatcggaagaaactggcagatatgattgcatccaggcagcagcaacaacagcagcagcaacagcaacaacaacaacaacaacaacaacaacaagcacaaacgctggcccaggcccaggctcaagttcaagctcacctgcagcaggagctgcagcaacaggctgccctgatccagtctcagctgtttaaccccaccctccttcctcacttccccatgacaactgagaccctgctgcaactacagcagcagcagcacctcctcttccctttctacatccccagtgctgagttccagcttaaccccgaggtgagcttgccagtgaccagtggggcactgacactgactgggacaggcccaggcctgctggaagatctgaaggctcaggttcaggtcccacagcagagccatcagcagatcttgccgcagcagcagcagaaccaactctctatagcccagagtcactctgccctccttcagccaagccagcaccccgaaaagaagaacaaattggtcatcaaagaaaaggaaaaagaaagccagagagagagggacagcgccgaggggggagagggcaacaccggtccgaaggaaacactgccagatgccttgaaggccaaagagaagaaagagttggcaccagggggtggttctgagccttccatgctccctccacgcattgcttcagatgccagagggaacgccaccaaggccctgctggagaactttggctttgagttggtcatccagtataatgagaacaagcagaaggtgcagaaaaagaatgggaagactgaccagggagagaacctggaaaagctcgagtgtgactcctgcggcaagttgttttccaacatcttgattttaaagagtcatcaagagcacgttcatcagaattactttcctttcaaacagctcgagaggtttgccaaacagtacagagaccactacgataaactgtacccactgaggccccagaccccagagccaccaccacctccccctccaccccctccacccccacttccggcagcgccgcctcagccggcgtccacaccagccatccccgcatcagccccacccatcacctcacctacaattgcaccggcccagccatcagtgccgctcacccagctctccatgccgatggagctgcccatcttctcgccgctgatgatgcagacgatgccgctgcagaccttgccggctcagctacccccgcagctgggacctgtggagcctctgcctgcggacctggcccaactctaccagcatcagctcaatccaaccctgctccagcagcagaacaagaggcctcgcaccaggatcacagatgatcagctccgagtcttgcggcaatattttgacattaacaactcccccagtgaagagcaaataaaagagatggcagacaagtccgggttgccccagaaagtgatcaagcactggttcaggaacactctcttcaaagagaggcagcgtaacaaggactccccttacaacttcagtaatcctcctatcaccagcctggaggagctcaagattgactcccggcccccttcgccggaacctccaaagcaggagtactggggaagcaagaggtcttcaagaacaaggtttacggactaccagctgagggtcttacaggacttcttcgatgccaatgcttacccaaaggatgatgaatttgagcaactctctaatttactgaaccttccaacccgagtgatagtggtgtggtttcagaatgcccgacagaaggccaggaagaattatgagaatcagggagagggcaaagatggagagcggcgtgagcttacaaatgatagatacattcgaacaagcaacttgaactaccagtgcaaaaaatgtagcctggtgtttcagcgcatctttgatctcatcaagcaccagaagaagctgtgttacaaggatgaggatgaggaggggcaggacgacagccaaaatgaggattccatggatgccatggaaatcctgacgcctaccagctcatcctgcagtaccccgatgccctcacaggcttacagcgccccagcaccatcagccaataatacagcttcctccgctttcttgcagcttacagcggaggctgaggaactggccaccttcaattcaaaaacagaggcaggcgatgagaaaccaaagctggcggaagctcccagtgcacagccaaaccaaacccaagaaaagcaaggacaaccaaagccagagctgcagcagcaagagcagcccgagcagaagaccaacactccccagcagaagctcccccagctggtgtccctgccttcgttgccacagcctcctccacaagcgccccctccacagtgccccttaccccagtcgagccccagtccttcccagctctcccacctgcccctcaagcccctccacacatcaactcctcaacagctcgcaaacctacctcctcagctaatcccctaccagtgtgaccagtgtaagttggcatttccgtcatttgagcactggcaggagcatcagcagctccacttcctgagcgcgcagaaccagttcatccacccccagtttttggacaggtccctggatatgcctttcatgctctttgatcccagtaacccactcctggccagccagctgctctctggggccatacctcagattccagcaagctcagccacttctccttcaactccaacctccacaatgaacactctcaagaggaagctggaggaaaaggccagtgcaagccctggcgaaaacgacagtgggacaggaggagaagagcctcagagagacaagcgtttgagaacaaccatcacaccggaacaactagaaattctctaccagaagtatctactggattccaatccgactcgaaagatgttggatcacattgcacacgaggtgggcttgaagaaacgtgtggtacaagtctggtttcagaacacccgagctcgggaaaggaaaggacagttccgggctgtaggcccagcgcaggcccacaggagatgccctttttgcagagcgctcttcaaagccaagactgctcttgaggctcatatccggtcccgtcactggcatgaagccaagagagctggctacaacctaactctgtctgcgatgctcttagactgtgatgggggactccagatgaaaggagatatttttgacggaactagcttttcccacctacccccaagcagtagtgatggtcagggtgtccccctctcacctgtgagtaaaaccatggaattgtcacccagaactcttctaagcccttcctccattaaggtggaagggattgaagactttgaaagcccctccatgtcctcagttaatctaaactttgaccaaactaagctggacaacgatgactgttcctctgtcaacacagcaatcacagataccacaactggagacgagggcaacgcagataacgacagtgcaacgggaatagcaactgaaaccaaatcctcttctgcacccaacgaagggttgaccaaagcggccatgatggcaatgtctgagtatgaagatcggttgtcatctggtctggtcagcccggccccgagcttttatagcaaggaatatgacaatgaaggtacagtggactacagtgaaacctcaagccttgcagatccctgctccccgagtcctggtgcgagtggatctgcaggcaaatctggtgacagcggagatcggcctgggcagaaacgttttcgcactcaaatgaccaatctgcagctgaaggtcctcaagtcatgctttaatgactacaggacacccactatgctagaatgtgaggtcctgggcaatgacattggactgccaaagagagtcgttcaggtctggttccagaatgcccgggcaaaagaaaagaagtccaagttaagcatggccaagcattttggtataaaccaaacgagttatgagggacccaaaacagagtgcactttgtgtggcatcaagtacagcgctcggctgtctgtacgtgaccatatcttttcccaacagcatatctccaaagttaaagacaccattggaagccagctggacaaggagaaagaatactttgacccagccaccgtacgtcagttgatggctcaacaagagttggaccggattaaaaaggccaacgaggtccttggactggcagctcagcagcaagggatgtttgacaacacccctcttcaggcccttaaccttcctacagcatatccagcgctccagggcattcctcctgtgttgctcccgggcctcaacagcccctccttgccaggctttactccatccaacacagctttaacgtctcctaagccgaacttgatgggtctgcccagcacaactgttccttcccctggcctccccacttctggattaccaaataaaccgtcctcagcgtcgctgagctccccaaccccagcacaagccacgatggcgatgggccctcagcaacccccccagcagcagcagcagcagcagcaaccacaggtgcagcagcctcccccgccgccagcagcccagccgccacccacaccacagctcccactgcaacagcagcagcaacgcaaggacaaagacagtgagaaagtaaaggagaaggaaaaggcacacaaagggaaaggggaacccctgcctgtccccaagaaggagaaaggagaggcccccacggcaactgcagccacgatctcagccccgctgcccaccatggagtatgcggtagaccctgcacagctgcaggccctgcaggccgcgttgacttcggaccccacagcattgctcacaagccagttccttccttactttgtaccaggcttttctccttattatgctccccagatccctggcgccctgcagagcgggtacctgcagcctatgtatggcatggaaggcctgttcccctacagccctgcactgtcgcaggccctgatggggctgtccccaggctccctactgcagcagtaccagcaataccagcagagtctgcaggaggcaattcagcagcagcagcagcggcaactacagcagcagcagcagcaaaaagtgcagcagcagcagcccaaagcaagccaaaccccagtcccccccggggctccttccccagacaaagaccctgccaaagaatcccccaaaccagaagaacagaaaaacaccccccgtgaggtgtcccccctcctgccgaaactccctgaagagccagaagcagaaagcaaaagtgcggactccctctacgaccccttcattgttccaaaggtgcagtacaagttggtctgccgcaagtgccaggcgggcttcagcgacgaggaggcagcgaggagccacctgaagtccctctgcttcttcggccagtctgtggtgaacctgcaagagatggtgcttcacgtccccaccggcggcggcggcggtggcagtggcggcggcggcggcggtggcggcggcggcggcggcggcggctcgtaccactgcctggcgtgcgagagcgcgctctgtggggaggaagctctgagtcaacatctcgagtcggccttgcacaaacacagaacaatcacgagagcagcaagaaacgccaaagagcaccctagtttattacctcactctgcctgcttccccgatcctagcaccgcatctacctcgcagtctgccgctcactcaaacgacagcccccctcccccgtcggccgccgccccctcctccgcttccccccacgcctccaggaagtcttggccgcaagtggtctcccgggcttcggcagcgaagcccccttcttttcctcctctctcctcatcttcaacggttacctcaagttcatgcagcacctcaggggttcagccctcgatgccaacagacgactattcggaggagtctgacacggatctcagccaaaagtccgacggaccggcgagcccggtggagggtcccaaagaccccagctgccccaaggacagtggtctgaccagtgtaggaacggacaccttcagattgtaagctttgaagatgaacaatacaaacaaatgaatttaaatacaaaaattaataacaaaccaatttcaaaaatagactaactgcaattccaaagcttctaaccaaaaaacaaaaaaaaaaaaaaaaagaaaaaaaagaaaaagcgtgggttgttttcccatatacctatctatgccggtgattttacattcttgtctttttcttttcttttaatattaaaaaaaaaaaaaaagccctaaccctgttacattgtgtccttttgaaggtactattggtctgggaaacagaagtccgcagggcctccctaatgtctttggagcttaaaccccttgtatatttgccccttttcaataaacgccccacgctgatagcacagaggagcccggcatgcactgtatgggaaagcagtccaccttgttacagttttaaatttcttgctatcttagcattcagataccaatggcttgctaaaagaaaaaaagaaatgtaatgtctttttattctcaggtcaatcgctcacactttgttttcagaatcattgttttatatattattgttttttcagtttttttttttttttttgttccagaaaagattttttgttttgttaacttaaaaatgggcagaaagtattcaagaaaaacaatgtgaactgctttagctttctggggatttttaaggatagcttttctgctgaagccaatttcaaggggaaaagttaagcactcccactttcaaaaaaaaaaaaaaataataacccacacacacaaagagtgttgaggacttgtagcttaaaaaaaataagttttaaaaactgactttctgtatttatgatagatatgaccatttttggtgttgagtagattgttgcattggaaatgaactgaagcagtatggtagatttaaaaggaaaaaaaaaaaaaaaccttttgtgtacatttagctttttgtatggtccagctgacagctcctcatttgatgttgtcttgttcattcctagcagatgatagattgcaatccgttgattcgcctaagcttttctccccttgtcccttaattccactttctctttcttgtcccttaattccactttctctttccttctcccacctcccgtcctataatctcccacttaaggtagctgccttcatttcttagagggagctgcagaattattttataaaactaaagaaagaatttcaagggattctaggggtcattaggatcctcacagattatttttggttggggagttgaaactttttaaaggcatataattctagttacctgtgtctgttagctttgtgcatttattttttatttatccttcttttggcttttttttctttgtaccccttcttttcctccttgtttggtaggagcttcaaatattctttttttttctatactaaaggatttgtttccatttgtgtaattggctgtgtacttttcttttctaaaaaaagtttttggttagggatttggtttttggttttgtgtttgttttttctttcctctctcagaaaaaaaaatttcatgctttaaataaaatccaaagacacaccctttcactgctgatgcagaaaaaagggaaagggttcttgttacttgagaatttgtttctgatttaaacaaacaagacttagtttaataaaagaaagagaaaaacaaaagattcccaggttgttatgtgcttcttctgcaagcagagaggcaaatgttaatgacaattccatataccaaaagacacattttttacttcaaagttttgtccttgtgttaggcagtctgagcagcgagtgatccagagcgcagccaacaaagcagcagatagcagtgtacagaaagcaaaaaaggaactgtatgtgaggcacttgtttctgttaatatccatattcctgttaacacacaccctttctcatgtaaaaagaaaaataaataaatggtctgaactttgaaaactttgtgctgctaaaacatagattttggagacaaataaatagatgctttgctgtttcactttcatagctaaacatcaacagaaaccatctccccttgcccccaaagtgtgaaatccttcttcccttcgttttcttccttatgtttcaaaagggaactttgaagactgtgaatacaggttccattggtcacctttcgggcttctttccccagtgctgaagccactcatcgactttgcaaaagactggagcattccaagatctgaaaatggattttttttctttttttcttttttagccgggactattttatttttatgaatttgtttttagtttaatgaaatagtagatcctgaaatgttgtacatatttctaactaggctgatgcacagtgcaaattccttttttaattgttttttttaagtagaaatactaaagaaagaataccatctaactattcataccagtatccagttgtagcataaggtgtcaaaagcaagtacgcaaaacatttactgttttaacaagctatttccttttaacaagaaatcttgtatttcttcctgtgtttgagatgaacatttttaaattttaaagttgtacagttttttgttttccattattttatcttgtttgtaactctatgaaatatatatatatatattttttgccatttaactgttgtatgttactctgtgtctgtaccatatagaaaaaaaattgtttttgtttttggttctctatgtgatatcagttaacaatgtaacactagctttacctgtcaaattctgctaggtcttctctgaaaacgttgtttttaaaaatgatattgcttggtaatagtgcaatttctatccttttccctcccccctcaacttttaagttcttttctttataattttgctgccccctccctgatggtttgggtttttgtttttgtttttgtttttttttttcatggagctactatgccatcctccctctgtgaggcagagtgactgtcagtgttttgttatgccatgccttgagctgtgggtgtttggcgacaataaggtggttgaatagattggctgagcacacttccacccacctagtgttctcagaggggttatgtgattgtttcaacctggagtgggttgcacccttaatgctttcctctgcaactaaaccgcccacatatatgttcattgaaaaaagtaagaataattctcagcactaacccagaagtagcaaagcagtcagtgatggtgaacattagaggtcaaacatgagttagatgtttgtgggctgacagccatcgtggctatgaccagtactatttacaaagcatgaattcactacaatgctcaactgtttgtttagctttatctcacttggggaatttattcctgtctgctgcattgtaggtagctgggtaggatatatttccacttgctttttaaattagttcttcacctccattgacactcgttttttggttttctccctatagtgtgggttggtgctagacaccagtctgacccacagaatgggagttatttcatccatctttcctccatccttccaaaaaccacatatctacacaaggaaaaatttaatacatctaggaattttttttttaattacaagctatttaaagagatgaatgtggccaaagttttacacaattgaaaataaagtaaaacagacggcatgtgtttaaacctgagtttatcaggcatggcaggaagttgcaggagagagaggcagtgacccaagccagtgcacttgatgttcatggacatatattttttttaaataataaattaaaacattttaaatagaagcataaattgagttgtttgttggcgctgagatactgcccactgtgaaacaaagctttgactagttttttgtttgtttactttcttcaggggggaggggggcaagtttgggtaggaaagaaagcataaatgaacgtgaccctgaggtgaagaggtatatgaacagcctttgcaatgtacaaaaagaaaaaaaaacaaaaaacaacaaaaaaaatagagcaagtgaaaccaaaaatgatgttcttggtgtttttctataatgtagtcttgttagcttttttgttactgtaacaatgctgatctcgaactgtaccaaaatacatggagactaacaaacagaaccacatggaactttcaaactgaaaaaaaaatttgtcacaaaaactttgttgtcatagttaagttgattgtagatggtaattgaatatactcctttgaaaatatttcatcaagtatgtttcctgctcattgtgatacattaaaaaaaaaatatgagcaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:463 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
GeneID:463 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:463 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:463 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:463 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:463 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
GeneID:463 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IGI
GeneID:463 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
GeneID:463 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
GeneID:463 -> Biological process: GO:0007517 [muscle organ development] evidence: IEA
GeneID:463 -> Biological process: GO:0045662 [negative regulation of myoblast differentiation] evidence: IDA
GeneID:463 -> Biological process: GO:0045663 [positive regulation of myoblast differentiation] evidence: IDA
GeneID:463 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:463 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
GeneID:463 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IDA
GeneID:463 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
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