LOCUS       NM_001135726            3175 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens homeobox containing 1 (HMBOX1), transcript variant 2,
            mRNA.
ACCESSION   NM_001135726
VERSION     NM_001135726.1  GI:209180433
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3175)
  AUTHORS   Gong,J., Liu,R., Zhuang,R., Zhang,Y., Fang,L., Xu,Z., Jin,L.,
            Wang,T., Song,C., Yang,K., Wei,Y., Yang,A., Jin,B. and Chen,L.
  TITLE     miR-30c-1* promotes natural killer cell cytotoxicity against human
            hepatoma cells by targeting the transcription factor HMBOX1
  JOURNAL   Cancer Sci. 103 (4), 645-652 (2012)
   PUBMED   22320217
  REMARK    GeneRIF: our results revealed a novel regulatory mechanism:
            miR-30c-1(*) promoted NK cell cytotoxicity against hepatoma cells
            by targeting HMBOX1.
REFERENCE   2  (bases 1 to 3175)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 3175)
  AUTHORS   Wu,L., Zhang,C., Zheng,X., Tian,Z. and Zhang,J.
  TITLE     HMBOX1, homeobox transcription factor, negatively regulates
            interferon-gamma production in natural killer cells
  JOURNAL   Int. Immunopharmacol. 11 (11), 1895-1900 (2011)
   PUBMED   21839858
  REMARK    GeneRIF: HMBOX1 may function as a negative regulator of IFN-gamma
            in NK cells.
REFERENCE   4  (bases 1 to 3175)
  AUTHORS   Wu,L., Zhang,C. and Zhang,J.
  TITLE     HMBOX1 negatively regulates NK cell functions by suppressing the
            NKG2D/DAP10 signaling pathway
  JOURNAL   Cell. Mol. Immunol. 8 (5), 433-440 (2011)
   PUBMED   21706044
  REMARK    GeneRIF: HMBOX1 negatively regulates the expression of NKG2D and
            the activation of the NKG2D/DAP10 signaling pathway in NK cells.
REFERENCE   5  (bases 1 to 3175)
  AUTHORS   Aghai,Z.H., Saslow,J.G., Meniru,C., Porter,C., Eydelman,R.,
            Bhat,V., Stahl,G., Sannoh,S., Pyon,K., Hewitt,C. and Bhandari,V.
  TITLE     High-mobility group box-1 protein in tracheal aspirates from
            premature infants: relationship with bronchopulmonary dysplasia and
            steroid therapy
  JOURNAL   J Perinatol 30 (9), 610-615 (2010)
   PUBMED   20182437
  REMARK    GeneRIF: higher HMGB1(homeobox containing 1) levels in Tracheal
            aspirates are associated with the development of bronchopulmonary
            dysplasia or death in ventilated premature infants.
REFERENCE   6  (bases 1 to 3175)
  AUTHORS   Zhang,M., Chen,S., Li,Q., Ling,Y., Zhang,J. and Yu,L.
  TITLE     Characterization of a novel human HMBOX1 splicing variant lacking
            the homeodomain and with attenuated transcription repressor
            activity
  JOURNAL   Mol. Biol. Rep. 37 (6), 2767-2772 (2010)
   PUBMED   19757162
  REMARK    GeneRIF: These findings suggest a distinct role of HMBOX1b, and the
            control of mRNA splicing might be involved in homeobox genes
            regulation.
REFERENCE   7  (bases 1 to 3175)
  AUTHORS   Dai,J., Wu,L., Zhang,C., Zheng,X., Tian,Z. and Zhang,J.
  TITLE     Recombinant expression of a novel human transcriptional repressor
            HMBOX1 and preparation of anti-HMBOX1 monoclonal antibody
  JOURNAL   Cell. Mol. Immunol. 6 (4), 261-268 (2009)
   PUBMED   19728927
  REMARK    GeneRIF: decreased expression in hepatic carcinoma
REFERENCE   8  (bases 1 to 3175)
  AUTHORS   De Marco,A., Biancotto,C., Knezevich,A., Maiuri,P., Vardabasso,C.
            and Marcello,A.
  TITLE     Intragenic transcriptional cis-activation of the human
            immunodeficiency virus 1 does not result in allele-specific
            inhibition of the endogenous gene
  JOURNAL   Retrovirology 5, 98 (2008)
   PUBMED   18983639
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3175)
  AUTHORS   Chen,S., Saiyin,H., Zeng,X., Xi,J., Liu,X., Li,X. and Yu,L.
  TITLE     Isolation and functional analysis of human HMBOX1, a homeobox
            containing protein with transcriptional repressor activity
  JOURNAL   Cytogenet. Genome Res. 114 (2), 131-136 (2006)
   PUBMED   16825764
  REMARK    GeneRIF: Hmbox1 is widely expressed in pancreas and the expression
            of this gene can also be detected in pallium, hippocampus and
            hypothalamus
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290683.1 and AC108449.5.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290683.1, AY522342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088, ERS025098 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2053              AK290683.1         1-2053
            2054-3175           AC108449.5         53541-54662
FEATURES             Location/Qualifiers
     source          1..3175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..3175
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="homeobox containing 1"
                     /db_xref="GeneID:79618"
                     /db_xref="HGNC:26137"
     exon            1..285
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       9
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73554876"
     variation       18..19
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="ggggg"
                     /db_xref="dbSNP:150724930"
     variation       28
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371361728"
     variation       124
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:13281590"
     variation       188
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374804523"
     variation       268
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367871343"
     exon            286..365
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       298
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190364776"
     variation       328
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375170302"
     misc_feature    337..339
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="upstream in-frame stop codon"
     variation       338
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143238324"
     CDS             343..1605
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="homeobox telomere-binding protein 1;
                     homeobox-containing protein PBHNF"
                     /codon_start=1
                     /product="homeobox-containing protein 1"
                     /protein_id="NP_001129198.1"
                     /db_xref="GI:209180434"
                     /db_xref="CCDS:CCDS6071.1"
                     /db_xref="GeneID:79618"
                     /db_xref="HGNC:26137"
                     /translation="

MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDKFGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPSNSYDTSPQPCTTNQNGRENNERLSTSNGKMSPTRYHANSMGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRPAPIPIEDPEWRQTPPPVSATSGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIEAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDDSTSHSDHQDPISLAVEMAAVNHTILALARQGANEIKTEALDDD

"
     misc_feature    1144..1362
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1144..1158,1162..1164,1213..1215,1231..1233,
                     1315..1317,1321..1326,1333..1338,1342..1350,1354..1359)
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1150..1152,1159..1161,1324..1326,1333..1338,
                     1345..1347)
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     variation       357
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369410329"
     exon            366..842
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       455
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372949481"
     variation       476
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377394078"
     variation       477
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368975966"
     variation       480
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150056601"
     variation       495
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145379672"
     variation       538
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375109128"
     variation       564
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376798312"
     variation       612
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370727503"
     variation       627
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374107196"
     variation       639
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148768782"
     variation       761
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113918455"
     variation       766
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111980547"
     variation       798
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367563195"
     variation       836
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201679029"
     exon            843..928
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     exon            929..1039
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       944
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374483267"
     variation       997
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144731490"
     variation       1011
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147891204"
     exon            1040..1193
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1041
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372681580"
     variation       1069
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376040742"
     variation       1075
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370049630"
     variation       1089
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373691508"
     variation       1111
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371498035"
     variation       1137
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201671682"
     exon            1194..1276
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1249
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372399969"
     exon            1277..1372
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1279
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57483862"
     exon            1373..1467
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     exon            1468..3175
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /inference="alignment:Splign:1.39.8"
     variation       1542
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377441971"
     variation       1559
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371243883"
     variation       1572
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202238043"
     variation       1573
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141568231"
     variation       1587
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370641360"
     variation       1609
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376300184"
     variation       1690
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142408867"
     variation       1694
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185761956"
     variation       1698
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11831"
     variation       1756
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150865526"
     variation       1807..1808
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="ggtt"
                     /db_xref="dbSNP:3830316"
     variation       1808..1809
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="aacc"
                     /db_xref="dbSNP:35389793"
     variation       1809..1810
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="ccaa"
                     /db_xref="dbSNP:146960848"
     variation       1817..1818
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="acca"
                     /replace="ccaa"
                     /db_xref="dbSNP:5890436"
     variation       1818..1819
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="ccaa"
                     /db_xref="dbSNP:34303559"
     variation       1819..1820
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="caac"
                     /db_xref="dbSNP:72378921"
     variation       1823..1824
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="aacc"
                     /db_xref="dbSNP:34984916"
     variation       1826
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:73669467"
     variation       1934
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139785494"
     variation       1937
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374383298"
     variation       1963
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144497394"
     STS             2009..2254
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /standard_name="WI-20805"
                     /db_xref="UniSTS:52353"
     variation       2027
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14015"
     variation       2143..2145
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="tat"
                     /db_xref="dbSNP:373733278"
     variation       2180
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14118"
     STS             2191..2331
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /standard_name="D8S2113"
                     /db_xref="UniSTS:57588"
     variation       2209
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146433919"
     variation       2302
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140779972"
     variation       2315
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187475748"
     variation       2343..2348
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="gtcatt"
                     /db_xref="dbSNP:375419031"
     variation       2348..2349
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:372815934"
     variation       2348
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1128136"
     variation       2349..2356
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="aaaaaaaa"
                     /db_xref="dbSNP:200587602"
     variation       2349
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="a"
                     /replace="aaaaaaaa"
                     /db_xref="dbSNP:11356150"
     variation       2349
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:78932143"
     variation       2357
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace=""
                     /replace="a"
                     /replace="aaaaaaaa"
                     /db_xref="dbSNP:34577722"
     variation       2368
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74597687"
     variation       2371
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:62502811"
     variation       2397
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:79251998"
     variation       2398
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:80024799"
     variation       2456
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10088428"
     variation       2560
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149659731"
     STS             3014..3152
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /standard_name="RH103807"
                     /db_xref="UniSTS:98132"
     variation       3091
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373069277"
     variation       3094
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192657387"
ORIGIN      

tgttgatatcaatatggcggttgtcagccagacaaagacagtcagtctgatgtgattgagacaagggaggtttttcagggggagactgggagataggggcctcccctcccccttctcctcttcctgcgccggcctcaacccctccccagtcccctcccgacgggcgccccacgcggaagacacccctccccctcccgccttccctcctccctatctcagcccttcgtactgggacgttggggagggggctgtgccgggcggagagaactcagcgaggattctgagaatggtagataacgcagatcatctctggaaaggatattgatccgcctcatgtaaagtatgcttagttcctttccagtggttttgctggaaaccatgtctcattatacagatgaacccagatttaccatagagcagatagatctgcttcagcgacttcggcgtactggaatgactaaacatgaaattctccatgccttggaaactttggaccgtcttgatcaagagcatagtgacaagtttggaagaaggtccagctatggaggaagttcatatgggaatagtactaacaatgtcccagcatcttcctctacagctacagcttccacacagacgcagcattcgggaatgtccccgtcacctagcaacagttatgatacttccccacagccttgcactaccaatcaaaatgggagggagaataatgagcgattatctacatccaatggaaagatgtcaccaactcgctaccatgcaaacagcatgggtcagaggtcatacagttttgaagcctcagaagaggacctagatgtagatgataaagtggaagaattaatgaggagggacagcagtgtgataaaagaggaaatcaaagcctttcttgccaatcggaggatttcccaagcagttgttgcacaggtaacaggtatcagtcagagccggatctctcattggctgttgcagcagggatcagacctgagtgaacagaagaaaagagcattttaccgatggtatcaacttgagaagacaaaccctggcgctacactaagtatgagaccagcccccattccaatagaggaccctgaatggagacaaacgcctcccccagtctctgccacatctggtactttccgactgcgacgagggagtcgatttacctggagaaaggagtgcctggctgttatggaaagttacttcaatgagaatcaatacccagatgaagcaaagagggaagaaattgcaaacgcttgcaatgcagttatacagaagccaggcaaaaagctgtcagatctggaaagagttacctccctgaaagtatataattggtttgctaacagaaggaaggagatcaagaggagagccaatattgaagcagcaatcctggagagtcatgggatagatgtgcagagtccaggaggccactcaaacagtgatgatgtcgacgggaatgactactctgagcaggatgacagtacgagccatagtgaccaccaagaccccatctcattagctgtggaaatggcagcagtcaaccacactatcttggcattggcccgacaaggagccaacgaaatcaagacagaggccctggatgatgactgatcagggaggttaaacatgacaagttaacttagtttagacgtagcaccttagcagactttcctcggtccttaacatgtgttcttacagtataacttgcagtttcttgtatgtcaggtagctgttagggtcttgttctgtgaagatggcatggtgccctcagcctttgcatatactctctcagtattaactcccagtaaataataaccaaccaaccaaccaaacttccctctcccagcccccgaggctagaaaatcttgctgctccgtcttagcattccaagaaagtgcttccaggtatttagatagccctcagttctcaaatattagactacgtgtaaaatcttgggtacctttagattcttgtaacactagtctgtactcccttttccttccccaagactgataggatgcaagctgaggtcgtggcacaggaatgacagacaccatttggggagtatccacagagtcaaaggaacactagaatccccacctcagcgtgaggataattgatttccagctgcaataagccgtgcctcattatagccacactgtggctagattatacttctttgggtgctgtgctaagaatgtcaatggaaaaagccgatctcagattttgtttgaagttaacatgcctgacacagacatcctttcctctcacaagctgtgtgacttagtagataaaatactgccttctgcctttgggaccatgattaaaaacaaagacaaaaaccaaaagtcattaaaaaaaaaaaaaaaaaaaacccagcttgagagcattggaaaaaaaaaatatgagctgaatgtctaatggatgctaagtccagttttcagaaccactgtacattccacggcacagttagcagtgcctgcctggaaaagttttggaggtcatcgtggaagttgctttgcctcctgtcagtgtcccctttccctgctaccaaaaaagtctttcaaggatggagctaaggtcaaaaatgagtgaaaaaacttgcagtgtttgtatccattaaacggaagccccctcactctgagaggtcactagaggacttcatagtggggttgtgctgcttatcacagatgcagacacttgcccagataggagcagagaaaagcaggggacgtttcctactcacattgtggctgtatgagaacacgatgggactgctttgctgttctctttactctgtccttggagaggtgtgaaaagctgtattgctacaggcaatttatttaataattggaagccatattgataatggatgtggtaatatttgtaaagtttaatctactttaagcggcagtaactaatggaatttttttccttgatcacatatgtagcacttttgttactttttaaagatatttatatttgataaatctttttttcattttgagaactcaaaataccaaacagtgaacttgcattctaaagtcaccctgtgatcaccttgtcatctagtagcaaaatgatgaactattcatgcatcaaagaaaattacatctgctggccttgtatgaaaatgatctcttggcatcccgattaaatgacacactgtcactgtgggtaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:79618 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:79618 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:79618 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:79618 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:79618 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:79618 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:79618 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA