GGRNA | NM_001131010.2

LOCUS       NM_001131010            4054 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens SATB homeobox 1 (SATB1), transcript variant 2, mRNA.
ACCESSION   NM_001131010
VERSION     NM_001131010.2  GI:306518682
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4054)
  AUTHORS   Zhang,J., Zhang,B., Zhang,X., Sun,Y., Wei,X., McNutt,M.A., Lu,S.,
            Liu,Y., Zhang,D., Wang,M., Lin,Z. and Niu,N.
  TITLE     SATB1 expression is associated with biologic behavior in colorectal
            carcinoma in vitro and in vivo
  JOURNAL   PLoS ONE 8 (1), E47902 (2013)
   PUBMED   23326301
  REMARK    GeneRIF: Findings suggest that SATB1 (Special AT-rich
            sequence-binding protein 1)is involved in the carcinogenesis,
            development and progression of colorectal cancer.
REFERENCE   2  (bases 1 to 4054)
  AUTHORS   Shukla,S., Sharma,H., Abbas,A., MacLennan,G.T., Fu,P.,
            Danielpour,D. and Gupta,S.
  TITLE     Upregulation of SATB1 is associated with prostate cancer
            aggressiveness and disease progression
  JOURNAL   PLoS ONE 8 (1), E53527 (2013)
   PUBMED   23308245
  REMARK    GeneRIF: SATB1 has ability to promote prostate cancer
            aggressiveness through epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 4054)
  AUTHORS   Ordinario,E., Han,H.J., Furuta,S., Heiser,L.M., Jakkula,L.R.,
            Rodier,F., Spellman,P.T., Campisi,J., Gray,J.W., Bissell,M.J.,
            Kohwi,Y. and Kohwi-Shigematsu,T.
  TITLE     ATM suppresses SATB1-induced malignant progression in breast
            epithelial cells
  JOURNAL   PLoS ONE 7 (12), E51786 (2012)
   PUBMED   23251624
  REMARK    GeneRIF: These data indicate a novel role for ATM as a suppressor
            of SATB1-induced malignancy in breast epithelial cells.
REFERENCE   4  (bases 1 to 4054)
  AUTHORS   Nodin,B., Johannesson,H., Wangefjord,S., O'Connor,D.P.,
            Lindquist,K.E., Uhlen,M., Jirstrom,K. and Eberhard,J.
  TITLE     Molecular correlates and prognostic significance of SATB1
            expression in colorectal cancer
  JOURNAL   Diagn Pathol 7, 115 (2012)
   PUBMED   22935204
  REMARK    GeneRIF: SATB1 expression is a factor of poor prognosis in
            colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4054)
  AUTHORS   Oda,M., Kanoh,Y., Watanabe,Y. and Masai,H.
  TITLE     Regulation of DNA replication timing on human chromosome by a
            cell-type specific DNA binding protein SATB1
  JOURNAL   PLoS ONE 7 (8), E42375 (2012)
   PUBMED   22879953
  REMARK    GeneRIF: These results reveal a novel role of SATB1 in cell
            type-specific regulation of replication timing along the
            chromosome.
REFERENCE   6  (bases 1 to 4054)
  AUTHORS   Reddy,P.H., Stockburger,E., Gillevet,P. and Tagle,D.A.
  TITLE     Mapping and characterization of novel (CAG)n repeat cDNAs from
            adult human brain derived by the oligo capture method
  JOURNAL   Genomics 46 (2), 174-182 (1997)
   PUBMED   9417904
REFERENCE   7  (bases 1 to 4054)
  AUTHORS   Xu,L., Deng,H.X., Xia,J.H., Yang,Y., Fan,C.H., Hung,W.Y. and
            Siddque,T.
  TITLE     Assignment of SATB1 to human chromosome band 3p23 by in situ
            hybridization
  JOURNAL   Cytogenet. Cell Genet. 77 (3-4), 205-206 (1997)
   PUBMED   9284917
REFERENCE   8  (bases 1 to 4054)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   9  (bases 1 to 4054)
  AUTHORS   Nakagomi,K., Kohwi,Y., Dickinson,L.A. and Kohwi-Shigematsu,T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol. Cell. Biol. 14 (3), 1852-1860 (1994)
   PUBMED   8114718
REFERENCE   10 (bases 1 to 4054)
  AUTHORS   Dickinson,L.A., Joh,T., Kohwi,Y. and Kohwi-Shigematsu,T.
  TITLE     A tissue-specific MAR/SAR DNA-binding protein with unusual binding
            site recognition
  JOURNAL   Cell 70 (4), 631-645 (1992)
   PUBMED   1505028
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB141938.1, BC001744.1,
            AK127242.1, AA001621.1 and DA938384.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 10, 2010 this sequence version replaced gi:196114998.
            
            Summary: This gene encodes a matrix protein which binds nuclear
            matrix and scaffold-associating DNAs through a unique nuclear
            architecture. The protein recruits chromatin-remodeling factors in
            order to regulate chromatin structure and gene expression. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate exon in the 3' coding region, compared to
            variant 3. Isoform 1 has a shorter C-terminus, compared to isoform
            2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                DB141938.1         1-61
            62-2959             BC001744.1         1-2898
            2960-3752           AK127242.1         4467-5259
            3753-3921           AA001621.1         324-492
            3922-4054           DA938384.1         473-605
FEATURES             Location/Qualifiers
     source          1..4054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p23"
     gene            1..4054
                     /gene="SATB1"
                     /note="SATB homeobox 1"
                     /db_xref="GeneID:6304"
                     /db_xref="HGNC:10541"
                     /db_xref="MIM:602075"
     exon            1..209
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     exon            210..444
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    225..227
                     /gene="SATB1"
                     /note="upstream in-frame stop codon"
     CDS             234..2525
                     /gene="SATB1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     special AT-rich sequence binding protein 1 (binds to
                     nuclear matrix/scaffold-associating DNA); DNA-binding
                     protein SATB1; special AT-rich sequence-binding protein 1"
                     /codon_start=1
                     /product="DNA-binding protein SATB1 isoform 1"
                     /protein_id="NP_001124482.1"
                     /db_xref="GI:196114999"
                     /db_xref="CCDS:CCDS2631.1"
                     /db_xref="GeneID:6304"
                     /db_xref="HGNC:10541"
                     /db_xref="MIM:602075"
                     /translation="

MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGAKMQGVPLKHSGHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVADMLQDVYHVVTLKIQLHSCPKLEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPLPNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKPLEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQSLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLISTPPSRPPQVKTATIATERNGKPENNTMNINASIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRWKEDPSPENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQQQQQQQQAPPPPQPQQQPQTGPRLPPRQPTVASPAESDEENRQKTRPRTKISVEALGILQSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEYKEEELLKDLEESVQDKNTNTLFSVKLEEELSVEGNTDINTDLKD

"
     misc_feature    291..353
                     /gene="SATB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01826.1);
                     Region: Nuclear localization signal"
     misc_feature    453..740
                     /gene="SATB1"
                     /note="N-terminal domain of SATB1 and similar proteins;
                     Region: SATB1_N; cd11585"
                     /db_xref="CDD:211426"
     misc_feature    order(456..458,462..464,513..527,531..533,627..629,
                     633..635,642..647,663..674,696..701,708..716,720..725)
                     /gene="SATB1"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:211426"
     misc_feature    501..845
                     /gene="SATB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01826.1);
                     Region: PDZ-like dimerization domain"
     misc_feature    639..641
                     /gene="SATB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (Q01826.1); acetylation site"
     misc_feature    648..662
                     /gene="SATB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01826.1);
                     Region: Protein interaction"
     misc_feature    786..788
                     /gene="SATB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q01826.1); phosphorylation site"
     misc_feature    903..1067
                     /gene="SATB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01826.1);
                     Region: Nuclear matrix targeting sequence (NMTS)"
     misc_feature    993..998
                     /gene="SATB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage, by caspases; propagated from
                     UniProtKB/Swiss-Prot (Q01826.1); cleavage site"
     misc_feature    1320..1577
                     /gene="SATB1"
                     /note="CUT domain; Region: CUT; pfam02376"
                     /db_xref="CDD:202226"
     misc_feature    1431..1463
                     /gene="SATB1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q01826.1);
                     Region: Matrix attachment region (MAR) DNA-binding"
     misc_feature    1686..1946
                     /gene="SATB1"
                     /note="CUT domain; Region: CUT; pfam02376"
                     /db_xref="CDD:202226"
     misc_feature    2169..2345
                     /gene="SATB1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(2169..2180,2184..2186,2238..2240,2256..2258,
                     2295..2297,2301..2306,2313..2318,2322..2330,2334..2339)
                     /gene="SATB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(2172..2174,2181..2183,2304..2306,2313..2318,
                     2325..2327)
                     /gene="SATB1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            445..621
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     exon            622..748
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     exon            749..872
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     exon            873..984
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     exon            985..1439
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     exon            1440..1652
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     variation       1619
                     /gene="SATB1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2229261"
     exon            1653..1808
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     exon            1809..2012
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     STS             1867..1994
                     /gene="SATB1"
                     /standard_name="SHGC-76756"
                     /db_xref="UniSTS:75453"
     STS             1895..2156
                     /gene="SATB1"
                     /standard_name="G64287"
                     /db_xref="UniSTS:158642"
     exon            2013..4054
                     /gene="SATB1"
                     /inference="alignment:Splign:1.39.8"
     STS             2208..3060
                     /gene="SATB1"
                     /standard_name="SATB1_8610"
                     /db_xref="UniSTS:468672"
     STS             2629..2815
                     /gene="SATB1"
                     /standard_name="D3S4171"
                     /db_xref="UniSTS:29541"
     STS             2650..2817
                     /gene="SATB1"
                     /standard_name="SHGC-8047"
                     /db_xref="UniSTS:7660"
     STS             2763..2929
                     /gene="SATB1"
                     /standard_name="STS-M97287"
                     /db_xref="UniSTS:21723"
     STS             2791..2932
                     /gene="SATB1"
                     /standard_name="RH18154"
                     /db_xref="UniSTS:209606"
     STS             3755..4025
                     /gene="SATB1"
                     /standard_name="SHGC-148967"
                     /db_xref="UniSTS:176709"
     variation       3977
                     /gene="SATB1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3935618"
ORIGIN

agagctatgacctgatttgtgacgcaccctcagaactgcagtaatggtccagctgcttcacaggcaactggtaaccacctcatttggggatgtttctgccttgctagcagtgccagagagaacttcatcattgtcacctcatcaaagactactttttcagacatctcctgtagggctagattcagagagcagcttctgatatttggagggtgatctttagacagtgactgagtatggatcatttgaacgaggcaactcaggggaaagaacattcagaaatgtctaacaatgtgagtgatccgaagggtccaccagccaagattgcccgcctggagcagaacgggagcccgctaggaagaggaaggcttgggagtacaggtgcaaaaatgcagggagtgcctttaaaacactcgggccatctgatgaaaaccaaccttaggaaaggaaccatgctgccagttttctgtgtggtggaacattatgaaaacgccattgaatatgattgcaaggaggagcatgcagaatttgtgctggtgagaaaggatatgcttttcaaccagctgatcgaaatggcattgctgtctctaggttattcacatagctctgctgcccaggccaaagggctaatccaggttggaaagtggaatccagttccactgtcttacgtgacagatgcccctgatgctacagtagcagatatgcttcaagatgtgtatcatgtggtcacattgaaaattcagttacacagttgccccaaactagaagacttgcctcccgaacaatggtcgcacaccacagtgaggaatgctctgaaggacttactgaaagatatgaatcagagttcattggccaaggagtgccccctttcacagagtatgatttcttccattgtgaacagtacttactatgcaaatgtctcagcagcaaaatgtcaagaatttggaaggtggtacaaacatttcaagaagacaaaagatatgatggttgaaatggatagtctttctgagctatcccagcaaggcgccaatcatgtcaattttggccagcaaccagttccagggaacacagccgagcagcctccatcccctgcgcagctctcccatggcagccagccctctgtccggacacctcttccaaacctgcaccctgggctcgtatcaacacctatcagtcctcaattggtcaaccagcagctggtgatggctcagctgctgaaccagcagtatgcagtgaatagacttttagcccagcagtccttaaaccaacaatacttgaaccaccctccccctgtcagtagatctatgaataagcctttggagcaacaggtttcgaccaacacagaggtgtcttccgaaatctaccagtgggtacgcgatgaactgaaacgagcaggaatctcccaggcggtatttgcacgtgtggcttttaacagaactcagggcttgctttcagaaatcctccgaaaggaagaggaccccaagactgcatcccagtctttgctggtaaaccttcgggctatgcagaatttcttgcagttaccggaagctgaaagagaccgaatataccaggacgaaagggaaaggagcttgaatgctgcctcggccatgggtcctgcccccctcatcagcacaccacccagccgtcctccccaggtgaaaacagctactattgccactgaaaggaatgggaaaccagagaacaataccatgaacattaatgcttccatttatgatgagattcagcaggaaatgaagcgtgctaaagtgtctcaagcactgtttgcaaaggttgcagcaaccaaaagccagggatggttgtgcgagctgttacgctggaaagaagatccttctccagaaaacagaaccctgtgggagaacctctccatgatccgaaggttcctcagtcttcctcagccagaacgtgatgccatttatgaacaggagagcaacgcggtgcatcaccatggcgacaggccgccccacattatccatgttccagcagagcagattcagcaacagcagcagcaacagcaacagcagcagcagcagcagcaggcaccgccgcctccacagccacagcagcagccacagacaggccctcggctccccccacggcaacccacggtggcctctccagcagagtcagatgaggaaaaccgacagaagacccggccacgaacaaaaatttcagtggaagccttgggaatcctccagagtttcatacaagacgtgggcctgtaccctgacgaagaggccatccagactctgtctgcccagctcgaccttcccaagtacaccatcatcaagttctttcagaaccagcggtactatctcaagcaccacggcaaactgaaggacaattccggtttagaggtcgatgtggcagaatataaagaagaggagctgctgaaggatttggaagagagtgtccaagataaaaatactaacacccttttttcagtgaaactagaagaagagctgtcagtggaaggaaacacagacattaatactgatttgaaagactgagataaaagtatttgtttcgttcaacagtgccactggtatttactaacaaaatgaaaagtccaccttgtcttctctcagaaaacctttgttgttcattgtttggccaatgaatcttcaaaaacttgcacaaacagaaaagttggaaaaggataatacagactgcactaaatgttttcctctgttttacaaactgcttggcagccccaggtgaagcatcaaggattgtttggtattaaaatttgtgttcacgggatgcaccaaagtgtgtaccccgtaagcatgaaaccagtgttttttgttttttttttagttcttattccggagcctcaaacaagcattataccttctgtgattatgatttcctctcctataattatttctgtagcactccacactgatctttggaaacttgccccttatttaaaaaaaaaaaagaaaaaaaagagtttgttactctattgtatgttacaaaagaactatagactgtggaatgcagtttaaagatgacatatgccaacaaatgccttgtattatatggcactgccgtaattcaaatttgtttttattttggaaataaaagttcactgtacttttttttcattctcattgttacatgattttttaaaaaaaggaaaagaaaatgtgaaacacaatttagtcctcattatttatttgtagatcctgcagcatcatgttgtaattaattttttggaagtttccgttaaatgtaatattgcttctcttgttaccatactgattcttttctatttataaatgtattttgatgggcagtaaaacaaagtgtcttaaaagttttaaatagagaaaatgtgctttacacagttgcctataaaaagtgctctatgttatccaagcaattcatactataagcttcactcttattgttgtatgcaatttttactatcatgcaaataagcttaggtaaataaaactaatagatcaccttagaaaattatgcaattaatgtgaaaataattgatgtttgcaatgtgtcttcctttggtttacaatcaattttaaagctacatctgtataaaatttctgtataaaggtgtatttcttttttatgagtttatggctatgaaaacagctattttgttacagctggctgtttttataagtgtatcacaattttctttatgcagaaatgttctgactaggagtggttattgactgtaactacacaattaaaattgtttgtatcgtatgacatggtagggtttgtctgcttatgtgaagtaactaaaggagtcaaaggatggccctctcatttaggtgcatgttaataacttgttatttcactgattttaaaaagagcaattgacaagttacttgaaacactgtaaatttaaatcacaaacacatgctcatttttaaataggtatgaaatttcacaatgaaaataacctgtttggttaacattttgcttaataagtagagataggatggtcaaaagactctccgacaaaaacaaatccagtctctagcagttatgttgttagaatgga

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