GGRNA | NM_001080488.1

LOCUS       NM_001080488            1485 bp    mRNA    linear   PRI 24-MAR-2012
DEFINITION  Homo sapiens one cut homeobox 3 (ONECUT3), mRNA.
ACCESSION   NM_001080488 XM_372702
VERSION     NM_001080488.1  GI:122937423
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1485)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   2  (bases 1 to 1485)
  AUTHORS   Vanhorenbeeck,V., Jacquemin,P., Lemaigre,F.P. and Rousseau,G.G.
  TITLE     OC-3, a novel mammalian member of the ONECUT class of transcription
            factors
  JOURNAL   Biochem. Biophys. Res. Commun. 292 (4), 848-854 (2002)
   PUBMED   11944891
REFERENCE   3  (bases 1 to 1485)
  AUTHORS   Venter,J.C., Adams,M.D., Myers,E.W., Li,P.W., Mural,R.J.,
            Sutton,G.G., Smith,H.O., Yandell,M., Evans,C.A., Holt,R.A.,
            Gocayne,J.D., Amanatides,P., Ballew,R.M., Huson,D.H., Wortman,J.R.,
            Zhang,Q., Kodira,C.D., Zheng,X.H., Chen,L., Skupski,M.,
            Subramanian,G., Thomas,P.D., Zhang,J., Gabor Miklos,G.L.,
            Nelson,C., Broder,S., Clark,A.G., Nadeau,J., McKusick,V.A.,
            Zinder,N., Levine,A.J., Roberts,R.J., Simon,M., Slayman,C.,
            Hunkapiller,M., Bolanos,R., Delcher,A., Dew,I., Fasulo,D.,
            Flanigan,M., Florea,L., Halpern,A., Hannenhalli,S., Kravitz,S.,
            Levy,S., Mobarry,C., Reinert,K., Remington,K., Abu-Threideh,J.,
            Beasley,E., Biddick,K., Bonazzi,V., Brandon,R., Cargill,M.,
            Chandramouliswaran,I., Charlab,R., Chaturvedi,K., Deng,Z., Di
            Francesco,V., Dunn,P., Eilbeck,K., Evangelista,C., Gabrielian,A.E.,
            Gan,W., Ge,W., Gong,F., Gu,Z., Guan,P., Heiman,T.J., Higgins,M.E.,
            Ji,R.R., Ke,Z., Ketchum,K.A., Lai,Z., Lei,Y., Li,Z., Li,J.,
            Liang,Y., Lin,X., Lu,F., Merkulov,G.V., Milshina,N., Moore,H.M.,
            Naik,A.K., Narayan,V.A., Neelam,B., Nusskern,D., Rusch,D.B.,
            Salzberg,S., Shao,W., Shue,B., Sun,J., Wang,Z., Wang,A., Wang,X.,
            Wang,J., Wei,M., Wides,R., Xiao,C., Yan,C., Yao,A., Ye,J., Zhan,M.,
            Zhang,W., Zhang,H., Zhao,Q., Zheng,L., Zhong,F., Zhong,W., Zhu,S.,
            Zhao,S., Gilbert,D., Baumhueter,S., Spier,G., Carter,C.,
            Cravchik,A., Woodage,T., Ali,F., An,H., Awe,A., Baldwin,D.,
            Baden,H., Barnstead,M., Barrow,I., Beeson,K., Busam,D., Carver,A.,
            Center,A., Cheng,M.L., Curry,L., Danaher,S., Davenport,L.,
            Desilets,R., Dietz,S., Dodson,K., Doup,L., Ferriera,S., Garg,N.,
            Gluecksmann,A., Hart,B., Haynes,J., Haynes,C., Heiner,C.,
            Hladun,S., Hostin,D., Houck,J., Howland,T., Ibegwam,C., Johnson,J.,
            Kalush,F., Kline,L., Koduru,S., Love,A., Mann,F., May,D.,
            McCawley,S., McIntosh,T., McMullen,I., Moy,M., Moy,L., Murphy,B.,
            Nelson,K., Pfannkoch,C., Pratts,E., Puri,V., Qureshi,H.,
            Reardon,M., Rodriguez,R., Rogers,Y.H., Romblad,D., Ruhfel,B.,
            Scott,R., Sitter,C., Smallwood,M., Stewart,E., Strong,R., Suh,E.,
            Thomas,R., Tint,N.N., Tse,S., Vech,C., Wang,G., Wetter,J.,
            Williams,S., Williams,M., Windsor,S., Winn-Deen,E., Wolfe,K.,
            Zaveri,J., Zaveri,K., Abril,J.F., Guigo,R., Campbell,M.J.,
            Sjolander,K.V., Karlak,B., Kejariwal,A., Mi,H., Lazareva,B.,
            Hatton,T., Narechania,A., Diemer,K., Muruganujan,A., Guo,N.,
            Sato,S., Bafna,V., Istrail,S., Lippert,R., Schwartz,R., Walenz,B.,
            Yooseph,S., Allen,D., Basu,A., Baxendale,J., Blick,L., Caminha,M.,
            Carnes-Stine,J., Caulk,P., Chiang,Y.H., Coyne,M., Dahlke,C.,
            Mays,A., Dombroski,M., Donnelly,M., Ely,D., Esparham,S., Fosler,C.,
            Gire,H., Glanowski,S., Glasser,K., Glodek,A., Gorokhov,M.,
            Graham,K., Gropman,B., Harris,M., Heil,J., Henderson,S., Hoover,J.,
            Jennings,D., Jordan,C., Jordan,J., Kasha,J., Kagan,L., Kraft,C.,
            Levitsky,A., Lewis,M., Liu,X., Lopez,J., Ma,D., Majoros,W.,
            McDaniel,J., Murphy,S., Newman,M., Nguyen,T., Nguyen,N., Nodell,M.,
            Pan,S., Peck,J., Peterson,M., Rowe,W., Sanders,R., Scott,J.,
            Simpson,M., Smith,T., Sprague,A., Stockwell,T., Turner,R.,
            Venter,E., Wang,M., Wen,M., Wu,D., Wu,M., Xia,A., Zandieh,A. and
            Zhu,X.
  TITLE     The sequence of the human genome
  JOURNAL   Science 291 (5507), 1304-1351 (2001)
   PUBMED   11181995
  REMARK    Erratum:[Science 2001 Jun 5;292(5523):1838]
REFERENCE   4  (bases 1 to 1485)
  AUTHORS   Jacquemin,P., Lannoy,V.J., Rousseau,G.G. and Lemaigre,F.P.
  TITLE     OC-2, a novel mammalian member of the ONECUT class of homeodomain
            transcription factors whose function in liver partially overlaps
            with that of hepatocyte nuclear factor-6
  JOURNAL   J. Biol. Chem. 274 (5), 2665-2671 (1999)
   PUBMED   9915796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC005256.2 and
            AC004755.2.
            On Jan 18, 2007 this sequence version replaced gi:113428036.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1192              AC005256.2         25665-26856
            1193-1485           AC004755.2         8235-8527
FEATURES             Location/Qualifiers
     source          1..1485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1485
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="one cut homeobox 3"
                     /db_xref="GeneID:390874"
                     /db_xref="HGNC:13399"
                     /db_xref="MIM:611294"
     CDS             1..1485
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="one cut domain, family member 3; OC-3;
                     transcription factor ONECUT-3"
                     /codon_start=1
                     /product="one cut domain family member 3"
                     /protein_id="NP_001073957.1"
                     /db_xref="GI:122937424"
                     /db_xref="CCDS:CCDS45900.1"
                     /db_xref="GeneID:390874"
                     /db_xref="HGNC:13399"
                     /db_xref="MIM:611294"
                     /translation="

MELSLESLGGLHSVAHAQAGELLSPGHARSAAAQHRGLVAPGRPGLVAGMASLLDGGGGGGGGGAGGAGGAGSAGGGADFRGELAGPLHPAMGMACEAPGLGGTYTTLTPLQHLPPLAAVADKFHQHAAAAAVAGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALASVGHLYGPYGKELPAMGSPLSPLPNALPPALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLLPPAAFEPHAALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAGAHGPHGGGGGPGGSGGGPSAGAAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTAPGGPAGATATFSKA

"
     misc_feature    955..1194
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="CUT domain; Region: CUT; pfam02376"
                     /db_xref="CDD:202226"
     misc_feature    1243..1419
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1243..1257,1261..1263,1312..1314,1330..1332,
                     1369..1371,1375..1380,1387..1392,1396..1404,1408..1413)
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1249..1251,1258..1260,1378..1380,1387..1392,
                     1399..1401)
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            1..1192
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /inference="alignment:Splign:1.39.8"
     variation       435
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148506212"
     variation       475
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:113059807"
     variation       930
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:188859576"
     variation       954
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370471416"
     variation       1047
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374879630"
     variation       1121
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377321907"
     exon            1193..1485
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /inference="alignment:Splign:1.39.8"
     variation       1224
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200909698"
     variation       1301
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375969253"
     variation       1334
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201566510"
     variation       1344
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12977335"
     variation       1448..1449
                     /gene="ONECUT3"
                     /gene_synonym="OC3"
                     /replace=""
                     /replace="cc"
                     /db_xref="dbSNP:140318443"
ORIGIN

atggagctgagcctggagagcctggggggcctgcacagcgtggcccacgcgcaggcgggcgagctgctgagcccgggccacgcgcgctcggcggcggcgcagcaccgcggcctggtggcgcccgggcgcccgggcctggtggccggcatggcgagcctgctggacggcggcggcggcggcggcggtgggggcgccgggggcgcgggcggcgcgggcagcgcgggcggcggcgcggacttccgcggggaactggcgggcccgctgcacccggcaatgggcatggcctgcgaggcgccgggcctgggcggcacctacacgacgctcacgcccctgcagcacctgccgccgctcgcggccgtggccgacaagttccaccagcacgcggcggccgcggccgtggccggggcgcacggcggccatccccacgcgcacccgcacccggcggccgcgccgcccccgccacccccgccgcagcgtctggcggccagcgtgagcggcagcttcaccctcatgcgcgacgagcgggcggcgctcgcctccgtgggccacctctacggaccctacggcaaggagctgcccgccatggggtcgccgctgtcgccgctgcccaacgcgctgccgcccgcgctgcacggcgccccgcagcccccgccgccgccaccacccccgccgctggccgcctacggcccgccaggccacctggctggggacaagctgctgccgcccgccgccttcgagccgcacgccgcgctgctgggacgcgcggaggacgcactggcccgcgggctgcccggaggcggcggcggcacaggcagcggcggagcgggcagcgggagcgccgcggggctgctggcgccgctgggcgggctggcggcggccggggcgcacgggccgcacgggggaggcggcggccccggcgggagcggcggcggccccagcgcgggcgcagcggccgaggagatcaacaccaaggaggtggcgcagcgcatcacggcggagctgaagcgctacagcatcccgcaggcaatcttcgcgcagcggatcctgtgtcgctctcagggcacgctctccgacctgctgcgcaaccccaagccgtggagcaagctcaaatccggccgcgagaccttccgcaggatgtggaagtggctgcaggagccagagttccagcgcatgtcggcgctgcgcttggcagcctgcaagcgcaaggaacaggagcagcagaaggagcgcgccctgcagcccaagaagcagcgcctggtgttcaccgacctgcagcgacgcacgctgatcgccatcttcaaggagaacaagcggccgtccaaggagatgcaggtcaccatctcgcagcagctcggcttggagctcaacaccgtcagcaacttcttcatgaacgcgcggcgccgctgcatgaaccgctgggctgaggagcccagcacggcccccgggggccccgccggcgccacggccactttctccaaggcctga

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