GGRNA | NM_001080461.1

LOCUS       NM_001080461            1596 bp    mRNA    linear   PRI 18-APR-2013
DEFINITION  Homo sapiens UNC homeobox (UNCX), mRNA.
ACCESSION   NM_001080461 NM_001085389 XM_294209 XM_941336
VERSION     NM_001080461.1  GI:122937320
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Okada,Y., Sim,X., Go,M.J., Wu,J.Y., Gu,D., Takeuchi,F.,
            Takahashi,A., Maeda,S., Tsunoda,T., Chen,P., Lim,S.C., Wong,T.Y.,
            Liu,J., Young,T.L., Aung,T., Seielstad,M., Teo,Y.Y., Kim,Y.J.,
            Lee,J.Y., Han,B.G., Kang,D., Chen,C.H., Tsai,F.J., Chang,L.C.,
            Fann,S.J., Mei,H., Rao,D.C., Hixson,J.E., Chen,S., Katsuya,T.,
            Isono,M., Ogihara,T., Chambers,J.C., Zhang,W., Kooner,J.S.,
            Albrecht,E., Yamamoto,K., Kubo,M., Nakamura,Y., Kamatani,N.,
            Kato,N., He,J., Chen,Y.T., Cho,Y.S., Tai,E.S. and Tanaka,T.
  CONSRTM   KidneyGen Consortium; CKDGen Consortium; GUGC consortium
  TITLE     Meta-analysis identifies multiple loci associated with kidney
            function-related traits in east Asian populations
  JOURNAL   Nat. Genet. 44 (8), 904-909 (2012)
   PUBMED   22797727
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   Venter,J.C., Adams,M.D., Myers,E.W., Li,P.W., Mural,R.J.,
            Sutton,G.G., Smith,H.O., Yandell,M., Evans,C.A., Holt,R.A.,
            Gocayne,J.D., Amanatides,P., Ballew,R.M., Huson,D.H., Wortman,J.R.,
            Zhang,Q., Kodira,C.D., Zheng,X.H., Chen,L., Skupski,M.,
            Subramanian,G., Thomas,P.D., Zhang,J., Gabor Miklos,G.L.,
            Nelson,C., Broder,S., Clark,A.G., Nadeau,J., McKusick,V.A.,
            Zinder,N., Levine,A.J., Roberts,R.J., Simon,M., Slayman,C.,
            Hunkapiller,M., Bolanos,R., Delcher,A., Dew,I., Fasulo,D.,
            Flanigan,M., Florea,L., Halpern,A., Hannenhalli,S., Kravitz,S.,
            Levy,S., Mobarry,C., Reinert,K., Remington,K., Abu-Threideh,J.,
            Beasley,E., Biddick,K., Bonazzi,V., Brandon,R., Cargill,M.,
            Chandramouliswaran,I., Charlab,R., Chaturvedi,K., Deng,Z., Di
            Francesco,V., Dunn,P., Eilbeck,K., Evangelista,C., Gabrielian,A.E.,
            Gan,W., Ge,W., Gong,F., Gu,Z., Guan,P., Heiman,T.J., Higgins,M.E.,
            Ji,R.R., Ke,Z., Ketchum,K.A., Lai,Z., Lei,Y., Li,Z., Li,J.,
            Liang,Y., Lin,X., Lu,F., Merkulov,G.V., Milshina,N., Moore,H.M.,
            Naik,A.K., Narayan,V.A., Neelam,B., Nusskern,D., Rusch,D.B.,
            Salzberg,S., Shao,W., Shue,B., Sun,J., Wang,Z., Wang,A., Wang,X.,
            Wang,J., Wei,M., Wides,R., Xiao,C., Yan,C., Yao,A., Ye,J., Zhan,M.,
            Zhang,W., Zhang,H., Zhao,Q., Zheng,L., Zhong,F., Zhong,W., Zhu,S.,
            Zhao,S., Gilbert,D., Baumhueter,S., Spier,G., Carter,C.,
            Cravchik,A., Woodage,T., Ali,F., An,H., Awe,A., Baldwin,D.,
            Baden,H., Barnstead,M., Barrow,I., Beeson,K., Busam,D., Carver,A.,
            Center,A., Cheng,M.L., Curry,L., Danaher,S., Davenport,L.,
            Desilets,R., Dietz,S., Dodson,K., Doup,L., Ferriera,S., Garg,N.,
            Gluecksmann,A., Hart,B., Haynes,J., Haynes,C., Heiner,C.,
            Hladun,S., Hostin,D., Houck,J., Howland,T., Ibegwam,C., Johnson,J.,
            Kalush,F., Kline,L., Koduru,S., Love,A., Mann,F., May,D.,
            McCawley,S., McIntosh,T., McMullen,I., Moy,M., Moy,L., Murphy,B.,
            Nelson,K., Pfannkoch,C., Pratts,E., Puri,V., Qureshi,H.,
            Reardon,M., Rodriguez,R., Rogers,Y.H., Romblad,D., Ruhfel,B.,
            Scott,R., Sitter,C., Smallwood,M., Stewart,E., Strong,R., Suh,E.,
            Thomas,R., Tint,N.N., Tse,S., Vech,C., Wang,G., Wetter,J.,
            Williams,S., Williams,M., Windsor,S., Winn-Deen,E., Wolfe,K.,
            Zaveri,J., Zaveri,K., Abril,J.F., Guigo,R., Campbell,M.J.,
            Sjolander,K.V., Karlak,B., Kejariwal,A., Mi,H., Lazareva,B.,
            Hatton,T., Narechania,A., Diemer,K., Muruganujan,A., Guo,N.,
            Sato,S., Bafna,V., Istrail,S., Lippert,R., Schwartz,R., Walenz,B.,
            Yooseph,S., Allen,D., Basu,A., Baxendale,J., Blick,L., Caminha,M.,
            Carnes-Stine,J., Caulk,P., Chiang,Y.H., Coyne,M., Dahlke,C.,
            Mays,A., Dombroski,M., Donnelly,M., Ely,D., Esparham,S., Fosler,C.,
            Gire,H., Glanowski,S., Glasser,K., Glodek,A., Gorokhov,M.,
            Graham,K., Gropman,B., Harris,M., Heil,J., Henderson,S., Hoover,J.,
            Jennings,D., Jordan,C., Jordan,J., Kasha,J., Kagan,L., Kraft,C.,
            Levitsky,A., Lewis,M., Liu,X., Lopez,J., Ma,D., Majoros,W.,
            McDaniel,J., Murphy,S., Newman,M., Nguyen,T., Nguyen,N., Nodell,M.,
            Pan,S., Peck,J., Peterson,M., Rowe,W., Sanders,R., Scott,J.,
            Simpson,M., Smith,T., Sprague,A., Stockwell,T., Turner,R.,
            Venter,E., Wang,M., Wen,M., Wu,D., Wu,M., Xia,A., Zandieh,A. and
            Zhu,X.
  TITLE     The sequence of the human genome
  JOURNAL   Science 291 (5507), 1304-1351 (2001)
   PUBMED   11181995
  REMARK    Erratum:[Science 2001 Jun 5;292(5523):1838]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC073094.11.
            On or before Sep 11, 2007 this sequence version replaced
            gi:145966738, gi:113418913, gi:113418425.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY145527.1, HY109188.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AC073094.11        73560-73833
            275-450             AC073094.11        74062-74237
            451-1596            AC073094.11        76374-77519
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..1596
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="UNC homeobox"
                     /db_xref="GeneID:340260"
                     /db_xref="HGNC:33194"
     CDS             1..1596
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="Unc4.1 homeobox; homeobox protein Uncx4.1"
                     /codon_start=1
                     /product="homeobox protein unc-4 homolog"
                     /protein_id="NP_001073930.1"
                     /db_xref="GI:122937321"
                     /db_xref="CCDS:CCDS34583.1"
                     /db_xref="GeneID:340260"
                     /db_xref="HGNC:33194"
                     /translation="

MMDGRLLEHPHAQFGGSLGGVVGFPYPLGHHHVYELAGHQLQSAAAAASVPFSIDGLLGGSCAAAASVVNPTPLLPAACGVGGDGQPFKLSDSGDPDKESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQGRHLHSPGGLSLHSAPSSDSDSGGGGLSPEPPEPPPPAAKGPGAHASGAAGTAPAPPGEPPAPGTCDPAFYPSQRSGAGPQPRPGRPADKDAASCGPGAAVAAVERGAAGLPKASPFSVESLLSDSPPRRKAASNAAAAAAAGLDFAPGLPCAPRTLIGKGHFLLYPITQPLGFLVPQAALKGGAGLEPAPKDAPPAPAVPPAPPAQASFGAFSGPGGAPDSAFARRSPDAVASPGAPAPAPAPFRDLASAAATEGGGGDCADAGTAGPAPPPPAPSPRPGPRPPSPAEEPATCGVPEPGAAAGPSPPEGEELDMD

"
     misc_feature    316..492
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(316..330,334..336,385..387,403..405,442..444,
                     448..453,460..465,469..477,481..486)
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(322..324,331..333,451..453,460..465,472..474)
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            1..274
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /inference="alignment:Splign:1.39.8"
     exon            275..450
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /inference="alignment:Splign:1.39.8"
     variation       298
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147792848"
     variation       299
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368326306"
     variation       376
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144353491"
     variation       381
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370880641"
     variation       414
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141776730"
     variation       435
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373600539"
     exon            451..1596
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /inference="alignment:Splign:1.39.8"
     variation       460
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200677757"
     variation       510
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369366233"
     variation       514
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199756495"
     variation       519
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202025313"
     variation       561
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:13308801"
     variation       579
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375923495"
     variation       584
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368899980"
     variation       585
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145518214"
     variation       634
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151119092"
     variation       638
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373988896"
     variation       644
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:80333419"
     variation       653
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376337553"
     variation       718
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200913289"
     variation       795
                     /gene="UNCX"
                     /gene_synonym="UNCX4.1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112828236"
ORIGIN

atgatggacggccgcctcctggaacacccgcatgcccagttcgggggctcgctgggcggcgtggtgggcttcccctacccgctgggccaccaccacgtgtacgagctggccgggcaccagctgcagtcggccgccgccgccgcctcggtgcccttctccatcgacggcctgctcgggggctcgtgcgccgccgccgcctcggtggtcaaccccacgccgctgctgccagccgcctgcggggtcggcggggacggccagcccttcaagctgtcagactcgggggacccggacaaggagagcccgggctgcaagcggcggcgcacccgcaccaacttcaccggctggcagctggaggagctggagaaggcgttcaacgagagccactatcccgacgtgttcatgcgcgaggcgctggcgctgcgcctagacctggtcgagtcccgagttcaggtctggttccaaaaccgccgggccaagtggaggaagaaggagaacacgaaaaagggcccggggcggccggcgcacaactcgcacccgaccacgtgcagcggcgagcccatggacccggaggagatcgcgcgcaaggagctggagaagatggagaagaagaagcgcaagcacgagaagaagctgctgaagagccagggccgccacttgcactcgcccggcggcctgtccctgcacagcgcgcccagctccgacagcgacagcggcggcggcggcctgtctccggagccgcccgagccgccgccgcccgccgccaagggccccggagcgcacgcctcgggcgccgcggggaccgcgcccgcccctcccggcgagccgcctgcacccggcacctgcgaccccgccttctacccgagccaaagaagcggcgccggcccacagccgcgcccaggtcgccctgcggacaaggacgcggcctcgtgcgggccaggggccgctgtggcggcggtggagcgcggcgccgcggggctgcccaaggccagcccattcagcgtggagagcctcctgtccgactcgccgccgcgccggaaagccgcttccaacgccgccgccgccgccgccgcggggctggacttcgcgcccgggctgccgtgcgcgccgcggaccctgatcggcaagggccacttcctcctctaccccatcacgcagccgctcggcttcctggtgccgcaggccgcgctcaagggcggcgcgggcctggagccggcgcccaaggacgcgccgcccgcgcccgccgtgccgcccgcgccgcctgcccaggccagtttcggggccttctcggggcccggcggcgccccggactcggccttcgcgcgtcgcagccccgacgccgtcgcctccccgggggccccagccccggccccggcgcctttccgggacctcgcctcggcagcggctaccgagggcggcggcggggactgcgcggacgcggggaccgccggccccgcgcccccgccgcccgcgccgtcgcccaggcccggccctcggcctcccagccccgccgaggagccggccacctgcggggttcccgagcctggcgcggcggccggacccagcccgccggagggcgaggagctggacatggactga

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