LOCUS       NM_001004329            2722 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens developing brain homeobox 2 (DBX2), mRNA.
ACCESSION   NM_001004329 XM_495922
VERSION     NM_001004329.2  GI:116174747
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2722)
  AUTHORS   Pierani,A., Moran-Rivard,L., Sunshine,M.J., Littman,D.R.,
            Goulding,M. and Jessell,T.M.
  TITLE     Control of interneuron fate in the developing spinal cord by the
            progenitor homeodomain protein Dbx1
  JOURNAL   Neuron 29 (2), 367-384 (2001)
   PUBMED   11239429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131230.1, AC089986.25 and AC079033.12.
            On Oct 14, 2006 this sequence version replaced gi:51972229.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-671               AK131230.1         1-671
            672-859             AC089986.25        9285-9472           c
            860-1050            AC089986.25        2006-2196           c
            1051-2722           AC079033.12        148452-150123       c
FEATURES             Location/Qualifiers
     source          1..2722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2722
                     /gene="DBX2"
                     /note="developing brain homeobox 2"
                     /db_xref="GeneID:440097"
                     /db_xref="HGNC:33186"
     misc_feature    <1..1672
                     /gene="DBX2"
                     /note="overlaps bases 1..2005 of clone AC089986"
                     /function="clone overlap"
     exon            1..575
                     /gene="DBX2"
                     /inference="alignment:Splign:1.39.8"
     CDS             173..1192
                     /gene="DBX2"
                     /note="developing brain homeobox protein 2"
                     /codon_start=1
                     /product="homeobox protein DBX2"
                     /protein_id="NP_001004329.2"
                     /db_xref="GI:116174748"
                     /db_xref="CCDS:CCDS31781.1"
                     /db_xref="GeneID:440097"
                     /db_xref="HGNC:33186"
                     /translation="

MLPSAVAAHAGAYWDVVASSALLNLPAAPGFGNLGKSFLIENLLRVGGAPTPRLQPPAPHDPATALATAGAQLRPLPASPVPLKLCPAAEQVSPAGAPYGTRWAFQVLSPSADSARLPGRAPGDRDCTFQPSAPAPSKPFLLSTPPFYSACCGGSCRRPASSTAFPREESMLPLLTQDSNSKARRGILRRAVFSEDQRKALEKMFQKQKYISKTDRKKLAINLGLKESQVKIWFQNRRMKWRNSKEKEVLSNRCIQEVGLQEDPLSRSALGFPSPCPSIWDVPQQHSSPRWRENSPEPSERLIQESSGAPPPEANSLQGALYLCSEEEAGSKGVLTGAV

"
     misc_feature    737..907
                     /gene="DBX2"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(737..745,749..751,800..802,818..820,857..859,
                     863..868,875..880,884..892,896..901)
                     /gene="DBX2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(737..739,746..748,866..868,875..880,887..889)
                     /gene="DBX2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            576..671
                     /gene="DBX2"
                     /inference="alignment:Splign:1.39.8"
     exon            672..859
                     /gene="DBX2"
                     /inference="alignment:Splign:1.39.8"
     variation       683
                     /gene="DBX2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2731038"
     exon            860..2722
                     /gene="DBX2"
                     /inference="alignment:Splign:1.39.8"
     variation       1186
                     /gene="DBX2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1224442"
     STS             1280..1415
                     /gene="DBX2"
                     /standard_name="G31040"
                     /db_xref="UniSTS:27260"
     STS             1308..1443
                     /gene="DBX2"
                     /standard_name="G31040"
     variation       1802
                     /gene="DBX2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1224443"
     variation       2553
                     /gene="DBX2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1224444"
     variation       2655
                     /gene="DBX2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1224445"
ORIGIN      

atcgttccaagtccgccgccgtcccgggtggcctttcctccctgcctggctccgcgcgctccagccctgcgggaggcggcggcgagaagctgcggctctgggtgcggtgcggggcgcccgggcgacaggcgggcgcaaggcgggcgcgcagcagaccggttggcgccgcactatgctccccagcgcggtcgcagcccacgccggtgcgtactgggacgttgtggcttcctccgcgctcctcaacctccccgctgcgcccggctttggcaacctgggcaagagtttcctgatcgagaatttgctgcgggtcgggggcgccccaacgcccaggctgcagccgcccgcgccccacgacccggcgaccgccctggccaccgcgggcgcgcagctccggcccctgcctgctagcccagttcccctaaagctgtgccccgcagccgaacaagttagccccgccggggcgccctacggaacgcggtgggcttttcaagtgctcagtccctctgcggacagtgcgaggctgccgggccgggctccgggggaccgagactgtaccttccagccttcagcgccagcaccttccaaacctttccttctgagcaccccgccattctactcggcgtgctgcggtgggtcctgtcggcgccctgcatcctccactgcttttccaagagaagagagcatgctgcctctcctgacacaggactctaattccaaagctcggaggggcattttaagaagagctgtcttttctgaggaccagagaaaggctctggagaaaatgtttcagaaacagaaatatatcagcaaaacagaccgaaagaaacttgccatcaacttgggactaaaggaatcacaggtgaaaatttggtttcagaacaggaggatgaaatggcggaattccaaagaaaaggaagtgctttccaacaggtgtatccaagaagtaggtcttcaagaggatcccctctcacggtctgctctgggtttcccttctccatgtccttcaatatgggacgtcccccaacagcactcaagtccaagatggagggagaattctccagaaccttcagaaagactaatccaggagagttcaggggcaccacccccagaagcaaattcactgcaaggtgccttatatttatgttctgaagaagaagctggaagcaagggtgtacttactggggctgtctgaatggaagcattcctccgtgttcatttaaaagaacgcttaatagtaacatctggactctaatgccagctagcttgtacctcatcagtgcttagagcctaacaactttggagcgatgtatgaactaatgctttaggaaacccactctagtgttctcttgtttggccctagactcaggcttaatttgtaagtggaatagaatctcccagcaagtatgacagaactgaaaagaaggagagcaacagctggctcggtccctgctctgagtatgtgtatatatgtgtttgtctctatgtgtgtgtatatacataaatatccattaaaatgtattagtagaaactagtttctctttaactattgcattgagtaaattcacttccttttatgtgaagaaaactaccattgacagaatgttattaactttttgaaaataatgtaaaatttggactttagtgcaaactttcataccccaaaaacatgtttttaaaaattctctattttctgacttcttttggtatccagctgtaagtgaattttaacaccttagctcagcagtcctcaacaaatgagccactgctagatacatacactgagaatatatatttaaaatgaacctaacaagcaaattagaagaatttctgtatataactattagtatccttaatctccaagtctctggaccatcgggccatcatgagggagagacccatttaactaataattattttttgatctcttctctgtaaagatgggcctagaccagggtttgcaaaataaaatgcctttaagagcctgtcaggtaaatagagggtatggcccacccagagatatttgagtcaagtaatttttcaaatactgtattggccaaacaaaatgtctatgccaagaagtttgtgacctctggctaagactaaagaaagccgtggtgtcacagttcttaaaatttttctaactggacttaaaaccacaatactaacagaatcaatgatgatttctgtttgcgcttctagttagggactcaattttccacttaggtggcatacactttatatatcaggttatttttatgtattaacaaacaccacacagatgttttgtgttttttgactaccctgaaattgtatctttctaaaattgcatttctggtaacgatttgctgagttaatccagaagtttttactccaggaccaagaagaaattatgtttcactttgaaggaaatgaaacaaaaataggaaatgatgtggttttgcattaaactcttatcaatctgtggacaagaaacactatcagaagttcattaagtggcattttgttagtgagtaagctgcataatgatggtggcttctaatttgctgaactccactagagtctgagaagttaacgtcttttgagggtttagtgtttagaaaagatatttcaggagataacggttttaatcaacagcaggaaattattttgtacgaatagaattggacttggtatgtcaacctgtgtctttaccacatgatcttttacttaaaagtcattttag

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:440097 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IEA
            GeneID:440097 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:440097 -> Cellular component: GO:0005634 [nucleus] evidence: IEA